Inflammatory memory is remnant of anti-pathogen responses that may be adaptive or maladaptive, leading to inflammatory, metabolic, and neurodegenerative diseases, and cancers. This meeting will highlight epigenetic mechanisms and consequences of inflammatory memory for human health and disease. Sessions will thus focus on mechanisms underlying:

1. formation and maintenance of innate memory across a spectrum of immune and non-immune cell types
2. inter and transgenerational inheritance of memory and disease phenotypes
3. the contribution of inflammatory training to chronic diseases
4. the role of environmental pollutants in inflammatory imprinting and disease susceptibility

This symposium will bring together experts in innate immunity, epigenetics, and disease biology, spanning diverse cell types and disease indication, to facilitate interdisciplinary interactions in this emerging field. The conference will be held jointly with the Keystone Symposium on T Cell Differentiation in Tissue Microenvironments to enable cross-disciplinary insights and collaborations towards understanding interconnectedness of innate and adaptive immunity. This provides a unique opportunity to understand non-cognate memory in adaptive immune cells and the beneficial role of innate training in anti-pathogen and vaccine responses. In addition, the meeting will include panel discussions on controversial topics including mechanisms of transgenerational inheritance in mammals and the role of inflammatory memory in inflammaging. This dynamic forum on inflammatory memory will bridge a number of different research communities and provide insights that forecast future directions in modulation of immune memory for therapeutics across a wide range of diseases.

Meeting Co-Organizer and Associate Professor of Dermatology at the Icahn School of Medicine at Mount Sinai, Dr. Shruti Naik, talks about why you should attend this meeting in the video below: