Mitochondria Signaling and Disease
Feb 12–15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Heidi M. McBride and Timothy Wai
In Person
On Demand
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Feb 12–15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Heidi M. McBride and Timothy Wai
Heidi M. McBride
Timothy Wai
Available Formats:
Supported by the Directors' Fund
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMerchandise Options
Registration Options
Booking Function
Fundraising
Monday, February 12, 2024
Arrival and Registration
4:00–8:00 PM
Van Horne Foyer
Welcome Mixer
6:00–8:00 PM
Van Horne Foyer
Tuesday, February 13, 2024
Breakfast
7:00–8:00 AM
Mezzanine 2
Welcome and Keynote Session (Joint)
8:00–9:30 AM
Van Horne B
* Heidi M. McBride, McGill University
Session Chair
Session Chair
* Jodi Nunnari, Altos Labs
Session Chair
Session Chair
Karin M. Reinisch, Yale University School of Medicine
Molecular basis for Inter-Organellar Lipid Transfer at Contact Sites
Molecular basis for Inter-Organellar Lipid Transfer at Contact Sites
Edward T. Chouchani, Dana-Farber Cancer Institute
Building an Architecture of Functional Metabolite-Protein Interactions
Building an Architecture of Functional Metabolite-Protein Interactions
Coffee Break
9:30–9:50 AM
Van Horne Foyer
Mitochondrial Dynamics (Joint)
9:50–11:15 AM
Van Horne B
* Timothy Wai, Institut Pasteur
Session Chair
Session Chair
* Gia K. Voeltz, University of Colorado Boulder
Session Chair
Session Chair
Luca Scorrano, University of Padova
Unbiased Screenings Illuminate Regulators of Mitochondrial Dynamics and Contact Sites
Unbiased Screenings Illuminate Regulators of Mitochondrial Dynamics and Contact Sites
Stefan Jakobs, Max Planck Institute for Multidisciplinary Sciences
Architecture of Mitochondria
Architecture of Mitochondria
Jodi Nunnari, Altos Labs
Lipid Trafficking at Mitochondria
Lipid Trafficking at Mitochondria
Poster Setup
11:15–1:00 PM
Mezzanine 2
On Own for Lunch
11:15–5:00 PM
Career Roundtable (Joint)
1:00–2:00 PM
Van Horne C
Leon O. Murphy, Casma Therapeutics
Senior Vice President Biology
Senior Vice President Biology
Ana J. García-Sáez, University of Cologne
Professor and Director of the Max Planck Institute of Biophysics
Professor and Director of the Max Planck Institute of Biophysics
Tamas Balla, NICHD, National Institutes of Health
Senior Investigator
Senior Investigator
Dustin Hancks, University of Texas Southwestern Medical Center
Assistant Professor
Assistant Professor
Poster Viewing
1:00–10:00 PM
Mezzanine 2
Workshop 1: Hot Topics in Mitochondrial Biology (Joint)
2:30–4:30 PM
Van Horne B
* Tim Shutt, University of Calgary
Session Chair
Session Chair
Barbora Turpin Knotkova, Heidelberg University
Building Bridges: Reconstitution and Molecular Characterisation of the Mitochondrial Membrane Contact Site
Building Bridges: Reconstitution and Molecular Characterisation of the Mitochondrial Membrane Contact Site
Brandon Chen, University of Michigan
BRD4-Mediated Epigenetic Regulation of Endoplasmic Reticulum-Mitochondria Contact Sites is Governed by Mitochondria Complex III Function
BRD4-Mediated Epigenetic Regulation of Endoplasmic Reticulum-Mitochondria Contact Sites is Governed by Mitochondria Complex III Function
Laurent Chatel-Chaix, Institut National de la Recherche Scientifique
Dengue Virus and Zika Virus Alter Endoplasmic Reticulum-Mitochondria Contacts to Regulate Respiration and Apoptosis
Dengue Virus and Zika Virus Alter Endoplasmic Reticulum-Mitochondria Contacts to Regulate Respiration and Apoptosis
Lena Ho, Duke-NUS Medical School
Microproteins Mediate Localized Mitochondrial Translation to Drive OXPHOS
Microproteins Mediate Localized Mitochondrial Translation to Drive OXPHOS
Marc Germain, Université du Québec à Trois-Rivières
Mitochondria- and ER-Associated Actin are Required for Mitochondrial Fusion
Mitochondria- and ER-Associated Actin are Required for Mitochondrial Fusion
Juan Cruz Landoni, EPFL
Mitochondrial Pearling as a Putative Content Management Mechanism
Mitochondrial Pearling as a Putative Content Management Mechanism
Will Hofstadter, Princeton Universtiy
Infection-Induced Peripheral Mitochondria Fission Drives ER Encapsulations and Inter-Mitochondria Contacts that Rescue Bioenergetics
Infection-Induced Peripheral Mitochondria Fission Drives ER Encapsulations and Inter-Mitochondria Contacts that Rescue Bioenergetics
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Emerging Quality Control Mechanisms
