Autophagosomes and Endolysosomes: From Fundamental Mechanisms to Disease Implications
Jun 25–28, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers:
Christina Towers, Rupert Beale, and Leon O. Murphy
In Person
On Demand
×
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Jun 25–28, 2025 | Fairmont Chateau Whistler, Whistler, BC, Canada
Scientific Organizers: Christina Towers, Rupert Beale, and Leon O. Murphy
Christina Towers
Rupert Beale
Leon O. Murphy
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandWednesday, June 25, 2025
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Macdonald Foyer
Welcome Mixer
6:00–8:00 PM
Macdonald Foyer
Thursday, June 26, 2025
Breakfast
7:00–8:00 AM
MacDonald CD
Poster Setup
7:30–8:30 AM
MacDonald CD
Poster Viewing
7:45–7:00 PM
MacDonald CD
Welcome and Keynote Address
8:00–9:00 AM
Macdonald AB
* Christina Towers, The Salk Institute for Biological Studies
Session Chair
Session Chair
Anne Simonsen, University of Oslo
Intracellular Membrane Trafficking Through Endolysosomes and Autophagy
Intracellular Membrane Trafficking Through Endolysosomes and Autophagy
Intersections of Endolysosomes and Autophagy
9:00–11:15 AM
Macdonald AB
* Christina Towers, The Salk Institute for Biological Studies
Session Chair
Session Chair
* Leon O. Murphy, Casma Therapeutics
Session Chair
Session Chair
Marja Jäättelä, Danish Cancer Institute
Targeting Lysosomal Ion and Lipid Homeostasis in Cancer Treatment
Targeting Lysosomal Ion and Lipid Homeostasis in Cancer Treatment
Chan Lee, Harvard Medical School
Short Talk: TRPML1 Activation Promotes CASM-Dependent Recruitment of DMXL1 to Lysosomes
Short Talk: TRPML1 Activation Promotes CASM-Dependent Recruitment of DMXL1 to Lysosomes
Malene Hansen, Buck Institute for Research on Aging
On Canonical and Non-Canonical Autophagy Gene Functions in Aging
On Canonical and Non-Canonical Autophagy Gene Functions in Aging
Rupert Beale, The Francis Crick Institute
Non-Canonical Autophagy Mechanisms
Non-Canonical Autophagy Mechanisms
Thi Phuong Thuy Nguyen, Dana Farber Cancer Institute
Women in Autophagy
Women in Autophagy
Coffee Break
9:30–9:50 AM
Macdonald Foyer
Lunch
11:15–12:15 PM
MacDonald CD
Women In Science Networking Session
11:20–12:20 PM
Macdonald AB
* Christina Towers, The Salk Institute for Biological Studies
Session Chair
Session Chair
* Anne Simonsen, University of Oslo
Session Chair
Session Chair
* Chiara Di Malta, Telethon Institute of Genetics and Medicine
Session Chair
Session Chair
* Malene Hansen, Buck Institute for Research on Aging
Session Chair
Session Chair
* Ana Maria Cuervo, Albert Einstein College of Medicine
Session Chair
Session Chair
* Marja Jäättelä, Danish Cancer Institute
Session Chair
Session Chair
* Rushika M. Perera, University of California, San Francisco
Session Chair
Session Chair
Poster Session 1
12:00–2:30 PM
MacDonald CD
Symposia Spotlight 1: New Insights on Targeting Autophagy and Lysosomes
2:30–4:30 PM
Macdonald AB
* Carmine Settembre, Telethon Foundation
Session Chair
Session Chair
* Sanjna Singh, South Australian Health and Medical Research Institute
Session Chair
Session Chair
Joseph D. Mancias, Dana-Farber Cancer Institute
Full Talk: Targeting Ferritinophagy in Cancer
Full Talk: Targeting Ferritinophagy in Cancer
Swetha Gowrishankar, University of Illinois at Chicago
Small Molecule Modulator of Neuronal Lysosome Positioning and Function Resolves Alzheimer’s Disease-Linked Pathologies in Cultured Human Neurons
