Malaria: Mechanisms of Immunity & Protection
March 30–April 02, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers:
Silvia Portugal, Marion Pepper, and Melissa Chola Kapulu
In Person
On Demand
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March 30–April 02, 2025 | Eldorado Hotel & Spa, Santa Fe, NM, United States
Scientific Organizers: Silvia Portugal, Marion Pepper, and Melissa Chola Kapulu
Silvia Portugal
Marion Pepper
Melissa Chola Kapulu
Available Formats:
Supported by the Directors' Fund
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandSunday, March 30, 2025
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Concourse
Welcome Mixer
6:00–8:00 PM
Cava Santa Fe
Monday, March 31, 2025
Breakfast
7:00–8:00 AM
Anasazi Ballroom
Poster Setup
7:30–8:00 AM
Anasazi Ballroom
Poster Viewing
7:45–7:00 PM
Anasazi Ballroom
Welcome and Keynote Address
8:00–9:00 AM
Eldorado Ballroom
* Silvia Portugal, Max Planck Institute for Infection Biology
* Marion Pepper, University of Washington
* Melissa Chola Kapulu, KEMRI-Wellcome Trust Research Programme
Lars Hviid, University of Copenhagen
Making Heads or Tails of it: Thoughts on Protective Immunity to Plasmodium Falciparum Malaria
Making Heads or Tails of it: Thoughts on Protective Immunity to Plasmodium Falciparum Malaria
Surviving Severe Malaria: The Quick Fix Protection
9:00–11:00 AM
Eldorado Ballroom
* Kattria van der Ploeg, Stanford University
Session Chair
Session Chair
Abdirahman I Abdi, Kenya Medical Research Institute(KEMRI)-Wellcome Trust Programme
Plasmodium falciparum Extracellular Vesicles in Malaria Pathogenesis and Immunity
Plasmodium falciparum Extracellular Vesicles in Malaria Pathogenesis and Immunity
Maria Bernabeu, European Molecular Biology Laboratory
In vitro 3D Blood-Brain Barrier Model and Cerebral Malaria
In vitro 3D Blood-Brain Barrier Model and Cerebral Malaria
Sai Sundar Rajan Raghavan, The Scripps Research Institute
Short Talk: Broadly Inhibitory Antibodies against Severe Malaria Associated PfEMP1
Short Talk: Broadly Inhibitory Antibodies against Severe Malaria Associated PfEMP1
Joy Kabagenyi, University of Glasgow
Short Talk: Innocent Residents or Drivers of Immune Reprogramming: Employing Single Cell and Spatial Transcriptomics to Elucidate Plasmodium Driven Immune Changes in the Bone Marrow and Spleen of Mice
Short Talk: Innocent Residents or Drivers of Immune Reprogramming: Employing Single Cell and Spatial Transcriptomics to Elucidate Plasmodium Driven Immune Changes in the Bone Marrow and Spleen of Mice
Cecilia E Lekpor, Morehouse School of Medicine
Short Talk: Neuregulin-1 Mitigates Heme-Induced Vascular Injury in iPSC-Derived Endothelial Cells Generated from Children with Various Hemoglobin Genotypes
Short Talk: Neuregulin-1 Mitigates Heme-Induced Vascular Injury in iPSC-Derived Endothelial Cells Generated from Children with Various Hemoglobin Genotypes
Coffee Break
9:30–9:50 AM
Concourse
Lunch
11:15–12:30 PM
Anasazi Ballroom
Poster Session 1
12:00–2:30 PM
Anasazi Ballroom
Symposia Spotlight 1: Research presentations selected from abstract submissions
2:30–4:30 PM
Eldorado Ballroom
* Maria del Pilar Crespo-Ortiz, Universidad del Valle
Session Chair
Session Chair
* Oscar K Kai, KEMRI-Wellcome Trust Research Program
Session Chair
Session Chair
Lauren Holz, University of Melbourne
Development of a Tissue-targeted Malaria mRNA Vaccine
Development of a Tissue-targeted Malaria mRNA Vaccine
Lauren Jatt, University of Washington
Cytokines Associated with Moderate and Severe Adverse Events and Parasitemia Following Vaccination with Chemo-attenuated Plasmodium Falciparum Sporozoite Vaccine
