Feb 25–28, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Trista E. North, Michael G. Kharas, and Nina Cabezas-Wallscheid

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Scientific Organizers: Trista E. North, Michael G. Kharas, and Nina Cabezas-Wallscheid
Trista E. North
Michael G. Kharas
Nina Cabezas-Wallscheid
***Meeting program subject to change.
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Sunday, February 25, 2024
Monday, February 26, 2024
Session Chair
Session Chair
Session Chair
Dissecting Human Hematopoietic Stem Cell Specification and Self-Renewal at Single Cell Level
Session Chair
Session Chair
Remote Presentation: Why do Human Haematopoietic Stem Cells Lose Function Ex Vivo?
Extrinsic Regulation of Hematopoietic Stem Cell Specification in the Vertebrate Embryo
Metabolic Regulation of Hematopoietic Development and Function
Short Talk: Short Talk: Modelling Human Post-Implantation Embryogenesis to Multilineage Yolk Sac Haematopoiesis Ex-Utero
Session Chair
Session Chair
Macropinocytosis Enforces Macrophage Lineage Fidelity
Origins of Primitive Erythropoiesis in Zebrafish
Mapping Genotypes to Chromatin Accessibility Profiles In Single Cells
Loss of integrin α4 Function During Development Leads to Premature Aging of Hematopoietic Stem and Progenitor Cells in Adulthood
Cohesin Mutations Prevent HSC Chromatin Silencing of Fli1 Targets to Exit Stemness
CD83 Marks an Effector State of Human Inflammatory Memory Hematopoietic Stem Cells
Session Chair
Session Chair
Epigenetic and Metabolic Regulation of Hematopoietic Stem Cell Dormancy
Metabolic Control of Hematopoietic Stem Cell Regeneration and Lineage Potential
Institute for Research on Cancer and Aging
Short Talk: Short Talk: Hematopoietic Stem Cell Extinction & Clonal Dominance Driven by Endogenous Formaldehyde
Short Talk: Short Talk: Gprasp2 Expression Identifies a Deeply Quiescent HSC Subset with Superior Stemness and Self-Renewal
Tuesday, February 27, 2024
Session Chair
Session Chair
Defining Cellular Interplay in the Hematopoietic Bone Marrow Niche
Long-term Engrafting Haematopoietic Cells Differentiated from Human Pluripotent Stem Cells
Remodeling and Regeneration of the Bone Marrow Microenvironment Post-Inflammatory Stress
Microenvironmental Regulation of the Bone Marrow Niche in Hematologic Disease States
Short Talk: Short Talk: Apelin-Mediated Clonal Expansion of Niche Endothelial Cells Drives Selection of Leukemic and Normal HSC Clones
Short Talk: Short Talk: Hematopoietic Stem Cell Numbers are Not Solely Determined by Niche Availability
Professor
Research Director
Associate Professor
Associate Editor
Session Chair
Session Chair
Inflammatory Regulation of Hematopoietic Homeostasis Drives Aging Phenotypes
Tracing Contributions of Hematopoietic Stem and Progenitor Population to Life-Long Hematopoiesis
Engineering Hematopoiesis by Homology Directed Repair Genome Editing
Short Talk: Short Talk: Mitochondrial Translation Regulates Fetal Erythropoiesis Through Regulation of Iron Homeostasis
Short Talk: Short Talk: Inflammation Drives Aberrant Hematopoiesis in the Spleens of Patients with Advanced Myelofibrosis
Wednesday, February 28, 2024
Session Chair
RNA Regulators and Control of Leukemic Cell Fate
The Role of AML Stem Cells in Patients Treated with Venetoclax
What Makes a Stem Cell a Stem Cell and How Does it Go Bad?
Insights into Disease Mechanisms and Discovery of New Therapeutic Targets for Myeloid Malignancies from Human iPSC Models
Short Talk: Short Talk: GATA2 Promotes Drug Resistance in KMT2A-rearranged Acute Myeloid Leukemia by Enhancing the Protein Stability of MDM2
Short Talk: Short Talk: Selenocysteine Recoding is a Vulnerability of FLT3-Mutant Leukemias
Session Chair
Session Chair
10x Spatial Transcriptomics of Human AML Core Bone Marrow Biopsies Reveals the Complex Remodeling of the Non-Hematopoietic Stromal Microenvironment Post-Treatment
EBF1: A New Regulator of Onco-Niche in Myelofibrosis
Bone Marrow B Cell Niche Signals Shape the Pre-Leukemic Cell Fate of B Cell Acute Lymphoblastic leukemia
p85⍺ Ubiquitination as a Target in Hematopoietic Malignancies
Myelodysplastic Syndrome HSCs’ Plasticity Drives Venetoclax Therapy Escape
Engineered hiPSC Derived CAR T Cells with Enhanced Safety Profile
Session Chair
Session Chair
Single-Cell Profiling of Clonal Evolution in Myeloid Malignancies
Cell-of-Origin, Pathobiology and Therapeutics of MLL-rearranged Pediatric B-cell ALL
Stem Cells in Human AML
Short Talk: Short Talk: Long-term Persisting HSCs Contribute During Early Neutrophil Recovery and Form Clonal Pools: Implications for Ex Vivo and In Vivo HSC Gene Therapy Applications
Thursday, February 29, 2024
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