Tuberculosis: Heterogeneity from Experimental Models to Human Disease

Feb 16–19, 2025 | Fairmont Copley Plaza, Boston, MA, United States
Scientific Organizers: JoAnne L Flynn, Bryan D. Bryson, and Henry C. Mwandumba

  In Person
  On Demand
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Feb 16–19, 2025 | Fairmont Copley Plaza, Boston, MA, United States

Scientific Organizers: JoAnne L Flynn, Bryan D. Bryson, and Henry C. Mwandumba

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, February 16, 2025
Registration  
4:00–8:00 PM
 Lobby
Welcome Mixer  
6:00–8:00 PM
 Venetian Room
Monday, February 17, 2025
Breakfast  
7:00–8:00 AM
 Oval/Venetian Rooms
Poster Setup  
7:30–8:00 AM
 Ballroom Foyer
Poster Viewing  
7:45–5:00 PM
 Ballroom Foyer
Welcome and Keynote Address  
8:00–9:00 AM
 Grand Ballroom
* JoAnne L Flynn, University of Pittsburgh School of Medicine
Session Chair
Sarah M. Fortune, Harvard TH Chan School of Public Health
The Intersection of Bacterial and Host Heterogeneity
The Spectrum of Tuberculosis  
9:00–11:15 AM
 Grand Ballroom
Philana Ling Lin, UPMC Children's Hospital of Pittsburgh
SIV/HIV M. tuberculosis Coinfection
Reinout van Crevel, Radboud University Nijmegen Medical Centre
Paradoxical TB
* Gerhard Walzl, Stellenbosch University
Dynamics of Human TB
Dylan Kain, OHSU
Short Talk: Lung Resident MR1T Cells Across the Spectrum of Mycobacterium tuberculosis Infection
Coffee Break  
9:30–9:50 AM
 Venetian Room
Lunch  
11:15–12:15 PM
 Oval/Venetian Rooms
Women in Science Networking Event  
11:20–12:20 PM
 Grand Ballroom
* Sarah M. Fortune, Harvard TH Chan School of Public Health
Session Chair
* JoAnne L Flynn, University of Pittsburgh School of Medicine
Session Chair
* Denise Kirschner, University of Michigan Medical School
Session Chair
* Sabine Ehrt, Weill Cornell Medical College
Session Chair
* Anne O'Garra, Francis Crick Institute
Session Chair
Poster Session 1  
12:30–2:30 PM
 Ballroom Foyer
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions  
2:30–4:30 PM
 Grand Ballroom
* Riti Sharan, Texas Biomedical Research Institute
Session Chair
Jacques Augenstreich, University of Maryland College Park
Dynamic Interplay of Autophagy and Membrane Repair During Mycobacterium tuberculosis Infection
Stanzin Dawa, Emory University
M. Tuberculosis Regulates Early Lung Immunometabolism to Promote Tuberculosis Pathogenesis
Zoltan Maliga, Harvard Medical School
Single Cell Atlas of Fibrosis in Pulmonary Tuberculosis
Charlie J Pyle, Duke University
An EMP2-FAK Axis Regulates Mycobacterial Granuloma Structure and Stability
Rachel Kinsella, Emory University School of Medicine
ATG5 Suppresses Type I Interferon-Dependent Neutrophil Swarming and NET Release
Caleb Nwongbouwoh Muefong, University of Chicago
Expression of Ly6G and PD-L1 Drive Neutrophil-Mediated Mtb Susceptibility
Christian T Michael, Michigan Medicine
- Ideal Antibiotic Regimens for Tuberculosis Treatments Depend on the Definition of Treatment Success in Virtual Pre-Clinical Trials
Coffee Available  
4:30–5:00 PM
 Venetian Room
Spatial Heterogeneity in TB  
5:00–7:00 PM
 Grand Ballroom
Jake D Estes, Oregon Health and Science University
Early Granuloma Formation
Shumin Tan, Tufts University School of Medicine
Spatial Relationships of Intra-lesion Heterogeneity from the Bacterial Perspective
Denise Kirschner, University of Michigan Medical School
Temporal and Spatial Analysis of Granulomas at Both Tissue and Whole Host Scale
* Maximiliano Gutierrez, Francis Crick Institute
Imaging Mtb-Host Interaction Dynamics
On Own for Dinner  
7:00–8:00 PM
Tuesday, February 18, 2025
Breakfast  
7:00–8:00 AM
 Oval/Venetian Rooms
Poster Setup  
7:30–8:00 AM
 Ballroom Foyer
Poster Viewing  
7:45–5:00 PM
 Ballroom Foyer
Bacterial Heterogeneity  
8:00–11:00 AM
 Grand Ballroom
* Bryan D. Bryson, Massachusetts Institute of Technology
Antigen Recognition in TB
Sabine Ehrt, Weill Cornell Medical College
Intersection of Bacterial Metabolism and Drug Susceptibility
Bree B Aldridge, Tufts University
Single Cell Microbiology
Anna-Lisa Lawrence, Tufts University School of Medicine
Short Talk: Elucidating Mycobacterium tuberculosis environmental and growth adaptation in spatiotemporal context during host colonization
Stephen M Carpenter, Case Western Reserve University
Short Talk: TCR Clonotype Analysis and Single-Cell Transcriptomics Distinguishes Human Memory CD4+ T Cells Linked to Recognition of Macrophages Infected with Mycobacterium Tuberculosis
Graham R Stewart, University of Surrey
Short Talk: Epigenetic Control of Replication, Gene Expression and Growth Phase By ADP-Ribosylation of DNA in Mycobacterium Tuberculosis
Margarida Saraiva, i3s
