Tumor Microenvironment: Metastasis and the Host
Jan 18–21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Mikala Egeblad, Julio Aguirre-Ghiso, and Manuel Valiente
In Person
On Demand
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Jan 18–21, 2025 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Mikala Egeblad, Julio Aguirre-Ghiso, and Manuel Valiente
Mikala Egeblad
Julio Aguirre-Ghiso
Manuel Valiente
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandSaturday, January 18, 2025
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Riverview Lounge
Welcome Mixer
6:00–8:00 PM
Riverview Lounge
Sunday, January 19, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Welcome and Keynote Address
8:00–9:00 AM
Cascade Ballroom
* Manuel Valiente, Spanish National Cancer Research Centre
Session Chair
Session Chair
Eduard Batlle, Institute for Research in Biomedicine
Plasticity, Therapy Resistance and Immune Evasion in Metastatic Colorectal Cancer
Plasticity, Therapy Resistance and Immune Evasion in Metastatic Colorectal Cancer
The Disseminated Cell in the Metastatic Niche
9:00–11:15 AM
Cascade Ballroom
* Don Nguyen, Yale School of Medicine
Session Chair
Session Chair
Julio Aguirre-Ghiso, Montefiore Einstein Cancer Center
Plasticity of Cancer Cells and Dormancy Programs
Plasticity of Cancer Cells and Dormancy Programs
Leah Cook, NCI, National Institutes of Health
Delineating the Role of Neutrophils in the Prostate Cancer-Bone Microenvironment
Delineating the Role of Neutrophils in the Prostate Cancer-Bone Microenvironment
Eric S. Lightcap, HiberCell
Perk Inhibition by Hc-5404 Alters the Tumor Microenvironment: Preclinical and Clinical Exploration
Perk Inhibition by Hc-5404 Alters the Tumor Microenvironment: Preclinical and Clinical Exploration
Elena Guido Vinzoni, ETH
Short Talk: In Vivo Crispra Screen of Ligands and Receptors in Liver Endothelial Cells Highlights the Impact of Early Interactions During Colorectal Cancer Metastatic Seeding
Short Talk: In Vivo Crispra Screen of Ligands and Receptors in Liver Endothelial Cells Highlights the Impact of Early Interactions During Colorectal Cancer Metastatic Seeding
Coffee Break
9:30–9:50 AM
Riverview Lounge
Poster Setup
11:15–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Cascade Ballroom
* Leah Cook, NCI, National Institutes of Health
Session Chair
Session Chair
Jelani C. Zarif, Johns Hopkins University School of Medicine
Glutamine Antagonist Prodrug JHU083 Reprograms Immunosuppressive Tumor-Associated Macrophages (TAMS) To Drive Tumor Immunity In Urologic Cancers
Glutamine Antagonist Prodrug JHU083 Reprograms Immunosuppressive Tumor-Associated Macrophages (TAMS) To Drive Tumor Immunity In Urologic Cancers
Don Nguyen, Yale School of Medicine
Epigenetic Regulation of Tumor Cell Clustering and Metastasis in Lung Adenocarcinoma
Epigenetic Regulation of Tumor Cell Clustering and Metastasis in Lung Adenocarcinoma
Christoph A Reichel, Department of Otorhinolaryngology, LMU Munich/Germany
Granulopoiesis and Thrombopoiesis Aberrantly Synergize in Cancer to Promote Tumor Progression
Granulopoiesis and Thrombopoiesis Aberrantly Synergize in Cancer to Promote Tumor Progression
Yuto Hamazaki, The University of Tokyo
Deciphering the Diversity of Cells and Exosome in Metastatic Mechanisms
Deciphering the Diversity of Cells and Exosome in Metastatic Mechanisms
Matthew Eason, University of Maryland School of Medicine
Pleckstrin Homology Domains Regulate PI3K/Akt to Quiet the Invasive Matrix Metalloproteinase Milieu and Block Breast Cancer Dissemination
Pleckstrin Homology Domains Regulate PI3K/Akt to Quiet the Invasive Matrix Metalloproteinase Milieu and Block Breast Cancer Dissemination
Coffee Available
4:30–5:00 PM
Riverview Lounge
Microenvironmental Regulation of Metastasis
5:00–7:00 PM
Cascade Ballroom
* Mikala Egeblad, Johns Hopkins University
Session Chair
Session Chair
Daniela F Quail, McGill University
Obesity as a Driver of Pro-Metastatic Niche Formation
Obesity as a Driver of Pro-Metastatic Niche Formation
Anwesha Dey, Genentech, Inc.
