Myeloid Targeting Strategies for Cancer Treatment

May 06–09, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Miriam Merad and Matthew F. Krummel

  In Person

May 06–09, 2024 | INEC Killarney Convention Centre, Killarney, KY, Ireland
Scientific Organizers: Miriam Merad and Matthew F. Krummel

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person
Monday, May 6, 2024
Arrival and Registration  
4:00–8:00 PM
 INEC Foyer
Welcome Mixer  
6:00–8:00 PM
 INEC Foyer
Tuesday, May 7, 2024
Breakfast  
7:00–8:00 AM
 Individual Hotel
Welcome and Keynote Address  
8:00–9:00 AM
 INEC Main Auditorium
* Miriam Merad, Mount Sinai School of Medicine
Session Chair
* Matthew F. Krummel, University of California, San Francisco
Session Chair
Martin Guilliams, Ghent University - VIB
DC and Macrophage Diversity in Health and Diseases
Developmental Regulation of Myeloid Cells in Cancer and Beyond  
9:00–11:15 AM
 INEC Main Auditorium
Miriam Merad, Mount Sinai School of Medicine
Enhancing DC Function in the TME
* Christine Carine Moussion, Genentech, Inc.
Spatial Organization of Myeloid Programs in the TME
Merav Cohen, Tel-Aviv University
Myeloid Cellular Cross-Talks During Cancer Development
Robert Samstein, Icahn School of Medicine at Mount Sinai
Short Talk: Short Talk: HLA Class II Mediated Immune Surveillance of Lung Cancer
Coffee Break  
9:30–9:50 AM
 INEC Foyer
Poster Setup  
11:15–1:00 PM
 INEC Foyer
On Own for Lunch  
11:15–5:00 PM
Poster Viewing  
1:00–10:00 PM
 INEC Foyer
Career Roundtable  
3:30–4:30 PM
 INEC Main Auditorium
Judith A. Varner, University of California, San Diego
Professor, Pathology
Venkataraman Sriram, Foundery Innovations
Founder, Managing Member, & Chief Scientific Officer
Matteo Iannacone, San Raffaele Scientific Institute & University
Group Leader
Coffee Available  
4:30–5:00 PM
 INEC Foyer
Enhancing DC Functionality in the TME  
5:00–7:00 PM
 INEC Main Auditorium
* Matthew F. Krummel, University of California, San Francisco
Session Chair
* Miriam Merad, Mount Sinai School of Medicine
Session Chair
Rony Dahan, Weizmann Institute of Science
Antibody Targeting of Dendritic Cells in Cancer
Ruth Lan, Asher Biotherapeutics
Cell-Specific Cytokine Delivery
Livia Lacerda Mariano, Institute Curie
Short Talk: Short Talk: The TRPML1 Calcium Lysosomal Channel Controls Dendritic Cell Migration and Anti-tumor Immunity
Raphael Mattiuz, Icahn School of Medicine at Mount Sinai
Short Talk: Short Talk: Dendritic Cells Form and Maintain Tertiary Lymphoid Structures (TLSs) in Cancer Contributing to Immunotherapeutic Responses
Social Hour with Lite Bites  
7:00–8:00 PM
 INEC Foyer
Poster Session 1  
7:30–10:00 PM
 INEC Foyer
Wednesday, May 8, 2024
Breakfast  
7:00–8:00 AM
 Individual Hotel
Boosting Macrophage Tumorigenic Function  
8:00–11:00 AM
 INEC Main Auditorium
* Julie Helft, Institut Cochin
FOLR2+ Macs and Antitumor Immunity
Jennifer Guerriero, Brigham and Women's Hospital
Metabolic Targeting of Tumor Macrophages
* Philippe Benaroch, INSERM Institut Curie
Myeloid Cell Engineering for Anti-Tumor Treatments
Ido Amit, Weizmann Institute
Mapping Macrophages Inflammatory Programs
Florent Ginhoux, Singapore Immunology Network
Regulation of Monocyte-Derived Cells Differentiation in Inflamed Tissues
Meijun Wang, City University of Hong Kong (Shenzhen) Research Institute
Short Talk: Short Talk: Investigate the Role of IRF5 in Macrophages and Myeloid Cells in Anti-Tumor Immunity
Lea Feldmann, Institut Pasteur
Short Talk: Short Talk: Understanding the Antitumoral Activity of CAR-Macrophages
Coffee Break  
9:00–9:20 AM
 INEC Foyer
Poster Setup  
11:00–1:00 PM
 INEC Foyer
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 INEC Foyer
Workshop  
2:30–4:30 PM
 INEC Main Auditorium
Dalton Hermans, National Institutes of Health
ACT-VAX-INNATE: An Integrated Approach for Enhancing Tumor Control with Adoptive T Cell Therapy
