Epigenetic modifications to our genomes impact chromatin organization and gene activity during organismal development, homeostasis and aging. Histone and DNA modifying enzymes, as well as chromatin remodelers, are frequently disrupted in developmental disorders and disease states, inspiring the development of numerous potential therapeutics to target these epigenetic regulators. Moreover, cellular metabolism can dramatically alter the availability of substrates for epigenetic enzymes, connecting the epigenetic state of a cell to its metabolic state.

To catalyze new discoveries in this important area, we bring together experts in epigenetics, leading minds in metabolism, and researchers studying diseases linked to epigenetic dysregulation to collectively drive the field forward. This conference provides an ideal environment to foster interactions and seed new collaborations between those studying the function and mechanisms of epigenetic regulators and those defining the clinical impact of their  disruption. The program will critically evaluate the mechanistic importance of histone modifications, non-catalytic roles for epigenetic complexes, and models for the establishment of epigenetic memory and inheritance.

Attendees will explore emerging science at the forefront of the field and be inspired to jump into new frontiers that will define the future of epigenetics research.  Trainees in particular will benefit from exposure to new ideas, with invaluable networking opportunities with field leaders and rising stars.

Finally, this conference will be held jointly with the Keystone Symposium on Chromatin Architecture, Transcription & Gene Regulation to allow attendees to appreciate the interplay between these two closely related fields and network across both domains. Joint sessions and meals will foster cross-disciplinary interactions, insights and collaborations towards integrating these fields and providing a holistic understanding of epigenetics in the context of chromatin architecture.