Neurodegeneration: From Mechanisms to Precision Diagnosis and Therapies

Apr 11–14, 2027 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Bruce Miller, Ana Maria Cuervo, and Brandy Matthews

  In Person
  On Demand
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Apr 11–14, 2027 | Whistler Conference Centre, Whistler, BC, Canada

Scientific Organizers: Bruce Miller, Ana Maria Cuervo, and Brandy Matthews

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, April 11, 2027
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Monday, April 12, 2027
Breakfast
7:00–8:00 AM
Welcome and Keynote Session (Joint)
8:00–9:30 AM
Alfred Njamnshi †, University of Yaoundé
Infectious Disease Life-Time Impact on Cognition
Daniel S. Reich †, NINDS, National Institutes of Health
Combining Advanced Imaging and Biological Insights for Better Disease Progression
Coffee Break
9:30–9:50 AM
Molecular Insights into the Interplay between Neurodegeneration and Neuroinflammation (Joint)
9:30–11:15 AM
Li Gan †, Weill Cornell Medicine
Converging Molecular Mechanisms of Neurodegeneration
Mariko Bennett, University of Pennsylvania
The Potential of Microglia-Based Therapies in Neurodegeneration
David M Holtzman †, Washington University
Innate and Adaptive Immune System in tau-Mediated Neurodegeneration
Short Talk(s) Chosen from Abstracts
Panel Discussion 1: New Modalities in Neuro-Diagnosis and Therapeutics (Joint)
11:15–12:15 PM
Poster Setup
12:15–1:00 PM
On Own for Lunch
12:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight 1: AI/Machine Learning - from basic Discovery to Clinical Diagnosis
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Cellular Mechanisms of Defense against Proteotoxicity in the Central Nervous System
5:00–7:00 PM
Carmela Sidrauski †, Calico Life Sciences LLC
The Integrated Stress Response in Neurodegeneration
Ana Maria Cuervo, Albert Einstein College of Medicine
Selective Autophagy Malfunction in Neurodegeneration
Lidia Wróbel, International Institute of Molecular and Cell Biology
Nuclear Protein Quality Control in Neurodegenerative Diseases
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Tuesday, April 13, 2027
Breakfast
7:00–8:00 AM
Genetic and Non-Genetic Disease Modifiers
8:00–11:00 AM
Daniel H. Geschwind †, University of California, Los Angeles
Gene Networks in Neurodegeneration
Sarah Marzi †, King's College London
Epigenetic Regulation of Neurodegenerative Diseases
Fen-Biao Gao †, University of Massachusetts Medical School
Pathogenic Pathways in ALS
Rosa Rademakers †, VIB-UAntwerp Center for Molecular Neurology
Advances in frontotemporal Dementia Genetics
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Poster Setup
11:00–1:00 PM
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Cognitive Decline Beyond AD: Non AD Dementias
5:00–7:00 PM
Bruce Miller, University of California, San Francisco
Non-AD Dementias
Fanny Elahi, Icahn School of Medicine at Mount Sinai
Vascular Aging and Dementia
Pedro Pinheiro-Chagas, University of California, San Francisco
AI Advances in the Clinic
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, April 14, 2027
Breakfast
7:00–8:00 AM
Translating Innovation: Clinical Advances in Neurodegeneration and Neuroimmunology (Joint)
8:00–11:00 AM
Henrik Zetterberg †, University of Gothenburg
Biomarkers in Neurodegeneration and Neuroinflammation
Manuela Polydoro †, Muna Therapeutics
Translational Biomarkers in Drug Discovery
James Keaney, F. Hoffmann-La Roche
Targeting Intrinsic and Extrinsic Mechanisms of Neurodegeneration in CNS Drug Discovery
Joy Yu Zuchero, Denali Therapeutics Inc
Challenges for CNS Drug-Discovery
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Emerging Therapeutics for Neurodegenerative Disorders
5:00–6:45 PM
Brandy Matthews, Eli Lilly and Company
Efficacy of Clinical Trials for Amyloid Lowering
Olga Uspenskaya-Cadoz †, VectorY Therapeutics
Investigational Therapeutics for FTD
Ivana Rubino †, Biogen
Challenges for Clinical Translation across Neuroinflammation and Neurodegeneration
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Social Hour with Dinner
7:00–8:00 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Thursday, April 15, 2027
Departure
12:00–11:59 PM

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