T and B lymphocytes collaborate to generate antibody responses, immune memory, and long-term protection against infection. Dysregulation of these interactions underlies autoimmunity, inflammatory disease, and defective immunity in aging. Despite significant progress, fundamental questions remain unresolved: how germinal center responses are regulated in space and time, how T follicular helper cells differentiate and direct B cell fates, and how tissue-resident T-B cell interactions shape protective and pathogenic immunity. Addressing these gaps is essential for advancing vaccines and immunotherapies.

This Keystone Symposia conference on B and T Cell Collaboration in Health and Disease will bring together basic immunologists, clinician-scientists, and computational biologists to address the most important unresolved questions in adaptive immune cell biology and align them with emerging tools and translational priorities. Discussions will help develop new conceptual frameworks and integrate insights across cellular, tissue, and systems-level studies.

The conference draws on expertise spanning germinal center biology, tissue immunity, autoimmunity, vaccination, infection, aging, allergies, lymphocyte biology, cell-cell communication, and bioinformatics. Bringing these communities together in a single-focused forum creates opportunities for integrative approaches that are difficult to achieve within individual disciplines. The program is designed to encourage exchange and collaboration across these areas. The conference has a joint keynote and two plenary sessions with the Keystone Symposia conference on B Cells in Health and Disease. Since many pathogenic B cell functions and depletion strategies (e.g., CAR T and bispecifics) hinge on T cell interactions, this conference pairing links mechanistic T-B cell crosstalk with its direct translational relevance to autoimmune and malignant B cell disease giving attendees a strategic bridge between basic biology and therapeutic application that neither conference alone would provide.

Although T-B cell interactions are fundamental to adaptive immunity, they remain fragmented across meetings focused on individual cell types, tissues, or diseases. The rapid maturation of single cell and spatial technologies has transformed our ability to dissect these interactions in vivo, creating a unique opportunity to reexamine fundamental concepts. This conference is organized to harness these advances.

Unique Career Development Opportunities

This meeting will feature a Career Roundtable where trainees and early-career investigators will have the opportunity to interact with field leaders from across academic and industry sectors for essential career development advice and networking opportunities. Find out more about Career Roundtables here: https://www.keystonesymposia.org/diversity/career-development-initiatives