Mar 23–26, 2025 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Mohammed AlQuraishi, Elizabeth Kellogg, and Possu Huang

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Scientific Organizers: Mohammed AlQuraishi, Elizabeth Kellogg, and Possu Huang
Mohammed AlQuraishi
Elizabeth Kellogg
Possu Huang
***Meeting program subject to change.
Available Formats: = In Person = On DemandSunday, March 23, 2025
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Monday, March 24, 2025
Session Chair
Session Chair
Cryo-Electron Tomography or the Power of Seeing the Whole Picture
Session Chair
Have Protein Language Models Learned Dynamics
Hacking AlphaFold to Do New Things
Understanding How AlphaFold Learns
Short Talk: Predicting the Conformational Flexibility of Antibody and T-cell Receptor CDRs
Short Talk: Improving Cryo-EM of Vesicle-Embedded Membrane Proteins: A Machine Learning Pipeline for Lipid Bilayer Subtraction
Session Chair
Building the Next Alphafold: Creating Public Databases and Benchmarks to Accelerate Machine Learning for Protein Engineering
Resolving the Conformational Ensemble of a Membrane Protein by Integrating Small-Angle Scattering with Alphafold
Protein Codes Promote Selective Subcellular Compartmentalization
Interplm: Discovering Interpretable Features in Protein Language Models Via Sparse Autoencoders
Deep Models of Protein Evolution
An Uncertainty-Aware Method for Single-Particle Cryo-Em Data Collection Using Online Feedback
Sliding Window Interaction Grammar (Swing): A Generalized Interaction Language Model for Peptide and Protein Interactions
Empowering Alphafold2 for Protein Conformation Selective Drug Discovery with Alphafold2-Rave
Fast Search Methods to Organize the Structural Protein Universe
From Content-Aware Denoising to Semantic Unmixing – One Way How AI is Transforming Scientific Image Data Analysis in The Life Sciences
Short Talk: Deep Learning Models for Protein Structure Elucidation from Different Types of Experimental Data
Short Talk: Machine Learning the Binding Affinities of Protein–Peptide Interactions in Cell Signaling
Short Talk: Protein Structure Classification in the Post-Alphafold Era
Session Chair
Session Chair
Session Chair
Session Chair
Tuesday, March 25, 2025
Session Chair
Making Cryo-ET Faster, Better, Cheaper
Single Molecule Localization and Structure Probing in Cells
Discovering New Biology with Cryo-ET
Structural Insights into CRISPR-Based Genome Editing
Short Talk: Automated Filtering of Particle Images in Single Particle CryoEM
Assistant Professor
Director of Scientific Projects
Head of Stem Cell Biology
Scientific Editor, Cell Systems
AI4BIO: Democratizing AI and Empowering Biologists with a Modular, Open-Source AI Toolkit
Decoding Binding Entropy Through Statistical Structural Biology and Conformational Ensembles
KnotFold: Improving Peptide Structure Prediction with Simulated Coevolution
Short Talk: Building iIn Silico Models Across Biological Scales to Accelerate Drug Discovery
Short Talk: Temporally Resolved and Interpretable Machine Learning Models of G-Protein Coupled Receptors
Wednesday, March 26, 2025
Session Chair
ML Design of Protein-Binding Peptides
Deep Generative Models for Protein Design
Expanding the Landscape of Structural and Functional Proteins by Computational Design
Short Talk: Fusing Motifs for Avid Sensing, Intracellular Reporters, and Crystalline Assemblies
Short Talk: De Novo Design of High-Affinity Dual-Target Binders for Drug Polypharmacology Augmentation
Computing the Human Interactome
Structural Basis of Small Molecule Binding by Machine Learning
Short Talk: Advancing Particle Identification In Cryo-Electron Tomograms With Deep Learning
Thursday, March 27, 2025
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