***Meeting program subject to change.
Available Formats: = Livestream
= In Person
= On Demand
4:00–8:00 PM
Macdonald Foyer
6:00–8:00 PM
Macdonald Foyer
7:00–8:00 AM
Macdonald EF
Welcome and Keynote Session (Joint)
8:00–9:30 AM
Macdonald ABCD
Christian Haass, Ludwig-Maximilians University Munich
Modulation of Microglial Function
Astrid Iversen, University of Oxford
Genomic Risk for Neuroinflammation
9:30–9:50 AM
Macdonald Foyer
Integrating Degeneration and Inflammation (Joint)
9:50–11:15 AM
Macdonald ABCD
Malú Gámez Tansey, Indiana University School of Medicine
Role of Central-Peripheral Neuroimmune Cross-Talk in Neurodegeneration
Bart De Strooper, University College London
Key Inflection Points in Alzheimer’s Disease Pathogenesis
Short Talk(s) Chosen from Abstracts
11:15–1:00 PM
Macdonald EF
1:00–10:00 PM
Macdonald EF
Panel Discussion: From Research to Clinical Practice
2:30–4:30 PM
Macdonald AB
4:30–5:00 PM
Macdonald Foyer
Neurodegenerative Disease Diagnostic to Therapeutics
5:00–7:00 PM
Macdonald AB
Yimin Zou, University of California, San Diego
Planar Cell Polarity Proteins in Synapse Degeneration
Henne Holstege, Amsterdam UMC
Biomarker for Centenarians
Matthias Brendel, LMU Munich
Molecular Imaging with PET for Translation towards Therapeutics
Short Talk(s) Chosen from Abstracts
7:00–8:00 PM
Macdonald EF
7:30–10:00 PM
Macdonald EF
7:00–8:00 AM
Macdonald EF
Disease Overarching Mechanisms of Neurodegenerative Diseases
8:00–11:00 AM
Macdonald AB
Julia TCW, Boston University
Lipophagic Defect by APOE4 in AD Glia
Justin Ichida, USC Keck School of Medicine
Using Patient Stem Cells to Identify Therapeutic Targets for Familial and Sporadic ALS
Aaron D. Gitler, Stanford University School of Medicine
Single Cell Mechanisms of Neurodegeneration
Short Talk(s) Chosen from Abstracts
9:00–9:20 AM
Macdonald Foyer
11:00–1:00 PM
Macdonald EF
1:00–10:00 PM
Macdonald EF
Perspectives: Personalized Medicine & Patient-Centered Strategies (Joint)
1:15–2:45 PM
Macdonald ABCD
Short Talk(s) Chosen from Abstracts
Career Roundtable (Joint)
3:00–4:30 PM
Macdonald AB
4:30–5:00 PM
Macdonald Foyer
Myeloid-Based Disease Mechanisms for Neurodegenerative Diseases
5:00–7:00 PM
Macdonald AB
Donna M. Wilcock, Indiana University School of Medicine
Therapeutic Trem2 Activation Ameliorates Amyloid-beta Deposition and Improves Cognition in the 5XFAD Model of Amyloid Deposition
Zhiqiang An, The University of Texas Health Science Center at Houston
Antibodies Targeting the LILRB2/TREM2 Axis in AD
Marco Colonna, Washington University School of Medicine
Microglial Neurodegeneration Mechanisms
Short Talk(s) Chosen from Abstracts
7:00–8:00 PM
Macdonald EF
7:30–10:00 PM
Macdonald EF
7:00–8:00 AM
Macdonald EF
8:00–11:00 AM
Macdonald ABCD
Fiona C. Elwood, Janssen R&D
Developing Drugs for CNS Disorders: Considerations for Therapies That Cross the BBB
Kate Monroe, Denali Therapeutics
Human Genetics Identifies Novel Microglial Targeting Therapeutic Approaches for Alzheimer's Disease
Sebastian Boland, Prevail Therapeutics, Eli Lilly
Talk Title to be Announced
Christopher J. Barnum, INmune Bio Inc.
Selective Targeting of Soluble TNF to Mitigate Neuroinflammation in Neurodegenerative Diseases
Short Talk(s) Chosen from Abstracts
9:00–9:20 AM
Macdonald Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Macdonald ABCD
11:00–5:00 PM
Macdonald EF
Symposia Spotlight: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Macdonald AB
Short Talks Chosen from Abstracts
4:30–5:00 PM
Macdonald Foyer
Target-Based Therapeutics
5:00–6:45 PM
Macdonald AB
Emma Mead, Oxford Drug Discovery Institute
USP11 Inhibitors and tau Proteostasis
Haiyan Peng, Alnylam Pharmaceuticals
The Application of RNAi Therapeutics in Neurodegenerative Diseases
Marcos Costa, F. Hoffmann-La Roche Ltd
Correcting RNA Mis-Splicing in TDP-43 Proteinopathy
Short Talk(s) Chosen from Abstracts
6:45–7:30 PM
Macdonald AB
Dennis J. Selkoe, Harvard Medical School
A Century of Alzheimer’s Research – Did We Finally Reach Our Goal?
Meeting Wrap-Up: Outcomes and Future Directions
7:30–7:45 PM
Macdonald AB
7:45–8:45 PM
Macdonald EF
8:00–9:00 PM
MacDonald CD
8:00–9:00 PM
Macdonald EF
