Tuberculosis: The Host-Pathogen Interface

Mar 24–27, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Marcel A. Behr, Lalita Ramakrishnan, and Kevin B. Urdahl

  Livestream
  In Person
  On Demand
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Mar 24–27, 2024 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Marcel A. Behr, Lalita Ramakrishnan, and Kevin B. Urdahl

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:     = Livestream   = In Person     = On Demand
Sunday, March 24, 2024
Arrival and Registration  
4:00–8:00 PM
 Longs Peak Foyer
Welcome Mixer  
6:00–8:00 PM
 Longs Peak Foyer
Monday, March 25, 2024
Breakfast  
7:00–8:00 AM
 Colorado Rockies Ballroom
Welcome and Keynote Address    
8:00–9:00 AM
 Longs/Grays Peak
Lluis Quintana-Murci, Institut Pasteur, CNRS UMR2000 and Collège de France
Lessons from the Human Genome about Past and Present Epidemics
Early Interactions I    
9:00–12:15 PM
 Longs/Grays Peak
Russell E. Vance, University of California, Berkeley
The Innate Immune Response to Mycobacterium Tuberculosis
Abiola F Ogunsola, University of Massachusetts Chan Medical School
Short Talk: Short Talk: A T-cell Independent Mechanism of BCG-mediated Protection to Tuberculosis in a Collaborative Cross Strain
Yogita Kapoor, CSIR-Centre for Cellular and Molecular Biology
Short Talk: Short Talk: Wag31, A Membrane Tether, is Crucial for Lipid Homeostasis in Mycobacteria
Rania Bouzeyen, UCSF
Short Talk: Short Talk: Antibody-mediated Immunity to Early M. Tuberculosis Infection in Mice Depends on NLRP3 Inflammasome Formation
Galit Alter, Moderna, Inc.
Antibodies and TB: Over-Looked but Under-Rated
Elisa Nemes, University of Cape Town
Host Blood Biomarkers for the Diagnosis, Prognosis and Treatment Response of Childhood Tuberculosis
Chetan Seshadri, University of Washington
Short Talk: Short Talk: T Cell Phenotypes in M. Tuberculosis ‘Resisters’ Correlate with Bacterial Control
Megan Proulx, University of Massachusetts Chan Medical School
Short Talk: Short Talk: Characterizing Non-canonical Immune Mechanisms in Genetically Diverse Mice
Coffee Break  
10:15–10:35 AM
 Longs Peak Foyer
Poster Setup  
12:15–1:00 PM
 Colorado Rockies Ballroom
On Own for Lunch  
12:15–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Colorado Rockies Ballroom
Career Roundtable  
3:00–4:30 PM
 Longs/Grays Peak
Gloria Marcela Rodriguez, Rutgers University
Associate Professor
Daniel L. Barber, NIAID, National Institutes of Health
Chief, T-Lymphocyte Biology Section
Elisa Nemes, University of Cape Town
Associate Professor/Principal Investigator
Alison Kraigsley, Bill and Melinda Gates Foundation
Program Officer, TB Vaccines
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Early Interactions II    
5:00–7:15 PM
 Longs/Grays Peak
Alissa C. Rothchild, University of Massachusetts Amherst
Alveolar Macrophages and the Initiation of Immunity
Kevin B. Urdahl, Seattle Children's Research Institute
Distinct Protective Roles for CD4 and CD8 T Cells in Vaccine-mediated Immunity against Tuberculosis
Chrissy M. Leopold Wager, Texas Biomedical Research Institute
Short Talk: Short Talk: Mycobacterium Tuberculosis Evades Host Defense by Activating Transcription Factor CREB in Human Macrophages
Prashant Bajpai, Emory University
Short Talk: Short Talk: Single Cell Transcriptomics of Lung Responses to Mycobacterium Tuberculosis in People Living with HIV Reveal Impaired TNF Signaling Networks
Todia Pediatama Setiabudiawan, Radboudumc