* Alexander B. Sigalov, SignaBlok, Inc.
Ligand-Independent TREM-1 Blockade in Cancer Treatment
Thomas Jaquin, IOmx Therapeutics AG
IOMX-0675 , a LILRB1 and LILRB2 Cross-Specific Antibody, Effectively Repolarizes Immunosuppressive Myeloid Cells and Activates T Cells Leading to Potent Tumor Cell Killing
Martina Molgora, Washington University School of Medicine
Lack of TREM2 During anti-PD1 Therapy Reprograms Intestinal Macrophages and Microbiota to Enhance Tumor Rejection
Daniela C Cerezo-Wallis, Yale University
Cancer Enables Auxiliary Pathways of Granulopoiesis to Potentiate Tumorassociated Neutrophils
* Damya Laoui, Vrije Universiteit Brussel-VIB
Intratumoral Delivery of Lipid Nanoparticle-Formulated mRNA Encoding IL-21, IL-7, and 4-1BBL Induces Anti-Tumor Immunity
Cristina Contreras Burrola, National Cancer Institute
Going the Distance: Uncovering a Global Myeloid Reprogramming in Human Metastatic and Adjacent Microenvironments
Garett Dunsmore, University of Paris Saclay
Timing and Location Dictate Monocyte Fate and Their Transition to Tumor-Associated Macrophages
Coffee Available  
4:30–5:00 PM
 INEC Foyer
Dampening Myeloid Regulatory Programs  
5:00–7:00 PM
 INEC Main Auditorium
* Martin Guilliams, Ghent University - VIB
Session Chair
Venkataraman Sriram, Foundery Innovations
Targeting Trem2 in Cancer Patients
* Judith A. Varner, University of California, San Diego
Targeting Immunosupressive Macrophages
Megan Clark, UPenn
Short Talk: Short Talk: Mitochondrial NDUFA4 is a Functional Switch Controlling TAM Function and Tumor Immunity
Nicoletta Caronni, Ospedale San Raffaele
Short Talk: Short Talk: IL-1β+ Macrophages Fuel Pathogenic Inflammation in Pancreatic Cancer
Matthew Arvedson, UCSF
Short Talk: Short Talk: Aire-Expressing Tumor-Associated Macrophages Promote Cancer Immune Evasion
Samarth Hegde, Icahn School of Medicine at Mount Sinai
Short Talk: Short Talk: Epigenetic Dysregulation of Myeloid Progenitors Fuel Immunosuppressive Macrophages in Tumor Microenvironment
Social Hour with Lite Bites  
7:00–8:00 PM
 INEC Foyer
Poster Session 2  
7:30–10:00 PM
 INEC Foyer
Thursday, May 9, 2024
Breakfast  
7:00–8:00 AM
 Individual Hotel
Myeloid Cell Control of the Tissue Ecosystem  
8:00–11:00 AM
 INEC Main Auditorium
* Matthew F. Krummel, University of California, San Francisco
Space-Time 'Movements' in Tissues
* Laurence Zitvogel, Institut Gustave Roussy
Bile Acids Module the Gut Immune Rheostat Tuning Cancer Immunosurveillance
Luke A. J. O'Neill, Trinity Biomedical Sciences Institute
A Break in Mitochondrial Endosymbiosis as a Basis for Inflammatory Diseases
Jo A. Van Ginderachter, Vrije Universiteit Brussel
Short Talk: Short Talk: Kupffer Cell-Derived MIF as Regulator of Liver Metastasis
Ayumi Kuratani, Osaka University
Short Talk: Short Talk: Identification of a Tumor-Specific Macrophage Subset and its Functional Analysis by Labeling and Depletion Using the Novel VeDTR Mouse System
Coffee Break  
9:00–9:20 AM
 INEC Foyer
On Own for Lunch  
11:00–5:00 PM
Coffee Available  
4:30–5:00 PM
 INEC Foyer
Myeloid Cells in Viral and Inflammatory Diseases  
5:00–6:45 PM
 INEC Main Auditorium
* Matteo Iannacone, San Raffaele Scientific Institute & University
Targeting Myeloid Cells in Viral Diseases
* Carla V. Rothlin, Yale University
Myeloid and Stromal Crosstalk in Non-Resolving Inflammation
Duale A Ahmed, Carleton University
Short Talk: Short Talk: Vaccinia-Induced Early Anti-Tumour Immune Responses Are Dependent on Differential Reprogramming of Myeloid Cell Populations in Highly Versus Weakly Immunogenic Murine Cancer Models
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 INEC Main Auditorium
Social Hour with Lite Bites  
7:00–8:00 PM
 INEC Foyer
Cash Bar  
8:00–9:00 PM
 INEC Foyer
Friday, May 10, 2024
Departure  
7:00–11:59 PM

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