5:00–7:00 PM
Van Horne B
* Shiori Sekine, University of Pittsburgh, Aging Institute
Session Chair
Session Chair
Hilla Weidberg, University of British Columbia
A Novel Role for Mitochondrial Targeting Sequences in Stress Signaling
A Novel Role for Mitochondrial Targeting Sequences in Stress Signaling
Peter Rehling, University Medical Centre Göttingen
Regulating Mitochondrial Gene Expression
Regulating Mitochondrial Gene Expression
Xingguo Liu, Guangzhou Institutes of Biomedicine and Health
Mitolysosomes as New Pathway in Quality Control
Mitolysosomes as New Pathway in Quality Control
Martin Graef, Cornell University
Short Talk: Short Talk: Autophagy Functions in Mitochondrial and Nuclear Genome Maintenance
Short Talk: Short Talk: Autophagy Functions in Mitochondrial and Nuclear Genome Maintenance
Natalie Niemi, Washington University in St. Louis
Short Talk: Short Talk: PPTC7 Maintains Mitochondrial Protein Content by Suppressing Receptor-mediated Mitophagy
Short Talk: Short Talk: PPTC7 Maintains Mitochondrial Protein Content by Suppressing Receptor-mediated Mitophagy
Social Hour with Lite Bites
7:00–8:00 PM
Mezzanine 2
Poster Session 1
7:30–10:00 PM
Mezzanine 2
Wednesday, February 14, 2024
Breakfast
7:00–8:00 AM
Mezzanine 2
Stress and Death Pathways
8:00–11:00 AM
Van Horne B
* Atan J. Gross, Weizmann Institute of Science
Session Chair
Session Chair
Ana J. García-Sáez, University of Cologne
Mitochondrial Membrane Remodeling During Death
Mitochondrial Membrane Remodeling During Death
Heidi M. McBride, McGill University
MDVs in Mitochondrial Homeostasis
MDVs in Mitochondrial Homeostasis
Lucas T. Jae, Ludwig-Maximilians-University Munich
Genetic Dissection of Mitochondrial Stress in Human Cells
Genetic Dissection of Mitochondrial Stress in Human Cells
Timothy Wai, Institut Pasteur
Stress Responses and Cardiac Health
Stress Responses and Cardiac Health
Hua Bai, Iowa State University
Short Talk: Short Talk: Role of Plasmalogen Ether Phospholipids in Mitochondrial Membrane Dynamics and Aging
Short Talk: Short Talk: Role of Plasmalogen Ether Phospholipids in Mitochondrial Membrane Dynamics and Aging
Jordyn VanPortfliet, Texas A&M School of Medicine
Short Talk: Short Talk: Hyperinflammatory Antibacterial Innate Immunity and Elevated Lung Immunopathology in a Model of PolG-Related Mitochondrial Disease
Short Talk: Short Talk: Hyperinflammatory Antibacterial Innate Immunity and Elevated Lung Immunopathology in a Model of PolG-Related Mitochondrial Disease
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Poster Setup
11:00–1:00 PM
Mezzanine 2
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Mezzanine 2
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Transfer of Mitochondria
5:00–7:00 PM
Van Horne B
* Marc Germain, Université du Québec à Trois-Rivières
Session Chair
Session Chair
Clair Crewe, Washington University School of Medicine in St. Louis
Inter-Organ Transport of Mitochondria
Inter-Organ Transport of Mitochondria
Minna Roh-Johnson, University of Utah
Mitochondrial Transfer in Cancer Models
Mitochondrial Transfer in Cancer Models
Chiara Zurzolo, Institut Pasteur
Tunneling Nanotubes and Mitochondrial Transfer
Tunneling Nanotubes and Mitochondrial Transfer
Luana Naia, Karolinska Institutet
Short Talk: Short Talk: Bidirectional Neuron-astrocyte Mitochondrial Transfer in Alzheimer´s Disease
Short Talk: Short Talk: Bidirectional Neuron-astrocyte Mitochondrial Transfer in Alzheimer´s Disease
Akhila Rajan, Fred Hutchinson Cancer Center
Short Talk: Short Talk: Mitochondrial Components as Adipokines: A Novel Fat-brain Communication Modality
Short Talk: Short Talk: Mitochondrial Components as Adipokines: A Novel Fat-brain Communication Modality
Social Hour with Lite Bites
7:00–8:00 PM
Mezzanine 2
Poster Session 2
7:30–10:00 PM
Mezzanine 2
Thursday, February 15, 2024
Breakfast
7:00–8:00 AM
Mezzanine 2
Metabolic Rewiring in Cell Fate Decisions (Joint)
8:00–11:00 AM
Van Horne B
* Mary-Ellen Harper, University of Ottawa
Session Chair
Session Chair
Lydia Finley, Memorial Sloan Kettering Cancer Center
Identifying and Exploiting Cell State-Dependent Metabolic Networks
Identifying and Exploiting Cell State-Dependent Metabolic Networks
Jessica B. Spinelli, University of Massachusetts Chan Medical School
Unlocking the Potential of the Mammalian Electron Transport Chain
Unlocking the Potential of the Mammalian Electron Transport Chain
Carmela Sidrauski, CalicoLabs
ISR Tuning of Metabolism and Cell Fate in Homeostasis and Disease