Small Molecule Modulator of Neuronal Lysosome Positioning and Function Resolves Alzheimer’s Disease-Linked Pathologies in Cultured Human Neurons
G. Jordan Ray, MIT
Lysosomal RNA Profiling Reveals Targeting of Specific Types of RNAs for Degradation
Lysosomal RNA Profiling Reveals Targeting of Specific Types of RNAs for Degradation
Chantell S Evans, Duke University School of Medicine
Full Talk: Investigating the Temporal Dynamics of Mitophagy in Neurons
Full Talk: Investigating the Temporal Dynamics of Mitophagy in Neurons
Suganthi Chittaranjan, British Columbia Cancer Agency
Torin-1 Reduces the Survival Rate of Cells Escaping Combined Treatment with the ATG4B and ATG4A Inhibitor LV320 and Metformin in PDAC Models
Torin-1 Reduces the Survival Rate of Cells Escaping Combined Treatment with the ATG4B and ATG4A Inhibitor LV320 and Metformin in PDAC Models
Matthew Shurtleff, Lycia Therapeutics
Catalytic Degradation of Circulating Targets with FcRn-Mediated cycling LYTACs
Catalytic Degradation of Circulating Targets with FcRn-Mediated cycling LYTACs
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Biophysics and Biochemistry of Autophagy
5:00–7:00 PM
Macdonald AB
* Dan Baird, Casma Tx
Session Chair
Session Chair
* Malene Hansen, Buck Institute for Research on Aging
Session Chair
Session Chair
Sascha Martens, University of Vienna
Mechanisms of Cargo Selection and Autophagosome Biogenesis
Mechanisms of Cargo Selection and Autophagosome Biogenesis
Jingyue Cassano, University of New Mexico
Short Talk: Lysosomes Collaborate with Biomolecular Condensates in Response to Damage
Short Talk: Lysosomes Collaborate with Biomolecular Condensates in Response to Damage
James H. Hurley, University of California, Berkeley
Mechanisms of Autophagy Initiation
Mechanisms of Autophagy Initiation
Tara D Fischer, National Institutes of Health
ATG8 and Ubiquitin Conjugation at Golgi-Related Membranes
ATG8 and Ubiquitin Conjugation at Golgi-Related Membranes
On Own for Dinner
7:00–8:00 PM
Friday, June 27, 2025
Breakfast
7:00–8:00 AM
MacDonald CD
Disease Relevance and Therapeutic Opportunities: Oncology and Metabolism
8:00–11:00 AM
Macdonald AB
* Joseph D. Mancias, Dana-Farber Cancer Institute
Session Chair
Session Chair
Christina Towers, The Salk Institute for Biological Studies
Targeting Autophagy in Cancer
Targeting Autophagy in Cancer
Rushika M. Perera, University of California, San Francisco
Lysosomes in Cancer
Lysosomes in Cancer
Caleb Cheng, University of Michigan
Short Talk: Targeting PIKfyve-Driven Lipid Metabolism in Pancreatic Cancer
Short Talk: Targeting PIKfyve-Driven Lipid Metabolism in Pancreatic Cancer
Noor Gammoh, The University of Edinburgh
Autophagy Regulates Oncogenic Signalling
Autophagy Regulates Oncogenic Signalling
Chiara Di Malta, Telethon Institute of Genetics and Medicine
TFEB in Metabolic Growth Disorders
TFEB in Metabolic Growth Disorders
Sharon Gorski, BC Cancer Research Institute
Short Talk: Suppression of Autophagy and PARP1 Activity by Dual Loss of Caspase 3 and Caspase 7
Short Talk: Suppression of Autophagy and PARP1 Activity by Dual Loss of Caspase 3 and Caspase 7
Coffee Break
9:00–9:20 AM
Macdonald Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Macdonald AB
Poster Setup
11:00–1:00 PM
MacDonald CD
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
MacDonald CD
Career Roundtable
3:30–4:30 PM
Macdonald AB
Christina Towers, The Salk Institute for Biological Studies
Assistant Professor
Assistant Professor
Dan Baird, Casma Tx
