Joint with: Targeted Protein Degradation
Proximity Based Therapeutics

Jan 21–24, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Ryan Potts and Michelle R. Arkin

  In Person
  On Demand
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Jan 21–24, 2024 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Ryan Potts and Michelle R. Arkin

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, January 21, 2024
Arrival and Registration  
4:00–8:00 PM
 Longs Peak Foyer
Welcome Mixer  
6:00–8:00 PM
 Longs Peak Foyer
Monday, January 22, 2024
Breakfast  
7:00–8:00 AM
 Quandary Peaks
Welcome and Keynote Address (Joint)  
8:00–9:00 AM
 Grays/Longs Peaks
Ning Zheng, University of Washington
Targeting Ubiquitin Ligases: From Hormones to Metabolites
Mechanisms of the Ubiquitin System (Joint)  
9:00–11:15 AM
 Grays/Longs Peaks
Brenda A. Schulman, Max Planck Institute of Biochemistry
Structural Mechanisms of Dynamic Multiprotein E3 Ligases
Michael Rape, University of California, Berkeley
Novel Cullin-RING E3 Ligase Mechanisms Discovered through Deciphering Pathways Underlying Cellular Differentiation
Henry M. Colecraft, Columbia University
Developing Targeted Deubiquitination: Opportunities for Therapeutic Protein Stabilization
Jin Wang, Baylor College of Medicine
Short Talk: Short Talk: Unexpected Discoveries Through Developing BTK PROTACs
Ana Marcu, Genentech
Short Talk: Short Talk: Developing Discovery Proteomics Technologies to Elucidate HLA Neoantigen Presentation
Coffee Break  
9:30–9:50 AM
 Longs Peak Foyer
Poster Setup  
11:15–1:00 PM
 Quandary Peaks
On Own for Lunch  
11:15–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Quandary Peaks
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Emerging Proximity Biology for Target Degradation  
5:00–7:00 PM
 Grays Peak
Leon O. Murphy, Casma Therapeutics
Drugging the Autophagy-Lysosomal Pathway
Ryan Potts, Amgen
RNATACs: Targeted mRNA Degradation
William Gibson, Dana Farber Cancer Institute
Short Talk: Short Talk: Bifunctional Small Molecules that Induce Nuclear Localization and Targeted Transcriptional Regulation
Ziwen Jiang, University of California, San Francisco
Short Talk: Short Talk: Autophagy Receptor-inspired Antibody-fusion Proteins for Targeted Intracellular Degradation
Social Hour with Lite Bites  
7:00–8:00 PM
 Quandary Peaks
Poster Session 1  
7:30–10:00 PM
 Quandary Peaks
Tuesday, January 23, 2024
Breakfast  
7:00–8:00 AM
 Quandary Peaks
Stabilizing Protein-Protein Interactions with Molecular Glues  
8:00–11:00 AM
 Grays Peak
Michelle R. Arkin, University of California, San Francisco
Modulating 14-3-3 Interactome
Jan Anne Smith, Revolution Medicines, Inc.
Targeting the Oncogenic State of RAS Mutants with Tricomplex Inhibitors
Goutham Narla, University of Michigan Medical School
From Mutations to Molecules: Lessons Learned from Protein Phosphatase 2A
Ella Livnah, Weizmann Institute of Science
Short Talk: Short Talk: Rationally Designed Bifunctional Ligands Induce Intracellular Precipitation of Symmetric Protein Targets
Coffee Break  
9:00–9:20 AM
 Longs Peak Foyer
Poster Setup  
11:00–1:00 PM
 Quandary Peaks
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Quandary Peaks
Women in TPD & IP Networking Social - Open to All!
1:30–2:30 PM
 Castle Peak 1-2
Career Roundtable (Joint)  
3:00–4:30 PM
 Longs Peak
Michelle R. Arkin, University of California, San Francisco
Professor & Chair, Codirector, Small Molecule Discovery Center (SMDC)
Helen Walden, University of Glasgow
