This conference is the first digital health meeting to focus specifically on the scientific foundations and health applications of digital technologies. Taking a novel sensor or new device from concept to clinic is remarkably complex, and the technologies are evolving rapidly. Digital technology offers novel capabilities that have great potential to drive chronic disease understanding and management at both an individual and population level, including the ability to deliver real-time interventions that can be connected to a healthcare system, in a community setting or in limited-resource settings. The increased use of digital capture devices has become a universal part of everyday life; however, more research is needed to provide evidence that wearables and even more sophisticated implantable medical devices will transform healthcare delivery quality and costs. This Keystone Symposia conference focuses on: 1) The scientific/medical gaps in knowledge and opportunities to fill them; 2) Required methodologies for medical and technical validation; and 3) Specifics of data and knowledge management. The conference explores the landscape at the intersection of digital technologies, molecular/genomic data and healthcare data by examining how these data streams can interface to enable precision health, drive research (patient-reported outcomes, continuous phenotypes) and impact clinical care (monitoring, feedback, adherence). The conference aims to enhance participants’ understanding of the state of the art for capturing digital phenotyping and of consumer/patient access and comprehension, regulatory jurisdiction, health care provider/system readiness, clinical utility, personal utility, integration with the electronic health record, quality standards and ethical considerations. It brings together clinicians, scientists, technology innovators, health economists and regulators to discuss and develop the new models of cross-disciplinary collaboration and business that will be required to deliver quality digital health strategies and solutions, and to illuminate areas of synergy between the academic, public and private sectors to inform a research agenda for the next five years.