Tumor Metabolism: Environmental Influences and Therapeutic Vulnerabilities
Mar 16–19, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers:
Shannon Mumenthaler, Kathryn E. Wellen, and Arkaitz Carracedo
In Person
On Demand
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Mar 16–19, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Shannon Mumenthaler, Kathryn E. Wellen, and Arkaitz Carracedo
Shannon Mumenthaler
Kathryn E. Wellen
Arkaitz Carracedo
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandSunday, March 16, 2025
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
British/Columbia Foyer
Welcome Mixer
6:00–8:00 PM
British/Columbia Foyer
Monday, March 17, 2025
Breakfast
7:00–8:00 AM
British Ballroom
Welcome and Keynote Session
8:00–9:30 AM
Columbia Ballroom
* Shannon Mumenthaler, University of Southern California
* Kathryn E. Wellen, University of Pennsylvania
Joshua D. Rabinowitz, Princeton University
Metabolic Flux Analysis in Cancer
Metabolic Flux Analysis in Cancer
Tomi Akinyemiju, Duke University
Embodiment: The Influence of Social Stressors on Cancer Outcomes
Embodiment: The Influence of Social Stressors on Cancer Outcomes
Coffee Break
9:30–9:50 AM
British/Columbia Foyer
Therapeutic Targeting of Metabolism
9:50–12:00 PM
Columbia Ballroom
* Christopher J Halbrook, University of California, Irvine
Session Chair
Session Chair
Issam Ben-Sahra, Northwestern University
Regulation of Nucleotide Metabolism in Cancer Cells
Regulation of Nucleotide Metabolism in Cancer Cells
Marianne Koritzinsky, University Health Network
Dependency of Cancer Cells on Cysteamine Dioxygenase (ADO)
Dependency of Cancer Cells on Cysteamine Dioxygenase (ADO)
Jonathan D. Powell, Calico Life Sciences
Glutamine Antagonism and Immunotherapy
Glutamine Antagonism and Immunotherapy
Ayelet Erez, Weizmann Institute of Science
Dissecting the tumor-host crosstalk to potentiate therapy
Dissecting the tumor-host crosstalk to potentiate therapy
Poster Setup
12:00–1:00 PM
British Ballroom
On Own for Lunch
12:00–1:30 PM
Poster Viewing
1:00–10:00 PM
British Ballroom
Symposia Spotlight 1: New Strategies for Therapeutic Targeting of Metabolism
1:30–3:15 PM
Columbia Ballroom
* Danielle Schmitt, University of California Los Angeles
Session Chair
Session Chair
Ruchika Pokhriyal, Dana-Farber Cancer Institute
Deciphering Resistance Mechanisms to DHODH Inhibition
Deciphering Resistance Mechanisms to DHODH Inhibition
Laurentz Schuhknecht, University of Basel
Annotating Drug Modes of Action by Large-scale Metabolic Fingerprinting
Annotating Drug Modes of Action by Large-scale Metabolic Fingerprinting
Yulseung Sung, Yonsei University
A Selective Allosteric Inhibition of Mitochondrial Glutamine Transporter, SLC1A5_Var, Induces Cancer Selective Metabolic Crisis and Creates Immune Vulnerabilities in the Tumor Microenvironment
A Selective Allosteric Inhibition of Mitochondrial Glutamine Transporter, SLC1A5_Var, Induces Cancer Selective Metabolic Crisis and Creates Immune Vulnerabilities in the Tumor Microenvironment
Li Du, Beckman Research Institute City of Hope
Targeting mitochondria metabolism through SUMOylation inhibition Sensitizes Acute Myeloid Leukemia to Venetoclax treatment
Targeting mitochondria metabolism through SUMOylation inhibition Sensitizes Acute Myeloid Leukemia to Venetoclax treatment
Alejandro Gutierrez, St. Jude Children's Research Hospital
G6PD Loss Confers Sensitivity to Asparaginase Through Ammonia Toxicity
G6PD Loss Confers Sensitivity to Asparaginase Through Ammonia Toxicity