ISR Tuning of Metabolism and Cell Fate in Homeostasis and Disease
Fabricio Loayza-Puch, German Cancer Research Center
Short Talk: Short Talk: Exploiting Mitochondrial Translation to Uncover Compartment-specific Metabolic Vulnerabilities
Short Talk: Short Talk: Exploiting Mitochondrial Translation to Uncover Compartment-specific Metabolic Vulnerabilities
Daria Ilatovskaya, Medical College of Georgia
Short Talk: Short Talk: Sex Hormones-mediated Differences in Renal Mitochondrial Bioenergetics and Metabolism
Short Talk: Short Talk: Sex Hormones-mediated Differences in Renal Mitochondrial Bioenergetics and Metabolism
Ryo Higuchi-Sanabria, University of Southern California
Short Talk: Short Talk: Branching Out From Actin Filaments: Actin and Organelle Homeostasis During Aging
Short Talk: Short Talk: Branching Out From Actin Filaments: Actin and Organelle Homeostasis During Aging
Erica Kane, Western Univesity
Short Talk: Short Talk: Interrogating the Mechanistic Role of Integrated Stress Response in Microglial Polarity
Short Talk: Short Talk: Interrogating the Mechanistic Role of Integrated Stress Response in Microglial Polarity
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Poster Setup
11:00–1:00 PM
Mezzanine 2
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Mezzanine 2
Workshop 2: Leading Edge Technologies: Mitochondrial Metabolism and Metabolomics (Joint)
2:30–4:30 PM
Van Horne B
* Sara Nowinski, Van Andel Institute
Session Chair
Session Chair
Isshin Shiiba, Gakushuin University
The Development of Organelle Contact Sites Quantification Tool and Exploration of the New Role of ER-Mitochondria Contact
The Development of Organelle Contact Sites Quantification Tool and Exploration of the New Role of ER-Mitochondria Contact
Satoko Shinjo, Fondazione per la ricerca biomedica avanzata VIMM
Imaging Various Interorganellar Distances with STACCATO, a Reversible, Multispectral Split-FAST Mitochondria-ER Contacts Probe
Imaging Various Interorganellar Distances with STACCATO, a Reversible, Multispectral Split-FAST Mitochondria-ER Contacts Probe
Ahmad A. Cluntun, University of Utah, HHMI
MCT1 Facilitates Direct Mitochondrial Oxidation of Lactate in the Heart
MCT1 Facilitates Direct Mitochondrial Oxidation of Lactate in the Heart
Zak Baker, Washington University in St. Louis
Multiomic Profiling Reveals a Critical Role for Triacylgycerol Mobilization in Surmounting Mitochondrial Dysfunction
Multiomic Profiling Reveals a Critical Role for Triacylgycerol Mobilization in Surmounting Mitochondrial Dysfunction
Ana Victoria Lechuga-Vieco, University of Oxford / The Kennedy Institute of Rheumatology
Metabolic Remodeling Through Mitochondrial Transfer: A Key to Enhanced Immune Responses
Metabolic Remodeling Through Mitochondrial Transfer: A Key to Enhanced Immune Responses
Gayathri Muthukumar, Whitehead Institute, MIT
Uncovering Biogenesis Pathways for Alpha-Helical Mitochondrial Outer Membrane Proteins Using Genome-Wide Approaches
Uncovering Biogenesis Pathways for Alpha-Helical Mitochondrial Outer Membrane Proteins Using Genome-Wide Approaches
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Mitochondria and Immunity
5:00–6:45 PM
Van Horne B
* Olaf Groß, University Medical Center Freiburg
Session Chair
Session Chair
Lena Pernas, University of California, Los Angeles and Max Planck Institute for Biology of Ageing
Organellar and Metabolic Dynamics of the Host-Pathogen Interaction
Organellar and Metabolic Dynamics of the Host-Pathogen Interaction
Robert O. Watson, Texas A&M University, School of Medicine
Mitochondrial ROS Promotes Susceptibility to Infection via Gasdermin D-Mediated Necroptosis
Mitochondrial ROS Promotes Susceptibility to Infection via Gasdermin D-Mediated Necroptosis
Julien Prudent, University of Cambridge
Inner Mitochondrial Membrane Remodeling and mtDNA Dynamics
Inner Mitochondrial Membrane Remodeling and mtDNA Dynamics
Dustin Hancks, University of Texas Southwestern Medical Center
Short Talk: Short Talk: Rewiring of Mitochondrial Metabolism Invokes Subprograms of the Interferon Response to Adapt Host Defenses
Short Talk: Short Talk: Rewiring of Mitochondrial Metabolism Invokes Subprograms of the Interferon Response to Adapt Host Defenses
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Van Horne B
Social Hour with Lite Bites
7:00–8:00 PM
Mezzanine 2
Poster Session 3
7:30–10:00 PM
Mezzanine 2
Friday, February 16, 2024
Departure
7:00–11:59 PM
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