Tumor Metabolism

Feb 12–15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Gina DeNicola, Rushika M. Perera, and David B. Shackelford

  In Person
  On Demand
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Feb 12–15, 2024 | Fairmont Banff Springs, Banff, AB, Canada

Scientific Organizers: Gina DeNicola, Rushika M. Perera, and David B. Shackelford

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Monday, February 12, 2024
Arrival and Registration  
4:00–8:00 PM
 Van Horne Foyer
Welcome Mixer  
6:00–8:00 PM
 Van Horne Foyer
Tuesday, February 13, 2024
Breakfast  
7:00–8:00 AM
 Mezzanine 2
Welcome and Keynote Address  
8:00–9:00 AM
 Van Horne A
* Gina DeNicola, Moffitt Cancer Center
Session Chair
Jared Rutter, University of Utah
Mitochondrial Bioenergetics
Organelles  
9:00–11:15 AM
 Van Horne A
* Gina DeNicola, Moffitt Cancer Center
Session Chair
Rushika M. Perera, University of California, San Francisco
Lysosome Mediated Regulation of Metabolism
Gerta Hoxhaj, UT Southwestern Medical Center
Regulation and Function of NADPH Metabolism
Wilhelm Palm, German Cancer Reserach Center
Metabolic Stress Adaptations in Cancer
Aakriti Jain, UC Berkeley
Short Talk: Short Talk: Identifying and Targeting Novel Lysosomal Enzymes in Pancreatic Cancer
Coffee Break  
9:30–9:50 AM
 Van Horne Foyer
Poster Setup  
11:15–1:00 PM
 Mezzanine 2
On Own for Lunch  
11:15–5:00 PM
Career Roundtable (Joint)  
1:00–2:00 PM
 Van Horne C
Leon O. Murphy, Casma Therapeutics
Senior Vice President Biology
Ana J. García-Sáez, University of Cologne
Professor and Director of the Max Planck Institute of Biophysics
Tamas Balla, NICHD, National Institutes of Health
Senior Investigator
Dustin Hancks, University of Texas Southwestern Medical Center
Assistant Professor
Poster Viewing  
1:00–10:00 PM
 Mezzanine 2
Workshop 1: Mitochondrial Regulation and Organelle Communication  
2:30–4:30 PM
 Van Horne A
* Rushika M. Perera, University of California, San Francisco
Session Chair
Srimayee Vaidyanathan, Peter MacCallum Cancer Centre
Cholesterol-dependent Remodeling of the Endoplasmic Reticulum Regulates CAF Function
Eduardo Cararo Lopes, Rutgers Cancer Institute of New Jersey
Tumor Respiration Defects Limit Serine Synthesis Required To Suppress Oxidative Stress
Celia de la Calle Arregui, University of Texas Southwestern medical center
Understanding the Role of mtDNA Alterations and Electron Transport Chain Function in Thyroid Cancer
Emily N. Arner, Vanderbilt University Medical Center
NDUFA4L2 Drives Metastasis in RCC by Inhibiting Oxidative Phosphorylation to Facilitate EMT
Lucia Minarrieta, University of Ottawa
Loss of Mitochondrial Fission Impairs Breast Cancer Metastasis
Karina Geurtzen, KU Leuven
Breast Cancer Cells Rely on Mitochondrial Respiration to Form Bone Metastases
Gilles Rademaker, UCSF
Differential Acquisition of Extracellular Lipid Correlates with Pancreatic Cancer Subtype and Metastatic Tropism
Coffee Available  
4:30–5:00 PM
 Van Horne Foyer
Stress  
5:00–7:00 PM
 Van Horne A
* Daniel A. Tennant, University of Birmingham
Session Chair
Elda Grabocka, Thomas Jefferson University
Stress Granules at the Crossroads of Cellular Stress and Pancreatic Cancer
Gina DeNicola, Moffitt Cancer Center
Cellular Adaptation to Cysteine Starvation
Russell G. Jones, Van Andel Research Institute