Roy Hajjar, Mayo Clinic
Dietary PPAR-Gamma Activators Modulate the Gut Microbiota and Prevent the Dissemination Of Colorectal Cancer Cells and the Growth of Extra-Intestinal Colorectal Tumors
Dietary PPAR-Gamma Activators Modulate the Gut Microbiota and Prevent the Dissemination Of Colorectal Cancer Cells and the Growth of Extra-Intestinal Colorectal Tumors
Taryn Morningstar, University of California, Irvine
Overcoming Heterogeneity in Pancreatic Cancer by Targeting Ref-1 and Mitochondrial Metabolism
Overcoming Heterogeneity in Pancreatic Cancer by Targeting Ref-1 and Mitochondrial Metabolism
Advancing Understanding in Tumor Metabolism: Bridging Research and Patient Care
3:30–4:30 PM
Columbia Ballroom
Alejandro Gutierrez, St. Jude Children's Research Hospital
Panelist
Panelist
Tomi Akinyemiju, Duke University
Panelist
Panelist
Stacey D Finley, University of Southern California
Panelist
Panelist
Sara Zanivan, MD Anderson Cancer Center
Panelist
Panelist
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Signaling, Epigenetics and Tumor Metabolism
5:00–7:00 PM
Columbia Ballroom
* Isaac Harris, University of Rochester Medical Center
Session Chair
Session Chair
Katherine Aird, University of Pittsburgh School of Medicine
CDKN2A-Low Cancer Cells Outcompete Macrophages for Microenvironmental Zinc to Drive Immunotherapy Resistance
CDKN2A-Low Cancer Cells Outcompete Macrophages for Microenvironmental Zinc to Drive Immunotherapy Resistance
Brendan D Manning, Harvard School of Public Health
mTOR Signaling and Metabolic Control in the Tumor Microenvironment
mTOR Signaling and Metabolic Control in the Tumor Microenvironment
Sara Sdelci, Centre for Genomic Regulation
Chromatome Profiling Uncovers Extensive Nuclear Localization of Metabolic Enzymes
Chromatome Profiling Uncovers Extensive Nuclear Localization of Metabolic Enzymes
Kathryn E. Wellen, University of Pennsylvania
Metabolism-epigenetics Crosstalk in Cancer
Metabolism-epigenetics Crosstalk in Cancer
Social Hour with Lite Bites
7:00–8:00 PM
British Ballroom
Poster Session
7:30–10:00 PM
British Ballroom
Tuesday, March 18, 2025
Breakfast
7:00–8:00 AM
British Ballroom
Poster Setup
7:30–8:00 AM
British Ballroom
Poster Viewing
7:45–5:00 PM
British Ballroom
Metabolic Crosstalk Between Tumor Cells and their Microenvironment
8:00–11:00 AM
Columbia Ballroom
* Sam McBrayer, UT Southwestern Medical Center
Session Chair
Session Chair
Shannon Mumenthaler, University of Southern California
Biomimetic Models to Study Tumor Metabolism in Context
Biomimetic Models to Study Tumor Metabolism in Context
M. Celeste Simon, University of Pennsylvania
Effects of Hypoxia on Cancer Metabolism
Effects of Hypoxia on Cancer Metabolism
Sara Zanivan, MD Anderson Cancer Center
Cell Metabolism in the TME: Sculpting Antitumor Immunity
Cell Metabolism in the TME: Sculpting Antitumor Immunity
Pankaj Singh, University of Oklahoma Health Science Center, Stephenson Cancer Center
Short Talk: Lipophagy-Dependent Fatty Acid Oxidation is a Metabolic Vulnerability for KRAS Signaling Inhibition in Pancreatic Cancer
Short Talk: Lipophagy-Dependent Fatty Acid Oxidation is a Metabolic Vulnerability for KRAS Signaling Inhibition in Pancreatic Cancer
Paolo Ceppi, University of Southern Denmark
Short Talk: Contact-Dependent Thymidylate Transfer as a Mechanism of Collective Tumor Growth
Short Talk: Contact-Dependent Thymidylate Transfer as a Mechanism of Collective Tumor Growth
Swagata Goswami, Massachusetts Institute of Technology
