Somatic Mosaicism in Human Development, Aging, and Diseases
Mar 07–10, 2027 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers:
Nuria Lopez-Bigas, Gilad Evrony, and Young Seok Ju
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Mar 07–10, 2027 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Nuria Lopez-Bigas, Gilad Evrony, and Young Seok Ju
Nuria Lopez-Bigas, PhD
IRB Barcelona
Nuria Lopez-Bigas Ph.D., is an ICREA Research Professor at the Institute for Research in Biomedicine in Barcelona. Her lab combines expertise in biology and bioinformatics and has made major contributions in the identification of cancer genes and cancer driver mutations across tumor types and in understanding the processes leading to the accumulation of mutations in cells. She currently leads the European project CGI-Clinics, which joins cancer hospitals across Europe to develop and implement a data-driven cancer genome platform for clinical decision making. She co-leads the Cancer Grand Challenge project PROMINENT.
Gilad Evrony
NYU Grossman School of Medicine
Gilad Evrony, M.D., Ph.D., is an Associate Professor of Pediatrics and Neuroscience at NYU Grossman School of Medicine and leads a research program focused on discovering mechanisms of somatic mutations in healthy tissues. His research includes development of the first single-cell DNA sequencing method for studying somatic mutation that was the first to identify somatic retrotransposition in human brain, as well as the first single-molecule sequencing method that resolves each DNA strand to detect mismatches, the precursors of many somatic mutations. Evrony’s laboratory also directs an Undiagnosed Diseases Program focused on identifying genetic causes of rare diseases that have failed clinical diagnostic tests, including somatic mosaic disorders that are often difficult to diagnose.
Young Seok Ju
Korea Advanced Institute of Science and Technology
Young Seok Ju, M.D., Ph.D., is a Professor at Graduate School of Medical Science and Engineering (GSMSE) at Korea Advanced Institute of Science and Technology (KAIST) and leads the Center for Somatic Mutation and Mosaicism. His research has defined somatic mutations arising during early human embryogenesis, as well as LINE-1 retrotransposition in normal human colon epithelium and mitochondrial DNA mosaicism. His research team has also made major contributions to cancer genomics, including the discovery of the KIF5B–RET fusion oncogene in lung adenocarcinoma, elucidation of genomic mechanisms underlying fusion oncogenes and large-scale characterization of breast cancer mutational landscapes. He is also co-founder of Inocras, a precision oncology company dedicated to advancing whole-genome sequencing–driven clinical applications.
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandMerchandise Options
Registration Options
Sunday, March 7, 2027
Fundraising
Registration
4:00–8:00 PM
British/Columbia Foyer
Welcome Mixer
6:00–8:00 PM
British/Columbia Foyer
Monday, March 8, 2027
Breakfast
7:00–8:00 AM
British/Columbia Ballroom
Welcome Remarks (Joint)
8:00–8:10 AM
British/Columbia Ballroom
Keynote Address (Joint)
8:10–9:00 AM
British/Columbia Ballroom
Benjamin L. Ebert, Dana-Farber Cancer Institute
Clonal Hematopoiesis as a Paradigm for Somatic Mosaicism
Clonal Hematopoiesis as a Paradigm for Somatic Mosaicism
Joint Session
9:00–11:30 AM
British/Columbia Ballroom
Laura A. Johnston, Columbia University
Cell Competition as a Framework for Diverse Areas of Biology
Cell Competition as a Framework for Diverse Areas of Biology
Nuria Lopez-Bigas, IRB Barcelona
Somatic Mosaicism and its Association to Cancer Risk
Somatic Mosaicism and its Association to Cancer Risk
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
British/Columbia Foyer
Poster Setup
11:30–1:00 PM
Vancouver Island Room
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
Vancouver Island Room
Symposia Spotlight 1
2:30–4:30 PM
British Ballroom
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Development and Modeling of Somatic Mosaicism
5:00–7:00 PM
British Ballroom
Tim Coorens, European Molecular Biology Laboratory
Somatic Mosaicism in Healthy Tissues as a Window into Cancer Development
Somatic Mosaicism in Healthy Tissues as a Window into Cancer Development
