Joint with: Regulatory RNAs: Emerging Mechanisms
RNA Modifications in Health and Disease

Dec 12–15, 2023 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Eric A. Miska, Ramesh S. Pillai, and Eva Maria Novoa Pardo

  In Person
  On Demand
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Dec 12–15, 2023 | Fairmont Banff Springs, Banff, AB, Canada

Scientific Organizers: Eric A. Miska, Ramesh S. Pillai, and Eva Maria Novoa Pardo

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Tuesday, December 12, 2023
Registration  
4:00–8:00 PM
 Van Horne Foyer
Welcome Mixer  
6:00–8:00 PM
 Van Horne Foyer
Wednesday, December 13, 2023
Breakfast  
7:00–8:00 AM
 Van Horne Ballroom C
Welcome and Keynote Address (Joint)  
8:00–9:00 AM
 Van Horne A
* Eric A. Miska, University of Cambridge
Session Chair
* Mitchell Guttman, California Institute of Technology
Session Chair
Caroline Dean, John Innes Centre
Antisense-Mediated Chromatin Silencing
RNAs in Immune Defenses (Joint)  
9:00–11:15 AM
 Van Horne A
* Faezeh Jame-Chenarboo, University of Alberta
Session Chair
Sandra L. Wolin, NCI, National Institutes of Health
Nicked tRNAs: Surveillance and Roles as Regulatory RNAs
Stacy M. Horner, Duke University Medical Center
RNA Modifications at the Virus-host Interface
Christian Bellodi, Lund University
Short Talk: Short Talk: A New Role for the Pseudouridine Synthase 10 (PUS10) in Retrotransposon-driven Inflammation
Diana Dou, Stanford University
Short Talk: Short Talk: Xist Ribonucleoproteins Promote Female Sex-biased Autoimmunity
Coffee Break  
9:30–9:50 AM
 Van Horne Foyer
Poster Setup  
11:15–1:00 PM
 President's Hall
On Own for Lunch  
11:15–5:00 PM
Poster Viewing  
1:00–10:00 PM
 President's Hall
Workshop 1: Molecular Mechanisms  
2:30–4:30 PM
 Van Horne Ballroom A
* Federica Accornero, Brown University
Session Chair
Andre Verdel, INSERM - CNRS - UGA
YTH Protein Mmi1 Dimerization by Erh1 Drives Chromatin-associated Multimodal Gene Silencing
Aldema Sas-Chen, Tel Aviv University
Quantitative Cross-evolutionary Mapping Reveals Potential Roles for Dynamic RNA Acetylation in Thermostability
Jinbiao Ma, Fudan University
Molecular Mechanism and Regulation of RNA N6-Methylasdenosine Modification
Kira Holton, University of Michigan
Cellular Context for mRNA Substrate Selection by Pseudouridine Synthase 7 (PUS7)
P. Cody He, University of Chicago
Exon Junction Complexes and Exon Architecture Control m6A Methylation and Gene Expression
Gunter Meister, University of Regensburg
Autophagy Contributes to YTHDF Protein Regulation during Contact Inhibition
Julian Konig, Institute of Molecular Biology
RNA Stability Controlled by m6A Methylation Contributes to X-to-autosome Dosage Compensation in Mammals
Coffee Available  
4:30–5:00 PM
 Van Horne Foyer
Novel Technologies to Study RNA Modifications  
5:00–7:00 PM
 Van Horne Ballroom A
* Ainara Castellanos-Rubio, University of Basque Country
Session Chair
* Jean-Denis Beaudoin, University of Connecticut Health
Session Chair
Schraga Schwartz, Weizmann Institute of Science
The 100-nt Code Governing mRNA Methylation and mRNA Stability
Chengqi Yi, Peking University
Quantitative Mapping of mRNA Modifications in the Transcriptome
Kalon Overholt, MIT
Short Talk: Short Talk: RNA-mediated Genome Architecture Revealed by High Resolution Mapping of Chromatin Contacts
Amanda Whipple, Harvard University
Short Talk: Short Talk: Direct Mapping of snoRNA Interactions Identifies Targets of Orphan snoRNAs
Isabel Naarmann-de Vries, University Hospital Heidelberg
Short Talk: Short Talk: Detecting m6A at Single-molecular Resolution via Direct-RNA Sequencing and Realistic Training Data
Matthew Tegowski, Duke University
Short Talk: Short Talk: m6A Methylation Pattern in the Mammalian Cortex using Single-cell m6A Profiling
Social Hour with Lite Bites  
7:00–8:00 PM
 Van Horne Ballroom C
Poster Session 1  
7:30–10:00 PM
 President's Hall
Thursday, December 14, 2023
Breakfast  
7:00–8:00 AM
 Van Horne Ballroom C
RNA Modifications in Development and Disease  
8:00–11:00 AM
 Van Horne Ballroom A
Eva Maria Novoa Pardo, Centre for Genomic Regulation
Remote Presentation: Epitranscriptome in Cancer at Single-Nucleotide Resolution
Ramesh S. Pillai, University of Geneva
RNA Modifications in Development and Disease
Alexander H. Dalpke, Universität Heidelberg
RNA Modification, Processing and Immune Recognition
Donal O'Carroll, University of Edinburgh
Safeguarding Germline Immortality
Victoria H. Cowling, Beatson Institute for Cancer Research
RNA Cap Regulation in Health and Disease
Anja Wagner, Medical University Vienna
