Systemic Autoimmune and Autoinflammatory Diseases

Feb 08–11, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mariana J. Kaplan, Georg Schett and Carola G. Vinuesa

  In Person
  On Demand

Feb 08–11, 2024 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mariana J. Kaplan, Georg Schett and Carola G. Vinuesa

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Thursday, February 8, 2024
Arrival and Registration  
4:00–8:00 PM
 Colorado Ballroom Foyer
Welcome Mixer  
6:00–8:00 PM
 Colorado Ballroom Foyer
Friday, February 9, 2024
Breakfast  
7:00–8:00 AM
 Summit Gallery
Welcome and Keynote Address  
8:00–9:00 AM
 Peaks 4 & 5
Kate A. Fitzgerald, University of Massachusetts Medical School
Nucleic Acid Sensors and Autoimmunity Development
Autoinflammatory Diseases  
9:00–11:15 AM
 Peaks 4 & 5
Seth L. Masters, Walter and Eliza Hall Institute
Remote Presentation: Disruptions of Organellar Homeostasis and Autoinflammation
Ivona Aksentijevich, NHGRI, National Institutes of Health
Disorders of Ubiquitination and Autoinflammation
Peter Grayson, NIAMS, National Institutes of Health
Somatic Mutations and Autoimmunity/Autoinflammation: VEXAS Syndrome
David Beck, NYU
Short Talk: Short Talk: UBA1-dependent Inflammation is Mediated by Proteotoxic Stress
Coffee Break  
9:30–9:50 AM
 Colorado Ballroom Foyer
Poster Setup  
11:15–1:00 PM
 Peaks 1-3
On Own for Lunch  
11:15–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Peaks 1-3
Career Roundtable  
3:00–4:30 PM
 Peaks 4 & 5
Aimee S. Payne, University of Pennsylvania
Irving Professor and Chair of Dermatology
Ivona Aksentijevich, NHGRI, National Institutes of Health
Associate Investigator, Medical Genetics Branch & Head, Inflammatory Disease Section
Jonathan Olsen, Bristol Myers Squibb
Senior Principal Scientist
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Innate Immune Dysregulation and Autoimmunity  
5:00–7:00 PM
 Peaks 4 & 5
Mariana J. Kaplan, NIAMS, National Institutes of Health
Neutrophils in the Initiation and Perpetuation of Systemic Autoimmunity
V. Michael Holers, University of Colorado Denver
Preclinical Pathogenesis and Prevention of Rheumatoid Arthritis
Chrysothemis Brown, Sloan Kettering Institute
Regulation of Immune Tolerance by RORgt+ Antigen-Presenting Cells
Carlos Donado, Harvard Medical School / Brigham and Women's Hospital
Short Talk: Short Talk: Granzyme K Activates a New Complement Pathway
Marcel F. Nold, Monash University
Short Talk: Short Talk: Monomeric IL-38 is a Checkpoint Inhibitor of the Pattern Recognition Receptor-interferon Axis
Social Hour with Lite Bites  
7:00–8:00 PM
 Peaks 1-3
Poster Session 1  
7:30–10:00 PM
 Peaks 1-3
Saturday, February 10, 2024
Breakfast  
7:00–8:00 AM
 Summit Gallery
B Cells and Autoimmunity  
8:00–11:00 AM
 Peaks 4 & 5
Nan Shen, Renji Hospital, Shanghai JiaoTong University School of Medicine
Transcriptional Regulation of ABCs and Autoimmunity
Ignacio Sanz, Emory University, School of Medicine
Autoantibody Responses in Autoimmunity and COVID-19
Claudia Mauri, University College London
Deciphering the Metabolic Requirements of Regulatory Versus Effector B Cells
Carola G. Vinuesa, Francis Crick Institute
Genetic Determinants of B Cell-Mediated Autoimmunity
Nida Pellett, University of Rochester
Short Talk: Short Talk: Insights Into RA Synovial Autoimmunity via Combined Single-cell Profiling of B cell Repertoire and Gene Expression
Amalie Grenov, Francis Crick Institute
Short Talk: Short Talk: Exploring Autoantibody Formation and Longevity
Coffee Break  
9:00–9:20 AM
 Colorado Ballroom Foyer
Poster Setup  
11:00–1:00 PM
 Peaks 1-3