Young Seok Ju, Korea Advanced Institute of Science and Technology
Clonal Dynamics in Early Human Embryogenesis Inferred from Somatic Mutations and Epimutations
Clonal Dynamics in Early Human Embryogenesis Inferred from Somatic Mutations and Epimutations
Mariona Graupera, Josep Carreras Leukaemia Research Institute
Somatic Mutations as the Cause of Vascular Malformations in Humans
Somatic Mutations as the Cause of Vascular Malformations in Humans
Joe Gleeson, University of California, San Diego
Somatic Mosaicism in Brain Development
Somatic Mosaicism in Brain Development
Social Hour with Dinner
7:00–8:00 PM
British/Columbia Ballroom
Poster Session 1
7:30–10:00 PM
Vancouver Island Room
Tuesday, March 9, 2027
Breakfast
7:00–8:00 AM
British/Columbia Ballroom
Aging and Mechanisms of Somatic Mosaicism
8:00–11:00 AM
British Ballroom
Inigo Martincorena, Wellcome Trust Sanger Institute
Large-Scale Profiling of Somatic Mutations as a New Epidemiologic Tool
Large-Scale Profiling of Somatic Mutations as a New Epidemiologic Tool
Gilad Evrony, NYU Grossman School of Medicine
Modifiers and Determinants of Somatic Mutation Burdens and Patterns
Modifiers and Determinants of Somatic Mutation Burdens and Patterns
Raheleh Rahbari, Wellcome Trust Sanger Institute
Aging-Related Germline Mutation and Selection
Aging-Related Germline Mutation and Selection
Seishi Ogawa, Kyoto University
Somatic Mosaicism in Human Tissues Related to Aging and Disease
Somatic Mosaicism in Human Tissues Related to Aging and Disease
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
British/Columbia Foyer
Poster Setup
11:00–1:00 PM
Vancouver Island Room
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Vancouver Island Room
Career Roundtable
3:00–4:30 PM
Columbia Ballroom
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Technology and Tool Development
5:00–7:00 PM
British Ballroom
Kathleen H Burns, Dana Farber Cancer Institute | Harvard Medical School
Scalable Detection of Somatic Retrotransposition
Scalable Detection of Somatic Retrotransposition
Speaker to be Announced
Fei Chen, Broad Institute of MIT and Harvard
High-Resolution Spatial Profiling of Somatic Mosaicism
High-Resolution Spatial Profiling of Somatic Mosaicism
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
British/Columbia Ballroom
Poster Session 2
7:30–10:00 PM
Vancouver Island Room
Wednesday, March 10, 2027
Breakfast
7:00–8:00 AM
British/Columbia Ballroom
Somatic Mosaicism in the Clinic
8:00–11:00 AM
British Ballroom
Steven A. McCarroll, Harvard Medical School
The Ticking DNA Clock: How Lifelong Somatic Expansion of DNA Repeats Leads to Neurodegeneration
The Ticking DNA Clock: How Lifelong Somatic Expansion of DNA Repeats Leads to Neurodegeneration
Jeong Ho Lee, Korea Advanced Institute of Science and Technology
Brain Somatic Mutations in MTOR as Cause of Focal Epilepsy
Brain Somatic Mutations in MTOR as Cause of Focal Epilepsy
Francesca Ciccarelli, Barts Cancer Institute
The Role of Somatic Mutations in Maintaining or Hindering Tissue Homeostasis
The Role of Somatic Mutations in Maintaining or Hindering Tissue Homeostasis
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
British/Columbia Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2
2:30–4:30 PM
British Ballroom
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Premalignancies, Cancer Initiation and Cancer Risk
5:00–6:45 PM
British Ballroom
Maria Alcolea, University of Cambridge
Tracing the Origin of Clonal Pathogenesis
Tracing the Origin of Clonal Pathogenesis
Rosana Risques, University of Washington
Detecting Somatic Cancer Driver Mutations in Normal Bladder and Urine with Duplex Sequencing
Detecting Somatic Cancer Driver Mutations in Normal Bladder and Urine with Duplex Sequencing
Dan A. Landau, Weill Cornell Medicine
New Technology to Study Functional, Temporal and Spatial Features of Somatic Cell Evolution
New Technology to Study Functional, Temporal and Spatial Features of Somatic Cell Evolution
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
British Ballroom
Social Hour with Dinner
7:00–8:00 PM
British/Columbia Ballroom
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Thursday, March 11, 2027
Departure
12:00–11:59 PM
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