Professor of Structural Biology, Head of School (Molecular Biosciences)
Ramon J. Whitson, Novartis
Principal Scientist II
Byram Hirsch Ozer, National Cancer Institute
Assistant Research Physician
Mishtu Dey, Cell Press
Editor-in-Chief
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Predicting and Discovering Ternary Complexes  
5:00–7:00 PM
 Grays Peak
Jesus Izaguirre, Stealth Startup
Towards Rational Design of Selective Protein Degraders
Georg A. Petzold, Monte Rosa Therapeutics
Teaching CRBN New Tricks
Heidi Greulich, Broad Institute of MIT and Harvard
Activation of the SLFN12 RNase by Velcrin-Induced PDE3A-SLFN12 Complex Formation
Pranam Chatterjee, Duke University
Short Talk: Short Talk: Design of Programmable Peptide-Guided Proteome Editors via Generative Language Models
Social Hour with Lite Bites  
7:00–8:00 PM
 Quandary Peaks
Poster Session 2  
7:30–10:00 PM
 Quandary Peaks
Wednesday, January 24, 2024
Breakfast  
7:00–8:00 AM
 Quandary Peaks
Controlling Post-Translational Modifications by Induced Proximity  
8:00–11:00 AM
 Grays Peak
Daniel K. Nomura, University of California, Berkeley
Reimagining Druggability Using Chemoproteomic Platforms
Amit Choudhary, Harvard Medical School
Protein Editing using Small Molecules
Gopal P. Sapkota, University of Dundee
Targeted Ubiquitylation and Dephosphorylation of Proteins Through Proximity-Induction
Endri Karaj, The Broad Institute of MIT and Harvard
Short Talk: Short Talk: Development of Haptenizing Chimeras from Known Drugs for Cancer Immunotherapy
Lionel Chia, Foghorn Therapeutics
Short Talk: Short Talk: Hijacking the Transcriptional Activation Potential of BAF for Novel Therapeutic Opportunities
Coffee Break  
9:00–9:20 AM
 Longs Peak Foyer
On Own for Lunch  
11:00–5:00 PM
Workshop: New Screening and Profiling Technologies
3:30–4:30 PM
 Grays Peak
Kyle Seamon, Revolution Medicines
Induction of Complexes Between Cyclophilin A and GTP-Bound RAS(ON) Enable Covalent Modification of KRAS(G12D) for Inhibition of G12D-Mutant Cancer Growth
Violeta L. Marin, AbbVie, Inc.
CRISPR Screen Reveals BRD2/4 Molecular Glue Degrader Via Recruitment of DCAF16
Madelon M. Maurice, University Medical Center Utrecht
Employing Membrane-bound E3 Ligases for Targeted Degradation of Cell Surface Proteins using SureTACs Technology
Erik Ehinger, La Jolla Institute for Immunology
Improving Anti-tumor Responses by Degrading Proteins that Impose T Cell Exhaustion
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Development and Discovery of Molecular Glues (Joint)  
5:00–6:45 PM
 Grays/Longs Peaks
Eric S. Fischer, Dana-Farber Cancer Institute
New Mechanism for Protein Degradation Therapeutics
Mary E. Matyskiela, Neomorph Inc.
Expanding the Target Space of Molecular Glue Degraders
Keriann Marie Backus, David Geffen School of Medicine at UCLA
Global Proteome Rewiring by Fragment Electrophiles
Varun Jayeshkumar Shah, Institute of Biochemistry II, Medical Dpt of Univ. Hosp. Frankfurt, Goethe University
Short Talk: Short Talk: Discovery of Novel Molecular Glue Degraders
Michael A. Erb, The Scripps Research Institute
Short Talk: Short Talk: Systematic Remodeling of Protein-Ligand Surfaces for Prospective Molecular Glue Discovery
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Grays/Longs Peaks
Social Hour with Lite Bites  
7:00–8:00 PM
 Quandary Peaks
Trivia  
8:00–9:00 PM
 Longs Peak
Cash Bar  
8:00–9:00 PM
 Quandary Peaks
Thursday, January 25, 2024
Departure  
7:00–11:59 PM

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