Genetic Medicines to Treat Cardiovascular Disease

Jan 25–28, 2027 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Rick Dewey, Litsa G. Kranias, and James S. Ware

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Jan 25–28, 2027 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Rick Dewey, Litsa G. Kranias, and James S. Ware

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:     = Livestream   = In Person     = On Demand
Monday, January 25, 2027
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, January 26, 2027
Breakfast
7:00–8:00 AM
Welcome Remarks
8:00–8:10 AM
Keynote Address
8:10–9:00 AM
Sekar Kathiresan, Verve Therapeutics
The Human Genome as Teacher and Target: Two Decades of Genomic Discovery to Genomic Medicines
New Trailheads: Target Identification for Genetic Medicines in CV Disease
9:00–11:15 AM
James S. Ware, Imperial College London
Large Scale Genomic Discovery of Causal Mechanisms in Heart Failure
Victoria Parikh, Stanford University School of Medicine
Genotype-Phenotype Correlation in Inherited Cardiovascular Disease
Rick Dewey, Versant Ventures
Target Selection for Genetic Medicines: Biobanks to Human Proof of Concept
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
Panel Discussion 1: Development, Regulatory, Safety, and Ethical Considerations (including long-term and off-target effects of genetic medicines)
11:15–12:15 PM
Rick Dewey, Versant Ventures
Silvia G. Priori †, Foundation Salvatore Maugeri
Laura F. Michael, Eli Lilly and Company
Poster Setup
11:15–1:00 PM
On Own for Lunch
11:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight 1: Emerging Biological Insights Driving the Next Generation of Genetics Medicines for CV Disease
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Mechanisms and Models: From Variation to Validation
5:00–7:00 PM
Cassady Rupert, Propria LLC
Modeling Human Cardiac Biology with Multi-Dimensional Engineered Human Heart Tissues
Leslie A Leinwand, University of Colorado Boulder
Nature- Inspired Solutions to Common Metabolic Challenges
Litsa G. Kranias, University of Cincinnati
Phospholamban Cardiomyopathy: From Bedside to Bench and Back
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, January 27, 2027
Breakfast
7:00–8:00 AM
Gene Silencing in Cardiovascular Disease and Promising Avenues
8:00–11:00 AM
Speaker to be Announced
Stefanie Dimmeler, Institute of Cardiovascular Regeneration
Deciphering Noncoding RNAs in Cardiovascular Disease for RNA Therapeutics
Euan A. Ashley, Stanford University
Allele-Specific Silencing in Cardiomyopathy
Jin Billy Li, Stanford University
Endogenous RNA Editing in CV Disease: Mechanisms and Therapeutic Applications
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Poster Setup
11:00–1:00 PM
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Therapeutic Gene Augmentation Strategies in CV Disease
5:00–7:00 PM
Roger J Hajjar, Mass General Brigham
Engineering the Failing Heart: Innovations in Cardiac Gene Therapy
Annemieke Aartsma-Rus, Leiden University Medical Center
Exon Skipping to Restore Gene Expression in Muscle Disease
Farah Sheikh, University of California, San Diego
From Cell Junctional Failure to Gene Therapy in Arrhythmogenic Cardiomyopathy
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Thursday, January 28, 2027
Breakfast
7:00–8:00 AM
Homing for Cures: Cardiomyocyte-Directed Delivery Approaches
8:00–11:00 AM
Luk H Vandenberghe, Harvard Medical School
Engineering Viral Delivery Systems
Anastasia Khvorova †, RNA Therapeutics Institute, UMass Chan Medical School
Novel Approaches for Oligonucleotide Delivery to Heart
James Dahlman, Georgia Tech / Emory Medical School
Lipid Nanoparticles: Past, Present, and Future of RNA Delivery
William M Flanagan, Avidity Biosciences, Inc.
Antibody-Oligo Conjugates for Striated Muscle-Enriched Delivery
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Panel Discussion 2: Navigating the Valley of Opportunity: Moving Ideas from Idea to Products for Patients with Academia, Venture Capital, and Pharma
11:00–12:00 PM
Sekar Kathiresan, Verve Therapeutics
Roger J Hajjar, Mass General Brigham
On Own for Lunch
11:00–5:00 PM
Symposia Spotlight 2: Emerging Translational Strategies in CV Disease
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Products to Patients: Therapeutic Development and Trial Design
5:00–6:15 PM
Laura F. Michael, Eli Lilly and Company
Lp(a) - From Genetic Insight to Novel Biology and Breakthrough Therapy
Silvia G. Priori †, Foundation Salvatore Maugeri
Therapeutic Development of Genetic Medicines for Arrhythmogenic Cardiovascular Disease
Short Talk(s) Chosen from Abstracts
Closing Keynote Address
6:15–7:00 PM
Christine E. Seidman, Harvard Medical School
Modeling Cardiovascular Disease: Genetics, Cellular Systems, Human Models
Meeting Wrap-Up: Outcomes and Future Directions
7:00–7:15 PM
Social Hour with Dinner
7:15–8:15 PM
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Friday, January 29, 2027
Departure
12:00–11:59 PM

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