Cytokines Associated with Moderate and Severe Adverse Events and Parasitemia Following Vaccination with Chemo-attenuated Plasmodium Falciparum Sporozoite Vaccine
Caroline Kijogi, Mount Kenya University
Placental Malaria Infection is Associated with Downregulation of STAT-6 and ANG-1 in Decidual Macrophages
Placental Malaria Infection is Associated with Downregulation of STAT-6 and ANG-1 in Decidual Macrophages
Manish Tripathi, All India Institute of Medical sciences
PvTRAg36.6 – CD71 along with Lipid Interaction Study - New Insight of Plasmodium Vivax Invasion into Human Reticulocyte
PvTRAg36.6 – CD71 along with Lipid Interaction Study - New Insight of Plasmodium Vivax Invasion into Human Reticulocyte
Luis M Molinos-Albert, ISGlobal
Potent Human Antibodies to the Major NANP Repeat Region of Plasmodium Falciparum Circumsporozoite Protein from RTS,S/AS01E Vaccinated African Children
Potent Human Antibodies to the Major NANP Repeat Region of Plasmodium Falciparum Circumsporozoite Protein from RTS,S/AS01E Vaccinated African Children
Courtney McDougal, University of Washington
Memory B Cells Specific to the Plasmodium Circumsporozoite Protein have Limited Ability to Self-renew, Leading to Memory Depletion after Repeated Exposure
Memory B Cells Specific to the Plasmodium Circumsporozoite Protein have Limited Ability to Self-renew, Leading to Memory Depletion after Repeated Exposure
Kaylee Norman, University of Iowa
Metabolic Regulation of Atypical Memory B Cell Development and Affinity Maturation during Malaria
Metabolic Regulation of Atypical Memory B Cell Development and Affinity Maturation during Malaria
Coffee Available
4:30–5:00 PM
Concourse
Slow Cooking Naturally Acquired Immunity & Repeated Malaria Cases
5:00–7:00 PM
Eldorado Ballroom
* Margaret Feeney, University of California, San Francisco
Session Chair
Session Chair
Gordon A Awandare, University of Ghana
How the Immune System Develops Tolerance to Plasmodium falciparum
How the Immune System Develops Tolerance to Plasmodium falciparum
Amy K Bei, Yale School of Public Health
Low and Slow: Investigating Mechanisms of Strain-Specific and Strain-Transcendent Naturally-Acquired Immunity
Low and Slow: Investigating Mechanisms of Strain-Specific and Strain-Transcendent Naturally-Acquired Immunity
Marion Pepper, University of Washington
Protective CSP-specific Memory B Cells Decline with Repeated Immunization or Infection in Humans and Mice
Protective CSP-specific Memory B Cells Decline with Repeated Immunization or Infection in Humans and Mice
Noah S. Butler, University of Iowa
Function of Plasmodium Parasite-Specific B Cells and T Cells During Malaria
Function of Plasmodium Parasite-Specific B Cells and T Cells During Malaria
On Own for Dinner
7:00–8:00 PM
Tuesday, April 1, 2025
Breakfast
7:00–8:00 AM
Anasazi Ballroom
Upgrading Malaria Immunity: NextGenVaccine Approaches
8:00–11:00 AM
Eldorado Ballroom
* Stefan Kappe, Seattle Children's Research Institute
Development of Genetically Engineered Whole Parasite Vaccines for Malaria
Development of Genetically Engineered Whole Parasite Vaccines for Malaria
Brandon Wilder, Oregon Health and Science University
MHC and Malaria Immunity
MHC and Malaria Immunity
Melissa Chola Kapulu, KEMRI-Wellcome Trust Research Programme
Immunity and protection in CHMI
Immunity and protection in CHMI
Ashley M. Vaughan, Seattle Children's Research Institute
Short Talk: Using Plasmodium Falciparum Experimental Genetic Crosses to Create Efficacious Pan-African Genetically Attenuated Parasite Vaccines
Short Talk: Using Plasmodium Falciparum Experimental Genetic Crosses to Create Efficacious Pan-African Genetically Attenuated Parasite Vaccines
Justin Boddey, Walter and Eliza Hall Institute of Medical Research
Short Talk: Long-acting Antimalarials that Attenuate Very-late Liver-stages for Malaria Chemovaccination
Short Talk: Long-acting Antimalarials that Attenuate Very-late Liver-stages for Malaria Chemovaccination
Bryce Chackerian, University of New Mexico School of Medicine
Short Talk: Virus-like Particle Based Vaccines Targeting the L9 Epitope in CSP Provide Strong Sterilizing Protection for Malaria Infection in a Mouse Challenge Model
Short Talk: Virus-like Particle Based Vaccines Targeting the L9 Epitope in CSP Provide Strong Sterilizing Protection for Malaria Infection in a Mouse Challenge Model
Coffee Break
9:00–9:20 AM
Concourse
Award Recipient Acknowledgement
9:20–9:25 AM
Eldorado Ballroom
Poster Setup
11:00–1:00 PM
Anasazi Ballroom
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Anasazi Ballroom
Career Roundtable
3:30–4:30 PM
Eldorado Ballroom
Amy K Bei, Yale School of Public Health
Associate Professor of Epidemiology
Associate Professor of Epidemiology
Gordon A Awandare, University of Ghana
Professor
Professor
Aurelio Bonavia, Gates Medical Research Institute
Vaccine/Monoclonal Development
Vaccine/Monoclonal Development
Coffee Available
4:30–5:00 PM
Concourse
Bypassing the Development of Malaria Immunity and Then What?
5:00–7:00 PM
Eldorado Ballroom
* James Huleatt, Gates Medical Research Institute
Session Chair
Session Chair
Kassoum Kayentao, University of Bamako
Remote Presentation: mAB Trials in Seasonal Settings
Remote Presentation: mAB Trials in Seasonal Settings
Azza Idris, Ragon Institute of Mass General Brigham, MIT, and Harvard
Leveraging Potent Monoclonal Antibodies to Guide the Design of Next-Generation Malaria Vaccines
Leveraging Potent Monoclonal Antibodies to Guide the Design of Next-Generation Malaria Vaccines
Hedda Wardemann, German Cancer Research Center
Molecular and Functional Properties of Human Plasmodium falciparum CSP C-terminus Antibodies
Molecular and Functional Properties of Human Plasmodium falciparum CSP C-terminus Antibodies
Paul Heinrich Gerstenhöfer, Institute for Research in Biomedicine Bellinzona
Short Talk: Exploration of the Infected RBC Immunosurfaceome as a Tool for Anti-Plasmodium Antibody Discovery
Short Talk: Exploration of the Infected RBC Immunosurfaceome as a Tool for Anti-Plasmodium Antibody Discovery
Social Hour with Lite Bites
7:00–8:00 PM
Anasazi Ballroom
Poster Session 2
7:30–10:00 PM
Anasazi Ballroom
Wednesday, April 2, 2025
Breakfast
7:00–8:00 AM
Anasazi Ballroom
Shoot the Messenger: Blocking Mosquitos and Malaria Transmission
8:00–11:00 AM
Eldorado Ballroom
* George O Ademowo, Institute for Advanced Medical Research and Training
Session Chair
Session Chair
Issaka Sagara, Malaria Research and Training Center
Remote Presentation: Malaria: Transmission Blocking Vaccine (TBV), Field Results and the Combination of a TBV (Pfs230) with an Approved Anti-Infection Malaria Vaccine (R21)
Remote Presentation: Malaria: Transmission Blocking Vaccine (TBV), Field Results and the Combination of a TBV (Pfs230) with an Approved Anti-Infection Malaria Vaccine (R21)
Wai-Hong Tham, Walter and Eliza Hall Institute of Medical Research
Nanobodies Blocking Malaria Transmission
Nanobodies Blocking Malaria Transmission
Nirbhay Kumar, Milken Institute School of Public Health
Elimination of Malaria will Require Combination Vaccines Targeting Multiple Parasite Stages in Multiple Plasmodium Species
Elimination of Malaria will Require Combination Vaccines Targeting Multiple Parasite Stages in Multiple Plasmodium Species
Priscilla W Ngotho, University of Glasgow
Characterising the Dynamics of Malaria Parasite Sexual Stage Immunity
Characterising the Dynamics of Malaria Parasite Sexual Stage Immunity
