Lung diseases represent leading causes of morbidity and mortality worldwide. Beginning with antenatal development, the lung undergoes changes throughout the life course as a consequence of aging as well as in response to infection and other injurious stimuli. Knowledge gaps exist in how individual cell populations coordinate and respond to these changes in states of health and disease over time. The goals of this Symposium are: 1) to address how specific cell populations contribute to the formation and regeneration of the lung over the life course; 2) to examine metabolism, epigenetics, stress responses, and cell-cell interactions as features that control lung biology and how control mechanisms change over stages of life; 3) to understand how emerging technologies and models will elucidate fundamental mechanisms of lung health and disease; and 4) to articulate how the host immune response to infection determines reparative and regenerative processes. As a result of this meeting, attendees will have a more comprehensive view of dynamic mechanisms that drive pulmonary biology as it relates to health and disease as well as the newest approaches with which to understand these concepts. Through positive interactions, attendees will forge new collaborations in distinct fields of study. Indeed, the unrivaled expertise of the speakers, organized into sessions arranged around diverse topic areas, will create a unique program unavailable via other venues. Ultimately, this Symposium will impact the field of lung biology by bringing together interdisciplinary groups of scientists that will synergize to propel discovery of mechanisms underlying lung health and disease.