The regulation of genome function through epigenetic mechanisms and 3D chromatin architecture is fundamental to development, physiology, and disease. Disruption of key epigenetic regulators—such as DNA and histone modifying enzymes, chromatin remodelers, and nuclear organizers—is increasingly linked to cancer, immune dysfunction, neurodevelopmental disorders, and aging-related decline. While epigenetic therapies and genome-editing tools are advancing toward the clinic, a deeper understanding of how these mechanisms govern cell fate and dysfunction is essential to unlocking new biological insights and developing more effective therapeutic strategies.

This meeting will bring together leading scientists across epigenetics, chromatin biology, developmental and disease biology, therapeutic discovery, and technology development. Core themes include chromatin modifications and function, 3D genome architecture, epigenetic inheritance and plasticity, and chromatin dysregulation in disease. Sessions will also highlight emerging technologies, such as epigenome editing, single-cell and spatial profiling, and high-resolution genome imaging, and explore their impact on both mechanistic discovery and translational advances.

The diverse lineup of topics and speakers aims to immerse attendees in cutting-edge science while fostering cross-disciplinary exchange and collaboration. Trainees will particularly benefit from late-breaking abstract talks, interactive panels, and career roundtables that provide invaluable opportunities to engage with leaders and rising stars in the field.