The Prostacyclin Receptor is an Nrf2-regulated Immune Checkpoint for CD8 T Cell Function
Dohoon Kim, University of Massachusetts Medical School
Short Talk: Short Talk: Uncovering and Exploiting Toxic Metabolite Pathways in Cancer Cells
Kenji Fujihara, New York University School of Medicine
Short Talk: Short Talk: Linking Cystine Deprivation to Selenium Insufficiency: A Novel Explanation for Cystine Deprivation-induced Ferroptosis
Social Hour with Lite Bites  
7:00–8:00 PM
 Mezzanine 2
Poster Session 1  
7:30–10:00 PM
 Mezzanine 2
Wednesday, February 14, 2024
Breakfast  
7:00–8:00 AM
 Mezzanine 2
Metabolic/Bioenergetic Heterogeneity  
8:00–11:00 AM
 Van Horne A
* Christopher J. Halbrook, University of California, Irvine
Session Chair
Shawn M. Davidson, Northwestern
Spatiotemporal Analysis of Metabolism
David B. Shackelford, University of California, Los Angeles
Three Dimesional Imaging of Cancer Mitochondria
Mariia Yuneva, Francis Crick Institute
Dissecting Metabolic Tumour Heterogeneity in vivo
David F. Kashatus, University of Virginia
Control of Tumor Cell Metabolism by Mitochondrial Dynamics
Thomas P Mathews, UT Southwestern Medical Center
Short Talk: Short Talk: Comprehensive Isotope Tracing of Fatty Acids in vivo Reveals Differences Between Primary Tumors and Metastatic Sites
Deepak Nagrath, University of Michigan
Short Talk: Short Talk: Machine Learning-based Method to Analyze Metabolic Fluxes of Patient Tumors
Coffee Break  
9:00–9:20 AM
 Van Horne Foyer
Poster Setup  
11:00–1:00 PM
 Mezzanine 2
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Mezzanine 2
Workshop 2: Metabolic Targets and Vulnerabilities  
2:30–4:30 PM
 Van Horne A
* David B. Shackelford, University of California, Los Angeles
Session Chair
Aki Ogawa-Iio, University of Cincinnati
Fueling the Way—The Role of Localized GTP Synthesis in Renal Cell Carcinoma Metastasis
Megan Radyk, University of Michigan
Loss of NADPH-producing Enzymes Accelerates Precancerous Lesions in the Pancreas
Rebekah Crake, University of Liege
Identifying Targetable Metabolic Adaptations in Drug Tolerant BRAFV600E Mutant Non-small Cell Lung Cancer
Remya Nair, Emory University
Heme Increases Purine Metabolism in Multiple Myeloma to Promote Resistance to Apoptosis
Amanda M Sherwood, Moffitt Cancer Center
Investigating the Roles of GSH and TXN Antioxidant Systems in NSCLC Tumor Progression
Krystle Kalafut, Harvard University
The Oncoprotein Grb7 is a Novel Physiological Target of mTORC1: Implications for Breast Cancer and Hepatic Insulin Resistance
Sheila K Singh, Centre for Discovery in Cancer Research, McMaster University
A Phenotypic Drug Discovery Screen Reveals de novo GTP Synthesis as a Targetable Metabolic Vulnerability in Brain Metastases
Coffee Available  
4:30–5:00 PM
 Van Horne Foyer
Targeting Metabolism  
5:00–7:00 PM
 Van Horne A
* Raul Mostoslavsky, Mass General Hospital- Harvard Medical School
Session Chair
Sarah-Maria Fendt, VIB-KU Leuven
Metabolic Vulnerabilities of Metastasis
Leon O. Murphy, Casma Therapeutics
Targeting Autophagy
Isaac Spencer Harris, University of Rochester
Understanding the Roles of Antioxidants in Cancer
Heather Christofk, University of California, Los Angeles
Metabolic Targeting for Rare Cancers
Social Hour with Lite Bites  