Short Talk: Genetically Diverse M. Tuberculosis Clinical Isolates Modulate IL-1β Responses with an Impact on the Outcome of Infection
Coffee Break  
9:00–9:20 AM
 Venetian Room
Award Recipient Acknowledgement  
9:20–9:25 AM
 Grand Ballroom
Lunch  
11:00–12:00 PM
 Oval/Venetian Rooms
Poster Session 2  
12:30–2:30 PM
 Ballroom Foyer
Career Roundtable  
3:00–4:30 PM
 Grand Ballroom
Gerhard Walzl, Stellenbosch University
Professor, Group Leader
Sagarika Haldar, PGIMER
Associate Professor
Khisimuzi E Mdluli, Bill & Melinda Gates Medical Research Institute
Discovery Project Leader
Monica Campo, University of Minnesota
Assistant Professor
Coffee Available  
4:30–5:00 PM
 Venetian Room
Functional Immune Heterogeneity I  
5:00–7:00 PM
 Grand Ballroom
Patricia S. Grace, University of Pittsburgh
Antibody Functions in TB
* JoAnne L Flynn, University of Pittsburgh School of Medicine
Compartment Heterogeneity and Protection
Munyaradzi Nyasha Musvosvi, University of Cape Town
Antigen Discovery for Vaccines
Chuangqi Wang, University of Colorado, Anschutz Medical Campus
Defining Humoral Immune Signatures for TB Progression and Preventive Treatment Failure
Michel Vierboom, Biomedical Primate Reserach Centre
Short Talk: Failure of Reactivation after Antimicrobial Treatment Reveals a Detrimental Effect of Therapeutic Mucosal BCG Vaccination in Rhesus Macaques.
Solomon Jauro, University of Pittsburgh
Short Talk: Protecting Simian Immunodeficiency Virus-Infected Macaques from Mycobacterium Tuberculosis by Intravenous Bacillus Calmette-Guérin Vaccination Requires Viral Control
On Own for Dinner  
7:00–8:00 PM
Wednesday, February 19, 2025
Breakfast  
7:00–8:00 AM
 Oval/Venetian Rooms
Poster Setup  
7:30–8:00 AM
 Ballroom Foyer
Poster Viewing  
7:45–5:00 PM
 Ballroom Foyer
Functional Immune Heterogeneity II  
8:00–11:00 AM
 Grand Ballroom
David G. Russell, Cornell University
Why Heterogeneity will Always Favor the Pathogen
* Henry C. Mwandumba, Liverpool School of Tropical Medicine
Human Lung Immunity
Anne O'Garra, Francis Crick Institute
Correlates and Mechanisms of M. Tuberculosis Infection Outcome
Molly Kanagy, Seattle Childrens Research Institute
Short Talk: CXCR2 as a Promising Target to Reshape Mtb Lesions and Reduce Neutrophil-driven Lung Pathology
Alex Mohapatra, UCSF Division of Experimental Medicine
Short Talk: A Novel Approach to Determine the Protective Value of ESAT-6-Specific T Cells in Tuberculosis
Manish Gupta, Johns Hopkins University
Short Talk: Female Protection from TB is Attributable to Superior T Cell Immunity and Maturation of B Cell Follicles
Monica Campo, University of Minnesota
Short Talk: Early Immune Activation of Human Alveolar Macrophages in Response to BCG
Coffee Break  
9:00–9:20 AM
 Venetian Room
Lunch  
12:00–1:00 PM
 Oval/Venetian Rooms
Poster Session 3  
12:30–2:30 PM
 Ballroom Foyer
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions  
2:30–4:30 PM
 Grand Ballroom
* Chuangqi Wang, University of Colorado, Anschutz Medical Campus
Session Chair
Rocky Lai, University of Massachusetts Medial School
Investigating Sexual Dimorphism in TB Disease Using Collaborative Cross Mice
Neha Jain, Ragon Insititute/MGH
Deciphering the Role of the ER Stress Response in Early Host Response Against Mtb Infection
Miriam Herbert, Max Planck Institute for Infection Biology
Deciphering the Complex Role of IL-4/IL-13 Signaling in Tuberculous Granuloma Formation
Xin Wang, Harvard University School of Public Health
Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model
Saradee Warit, TB Team, IMBG, BIOTEC, NSTDA
Heterogeneity of Mycobacterium Tuberculosis Infection and Pathogenesis in Naturally Mtb-Infected Cynomolgus Macaques
Benjamin Koleske, Johns Hopkins University School of Medicine
Loss of the PPE71-esxX-esxY-PPE38 Locus Drives Adaptive Transcriptional Responses and Hypervirulence of Mycobacterium Tuberculosis Lineage 2
Fikadu G. Tafesse, Oregon Health Sciences University, OHSU
Nanobodies as Probes to Study M. Tuberculosis Cellular Pathways and Granuloma Development
Coffee Available  
4:30–5:00 PM
 Venetian Room
Translational TB Research  
5:00–6:45 PM
 Grand Ballroom
Rada Savic, University of California, San Francisco
Shortening Treatment
Alexander C. Schmidt, Gates Medical Research Institute
TB Vaccine Development – Challenges and Opportunities
* Galit Alter, Ragon Institute of MGH, MIT, and Harvard
Correlate Inspired mRNA Vaccine Design
Yating Wang, Tsinghua University
Short Talk: IV-BCG Reprograms Monocytes to Induce Tissue Resident CD4 T Cells in Mice
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Grand Ballroom
On Own for Dinner
7:00–8:00 PM
Thursday, February 20, 2025
Departure  
12:00–11:59 PM

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