RNA Modifications: Bridging Biological Function and Therapeutic Potential
Mar 09–12, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Michaela Frye, Schraga Schwartz, Yunsun Nam, and Eckhard Jankowsky
In Person
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Mar 09–12, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Michaela Frye, Schraga Schwartz, Yunsun Nam, and Eckhard Jankowsky
Michaela Frye, PhD
Deutsches Krebsforschungszentrum
Michaela Frye, Ph.D., is a Professor for Tumour and Cell Biology and deputy scientific director at the German Cancer Research Center (the DKFZ) in Heidelberg. Overall, her work has expanded the understanding of how RNA modifications function as key regulators in gene expression, with profound implications for cancer research and therapeutic interventions. She has extensive experience in organizing scientific conferences, fostering interdisciplinary collaborations, and supporting an array of scientific perspectives in biomedical research.
Schraga Schwartz, PhD
Weizmann Institute of Science
Schraga Schwartz, Ph.D., is an Associate Professor and group leader at the Weizmann Institute of Science. His lab focuses on deciphering the roles played by post-transcriptional modifications on RNA. His work has pioneered approaches for genome-wide approaches to quantify, map, and characterize an array of RNA modifications in health and disease. Dr. Schwartz is the recipient of many research awards and has organized several conferences in the field of RNA biology and epitranscriptomics. He has been a speaker at many scientific meetings, including the Keystone Symposia on RNA Modifications, as well as at Gordon Research Conferences and EMBO Workshops.
Yunsun Nam, PhD
University of Texas Southwestern Medical Center
Yunsun Nam, Ph.D., is an Associate Professor in the Department of Biochemistry at University of Texas Southwestern Medical Center. She is also a member of the Department of Biophysics, Simmons Comprehensive Cancer Center, and the O’Donnell Brain Institute at UT Southwestern. Her research has elucidated the mechanisms of substrate recognition, catalysis, and regulation of multiple RNA methyltransferase enzymes, including how dysregulated specificity and efficiency of RNA modifications are linked to disease. Dr. Nam has co-organized an RNA symposium at UT Southwestern and served on numerous panels in local and international meetings.
Eckhard Jankowsky, PhD
Moderna
Eckhard Jankowsky, Ph.D., is the Vice President of RNA Science at Moderna. Prior to his role at Moderna, he was Professor of Biochemistry and Director of the Center for RNA Science and Therapeutics at Case Western Reserve University. His work has provided new insights into the function of proteins that interact with and remodel RNA and into the regulation of gene expression at the RNA level, specifically for the regulation of translation. Dr. Jankowsky is a frequent Keynote speaker and has served on several organizing committees including the recent mRNA Health Conference 2024.
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In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMonday, March 9, 2026
Fundraising
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Registration
4:00–8:00 PM
Longs Peak Foyer
Welcome Mixer
6:00–8:00 PM
Longs Peak Foyer
Tuesday, March 10, 2026
Breakfast
7:00–8:00 AM
Longs Peak
Welcome Remarks
8:00–8:10 AM
Grays Peak
Keynote Address
8:10–9:00 AM
Grays Peak
Tsutomu Suzuki, University of Tokyo
Expanding Chemical Space of RNA Modifications
Expanding Chemical Space of RNA Modifications
Molecular Mechanisms of RNA Modifications
9:00–11:15 AM
Grays Peak
Yunsun Nam, University of Texas Southwestern Medical Center
Structure and Function of RNA Modifying Protein
Structure and Function of RNA Modifying Protein
Olivier Duss, European Molecular Biology Laboratory
Dynamic RNA Biology at the Single-Molecule Level: Watching how Interconnected Processes Work in Real-Time
Dynamic RNA Biology at the Single-Molecule Level: Watching how Interconnected Processes Work in Real-Time
Sara H. Rouhanifard, Northeastern University
RNA Modifications on the Single Molecular Level and Spatial Transcriptomics
RNA Modifications on the Single Molecular Level and Spatial Transcriptomics
Coffee Break
9:30–9:50 AM
Longs Peak Foyer
Meet the Editors
11:15–12:15 PM
Grays Peak
Poster Setup
12:15–1:00 PM
Longs Peak
On Own for Lunch
12:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Longs Peak
Symposia Spotlight 1
2:30–4:30 PM
Grays Peak
W.S. Sho Goh, Shenzhen Bay Laboratory
I Read, therefore I m6Am: Deciphering m6Am’s functional impact through its Reader & Anti-Reader
I Read, therefore I m6Am: Deciphering m6Am’s functional impact through its Reader & Anti-Reader
Benedetta Ricci, Columbia University
The Dynamic Regulation of YTHDF-dependent m6A-mRNA Decay
The Dynamic Regulation of YTHDF-dependent m6A-mRNA Decay
hemendra singh panwar, Van Andel Institute
Structural Basis of Functional Asymmetry in Eukaryotic H/ACA snoRNPs
Structural Basis of Functional Asymmetry in Eukaryotic H/ACA snoRNPs
Keita Miyoshi, National Institute of Genetics
The Mammalian Rapid tRNA Decay Pathway Is Critical for N⁷‑Methylguanosine-Hypomodified tRNA Degradation under Physiological Conditions
The Mammalian Rapid tRNA Decay Pathway Is Critical for N⁷‑Methylguanosine-Hypomodified tRNA Degradation under Physiological Conditions
Rui Su, City of Hope
Mitochondrial RNA Methylation Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication
Mitochondrial RNA Methylation Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication
Stacy M Horner, Duke University School of Medicine
m⁶A Remodeling During Zika Virus Infection by Isoform-Specific Targeting of METTL3
m⁶A Remodeling During Zika Virus Infection by Isoform-Specific Targeting of METTL3
Jeffrey Mugridge, University of Delaware
How Vitamin C Tunes the Activity and Selectivity of RNA Demethylases to Shape the Epitranscriptome
How Vitamin C Tunes the Activity and Selectivity of RNA Demethylases to Shape the Epitranscriptome
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Language Models Predicting RNA Modifications and Functions
5:00–7:00 PM
Grays Peak
Schraga Schwartz, Weizmann Institute of Science
Computational and Functional Analyses of Modifications
Computational and Functional Analyses of Modifications
Prashant Mali, University of California, San Diego
Transcriptome Engineering Toolsets
Transcriptome Engineering Toolsets
Eduardo Eyras, EMBL Australia, Australian National University
Machine Learning to Study Transcriptomes and Epitranscriptomes in RNA Biology and Cancer.
Machine Learning to Study Transcriptomes and Epitranscriptomes in RNA Biology and Cancer.
Jonathan Goeke, Genome Institute of Singapore
Short Talk: Direct RNA-Seq for unbiased identification of RNA modifying enzymes in large-scale CRISPR screens
Short Talk: Direct RNA-Seq for unbiased identification of RNA modifying enzymes in large-scale CRISPR screens
Social Hour with Dinner
7:00–8:00 PM
Longs Peak
Poster Session 1
7:30–10:00 PM
Longs Peak
Wednesday, March 11, 2026
Breakfast
7:00–8:00 AM
Longs Peak
RNA Therapeutics
8:00–11:00 AM
Grays Peak
Caroline Köhrer, Alltrna
tRNA Therapeutics
tRNA Therapeutics
Peter C. Dedon, Massachusetts Institute of Technology
High Throughput Platforms for Epitranscriptomic Drug Discovery
High Throughput Platforms for Epitranscriptomic Drug Discovery
Eckhard Jankowsky, Moderna
Biogenesis and Function of RNA Modifications
Biogenesis and Function of RNA Modifications
Gudrun Stengel, Alida Biosciences
Short Talk: RNA Modifications in PBMCs Enable Disease Classification Where Transcript Abundance Lacks Discriminatory Power
Short Talk: RNA Modifications in PBMCs Enable Disease Classification Where Transcript Abundance Lacks Discriminatory Power
Ivan Correa, New England Biolabs
Short Talk: Precision at the Ribosome: N2,7-Dimethylguanosine Formation by 16S rRNA Methyltransferase
Short Talk: Precision at the Ribosome: N2,7-Dimethylguanosine Formation by 16S rRNA Methyltransferase
Kohki Yamada, UT Southwestern Medical Center
Short Talk: Co-Transcriptional Modifications of 2’-Hydroxyls on Synthetic mRNA Enhance Ribonuclease Resistance and mRNA Lipid Nanoparticle Thermostability
Short Talk: Co-Transcriptional Modifications of 2’-Hydroxyls on Synthetic mRNA Enhance Ribonuclease Resistance and mRNA Lipid Nanoparticle Thermostability
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Grays Peak
Poster Setup
11:00–1:00 PM
Longs Peak
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Longs Peak
Career Roundtable
1:45–3:15 PM
Grays Peak
Panel Discussion: Science Meets Industry
3:30–4:30 PM
Grays Peak
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
RNA Modifications in Diseases I
5:00–7:00 PM
Grays Peak
Samie Jaffrey, Weill Medical College of Cornell University