Targeting the Hippo Pathway in Cancers
Targeting the Hippo Pathway in Cancers
Clare M Isacke, Institute of Cancer Research
Microenvironmental Changes Driving Breast Cancer Metastatic Relapse
Microenvironmental Changes Driving Breast Cancer Metastatic Relapse
Laura Alvaro, CNIO
Short Talk: Targeting a Disease-Associated Subpopulation of Macrophages/ Microglia Uncovers a Novel Vulnerability of Brain Metastasis
Short Talk: Targeting a Disease-Associated Subpopulation of Macrophages/ Microglia Uncovers a Novel Vulnerability of Brain Metastasis
Meera Murgai, National Cancer Institute, National Institutes of Health
Short Talk: Pericyte-Tumor Crosstalk Promotes Metastatic Tumor Dormancy Through Calcium Activated Phospholipid Transfer.
Short Talk: Pericyte-Tumor Crosstalk Promotes Metastatic Tumor Dormancy Through Calcium Activated Phospholipid Transfer.
Social Hour with Lite Bites
7:00–8:00 PM
Alberta/New Brunswick
Poster Session 1
7:30–10:00 PM
Alberta/New Brunswick
Monday, January 20, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Defining and Shaping the Metastatic Microenvironment (Joint)
8:00–11:00 AM
Cascade Ballroom
* Maria S Sosa, Albert Einstein College of Medicine
Session Chair
Session Chair
* Lyse A. Norian, University of Alabama, Birmingham
Session Chair
Session Chair
Devon A. Lawson, University of California, Irvine
Conserved Microenvironmental Interactions Mediating Multi-Organ Metastasis
Conserved Microenvironmental Interactions Mediating Multi-Organ Metastasis
David Lyden, Weill Cornell Medical College
Tumor Induced Liver Metabolic Dysfunction Drives Metastasis
Tumor Induced Liver Metabolic Dysfunction Drives Metastasis
Sergei Grivennikov, Cedars-Sinai Medical Center
Microbiota Induced Cytokines Control Anti-Tumor Immunity and Colorectal Cancer Metastasis.
Microbiota Induced Cytokines Control Anti-Tumor Immunity and Colorectal Cancer Metastasis.
