A revolution is sweeping the RNA world. The human genome contains over 60,000 long noncoding RNA genes, three times the number of protein coding genes. Many important questions are outstanding, including physiologic functions of regulatory RNAs, their molecular mechanisms, and therapeutic potential. This conference will bring together leaders in RNA biology, technology, and medicine to present the latest findings in these respective areas. We anticipate that this conference will provide an integrated view of the cutting edge of this rapidly advancing scientific area and create many opportunities for synergy and cross fertilization.