Program Enrichment

The Maillard laboratory is interested in studying the dynamics, energetics and mechanics of the macromolecular interactions occurring in signaling pathways. To quantify the interactions between small ligands, allosteric protein complexes and membranes, my laboratory uses various approaches including biochemical, bulk biophysical (spectroscopic and calorimetric) and single-molecule methods. In particular, we use novel optical tweezers instrumentation that allows the mechanical manipulation and application of force to individual biological macromolecules in order to study their dynamic behavior and functional mechanisms.