Mikala Egeblad, Johns Hopkins University
Immune Control and Escape at the Metastatic Site
Immune Control and Escape at the Metastatic Site
Alexandra Newman, New York University
Short Talk: Myocardial Infarction Increases Metastatic Cancer in The Lung
Short Talk: Myocardial Infarction Increases Metastatic Cancer in The Lung
Morgan Fox, University of Colorado
Short Talk: Non-Canonical Activation of FGFR1 Drives ER+ Breast Cancer Brain Metastasis in the Aged and E2-Depleted TME
Short Talk: Non-Canonical Activation of FGFR1 Drives ER+ Breast Cancer Brain Metastasis in the Aged and E2-Depleted TME
Coffee Break
9:00–9:20 AM
Riverview Lounge
Award Recipient Acknowledgement
9:20–9:25 AM
Cascade Ballroom
Poster Setup
11:00–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Career Roundtable (Joint)
2:30–4:00 PM
Alhambra
Frank Winkler, University Hospital Heidelberg
Professor, Physician, and Group Leader
Professor, Physician, and Group Leader
Eric S. Lightcap, HiberCell
Vice President of Translational Sciences
Vice President of Translational Sciences
Meera Murgai, National Cancer Institute, National Institutes of Health
Stadtman Investigator
Stadtman Investigator
Mario Flores, University of Texas at San Antonio
Assistant Professor
Assistant Professor
Coffee Break with Hot Chocolate, Firepits & Mountain Views
4:00–5:00 PM
Conservatory Terrace
The Brain-Body Axis in Metastasis (Joint)
5:00–7:00 PM
Cascade Ballroom
* Michelle Monje, Stanford University
Session Chair
Session Chair
* Donna L Senger, Lady Davis Institute for Medical Research/ McGill University
Session Chair
Session Chair
Humsa Venkatesh, Brigham and Women's Hospital
Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression
Neuronal-Activity Dependent Mechanisms of Small Cell Lung Cancer Progression
Manuel Valiente, Spanish National Cancer Research Centre
Strategies to Challenge Brain Metastasis Lethality in Mice and Human/The Effects of Brain Metastasis on Neural Circuits
Strategies to Challenge Brain Metastasis Lethality in Mice and Human/The Effects of Brain Metastasis on Neural Circuits
Erica K Sloan, Monash University
Blocking Stress Signaling to Control Metastatic Breast Cancer
Blocking Stress Signaling to Control Metastatic Breast Cancer
Golnaz Morad, MD Anderson Cancer Center
Short Talk: Metastatic Brain Tumors Harbor Intracellular Bacterial Signals Associated with the Oral Microbiota
Short Talk: Metastatic Brain Tumors Harbor Intracellular Bacterial Signals Associated with the Oral Microbiota
Kylynda C Bauer, National Institutes of Health - National Cancer Institute
Short Talk: Gut Microbiome Modulates Liver Cancer Via Neuroimmune Crosstalk
Short Talk: Gut Microbiome Modulates Liver Cancer Via Neuroimmune Crosstalk
Social Hour with Lite Bites
7:00–8:00 PM
Alberta/New Brunswick
Women in Science Networking Session
7:05–8:05 PM
Alberta/New Brunswick
* Maria S Sosa, Albert Einstein College of Medicine
Session Chair
Session Chair
* Michelle Monje, Stanford University
Session Chair
Session Chair
* Deisy L Segura-Villalobos, Albert Einstein College of Medicine
Session Chair
Session Chair
* Anna Adam Artigues, Albert Einstein College of Medicine
Session Chair
Session Chair
* Elizabeth A. Repasky, Roswell Park Cancer Institute
Session Chair
Session Chair
Poster Session 2
7:30–10:00 PM
Alberta/New Brunswick
Tuesday, January 21, 2025
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Cancer Cell Plasticity and Evolution During Metastasis
8:00–11:00 AM
Cascade Ballroom
* Devon A. Lawson, University of California, Irvine
Session Chair
Session Chair
Gelareh Zadeh, University Health Network
Remote Presenter: Methylation and Proteomic Signatures of Lung Cancer as Predictive Biomarkers of Brain Metastasis
Remote Presenter: Methylation and Proteomic Signatures of Lung Cancer as Predictive Biomarkers of Brain Metastasis
Samra Turajlic, Francis Crick Institute
Genetic and Transcriptional Determinants of Metastatic Competence
Genetic and Transcriptional Determinants of Metastatic Competence
Jean-Christophe W Marine, Vlaams Interuniversitair Instituut, Katholieke Universiteit Leuven
Influence of the Niche on Cancer Cell Hierarchy
Influence of the Niche on Cancer Cell Hierarchy
Ashley M Laughney, Weill Cornell Medicine
Tackling the Genotype-to-Phenotype Problem in Cancer Evolution
Tackling the Genotype-to-Phenotype Problem in Cancer Evolution
Myriam Labelle, St. Jude Children's Research Hospital
Short Talk: ZBTB18 Limits Tumor Cell Pliancy and Tumor Cell-Immune Cell Crosstalk to Inhibit Metastasis
Short Talk: ZBTB18 Limits Tumor Cell Pliancy and Tumor Cell-Immune Cell Crosstalk to Inhibit Metastasis
Maria S Sosa, Albert Einstein College of Medicine
Short Talk: Contributions of Evolutionarily Distinct Types of Disseminated Cancer Cells to the Metastatic Disease
Short Talk: Contributions of Evolutionarily Distinct Types of Disseminated Cancer Cells to the Metastatic Disease
Coffee Break
9:00–9:20 AM
Riverview Lounge
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Cascade Ballroom
* Julio Aguirre-Ghiso, Montefiore Einstein Cancer Center
Session Chair
Session Chair
Yunfan Sun, Zhongshan Hospital, Fudan University
Spatiotemporal Multi-Omics Uncover Tumor Ecosystem Dynamics Driving Metastatic Colonization
Spatiotemporal Multi-Omics Uncover Tumor Ecosystem Dynamics Driving Metastatic Colonization
Rebecca Dodd, University of Iowa
Epigenetic Plasticity Drives Sarcoma Metastasis through PRC2-Dependent Stromal Remodeling and IL-17D Signaling
Epigenetic Plasticity Drives Sarcoma Metastasis through PRC2-Dependent Stromal Remodeling and IL-17D Signaling
Anna Adam Artigues, Albert Einstein College of Medicine
Peripheral Sympathetic Nerve Damage Induces a Loss of Brain Niche Homeostasis Stimulating Metastatic Outgrowth of Disseminated Cancer Cells.
Peripheral Sympathetic Nerve Damage Induces a Loss of Brain Niche Homeostasis Stimulating Metastatic Outgrowth of Disseminated Cancer Cells.
Jonathan Rennhack, Loyola University Chicago
Transcription Factor Dynamics Induced by Cytokine Interaction in Metastatic Sites of Colorectal Cancer
Transcription Factor Dynamics Induced by Cytokine Interaction in Metastatic Sites of Colorectal Cancer
Mary Clare Beytagh, UCSF
Dissecting Mechanisms of Medulloblastoma Metastasis in Vivo
Dissecting Mechanisms of Medulloblastoma Metastasis in Vivo
Coffee Available
4:30–5:00 PM
Riverview Lounge
Engineering and Targeting of Host Mechanisms of Metastasis
5:00–6:45 PM
Cascade Ballroom
* Sergei Grivennikov, Cedars-Sinai Medical Center
Session Chair
Session Chair
Edgar G. Engleman, Stanford University School of Medicine
Remote Presenter: Harnessing Innate Immune Response to Reduce Metastatic Seeding
Remote Presenter: Harnessing Innate Immune Response to Reduce Metastatic Seeding
Ronit Satchi-Fainaro, Tel Aviv University
3D Bioprinted Cancer Models: From Basic Biology to Drug Development
3D Bioprinted Cancer Models: From Basic Biology to Drug Development
Daniel A. Heller, Memorial Sloan Kettering Cancer Center
Nanotherapeutic Targeting of Metastatic Cancer to the Brain
Nanotherapeutic Targeting of Metastatic Cancer to the Brain
Pierina Barturen-Larrea, California Institute of Technology
Short Talk: Acoustic Reporter Genes for In Situ Monitoring of Metastasis Dynamics
Short Talk: Acoustic Reporter Genes for In Situ Monitoring of Metastasis Dynamics
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Cascade Ballroom
Social Hour with Lite Bites
7:00–8:00 PM
Alberta/New Brunswick
Trivia
8:00–9:00 PM
Cascade Ballroom
Wednesday, January 22, 2025
Departure
12:00–11:59 PM
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