Recent technological advances in spatial transcriptomics, multiplexed proteomics, and intravital imaging have transformed immunology by revealing the composition, organization, and dynamics of immune niches across tissues. Together with integrative computational tools and cellular atlases, these approaches have underscored the critical role of local microenvironments and systemic signals in shaping immune responses. Yet, how spatial context governs immune cell function, communication, and fate in health and disease remains an open question.

This meeting will bring together a diverse community of immunologists, clinicians, technologists, and computational scientists to explore the emerging field of spatial and tissue immunology. The program will highlight novel technologies and conceptual advances that challenge traditional paradigms and expand our understanding of tissue-resident and migratory immune networks, cross-organ immune regulation, and the integration of structural biology, imaging, and modeling. Topics will span translational contexts including cancer, infection, neuroinflammation, and autoimmunity.

Jointly held with a Keystone meeting on Single Cell Biology, this symposium will offer attendees a unique opportunity to integrate spatial and high-resolution single-cell approaches. The format is designed to promote interdisciplinary exchange and collaboration among scientists who rarely interact at other conferences.

This meeting fills a growing need for focused discussion on spatial context in immunity and will catalyze innovative research, cross-disciplinary partnerships, and therapeutic insights across basic and translational domains.