Short Talk: Short Talk: Immune Correlates of Early Clearance of Mycobacterium Tuberculosis among Tuberculosis Household Contacts in Indonesia
Sarah Schmidiger, Swiss Tropical and Public Health Institute
Short Talk: Short Talk: A Battlefield in the Spotlight: CyTOF Immune Profiling of Ex Vivo-Induced TB Granulomas
Alexander C. Schmidt, Gates Medical Research Institute
Short Talk: Short Talk: Safety and Efficacy of BCG Revaccination for the Prevention of Sustained Mycobacterium tuberculosis Infection
Social Hour with Lite Bites  
7:15–8:15 PM
 Colorado Rockies Ballroom
Poster Session 1  
7:30–10:00 PM
 Colorado Rockies Ballroom
Tuesday, March 26, 2024
Breakfast  
7:00–8:00 AM
 Colorado Rockies Ballroom
Within-Granuloma Battle I    
8:00–10:15 AM
 Longs/Grays Peak
Gloria Marcela Rodriguez, Rutgers University
Nutritional Immunity of M. tuberculosis Infection
Michael Y. Gerner, University of Washington
Dissecting the Mechanisms Leading to Granuloma Formation and Structure
Clare M. Smith, Duke University
Host-Pathogen Interactions Underlie Distinct Infection Microenvironments
Edward A. Miao, Duke University
Short Talk: Short Talk: CCR2 is Essential to Assemble an Innate Granuloma that Eradicates Infection
Carl Feng, University of Sydney
Short Talk: Short Talk: Organization of Human Tuberculosis Granuloma at Single-cell Resolution
Sarah Monard, Institute of Pharmacology and Structural Biology
Short Talk: Short Talk: Identification of a Novel Nerve Cell Population in Lung Granulomas during Tuberculosis
Coffee Break  
10:15–10:35 AM
 Longs Peak Foyer
Autophagy Workshop    
10:35–12:20 PM
 Longs/Grays Peak
Antonio J. Pagan, University of Cambridge / Stanford University
Non-canonical Roles of Autophagy-related Proteins in Tuberculosis
Pooja Uchil, Ragon Institute of MGH, MIT and Harvard
Host Factors Engaged in the Repair of the Mtb Containing Phagosome Membrane
Ekansh Mittal, School of Medicine Washington University in St. Louis
Phthiocerol Dimycocerosate (PDIM) Promotes Growth of Mycobacterium Tuberculosis in vivo by Counteracting Autophagy
Yating Wang, Tsinghua University
Redefine the Role of Autophagy in Mycobacterium tuberculosis Infection
Bennett H. Penn, University of California, Davis
Ubiquitin Signaling Regulates the Macrophage Response to M. Tuberculosis
Weihao Zheng, UCSF
Mycobacterium Tuberculosis Resides in Lysosome-poor Monocyte-derived Lung Cells during Chronic Infection
Poster Setup  
12:20–1:00 PM
 Colorado Rockies Ballroom
On Own for Lunch  
12:20–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Colorado Rockies Ballroom
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Within-Granuloma Battle II    
5:00–7:00 PM
 Longs/Grays Peak
Daniel L. Barber, NIAID, National Institutes of Health
Role of IFN? in the Structure and Function of Rhesus Macaque Tuberculomas
Igor B. Kramnik, Boston University
Short Talk: Short Talk: Macrophage Redox Reprogramming by Myc Fuels Iron-mediated Lipid Peroxidation, Type I Interferon Hyperactivity and Pulmonary TB Progression
Vivek V. Thacker, University of Heidelberg
Short Talk: Short Talk: Mechanopathology of Biofilm-like Mycobacterium Tuberculosis Cords
Lalita Ramakrishnan, University of Cambridge
Mechanisms of Granuloma Necrosis
Marta Lisete Santos da Silva, I3S
Short Talk: Short Talk: Timely Activation of the LXR Pathway is a Promising Host-Directed Therapy for Tuberculosis
Gowri Vishal Gupta Kolluru, IISc Bangalore
Short Talk: Short Talk: Three-dimensional (3D) Hydrogel Culture Systems to Study Host-pathogen Interaction and Drug Efficacy in Tuberculosis