Short Talk: Ceramides Drive Colorectal Cancer Metastasis Through a Revival Stemness Program
Short Talk: Ceramides Drive Colorectal Cancer Metastasis Through a Revival Stemness Program
Manas Kohli, Institute of Cancer Research
Short Talk: A Pan-Cancer Atlas of Tumour Metabolism Through Flux Balance Analysis
Short Talk: A Pan-Cancer Atlas of Tumour Metabolism Through Flux Balance Analysis
Coffee Break
9:00–9:20 AM
British/Columbia Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Columbia Ballroom
Lunch
11:00–12:00 PM
British Ballroom
Poster Session
12:00–2:30 PM
British Ballroom
Career Roundtable
3:00–4:30 PM
Columbia Ballroom
Katherine Aird, University of Pittsburgh School of Medicine
Associate Professor
Associate Professor
Alejandro Gutierrez, St. Jude Children's Research Hospital
Principal Investigator, Member
Principal Investigator, Member
Jintan Liu, Merck
Associate Principal Scientist
Associate Principal Scientist
Alfredo Gimenez-Cassina, Nature Metabolism
Senior Editor
Senior Editor
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Immune Microenvironment and Metabolism
5:00–7:00 PM
Columbia Ballroom
* Julie-Aurore Losman, Dana-Farber Cancer Institute
Session Chair
Session Chair
Costas A. Lyssiotis, University of Michigan
Targeting Lipid Metabolism in Pancreatic Cancer
Targeting Lipid Metabolism in Pancreatic Cancer
Stacey D Finley, University of Southern California
Systems Biology Modeling of Metabolic Interactions in the Tumor Microenvironment
Systems Biology Modeling of Metabolic Interactions in the Tumor Microenvironment
Deanna N. Edwards, Vanderbilt University Medical Center
Short Talk: Transendothelial Delivery of Long Chain Fatty Acids during Metastatic Outgrowth Suppresses Anti-tumor Immunity
Short Talk: Transendothelial Delivery of Long Chain Fatty Acids during Metastatic Outgrowth Suppresses Anti-tumor Immunity
Michael S Dahabieh, Van Andel Institute
Short Talk: Unveiling NRF2-Mediated Crosstalk in Tumor Metabolism and Immunotherapy Resistance
Short Talk: Unveiling NRF2-Mediated Crosstalk in Tumor Metabolism and Immunotherapy Resistance
On Own for Dinner
7:00–8:00 PM
Wednesday, March 19, 2025
Breakfast
7:00–8:00 AM
British Ballroom
Systemic Influences on Tumor Metabolism
8:00–11:00 AM
Columbia Ballroom
* Kathryn Lemberg, Johns Hopkins School of Medicine
Session Chair
Session Chair
* Shuang Liang, UT Southwestern Medical Center
Session Chair
Session Chair
Matthew G Vander Heiden, Massachusetts Institute of Technology
Diet and Tumor Metabolism
Diet and Tumor Metabolism
Sarah-Maria Fendt, VIB-KU Leuven
Metabolic Vulnerabilities of Metastatic Cancer Cells
Metabolic Vulnerabilities of Metastatic Cancer Cells
Marcus D. Goncalves, NYU Langone
Cancer Cachexia
Cancer Cachexia
George Poulogiannis, Institute of Cancer Research
Short Talk: Dietary Omega-6/3 Fats and Aspirin Govern PI3Kα-Induced Oncogenicity
Short Talk: Dietary Omega-6/3 Fats and Aspirin Govern PI3Kα-Induced Oncogenicity
Sarah Cherkaoui, University Children's Hospital Zurich
Short Talk: Reprogramming Neuroblastoma by Diet-Enhanced Polyamine Depletion
Short Talk: Reprogramming Neuroblastoma by Diet-Enhanced Polyamine Depletion
Christian F Ruiz, Yale University
Short Talk: Dietary Fats Dictate Pancreatic Cancer Fate Via Phospholipid Saturation
Short Talk: Dietary Fats Dictate Pancreatic Cancer Fate Via Phospholipid Saturation
Evan C Lien, Van Andel Institute
Short Talk: Lipid Availability Influences Ferroptosis Sensitivity in Cancer Cells by Regulating Polyunsaturated Fatty Acid Trafficking