VP of Molecular Biology
VP of Molecular Biology
Andrea Marat, Journal of Cell Biology
Deputy Editor
Deputy Editor
Coffee Available
4:30–5:00 PM
Macdonald Foyer
Disease Relevance and Therapeutic Opportunities: Neurodegeneration
5:00–7:00 PM
Macdonald AB
* Chantell S Evans, Duke University School of Medicine
Session Chair
Session Chair
* Monther Abu-Remaileh, Stanford University
Session Chair
Session Chair
Yvette C. Wong, Northwestern University
Inter-Organelle Lysosome Contact Sites in Health and Neurodegeneration
Inter-Organelle Lysosome Contact Sites in Health and Neurodegeneration
Mathieu Bourdenx, University College London
Short Talk: Subcellular Proteomics Identify a Late-Endosome-Specific Signature Predicting Alzheimer's Disease Progression
Short Talk: Subcellular Proteomics Identify a Late-Endosome-Specific Signature Predicting Alzheimer's Disease Progression
Beat Nyfeler, Novartis Biomedical Research
Identification of Entry Points for Autophagy-Mediated Targeted Protein and Organelle Degradation using an Induced-Proximity Screen
Identification of Entry Points for Autophagy-Mediated Targeted Protein and Organelle Degradation using an Induced-Proximity Screen
Claire E Richardson, UW Madison
Short Talk: TFEB/HLH-30-Mediated Expansion of Neuronal Lysosomal Capacity in Early Adulthood Maintains Dendrite Morphology and Neurotransmission During Caenorhabditis Elegans Aging
Short Talk: TFEB/HLH-30-Mediated Expansion of Neuronal Lysosomal Capacity in Early Adulthood Maintains Dendrite Morphology and Neurotransmission During Caenorhabditis Elegans Aging
Juan S. Bonifacino, National Institutes of Health
AP-4 Delivers Autophagy Effectors from the TGN to Phagophore Assembly Sites
AP-4 Delivers Autophagy Effectors from the TGN to Phagophore Assembly Sites
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CD
Poster Session 2
7:30–10:00 PM
MacDonald CD
Saturday, June 28, 2025
Breakfast
7:00–8:00 AM
MacDonald CD
Disease Relevance and Therapeutic Opportunities: Infection and Immunity
8:00–11:00 AM
Macdonald AB
* James H. Hurley, University of California, Berkeley
Session Chair
Session Chair
* Tara D Fischer, National Institutes of Health
Session Chair
Session Chair
Feng Shao, National Institute of Biological Sciences
The Role of Autophagy Machinery in Anti-Bacterial Mechanisms
The Role of Autophagy Machinery in Anti-Bacterial Mechanisms
Maximiliano Gutierrez, Francis Crick Institute
Xenophagy: Implications for Tuberculosis
Xenophagy: Implications for Tuberculosis
Damian Gatica, University of Ottawa
Short Talk: The ER-Phagy Receptor FAM134B/RETREG1 is Targeted by Salmonella Typhimurium to Promote Infection
Short Talk: The ER-Phagy Receptor FAM134B/RETREG1 is Targeted by Salmonella Typhimurium to Promote Infection
James Phelan, National Cancer Institute
Autophagic Control of Oncogenic Signaling in Lymphoma
Autophagic Control of Oncogenic Signaling in Lymphoma
Kathryn Jacobs, VIB center for cancer biology
Short Talk: Autophagy as a Key Regulator of High Endothelial Venule Identity and Function During Inflammation
Short Talk: Autophagy as a Key Regulator of High Endothelial Venule Identity and Function During Inflammation
Corey N Cunningham, University of Utah
Short Talk: The Orphan Transporter SLC16A6 is Required For Melanogenesis And Lysosomal Acidification
Short Talk: The Orphan Transporter SLC16A6 is Required For Melanogenesis And Lysosomal Acidification
Coffee Break
9:00–9:20 AM
Macdonald Foyer
Autophagy and Autophagy Reports Poster Award
