Joint with: Cell Competition: Fitness, Diversity, and Adaptation Across Scales and Species
Somatic Mosaicism in Human Development, Aging, and Diseases

Mar 07–10, 2027 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Nuria Lopez-Bigas, Gilad Evrony, and Young Seok Ju

  In Person
  On Demand
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Mar 07–10, 2027 | Fairmont Hotel Vancouver, Vancouver, BC, Canada

Scientific Organizers: Nuria Lopez-Bigas, Gilad Evrony, and Young Seok Ju

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, March 7, 2027
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Monday, March 8, 2027
Breakfast
7:00–8:00 AM
Welcome and Keynote Address (Joint)
8:00–9:00 AM
Benjamin L. Ebert †, Dana-Farber Cancer Institute
Clonal Expansions in the Hematopoetic System in Health and Disease
Joint Session
9:00–11:15 AM
Laura A. Johnston, Columbia University
Cell Competition as a Framework for Diverse Areas of Biology
Nuria Lopez-Bigas, IRB Barcelona
Somatic Mosaicism and its Association to Cancer Risk
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
Poster Setup
11:15–1:00 PM
On Own for Lunch
11:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Development and Modeling of Somatic Mosaicism
5:00–7:00 PM
Tim Coorens, European Molecular Biology Laboratory
Somatic Mosaicism in Healthy Tissues as a Window into Cancer Development
Young Seok Ju, Korea Advanced Institute of Science and Technology
Clonal Dynamics in Early Human Embryogenesis Inferred from Somatic Mutations and Epimutations
Joe Gleeson †, University of California, San Diego
Somatic Mosaicism in Brain Development
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Tuesday, March 9, 2027
Breakfast
7:00–8:00 AM
Aging and Mechanisms of Somatic Mosaicism
8:00–11:00 AM
Inigo Martincorena †, Wellcome Trust Sanger Institute
Large-Scale Profiling of Somatic Mutations as a New Epidemiologic Tool
Gilad Evrony, NYU Grossman School of Medicine
Modifiers and Determinants of Somatic Mutation Burdens and Patterns
Raheleh Rahbari, Wellcome Trust Sanger Institute
Aging-Related Germline Mutation and Selection
Seishi Ogawa †, Kyoto University
Somatic Mosaicism in Human Tissues Related to Aging and Disease
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Poster Setup
11:00–1:00 PM
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Technology and Tool Development
5:00–7:00 PM
Kathleen H Burns, Dana Farber Cancer Institute | Harvard Medical School
Scalable Detection of Somatic Retrotransposition
Fei Chen †, Broad Institute of MIT and Harvard
High-Resolution Spatial Profiling of Somatic Mosaicism
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, March 10, 2027
Breakfast
7:00–8:00 AM
Somatic Mosaicism in the Clinic
8:00–11:00 AM
Steven A. McCarroll, Harvard Medical School
The Ticking DNA Clock: How Lifelong Somatic Expansion of DNA Repeats Leads to Neurodegeneration
Mariona Graupera, Josep Carreras Leukaemia Research Institute
Somatic Mutations as the cause of Vascular Malformations in Humans
Jeong Ho Lee, Korea Advanced Institute of Science and Technology
Brain Somatic Mutations in MTOR as cause of Focal Epilepsy
Francesca Ciccarelli, Barts Cancer Institute
The Role of Somatic Mutations in Maintaining or Hindering Tissue Homeostasis
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Premalignancies, Cancer Initiation and Cancer Risk
5:00–6:45 PM
Maria Alcolea, University of Cambridge
Tracing the Origin of Clonal Pathogenesis
Rosana Risques, University of Washington
Detecting Somatic Cancer Driver Mutations in Normal Bladder and Urine with Duplex Sequencing
Dan A. Landau, Weill Cornell Medicine
New Technology to Study Functional, Temporal and Spatial Features of Somatic Cell Evolution
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:00–7:00 PM
Social Hour with Dinner
7:00–8:00 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Thursday, March 11, 2027
Departure
12:00–11:59 PM

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