Cap Modifications in Healthy Cells and Disease
Cap Modifications in Healthy Cells and Disease
Jordan L Meier, National Cancer Institute
Cytidine Acetylation across the Tree of Life
Cytidine Acetylation across the Tree of Life
Michaela Frye, Deutsches Krebsforschungszentrum
tRNA Modifications in Cancer
tRNA Modifications in Cancer
Cornelius Pauli, University hospital heidelberg
Short Talk: A Ribosomal RNA 2ʹ-O-Methylation Signature Drives a Pro-metastatic Phenotype in Lung Adenocarcinoma
Short Talk: A Ribosomal RNA 2ʹ-O-Methylation Signature Drives a Pro-metastatic Phenotype in Lung Adenocarcinoma
Natalia Pinello, Insitut Pasteur de Montevideo
Short Talk: Loss of NLRP3 m6A Methylation via Single Nucleotide Variant Underpins Autoinflammatory Disease
Short Talk: Loss of NLRP3 m6A Methylation via Single Nucleotide Variant Underpins Autoinflammatory Disease
Social Hour with Dinner
7:00–8:00 PM
Longs Peak
Poster Session 2
7:30–10:00 PM
Longs Peak
Thursday, March 12, 2026
Breakfast
7:00–8:00 AM
Longs Peak
RNA Engineering and Editing Approaches
8:00–11:00 AM
Grays Peak
Namita Bisaria, AIRNA
Therapeutics based on ADAR -Base Editing
Therapeutics based on ADAR -Base Editing
Nicole Martinez, Stanford University
RNA Modifications and Pre-mRNA Processing
RNA Modifications and Pre-mRNA Processing
Kate Meyer, Duke University
Genetically Encoded Tools for Studying mRNA Methylation
Genetically Encoded Tools for Studying mRNA Methylation
Jin Billy Li, Stanford University
RNA Editing and Sensing as a Common Mechanism Underlying the Genetic Risk of Inflammation
RNA Editing and Sensing as a Common Mechanism Underlying the Genetic Risk of Inflammation
Qi Chen, University of Utah School of Medicine
Short Talk: Complete Decoding of tsRNA Modifications Reveals a Single-Site Switch for RNA Structure and Function
Short Talk: Complete Decoding of tsRNA Modifications Reveals a Single-Site Switch for RNA Structure and Function
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
On Own for Lunch
12:00–5:00 PM
Symposia Spotlight 2
2:30–4:00 PM
Grays Peak
Thomas J Santangelo, Colorado State University
Targeted, Efficient, Site-specific Modification of Selected RNAs in vivo
Targeted, Efficient, Site-specific Modification of Selected RNAs in vivo
Matthias Soller, University of Manchester
Decoding of TOP Messenger RNA 2`-O-methylation Status for mRNA Stability and Localization to Synapses
Decoding of TOP Messenger RNA 2`-O-methylation Status for mRNA Stability and Localization to Synapses
Hong Li, Van Andel Institute
Making Ribosomes: Critical Roles of Chemical Modifications in rRNA
Making Ribosomes: Critical Roles of Chemical Modifications in rRNA
Homa Ghalei, Emory University
Ribosomal RNA Modification Heterogeneity in Biology and Cancer
Ribosomal RNA Modification Heterogeneity in Biology and Cancer
Aurora Esquela Kerscher, Virginia Health Sciences at Old Dominion University
Glycosylated RNA as a Molecular Indicator of Reduced Tumor Aggressiveness in Prostate Cancer
Glycosylated RNA as a Molecular Indicator of Reduced Tumor Aggressiveness in Prostate Cancer
Eleni Liapi, Aarhus University
Dynamic RNA Acetylation during Oxidative Stress in Mammalian Cells
Dynamic RNA Acetylation during Oxidative Stress in Mammalian Cells
Coffee Available
4:00–4:30 PM
Longs Peak Foyer
RNA Modifications Diseases II
4:30–6:15 PM
Grays Peak
Zoya Ignatova, University of Hamburg
tRNA Engineering to Suppress Nonsense Mutations in Disease
tRNA Engineering to Suppress Nonsense Mutations in Disease
Victoria H. Cowling, Cancer Research UK Scotland Institute
RNA Cap Modifications in T Cell Function
RNA Cap Modifications in T Cell Function
Chuan He, University of Chicago
RNA Modifications in Physiology and Immune-Related Disease
RNA Modifications in Physiology and Immune-Related Disease
Zhangli Su, University of Alabama at Birmingham
Short Talk: Friend or Foe: TRMT6/61A in Cellular Stress and Human Disease
Short Talk: Friend or Foe: TRMT6/61A in Cellular Stress and Human Disease
Closing Keynote Address
6:15–7:00 PM
Grays Peak
Muthiah Manoharan, Alnylam Pharmaceuticals, Inc.
siRNA Therapeutics
siRNA Therapeutics
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–7:15 PM
Grays Peak
Social Hour with Dinner
7:15–8:15 PM
Longs Peak
Entertainment
8:00–9:00 PM
Longs Peak
Cash Bar
8:15–9:00 PM
Longs Peak
Friday, March 13, 2026
Departure
12:00–11:59 PM
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