11:00–11:15 AM
Macdonald AB
On Own for Lunch
11:00–2:15 PM
Symposia Spotlight 2: Novel Techniques and Models to Interrogate Autophagosomes and Endolysosomes
2:15–4:30 PM
Macdonald AB
* Maximiliano Gutierrez, Francis Crick Institute
Session Chair
Session Chair
* Adam L Yokom, University of Missouri
Session Chair
Session Chair
Oluwatobi A Adeosun, University of Osnabrueck
Transbilayer Lipid Dynamics and Signaling in Lysosomal Repair
Transbilayer Lipid Dynamics and Signaling in Lysosomal Repair
Monther Abu-Remaileh, Stanford University
Full Talk: Unlocking The Secrets of the Lysosome in Neurodegeneration: From Tool Development to Novel Biology and Back
Full Talk: Unlocking The Secrets of the Lysosome in Neurodegeneration: From Tool Development to Novel Biology and Back
Elizabeth Delorme-Axford, Oakland University
The Nonsense-Mediated mRNA Decay Factor Upf3 is a Negative Regulator of Autophagy in Yeast
The Nonsense-Mediated mRNA Decay Factor Upf3 is a Negative Regulator of Autophagy in Yeast
Michael A Mandell, University of New Mexico School of Medicine
TRIM46 maintains microtubule organization to restrain Golgi atg8ylation and lysosomal biogenesis
TRIM46 maintains microtubule organization to restrain Golgi atg8ylation and lysosomal biogenesis
Karyn King, University of Ottawa
Discovery of Regulatory Pathways for CASM
Discovery of Regulatory Pathways for CASM
Tara Tigani, Peter MacCallum Cancer Centre
Employing a Metabolism Focused CRISPR Screen to Identify Novel Regulators of Lysosomal Biogenesis
Employing a Metabolism Focused CRISPR Screen to Identify Novel Regulators of Lysosomal Biogenesis
Samit Desai, University of Basel
Mitochondria-ER Contact Sites Facilitate Endocytic Lysosomal Reformation Via DRP1-Dependent Fission
Mitochondria-ER Contact Sites Facilitate Endocytic Lysosomal Reformation Via DRP1-Dependent Fission
Rhiannon Brown, University of Sheffield
Stratifying Sporadic Parkinson’s Disease Patients Based on Mitochondrial and Lysosomal Dysfunction
Stratifying Sporadic Parkinson’s Disease Patients Based on Mitochondrial and Lysosomal Dysfunction
Coffee Available
4:30–5:00 PM
Macdonald Foyer
What Don't We Know About the Autophagy Pathway
5:00–6:45 PM
Macdonald AB
* Rupert Beale, The Francis Crick Institute
Session Chair
Session Chair
* Anne Simonsen, University of Oslo
Session Chair
Session Chair
Leon O. Murphy, Casma Therapeutics
Targeting Autophagy: Where the Field Has Been and Where is it Going
Targeting Autophagy: Where the Field Has Been and Where is it Going
Timothy Sargeant, SAHMRI
Short Talk: Physiological Human Autophagy Increases in the PBMC Pool In Human Ageing And Human Age-Related Disease
Short Talk: Physiological Human Autophagy Increases in the PBMC Pool In Human Ageing And Human Age-Related Disease
Ana Maria Cuervo, Albert Einstein College of Medicine
Chaperone Mediated Autophagy: Where the Field has Been and Where is it Going?
Chaperone Mediated Autophagy: Where the Field has Been and Where is it Going?
Noboru Mizushima, University of Tokyo
Autophagy in the nervous system: Where the Field has Been and Where is it Going?
Autophagy in the nervous system: Where the Field has Been and Where is it Going?
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Macdonald AB
Social Hour with Lite Bites
7:00–8:00 PM
MacDonald CD
Entertainment
8:00–9:00 PM
Macdonald AB
Cash Bar
8:00–9:00 PM
MacDonald CD
Sunday, June 29, 2025
Departure
12:00–11:59 PM
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