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Peaks 1-3
Workshop  
2:30–4:30 PM
 Peaks 4 & 5
Mariasilvia Colantuoni, Boston Children's Hospital
Immune-Mediated IL-1RA Gene Therapy: A Breakthrough Treatment For A Spectrum Of Inflammatory Diseases
Jessica A. Hamerman, Benaroya Research Institute
Lupus IgA1 Autoantibodies Synergize with IgG to Enhance pDC Responses to RNA-Containing Immune Complexes
Danni Zhu, Harvard Medical School
Lupus-Associated Innate Receptors Drive Extrafollicular Evolution of Autoreactive B Cells
Evaristus Mbanefo, NIH/NEI
Interleukin-35-Producing Regulatory B-Cells Secrete IL-35-Containing Exosomes and Suppress Autoinflammation and GVHD by Upregulating Inhibitory Receptors
Jun Inamo, University of Colorado
Deciphering Pathogenic Phenotypes by Deep Single-Cell Blood Immunophenotyping in Individuals At-Risk for Rheumatoid Arthritis
Eduardo Patino Martinez, NIH
Aconitate Decarboxylase 1 Modulates Murine Lupus and Associates with Markers of Cardiometabolic Function in Systemic Lupus Erythematosus
Atika Dhar, NIH
Blau Syndrome NOD2 Mutations Result in Loss of NOD2 Cross-Regulatory Function
Anna Helena Jonsson, University of Colorado
Cell-Type Abundance Phenotypes (CTAPs) Classify Rheumatoid Arthritis Synovial Tissue into Clinically Relevant Inflammatory Subtypes
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Infections and Autoimmunity  
5:00–7:00 PM
 Peaks 4 & 5
Jose Scher, NYU Langone Health
The Microbiome in Chronic Inflammatory Arthritides
William H. Robinson, Stanford University School of Medicine
EBV and Systemic Autoimmunity
Maureen McGargill, St Jude Children's Research Hospital
The Intersection of Viral Immunity and Autoimmunity
Stefan Uderhardt, University of Erlangen
Short Talk: Short Talk: Tissue Homeostats Determine Inflammation Thresholds In Vivo Through Dynamic Network Communication
Social Hour with Lite Bites  
7:00–8:00 PM
 Peaks 1-3
Poster Session 2  
7:30–10:00 PM
 Peaks 1-3
Sunday, February 11, 2024
Breakfast  
7:00–8:00 AM
 Summit Gallery
T Cells and Systemic Autoimmunity  
8:00–11:00 AM
 Peaks 4 & 5
Avery August, Cornell University
Tec Kinases and Autoimmunity
Cornelia M. Weyand, Stanford University
T Cell Senescence and Autoimmunity
Diane Mathis, Harvard Medical School
Thymic Mimetics and Systemic Autoimmunity
Hussein Al-Mossawi, Immunocore
Soluble-TCR Therapies in Autoimmunity and Cancer
Kenji Ichiyama, Osaka University
Short Talk: Short Talk: Ikzf1 Association With Foxp3 for Foxp3-Dependent Gene Repression in Treg Cells: Induction of Autoimmunity by Disrupting the Association
Catherine Lu, New York University
Short Talk: Short Talk: Immune-Mesenchymal TNFa-CXCL13 Feedback Initiates the Formation of the Tertiary Lymphoid Structures in Human Skin Autoimmune Pathogenesis
Coffee Break  
9:00–9:20 AM
 Colorado Ballroom Foyer
On Own for Lunch  
11:00–5:00 PM
Coffee Available  
4:30–5:00 PM
 Colorado Ballroom Foyer
Novel Therapies in Autoimmunity and Autoinflammation  
5:00–6:45 PM
 Peaks 4 & 5
Frank Oliver Nestle, Sanofi
Novel Therapeutics Approaches for Chronic Inflammatory Disease
Georg Schett, Universitätsklinikum Erlangen
CART Cells and the Treatment of Systemic Autoimmunity
Aimee S. Payne, University of Pennsylvania
Chimeric Autoantibody Receptor T Cells: A Precision Cellular Immunotherapy for Antigen-Specific B Cell Depletion
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Peaks 4 & 5
Social Hour with Lite Bites  
7:00–8:00 PM
 Peaks 1-3
Cash Bar  
8:00–9:00 PM
 Peaks 1-3
Monday, February 12, 2024
Departure  
7:00–11:59 PM

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