Targeted Protein Degradation and other Induced-Proximity Modalities beyond are now established concepts for fundamental academic chemical biology and are revolutionizing therapeutic discovery. The Keystone 2027 symposium titled, 'Induced Proximity and Targeted Protein Degradation: Emerging Technologies and Therapeutic Applications', will provide an opportunity to showcase the latest mechanistic insights, progress in the clinic of advanced systems, highlight emerging innovations in the field, foster interactions to catalyze the exchange of new ideas for disease targeting strategies, and bring together recognized leaders with new scientists providing fresh perspectives and new systems. At the heart of this field is the chemical remodeling and rewiring of protein to control biomolecular interactions whose paradigms have now delivered impact across basic and translational research. The goal of this meeting is to bring together a community that spans leaders from the lab to the clinic and inspire new ideas and opportunities for collaborations to deliver the next wave of breakthroughs for TPD and Induced Proximity. We will emphasize anticipated frontiers of the field in 2027 that will come to bear in the clinic, in the form of new E3 ligases and induced proximity modalities, focus on the discovery chemistry and biology that underpins these innovations, and look towards the future using emerging next-generation technologies such as artificial intelligence to develop the next wave of insights and discoveries.