Feb 12–15, 2024 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Gina DeNicola, Rushika M. Perera, and David B. Shackelford

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Scientific Organizers: Gina DeNicola, Rushika M. Perera, and David B. Shackelford
Gina DeNicola
Rushika M. Perera
David B. Shackelford
***Meeting program subject to change.
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Monday, February 12, 2024
Tuesday, February 13, 2024
Session Chair
Mitochondrial Bioenergetics
Session Chair
Lysosome Mediated Regulation of Metabolism
Regulation and Function of NADPH Metabolism
Metabolic Stress Adaptations in Cancer
Short Talk: Short Talk: Identifying and Targeting Novel Lysosomal Enzymes in Pancreatic Cancer
Senior Vice President Biology
Professor and Director of the Max Planck Institute of Biophysics
Senior Investigator
Assistant Professor
Session Chair
Cholesterol-dependent Remodeling of the Endoplasmic Reticulum Regulates CAF Function
Tumor Respiration Defects Limit Serine Synthesis Required To Suppress Oxidative Stress
Understanding the Role of mtDNA Alterations and Electron Transport Chain Function in Thyroid Cancer
NDUFA4L2 Drives Metastasis in RCC by Inhibiting Oxidative Phosphorylation to Facilitate EMT
Loss of Mitochondrial Fission Impairs Breast Cancer Metastasis
Breast Cancer Cells Rely on Mitochondrial Respiration to Form Bone Metastases
Differential Acquisition of Extracellular Lipid Correlates with Pancreatic Cancer Subtype and Metastatic Tropism
Session Chair
Stress Granules at the Crossroads of Cellular Stress and Pancreatic Cancer
Cellular Adaptation to Cysteine Starvation
The Prostacyclin Receptor is an Nrf2-regulated Immune Checkpoint for CD8 T Cell Function
Short Talk: Short Talk: Uncovering and Exploiting Toxic Metabolite Pathways in Cancer Cells
Short Talk: Short Talk: Linking Cystine Deprivation to Selenium Insufficiency: A Novel Explanation for Cystine Deprivation-induced Ferroptosis
Wednesday, February 14, 2024
Session Chair
Spatiotemporal Analysis of Metabolism
Three Dimesional Imaging of Cancer Mitochondria
Dissecting Metabolic Tumour Heterogeneity in vivo
Control of Tumor Cell Metabolism by Mitochondrial Dynamics
Short Talk: Short Talk: Comprehensive Isotope Tracing of Fatty Acids in vivo Reveals Differences Between Primary Tumors and Metastatic Sites
Short Talk: Short Talk: Machine Learning-based Method to Analyze Metabolic Fluxes of Patient Tumors
Session Chair
Fueling the Way—The Role of Localized GTP Synthesis in Renal Cell Carcinoma Metastasis
Loss of NADPH-producing Enzymes Accelerates Precancerous Lesions in the Pancreas
Identifying Targetable Metabolic Adaptations in Drug Tolerant BRAFV600E Mutant Non-small Cell Lung Cancer
Heme Increases Purine Metabolism in Multiple Myeloma to Promote Resistance to Apoptosis
Investigating the Roles of GSH and TXN Antioxidant Systems in NSCLC Tumor Progression
The Oncoprotein Grb7 is a Novel Physiological Target of mTORC1: Implications for Breast Cancer and Hepatic Insulin Resistance
A Phenotypic Drug Discovery Screen Reveals de novo GTP Synthesis as a Targetable Metabolic Vulnerability in Brain Metastases
Session Chair
Metabolic Vulnerabilities of Metastasis
Targeting Autophagy
Understanding the Roles of Antioxidants in Cancer
Metabolic Targeting for Rare Cancers
Thursday, February 15, 2024
Session Chair
Branched chain amino acid metabolism and pancreatic tumorigenesis
Metabolic Adaptations to Glutamine Mimetics: From Discovery to Therapeutics
Harnessing Chemical Interactions to Explore Tumor Cell Biological Responses to Fluctuations in Metal and Micronutrient Availability
Short Talk: Short Talk: Conditional Lethality Profiling in Human Cancer Cells
Short Talk: Short Talk: Trans-vaccenic Acid Reprograms CD8+ T Cells and Anti-tumour Immunity
Short Talk: Short Talk: Nutrient Constrain-induced Metabolic Rewiring Impacts NK Cell Function in Pancreatic Cancer
Short Talk: Short Talk: Branched-chain Keto Acids Promote an Immune-suppressive and Neurodegenerative Microenvironment in Leptomeningeal Disease
Session Chair
Altered Exocrine Function Promotes Pancreatic Cancer-associated Autophagic Proteolysis in the Muscle
Assessing the Mechanism of Iron Mediated Cell Toxicity in Colon Cancer
The Oncogenic Roles of Glycogen in PI3K/AKT/mTOR Signaling
Selective Dependence on Stromal Acetate-induced Polyamine Metabolism Provides Unique Therapeutic Opportunities in Pancreatic Cancer
Modulating JAK-STAT Signaling in the Tumor Microenvironment by Regulating Arginine Cross-Talks
A Forward Genetic Approach Reveals Mechanisms of Alpha-Ketoglutarate Regulation in the Nucleus
Session Chair
Metabolic Reprogramming: A Bridge Between Aging and Cancer
Metabolism in situ
A Metabolic Atlas of Aging
Short Talk: Short Talk: The Gut Microbiome Regulates the Anti-cancer Activity of PI3K Inhibitors
Friday, February 16, 2024
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