There have been tremendous advances in developing novel nucleic acid-based strategies for treating human diseases. Recent clinical successes have validated nucleic acid-based platforms, documenting that they can provide life-changing medicines to patients who need them. However, efficient delivery of these nucleic acid payloads to the cell type of interest and the appropriate subcellular compartment still limits their full potential despite significant progress over the past decade. This meeting is designed to bring together scientists from multiple disciplines all working on delivery of nucleic acid cargos to cells. The meeting will cover the latest designs for viral vectors, lipid nanoparticle systems, virus-like particles, and ligand conjugates to enhance delivery of nucleic acid payloads. This meeting is unique in bringing scientists working on these different strategies for drug delivery into a single venue. Although these strategies have the common goal of enhancing intracellular delivery of nucleic acid cargo they tend to be siloed. A key goal of the meeting is to bring scientists together who have different expertise and perspectives to learn from each other enabling more rapid and effective solutions for these delivery challenges. This will be joint conference with the genome engineering meeting which creates alot of synergies. The genome engineering will discuss various nucleic acid cargo, while this meeting will focus on delivery technologies for the nucleic acid cargo.