Apr 22–25, 2025 | Asilomar Hotel and Conference Grounds, Pacific Grove, CA, United States
Scientific Organizers:
Daniela Cota, Timo D. Müller, and Dana M. Small

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Scientific Organizers: Daniela Cota, Timo D. Müller, and Dana M. Small
Daniela Cota
Timo D. Müller
Dana M. Small
***Meeting program subject to change.
Available Formats: = In Person = On DemandTuesday, April 22, 2025
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Wednesday, April 23, 2025
Multi-Receptor Drugs for Obesity: Discovery, Mechanism & Clinical Impact
Session Chair
A Novel Incretin-based Quintuple Agonist for the Treatment of Obesity and Diabetes
Novel Drugs Targeting CNS Mechanisms of Body Weight Loss: The Oral GLP-1R Agonist, Orforglipron
CNS Mechanisms of Cagrilintide-Semaglutide Combinatorial Therapy to Treat Obesity
Deciphering the Mechanisms of Survodutide as an Anti-Obesity Therapy
Session Chair
Binge-Eating Disorder Vulnerability Is Determined By Tet1 Dosage In Midbrain Dopamine Neurons
From Metabolism To Memory: Exploring Amylin's Physiological Role In The Hippocampus
Hippocampal Response To Central Insulin Is Reduced With Age In Females With Unhealthy Fat Distribution
Apolipoprotein E Regulates Microglial Remodeling Of Hypothalamic Myelin In Obesity
Molecular Representation Of Peripheral Energy Levels By Neuronal Cilia
Role Of Hypothalamic Gabra5 Neurons And Astrocytic Gaba In Fat Regulation And Obesity
Mediobasal Hypothalamic Aryl Hydrocarbon Receptor Is Critical For Metabolic Homeostasis Via Regulation Of Hypothalamic Inflammation
Defining The Gut-Pancreas Neuronal Circuit That Controls Insulin Secretion
Session Chair
Learning from Post-Ingestive Rewards
The Gut-Brain Axis in Feeding Behavior
Hindbrain Circuits in the Control of Eating Behavior and Energy Balance
Short Talk: The Ups And Downs Of Brain-Gut-Brain Endocannabinoid Signaling In Food Intake And Reward
Short Talk: Gut-To-Brain Communication Protects Against Dietary Protein Toxicity During Recovery From Catabolic States
Thursday, April 24, 2025
Session Chair
Need State Regulation of Motivational Drive
Neural Circuits Integrating Hunger and Food Choices
Neural Circuits Underlying Stress-Related Eating
Short Talk: Habitual Feeding Schedule Enhances The Metabolic And Physiological Effects Of Calorie Restriction
Short Talk: Dopamine Signaling Regulates Feeding Behavior During Lactation In Mice
Short Talk: A Hypothalamic Circuit For Anticipating Future Changes In Energy Balance
Short Talk: Disruption Of The Developmental Factor Otp In The Adult Forebrain Reveals Its Diverse Physiological Functions
Senior Vice President, Global Drug Discovery
Associate Professor
Professor, Research Group Leader
Senior Scientific Director
Session Chair
Session Chair
Panelist
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GIP and GLP-1 Signaling in Satiety and Nausea
GDF15 in Nausea and Beyond
Genetic and Biological Determinants of Anorexia Nervosa
Cancer Cachexia: Bridging the CNS with Peripheral Wasting
Friday, April 25, 2025
Session Chair
REMOTE PRESENTER: Precision Medicine Approach in Patients with Melanocortin Pathway Disorders
Hypothalamic Responses to Energy Surfeit in the Regulation of Energy Balance
Brain Circuits for Amylin Action
Short Talk: A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs
Short Talk: A Postprandial Python Metabolite Mediates A Gut-Liver-Brain Feeding Axis
Short Talk: Interactions Between Olfactory Bulb Glp-1, Sensory Perception Of Food And Feeding Behaviour
Short Talk: Hedonic Eating Is Controlled By Dopamine Neurons That Oppose Glp-1r Satiety
Session Chair
Gipr Agonism and Antagonism Decrease Body Weight and Food Intake Via Different Mechanisms of Action
Biased Agonism Of The Glp-1r Maintains Glycemic Control Without Producing Nausea Or Emesis In Preclinical Models
A Novel Monogenic Agouti-Like Obesity Trait: New Insights From Mice And Men
Cross-Species Atlas Of The Dorsal Vagal Complex Reveals Neural Mediators Of Cagrilintide’s Effects On Energy Balance
Glucose-Dependent Insulinotrophic Polypeptide Regulates Food Intake And Body Weight Via The Area Postrema In Mice
Regulation Of Food Intake By The Locus Coeruleus
The Cellular And Molecular Basis For Leptin Regulation Of Energy Balance
A New Crispri Approach To Investigate The Pathogenic Mechanism Of Obesity-Associated Genes
Session Chair
Circuits of Hedonic Feeding in Health and Disease
Sugar and Fat: Distinct Reinforcement Mechanisms and Adaptations in Obesity
Neural Determinants of Decision Making in Feeding Behavior
Saturday, April 26, 2025
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