Metabolic alterations and inflammatory abnormalities are key contributors to the development of cardiovascular diseases. Recent evidence shows that a chronic low-grade inflammatory response of metabolic origin, termed “metainflammation,” is a defining feature of various cardiovascular diseases, including heart failure and atherosclerosis. Consequently, this Keystone Symposium will bring together leading investigators in the areas of cardiac biology, immunity, vascular inflammation, and obesity-induced cardiovascular disease to elucidate immunometabolic mechanisms in the trajectory to heart failure. Sessions will encompass a broad range of topics highlighting the importance of, and mechanisms whereby, metabolic inflammation contributes to the pathogenesis of myocardial dysfunction and vascular dysfunction.

Specifically, the program will cover:

1) HFrEF (ischemic, hypertensive, and other)
2) vascular biology
3) HFpEF (cardiometabolic and other phenogroups).

Each session will span basic studies through translational research and clinical insights, integrating these perspectives to gain a holistic understanding of disease pathology. To our knowledge, this is the first international congress focusing on “metabolic inflammation” and its consequences in the heart and vasculature. This is an exciting and timely topic in light of the global pandemic of obesity, metabolic stress, and diabetes. Attendees will benefit from comprehensive coverage of these topics by international thought leaders, and a highly interactive and dynamic atmosphere to encourage connection and collaboration.

The conference will be held jointly with the Keystone Symposium on Immunometabolism in Tissue Homeostasis and Disease to enable cross-disciplinary insights and collaborations towards understanding immunometabolic underpinnings of cardiovascular disease.

Meeting Co-Organizer, and Professor in the Department of Internal Medicine at UT Southwestern Medical Center, Joseph Hill, talks about why you should attend this meeting in the video below: