Metabolic processes and enzymes provide regulatory circuits that tailor the behavior of immune cells in response to local and systemic metabolic states. Progress in the field of immunometabolism over the past 5 years has opened new horizons and potential therapeutic strategies for diseases of aging, cancer, and metabolic disorders. However, our understanding of the intersection of immunity and metabolism remains largely restricted to the cellular and molecular levels. To facilitate the translational impact of immunometabolism, this meeting will bring together leading scientists in the areas of aging, cardiovascular diseases, cancer, and microbiome to explore beyond the molecular and cellular level, to collectively address unmet medical needs that can be targeted with immunometabolic interventions.

Specifically, the program will cover the following topics:

1) Immunometabolic crosstalk in tissues and systemic aging;
2) vascular biology;
3) cancer and cancer immunotherapies harnessing immunometabolism;
4) Microbiome-mediated immunometabolic regulations;
5) Metabolite-guided signaling regulations in immune responses.

Each session will integrate basic research with translational and industry perspectives to achieve a comprehensive and holistic understanding. The meeting will feature highly interactive discussions and brainstorming sessions, driving interdisciplinary interactions and collaborations that will broaden the scope and impact of the field of immunometabolism.

The conference will be held jointly with the Keystone Symposium on Trajectories to Heart Failure: Immunometabolic Mechanisms to enable cross-disciplinary insights and collaborations towards understanding immunometabolic underpinnings of cardiovascular disease.

Meeting Co-Organizer and Head of the Immunometabolism and Inflammation Laboratory at Centro de Biología Molcular Severo Ochoa, María Mittelbrunn, talks about why you should attend this meeting in the video below: