Hematopoiesis

Feb 25–28, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Trista E. North, Michael G. Kharas and Nina Cabezas-Wallscheid

  In Person
  On Demand

Feb 25–28, 2024 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Trista E. North, Michael G. Kharas and Nina Cabezas-Wallscheid

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, February 25, 2024
Arrival and Registration  
4:00–8:00 PM
 Longs Peak Foyer
Welcome Mixer  
6:00–8:00 PM
 Longs Peak Foyer
Monday, February 26, 2024
Breakfast  
7:00–8:00 AM
 Longs Peak
Welcome and Keynote Address  
8:00–9:00 AM
 Grays Peak
* Trista E. North, Boston Children’s Hospital
Session Chair
* Nina Cabezas-Wallscheid, Max Planck Institute of Immunobiology and Epigenetics
Session Chair
* Michael G. Kharas, Memorial Sloan Kettering Cancer Center
Session Chair
Hanna K.A. Mikkola, University of California, Los Angeles
Dissecting Human Hematopoietic Stem Cell Specification and Self-Renewal at Single Cell Level
Developmental Hematopoiesis  
9:00–11:15 AM
 Grays Peak
* Trista E. North, Boston Children’s Hospital
Session Chair
* Andrew G Elefanty, Murdoch Children's Research Institute
Session Chair
Elisa Laurenti, University of Cambridge
Remote Presentation: Why do Human Haematopoietic Stem Cells Lose Function Ex Vivo?
Trista E. North, Boston Children’s Hospital
Extrinsic Regulation of Hematopoietic Stem Cell Specification in the Vertebrate Embryo
Anna E. Beaudin, University of Utah School of Medicine
Metabolic Regulation of Hematopoietic Development and Function
Mo Ebrahimkhani, University of Pittsburgh School of Medicine
Short Talk: Short Talk: Modelling Human Post-Implantation Embryogenesis to Multilineage Yolk Sac Haematopoiesis Ex-Utero
Coffee Break  
9:30–9:50 AM
 Longs Peak Foyer
Poster Setup  
11:15–1:00 PM
 Longs Peak
On Own for Lunch  
11:15–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Longs Peak
Workshop 1: Biological Basis of Blood Development and Disease  
2:30–4:30 PM
 Grays Peak
* Hanzhi Luo, Memorial Sloan Kettering Cancer center
Session Chair
* Simona Colla, University of Texas MD Anderson Cancer Center
Session Chair
Alissa J Trzeciak, Memorial Sloan Kettering Cancer Center
Macropinocytosis Enforces Macrophage Lineage Fidelity
Ondrej Svoboda, Institute of Molecular Genetics
Origins of Primitive Erythropoiesis in Zebrafish
Franco Izzo, Weill Cornell Medicine
Mapping Genotypes to Chromatin Accessibility Profiles In Single Cells
Nicole Woodhead, UW-Madison
Loss of integrin α4 Function During Development Leads to Premature Aging of Hematopoietic Stem and Progenitor Cells in Adulthood
Aaron D. Viny, Columbia University Irving Medical Center
Cohesin Mutations Prevent HSC Chromatin Silencing of Fli1 Targets to Exit Stemness
Stephanie Z Xie, University Health Network
CD83 Marks an Effector State of Human Inflammatory Memory Hematopoietic Stem Cells
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Hematopoietic Stem Cell Biology  
5:00–7:00 PM
 Grays Peak
* Keisuke Ito, Albert Einstein College of Medicine
Session Chair
* Vanessa M Scanlon, UConn Health
Session Chair
Nina Cabezas-Wallscheid, Max Planck Institute of Immunobiology and Epigenetics
Epigenetic and Metabolic Regulation of Hematopoietic Stem Cell Dormancy
Toshio Suda, Cancer Science Institute of Singapore
Metabolic Control of Hematopoietic Stem Cell Regeneration and Lineage Potential
Eirini D. Trompouki, IRCAN-Institute for research on Cancer and Aging
Institute for Research on Cancer and Aging
Ashley N. Kamimae-Lanning, MRC Weatherall Institute of Molecular Medicine - University of Oxford
Short Talk: Short Talk: Hematopoietic Stem Cell Extinction & Clonal Dominance Driven by Endogenous Formaldehyde
Alanna Van Huizen, St. Jude Children's Research Hospital
Short Talk: Short Talk: Gprasp2 Expression Identifies a Deeply Quiescent HSC Subset with Superior Stemness and Self-Renewal
Social Hour with Lite Bites  
7:00–8:00 PM
 Longs Peak
Poster Session 1  
7:30–10:00 PM
 Longs Peak
Tuesday, February 27, 2024
Breakfast  
7:00–8:00 AM
 Longs Peak
Hematopoietic Microenvironment  
8:00–11:00 AM
 Grays Peak
* Owen J. Tamplin, University of Wisconsin-Madison
Session Chair
* Marta Derecka, St. Jude Children's Research Hospital
Session Chair
Claudia Waskow, Friedrich Schiller University Jena
Defining Cellular Interplay in the Hematopoietic Bone Marrow Niche
Elizabeth S. Ng, Murdoch Children's Research Institute
Long-term Engrafting Haematopoietic Cells Differentiated from Human Pluripotent Stem Cells
César Nombela-Arrieta, University Hospital Zurich
Remodeling and Regeneration of the Bone Marrow Microenvironment Post-Inflammatory Stress
David T. Scadden, Massachusetts General Hospital and Harvard University
Microenvironmental Regulation of the Bone Marrow Niche in Hematologic Disease States
Chloe Baron, Boston Children's Hospital
Short Talk: Short Talk: Apelin-Mediated Clonal Expansion of Niche Endothelial Cells Drives Selection of Leukemic and Normal HSC Clones
Kira Gritsman, Albert Einstein College of Medicine
Short Talk: Short Talk: Hematopoietic Stem Cell Numbers are Not Solely Determined by Niche Availability
Coffee Break  
9:00–9:20 AM
 Longs Peak Foyer
Poster Setup  
11:00–1:00 PM
 Longs Peak
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Longs Peak
Career Roundtable  
3:00–4:30 PM
 Grays Peak
Ravi Majeti, Stanford University
Professor
Eirini D. Trompouki, IRCAN-Institute for research on Cancer and Aging
Research Director
Anna E. Beaudin, University of Utah School of Medicine
Associate Professor
Yahyah Aman, Springer Nature
Associate Editor
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Aging and Stress Hematopoiesis  
5:00–6:45 PM
 Grays Peak
* Stephanie Z Xie, University Health Network
Session Chair
* Franco Izzo, Weill Cornell Medicine
Session Chair
Emmanuelle Passegué, Columbia University
Inflammatory Regulation of Hematopoietic Homeostasis Drives Aging Phenotypes
Fernando D. Camargo, Boston Children's Hospital
Tracing Contributions of Hematopoietic Stem and Progenitor Population to Life-Long Hematopoiesis
Matthew Porteus, Stanford University School of Medicine
Engineering Hematopoiesis by Homology Directed Repair Genome Editing
Hitoshi Takizawa, Kumamoto University
Short Talk: Short Talk: Mitochondrial Translation Regulates Fetal Erythropoiesis Through Regulation of Iron Homeostasis
Rebecca Austin, NYU Langone
Short Talk: Short Talk: Inflammation Drives Aberrant Hematopoiesis in the Spleens of Patients with Advanced Myelofibrosis
Social Hour with Lite Bites  
7:00–8:00 PM
 Longs Peak
Poster Session 2  
7:30–10:00 PM
 Longs Peak
Wednesday, February 28, 2024
Breakfast  
7:00–8:00 AM
 Longs Peak
Hematologic Malignancies  
8:00–11:00 AM
 Grays Peak
* Aaron D. Viny, Columbia University Irving Medical Center
Session Chair
Michael G. Kharas, Memorial Sloan Kettering Cancer Center
RNA Regulators and Control of Leukemic Cell Fate
Andreas Trumpp, German Cancer Research Center
The Role of AML Stem Cells in Patients Treated with Venetoclax
John E. Dick, Princess Margaret Cancer Centre
What Makes a Stem Cell a Stem Cell and How Does it Go Bad?
Eirini P. Papapetrou, Icahn School of Medicine at Mount Sinai
Insights into Disease Mechanisms and Discovery of New Therapeutic Targets for Myeloid Malignancies from Human iPSC Models
Fatemeh Alikarami, Children's Hospital of Philadelphia
Short Talk: Short Talk: GATA2 Promotes Drug Resistance in KMT2A-rearranged Acute Myeloid Leukemia by Enhancing the Protein Stability of MDM2
Daisuke Nakada, Baylor College of Medicine
Short Talk: Short Talk: Selenocysteine Recoding is a Vulnerability of FLT3-Mutant Leukemias
Coffee Break  
9:00–9:20 AM
 Longs Peak Foyer
On Own for Lunch  
11:00–5:00 PM
Workshop 2: Novel Technologies and Therapeutics Discovery in Hematology  
2:30–4:30 PM
 Grays Peak
* David A. Alagpulinsa, Yale University School of Medicine
Session Chair
* Chloe Baron, Boston Children's Hospital
Session Chair
Makayla Pardo, Brown University
10x Spatial Transcriptomics of Human AML Core Bone Marrow Biopsies Reveals the Complex Remodeling of the Non-Hematopoietic Stromal Microenvironment Post-Treatment
Marta Derecka, St. Jude Children's Research Hospital
EBF1: A New Regulator of Onco-Niche in Myelofibrosis
Stéphane J. C. Mancini, INSERM
Bone Marrow B Cell Niche Signals Shape the Pre-Leukemic Cell Fate of B Cell Acute Lymphoblastic leukemia
Kasidy Dobish, University of Utah
p85⍺ Ubiquitination as a Target in Hematopoietic Malignancies
Juan Jose Rodriguez-Sevilla, MD Anderson Cancer Center
Myelodysplastic Syndrome HSCs’ Plasticity Drives Venetoclax Therapy Escape
Caroline Kubaczka, Boston Children's Hospital
Engineered hiPSC Derived CAR T Cells with Enhanced Safety Profile
Coffee Available  
4:30–5:00 PM
 Longs Peak Foyer
Directed Differentiation and Therapeutics  
5:00–7:00 PM
 Grays Peak
* Stéphane J. C. Mancini, INSERM
Session Chair
* Adrienne Dorrance, Huntsman Cancer Institute
Session Chair
Ross L. Levine, Memorial Sloan Kettering Cancer Center
Single-Cell Profiling of Clonal Evolution in Myeloid Malignancies
Pablo Menendez, Josep Carreras Leukaemia Institute
Cell-of-Origin, Pathobiology and Therapeutics of MLL-rearranged Pediatric B-cell ALL
Ravi Majeti, Stanford University
Stem Cells in Human AML
Stefan Radtke, Fred Hutchinson Cancer Center
Short Talk: Short Talk: Long-term Persisting HSCs Contribute During Early Neutrophil Recovery and Form Clonal Pools: Implications for Ex Vivo and In Vivo HSC Gene Therapy Applications
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Grays Peak
Social Hour with Lite Bites  
7:00–8:00 PM
 Longs Peak
Trivia  
8:00–9:00 PM
 Grays Peak
Cash Bar  
8:00–9:00 PM
 Longs Peak
Thursday, February 29, 2024
Departure  
7:00–11:59 PM

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