Short Talk: Short Talk: Deciphering rRNA Modification Changes in Cellular and Organismal Aging by Direct RNA Sequencing
Shunya Kaneko, National Institute of Genetics
Short Talk: Short Talk: Mettl1-dependent m7G tRNA Modification is Essential for Maintaining Spermatogenesis and Fertility in Drosophila Melanogaster
Coffee Break  
9:00–9:20 AM
 Van Horne Foyer
Poster Setup  
11:00–1:00 PM
 President's Hall
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 President's Hall
Career Roundtable (Joint)  
3:00–4:30 PM
 Van Horne A
Juan Alfonzo, Brown University
Professor of Molecular Biology, Cell Biology and Biochemistry
Sandra L. Wolin, NCI, National Institutes of Health
Chief and Senior Investigator, RNA Biology Laboratory
Asifa Akhtar, Max Planck Institute of Immunobiology and Epigenetics
Senior Group Leader & Director
Gudrun Stengel, Alida Biosciences
CEO & Co-Founder
Coffee Available  
4:30–5:00 PM
 Van Horne Foyer
Cancer and RNA Modifications  
5:00–7:00 PM
 Van Horne Ballroom A
* Kathy Liu, University of Pennsylvania
Session Chair
Michaela Frye, Deutsches Krebsforschungszentrum
RNA Modifications in Cancer
Yunsun Nam, University of Texas Southwestern Medical Center
RNA Substrate Recognition by Modification Enzymes
Kathy Liu, University of Pennsylvania
Catalytic-independent and -dependent Roles of rRNA Modifying Enzymes in Leukemogenesis
Giuseppe Quarto, Université libre de Bruxelles
Short Talk: Short Talk: SRSF2 Plays an Unexpected Role as Reader of m5C on mRNA, Linking Epitranscriptomics to Cancer
Social Hour with Lite Bites  
7:00–8:00 PM
 Van Horne Ballroom C
Poster Session 2  
7:30–10:00 PM
 President's Hall
Friday, December 15, 2023
Breakfast  
7:00–8:00 AM
 Van Horne Ballroom C
Translating RNA to Industry  
8:00–11:00 AM
 Van Horne Ballroom A
* Christopher Maher, Washington University
Session Chair
Eric A. Miska, University of Cambridge
Harnessing RNA Modifications for Therapeutics
Wendy V. Gilbert, Yale University
Decoding the Untranslated to Engineer Next-generation mRNA Therapeutics
Gudrun Stengel, Alida Biosciences
Short Talk: Short Talk: Mapping the Epitranscriptome Using a Multiplexed Barcoding Assay Platform
Ana Rita Poim, Universidade de Aveiro
Short Talk: Short Talk: Experimental Evolution and Dynamics of Adaptation of Yeast Lacking tRNA-Modifying Enzymes
Anindhya S Das, Brown University
Short Talk: Short Talk: AIMP3 is a Key Regulator of Cardiac Proteostasis
Coffee Break  
9:00–9:20 AM
 Van Horne Foyer
On Own for Lunch  
11:00–5:00 PM
Workshop 2: RNA Modifications and Therapeutics  
2:30–4:30 PM
 Van Horne Ballroom A
* Trushar R. Patel, University of Lethbridge
Session Chair
* Elena Piskounova, Weill Cornell Medicine
Session Chair
Cindy Ann Collins, Accent Therapeutics
Discovery of Small Molecule Inhibitors of ADAR1
Louna Fruchard, Institut Pasteur
Aminoglycoside Tolerance in Vibrio Cholerae Engages Translational Reprogramming Associated to Queuosine tRNA Modification
Pedro J. Batista, NCI, National Institutes of Health
Rewiring of RNA Methylation by the Oncometabolite Fumarate in Renal Cell Carcinoma
Inna Ricardo-Lax, Rockefeller University
RNA Modification By M5c – Lessons from RNA Viruses
Kamil R. Kranc, The Institute of Cancer Research
Targeting mRNA Modifications to Eradicate Cancer Stem Cells in Acute myeloid Leukaemia
Christopher Lee Holley, Duke University
SnoRNAs Regulating Cardiovascular Disease
Carre Clement, Sorbonne University - CNRS - Institut de Biologie Paris Seine -
The Ribose Methylation Enzyme FTSJ1 has a Conserved Role in Neuron Morphology and Learning Performance
Coffee Available  
4:30–5:00 PM
 Van Horne Foyer
Ki-Jun Yoon, Korea Advanced Institute of Science and Technology
Session Chair
Eva Kowalinski, European Molecular Biology Laboratory
Structural Studies of tRNA Modification Complexes
Juan Alfonzo, Brown University
Dynamic Interplay Between tRNA Transport, Processing and Modifications
Tsutomu Suzuki, University of Tokyo
Glycosylation of Queuosine in tRNAs Contributes to Optimal Translation and Post-embryonic Growth in Vertebrates
JeanYves Roignant, CIG, University of Lausanne
Pseudouridine Synthase 7 Controls Aggressiveness through Modulation of Glycolysis
Elena Piskounova, Weill Cornell Medicine
Short Talk: Short Talk: The Role of Codon-biased Translation and tRNA Modifications in Melanoma Metastasis
Non-Coding RNA Modifications  
5:00–7:30 PM
 Van Horne Ballroom A
Entertainment
Cash Bar
Social Hour with Lite Bites  
7:00–8:00 PM
 Van Horne Ballroom C
Saturday, December 16, 2023
Departure  
12:00–11:59 PM

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