Shehu S Awandu, Jaramogi Oginga Odinga University of Science and Technology
Short Talk: The Melanization Response in Anopheles Coluzii Mosquitoes Impacts Malaria Transmission and Infectivity in Natural Settings
Short Talk: The Melanization Response in Anopheles Coluzii Mosquitoes Impacts Malaria Transmission and Infectivity in Natural Settings
Coffee Break
9:00–9:20 AM
Concourse
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Research presentations selected from abstract submissions
3:00–4:30 PM
Eldorado Ballroom
* David S Schneider, Stanford University
Session Chair
Session Chair
* Henk Schallig, Amsterdam University Medical Center
Session Chair
Session Chair
Ana Rodrigues, Gulbenkian Institute for Molecular Medicine
Running for Protection: The Role of Cell Traversal in the Establishment of Sterile Immunity against Plasmodium
Running for Protection: The Role of Cell Traversal in the Establishment of Sterile Immunity against Plasmodium
Henrietta Esi Mensah-Brown, University of Ghana
Blocking Plasmodium Merozoite Invasion of Red Blood Cells: Molecular Docking Analysis of Small Molecule Inhibitors of the RH5-CyRPA-RIPR Complex
Blocking Plasmodium Merozoite Invasion of Red Blood Cells: Molecular Docking Analysis of Small Molecule Inhibitors of the RH5-CyRPA-RIPR Complex
Daniel Neafsey, Harvard TH Chan School of Public Health
Insights into Malaria Immunity from Longitudinal Genotyping Studies that Reveal Complete Infection Dynamics
Insights into Malaria Immunity from Longitudinal Genotyping Studies that Reveal Complete Infection Dynamics
Helena Nunes-Cabaço, Gulbenkian Institute for Molecular Medicine
Age is a Major Determinant of the Efficacy of Whole-sporozoite Malaria Vaccination in MIce
Age is a Major Determinant of the Efficacy of Whole-sporozoite Malaria Vaccination in MIce
Alina Batzilla, EMBL Barcelona
The Contribution of Leukocytes to Cerebral Malaria Vascular Pathogenesis in a 3D Blood-Brain Barrier Model
The Contribution of Leukocytes to Cerebral Malaria Vascular Pathogenesis in a 3D Blood-Brain Barrier Model
Ann M Moormann, University of Massachusetts Chan Medical School
A Systems Serology Approach to Distinguish Divergent Exposures to Plasmodium Falciparum for Children Living in Malaria Endemic Regions
A Systems Serology Approach to Distinguish Divergent Exposures to Plasmodium Falciparum for Children Living in Malaria Endemic Regions
Coffee Available
4:30–5:00 PM
Concourse
Systems Immunology Applied to Malaria
5:00–6:45 PM
Eldorado Ballroom
* Prasanna Jagannathan, Stanford University School of Medicine
Session Chair
Session Chair
Maria Yazdanbakhsh, Leiden University Medical Center
Remote Presentation: Systems Immunology and Innate Immunity to Malaria
Remote Presentation: Systems Immunology and Innate Immunity to Malaria
Tuan M Tran, Indiana University School of Medicine
Systems Immunology and RNAseq Integration Methods
Systems Immunology and RNAseq Integration Methods
Silvia Portugal, Max Planck Institute for Infection Biology
Asymptomatic Persistence of Malaria Parasites
Asymptomatic Persistence of Malaria Parasites
Katarina DiLillo, Massachusetts Institute of Technology
Short Talk: Differential Network Analysis of Pediatric Immune Responses to Malaria Vaccination
Short Talk: Differential Network Analysis of Pediatric Immune Responses to Malaria Vaccination
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Eldorado Ballroom
Social Hour with Lite Bites
7:00–8:00 PM
Anasazi Ballroom
Entertainment
8:00–9:00 PM
Eldorado Ballroom
Cash Bar
8:00–9:00 PM
Anasazi Ballroom
Thursday, April 3, 2025
Departure
12:00–11:59 PM
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