7:00–8:00 PM
 Mezzanine 2
Poster Session 2  
7:30–10:00 PM
 Mezzanine 2
Thursday, February 15, 2024
Breakfast  
7:00–8:00 AM
 Mezzanine 2
Nutrient Acquisition and Utilization  
8:00–11:00 AM
 Van Horne A
* Roberto Zoncu, University of California, Berkeley
Session Chair
Kathryn E. Wellen, University of Pennsylvania
Branched chain amino acid metabolism and pancreatic tumorigenesis
Cosimo Commisso, Sanford Burnham Prebys Medical Discovery Institute
Metabolic Adaptations to Glutamine Mimetics: From Discovery to Therapeutics
Donita C. Brady, University of Pennsylvania
Harnessing Chemical Interactions to Explore Tumor Cell Biological Responses to Fluctuations in Metal and Micronutrient Availability
Jason R. Cantor, Morgridge Institute for Research, University of Wisconsin-Madison
Short Talk: Short Talk: Conditional Lethality Profiling in Human Cancer Cells
Hao Fan, The University of Chicago
Short Talk: Short Talk: Trans-vaccenic Acid Reprograms CD8+ T Cells and Anti-tumour Immunity
Kamiya Mehla, University of Oklahoma Health Science Center
Short Talk: Short Talk: Nutrient Constrain-induced Metabolic Rewiring Impacts NK Cell Function in Pancreatic Cancer
Inna Smalley, H. Lee Moffitt Cancer Center & Research Institute, Inc.
Short Talk: Short Talk: Branched-chain Keto Acids Promote an Immune-suppressive and Neurodegenerative Microenvironment in Leptomeningeal Disease
Coffee Break  
9:00–9:20 AM
 Van Horne Foyer
Poster Setup  
11:00–1:00 PM
 Mezzanine 2
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Mezzanine 2
Workshop 3: Nutrient Requirements and Toxicities  
2:30–4:30 PM
 Van Horne A
* Yanxiang (Jessie) Guo, Rutgers University
Session Chair
Yetis Gultekin, MIT
Altered Exocrine Function Promotes Pancreatic Cancer-associated Autophagic Proteolysis in the Muscle
Chesta Jain, University of Michigan
Assessing the Mechanism of Iron Mediated Cell Toxicity in Colon Cancer
Tashbib Khan, BIDMC - Harvard Medical School
The Oncogenic Roles of Glycogen in PI3K/AKT/mTOR Signaling
Pankaj Singh, OUHSC
Selective Dependence on Stromal Acetate-induced Polyamine Metabolism Provides Unique Therapeutic Opportunities in Pancreatic Cancer
Hila Tishler, Weizmann Institute of Science
Modulating JAK-STAT Signaling in the Tumor Microenvironment by Regulating Arginine Cross-Talks
Alex C. Sternisha, UT Southwestern Medical Center
A Forward Genetic Approach Reveals Mechanisms of Alpha-Ketoglutarate Regulation in the Nucleus
Coffee Available  
4:30–5:00 PM
 Van Horne Foyer
Tumor-Host Interactions  
5:00–6:45 PM
 Van Horne A
* Kristin K Brown, Peter MacCallum Cancer Centre
Session Chair
Ana P. Gomes, Lee Moffitt Cancer Center & Research Institute
Metabolic Reprogramming: A Bridge Between Aging and Cancer
Ralph J. DeBerardinis, University of Texas Southwestern Medical Center
Metabolism in situ
Peter James Mullen, University of Southern California
A Metabolic Atlas of Aging
Asael Roichman, Princeton University
Short Talk: Short Talk: The Gut Microbiome Regulates the Anti-cancer Activity of PI3K Inhibitors
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Van Horne A
Social Hour with Lite Bites  
7:00–8:00 PM
 Mezzanine 2
Poster Session 3  
7:30–10:00 PM
 Mezzanine 2
Friday, February 16, 2024
Departure  
7:00–11:59 PM

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