Short Talk: Lipid Availability Influences Ferroptosis Sensitivity in Cancer Cells by Regulating Polyunsaturated Fatty Acid Trafficking
Coffee Break
9:00–9:20 AM
British/Columbia Foyer
On Own for Lunch
11:00–1:30 PM
Symposia Spotlight 2: Understanding how Environment (Local and Systemic) Impacts Tumorigenesis
1:30–3:15 PM
Columbia Ballroom
* Brandon Faubert, University of Chicago
Session Chair
Session Chair
Genevieve Deblois, University of Montreal
Mitochondrial Stress-Induced Metabolic Signaling Modulates Chromatin Accessibility to Support Adaptation in Breast Cancer
Mitochondrial Stress-Induced Metabolic Signaling Modulates Chromatin Accessibility to Support Adaptation in Breast Cancer
Milan R. Savani, University of Texas Southwestern Medical Center
Nitrogen Metabolism Profiling Reveals Mechanisms of Pyrimidine Synthesis Pathway Choice
Nitrogen Metabolism Profiling Reveals Mechanisms of Pyrimidine Synthesis Pathway Choice
Sonia Boscenco, Memorial Sloan Kettering Cancer Center
Mitochondrial Ribosomal RNA is the Target Of Functionally Dominant Hotspot Mutations in Cancer
Mitochondrial Ribosomal RNA is the Target Of Functionally Dominant Hotspot Mutations in Cancer
Alphonse N Dimeck, Roswell Park Comprehensive Caner Center
Mitochondrial Metabolic Enzymes in Prostate Tumors Regulate the Immunosuppressive Tumor Microenvironment
Mitochondrial Metabolic Enzymes in Prostate Tumors Regulate the Immunosuppressive Tumor Microenvironment
Julien Guillard, University of Chicago
From Waste to Nutrient: Ammonia's Recycling by Fibroblasts to Sustain Collagen Production
From Waste to Nutrient: Ammonia's Recycling by Fibroblasts to Sustain Collagen Production
Toshitha Kannan, University of Würzburg
Uncoupling of Tumor and Host Metabolism Induces Immune-Dependent Remission of PDAC
Uncoupling of Tumor and Host Metabolism Induces Immune-Dependent Remission of PDAC
Won-Suk Song, University of California, Irvine
Polyunsaturated Fatty Acid Elongation as a Mechanism of Ferroptosis Evasion in Liver Cancer
Polyunsaturated Fatty Acid Elongation as a Mechanism of Ferroptosis Evasion in Liver Cancer
Panel Discussion: Innovative Clinical Trial Strategies
3:30–4:30 PM
Columbia Ballroom
* Jonathan D. Powell, Calico Life Sciences
Panel Moderator
Panel Moderator
Chi V Dang, Ludwig Institute for Cancer Research
Panelist
Panelist
Marianne Koritzinsky, University Health Network
Panelist
Panelist
Marcus D. Goncalves, NYU Langone
Panelist
Panelist
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Challenges in Targeting Cancer Metabolism: Lessons Learned
5:00–6:15 PM
Columbia Ballroom
* Jiyoung Lee, George Washington University
Session Chair
Session Chair
Chi V Dang, Ludwig Institute for Cancer Research
MYC and The Complexity of Targeting Cell Metabolism
MYC and The Complexity of Targeting Cell Metabolism
Andrew M. Intlekofer, Memorial Sloan Kettering Cancer Center
Acquired resistance to IDH inhibition
Acquired resistance to IDH inhibition
Asael Roichman, Princeton University
Short Talk: Microbiome Metabolism of Dietary Phytochemicals Controls the Anticancer Activity of PI3K Inhibitors
Short Talk: Microbiome Metabolism of Dietary Phytochemicals Controls the Anticancer Activity of PI3K Inhibitors
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:15–6:30 PM
Columbia Ballroom
Social Hour with Lite Bites
6:30–7:30 PM
British Ballroom
Entertainment
7:30–8:30 PM
Columbia Ballroom
Thursday, March 20, 2025
Departure
12:00–11:59 PM
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