Obesity remains one of the most pressing global health challenges, and incretin- and amylin-based therapies have transformed the treatment paradigm in the clinic. Yet key biological questions persist across this systems-level disease: the central and peripheral mechanisms driving weight loss, tissue-specific weight loss “quality,” and the pathways underlying efficacy, durability, metabolic resilience, and resolution of cardiometabolic comorbidities.

This Keystone Symposia conference on Obesity Therapeutics: From Biology to Clinical Breakthroughs will address critical gaps at the interface of basic biology and therapeutic innovation, convening thought leaders to define the next-generation priorities in obesity treatment. Plenary sessions extend beyond incretins and amylin to spotlight novel mechanisms, emerging targets, determinants of weight loss quality, and strategies for treating obesity-related comorbidities. Outcomes include new academic-industry collaborations, alignment on high-priority targets, and actionable strategies that will catalyze next-generation discovery and clinical development.

The conference will accelerate mechanistic understanding and translation by integrating systemic physiology, neuroendocrinology, immunometabolism, genetics, and drug discovery. Designed as a highly interactive forum of interdisciplinary researchers, the conference will convene academic researchers, trainees, industry scientists, and clinicians across basic science, metabolism, drug discovery, and translational medicine. This deliberate mix enables connections and insights that would be unattainable within siloed communities.

At a moment when the field is rapidly advancing yet remains biologically complex, this conference is both timely and essential. With the overarching commitment to scientific excellence, this conference offers a unique opportunity to pair mechanistic biology with emerging targets and new clinical insights, helping to influence the next wave of obesity therapeutics.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives