This meeting will dive deep into the interactions between tumor and host metabolism; how environmental and whole-body changes can help or hinder tumor growth. The meeting will emphasize whole body crosstalk in cancer mechanisms, how tumors can hijack metabolites locally and systemically, and the role of systemic metabolic fitness and aging fitness, on cancer progression. The program will feature novel mechanisms of how tumors rewire metabolic pathways to support growth and evade immune surveillance. It will also highlight the impact of obesity and aging on tumorigenesis through cancer adaptability versus vulnerabilities through metabolic and inflammatory alterations, and how dietary factors influence these processes.  Importantly, there will be discussion of emerging therapeutic strategies, including dietary changes and novel ways to target tumor metabolism. Finally, cutting-edge technologies will be central to dissecting these complex interactions across biological scales, and how AI can be harnessed to understand complex systems operating in tandem. These tools enable detailed mapping of metabolic fluxes and pathway modulation, revealing promising targets for intervention. Ultimately, this interdisciplinary approach will foster collaborations that accelerate the translation of metabolic research into clinical applications, improving outcomes for cancer patients.