Mark Hatherill, University of Cape Town
Short Talk: Short Talk: Efficacy of H56:IC31 Vaccine for Prevention of Recurrent Tuberculosis: A Randomized, Double-blind, Placebo-controlled Trial
Social Hour with Lite Bites  
7:00–8:00 PM
 Colorado Rockies Ballroom
Poster Session 2  
7:30–10:00 PM
 Colorado Rockies Ballroom
Wednesday, March 27, 2024
Breakfast  
7:00–8:00 AM
 Colorado Rockies Ballroom
Onward Spread: Transmissible Pathology    
8:00–10:15 AM
 Longs/Grays Peak
Marcel A. Behr, McGill University
Lineage Specific Virulence Factors and the Outcome of Infection
Emily B. Wong, Africa Health Research Institute
Subclinical TB and its Potential Role in Mtb Transmission in Rural KwaZulu-Natal
Michael Shiloh, University of Texas Southwestern Medical Center
Closing the Loop: Experimental Transmission of M. tuberculosis
Nicole Howard, Harvard T.H. Chan School of Public Health
Short Talk: Short Talk: Leveraging a Paired Analysis of Host and Pathogen Genomes to Identify Determinants of Human Tuberculosis
Vaishnavi Satish Kaipilyawar, Rutgers New Jersey Medical School
Short Talk: Short Talk: Immune Mechanisms Regulating Distinct Immunopathologies in High- and Low-Transmission Mycobacterium Tuberculosis Infections
William Bishai, Johns Hopkins School of Medicine
Short Talk: Short Talk: Female Protection from TB Disease Progression is Strongly Associated with Improved T Cell Immunity and Maturation of B Cell Follicles
Coffee Break  
10:15–10:35 AM
 Longs Peak Foyer
Workshop: Deadly Detour: TB Meningitis    
10:35–12:20 PM
 Longs/Grays Peak
Xavier S. Nassif, Institut Necker Enfants-Malades and Université Paris Cité
The Blood Brain Barrier and Bacterial Infections
Cressida Madigan, University of California, San Diego
How Mycboacteria Cross the Blood Brain Barrier
Guy Edward Thwaites, Oxford University Clinical Research Unit
New Insights into TBM Pathogenesis from Clinical Cohorts
Arjan van Laarhoven, Radboud University Medical Centre
Short Talk: Short Talk: Cerebrospinal Fluid Fatty Acid Metabolism and Tuberculous Meningitis Mortality
On Own for Lunch  
12:20–5:00 PM
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Inflammation and Neutrophils: TB and Beyond    
5:00–6:00 PM
 Longs/Grays Peak
Andrew R. DiNardo, Baylor College of Medicine
Short Talk: Short Talk: Metabolic and Epigenetic Drivers of Persistent Inflammation Despite Successful Anti-Tuberculosis Therapy
Ananda Rankin, Washington University in St. Louis
Short Talk: Short Talk: Investigating How Mycobacterium Tuberculosis Promotes its Survival in Neutrophils
Krishna C. Chinta, The University of Alabama at Birmingham
Short Talk: Short Talk: Nutrient Availability and HO-1 Alter Neutrophil Bioenergetics and Immunometabolism During Mycobacterium Tuberculosis Infection
Elizabeth Gold, Seattle Children's Research Institute
Short Talk: Short Talk: APOE Protects Against Severe Infection with Mycobacterium Tuberculosis by Restraining Production of Neutrophil Extracellular Traps
Closing Keynote Address    
6:00–6:45 PM
 Longs/Grays Peak
Paul Kubes, University of Calgary
Intravital Imaging of Pulmonary Infections
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)    
6:45–7:00 PM
 Longs/Grays Peak
Social Hour with Lite Bites  
7:00–8:30 PM
 Colorado Rockies Ballroom
Poster Session 3  
7:15–10:00 PM
 Colorado Rockies Ballroom
Thursday, March 28, 2024
Departure  
8:00–8:00 AM

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