Next-Generation Nanomedicine

Sep 06–08, 2023 | 
Scientific Organizers: Philip L. Felgner, Anna K. Blakney and Norbert Pardi

  Livestream

Sep 06–08, 2023 | Virtual at Your Computer
Scientific Organizers: Philip L. Felgner, Anna K. Blakney and Norbert Pardi

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:     = Livestream
Wednesday, September 6, 2023
Welcome and Keynote Address  
3:00–3:30 AM
Pieter Cullis, University of British Columbia
Rational Design of Lipid Nanoparticle Delivery Systems for Nucleic Acid-Based Drugs
Challenges in Anatomical and Physiological Nanomedicine Delivery  
3:30–6:00 AM
Jayesh Kulkarni, NanoVation Therapeutics
Universal Delivery
Daniel J. Siegwart, University of Texas Southwestern Medical Center
Multiplexed SORT LNPs for Enhancing CRISPR/Cas Gene Editing Cancer Therapy through Modulating Tumor Mechanical Properties
James Dahlman, Georgia Tech / Emory Medical School
LNP Barcoding
Kathryn Whitehead, Carnegie Mellon University
From Farm to Pharmacy: A Strawberry-Derived Solution to Oral Protein Delivery
Maria José Alonso, University of Santiago de Compostela
Nanoemulsions vs. LNPs for RNA Delivery
Poster Session  
8:00–9:00 AM
Immunoengineering in Nanomedicine  
9:30–12:30 PM
Parinaz Fathi, NIBIB, National Institutes of Health
Biologically-Derived Nanomaterials
Jeffrey A. Hubbell, University of Chicago
Engineering Polymer Conjugates and Protein Fusions for Immune Modulation
Jessica Weaver, Arizona State University
Placenta-Iinspired Approaches to Engineering Immune Tolerance
Thursday, September 7, 2023
Keynote Address  
3:00–3:30 AM
Drew Weissman, University of Pennsylvania
Nucleoside Modified mRNA-LNP Therapeutics
AI and Big Data in Nanomedicine / Progress in RNA Vaccines I  
3:30–5:45 AM
Daniel Reker, Duke University
Machine Learning for Self-Assembling Nanoparticles
Ramya Kumar, Colorado School of Mines
Machine Learning for Nucleic Acid Delivery
Career Roundtable  
8:00–9:00 AM
Denise Hsu, Moderna
Director, Clinical Development, Infectious Diseases
Progress in RNA Vaccines II  
9:30–12:30 PM
Mustafa Diken, BioNTech
mRNA Vaccines against Cancer
Philip L. Felgner, University of California, Irvine
150 Years of Vaccine Science
Michela Locci, University of Pennsylvania
Immunological Mechanisms of mRNA-LNP Vaccines
Norbert Pardi, University of Pennsylvania
Development of Broadly Protective Influenza Vaccines Using Nucleoside-Modified mRNA
Denise Hsu, Moderna
Moderna Seasonal Influenza Vaccine Portfolio
Friday, September 8, 2023
Applications of RNA Beyond Vaccines  
3:00–6:00 AM
Anna K. Blakney, University of British Columbia
Optimizing Self-Amplifying RNA Vectors for Applications Beyond Vaccines
Jesse Erasmus, HDT Bio / University of Washington
Enabling High-Dose Administration of Replicating mRNA for Multivalent Vaccination and Therapeutic Applications
Zoltan Jakus, Semmelweis University
Treatment of Lymphedema with VEGFC mRNA
Valerie Gouon-Evans, Boston University
Treatment of Liver Diseases with mRNA Encoded Factors
Delivery Technologies  
9:30–12:30 PM
Cyrus Safinya, University of California, Santa Barbara
Fluid Lipid Nanodiscs and Exosome Derived Vectors in Delivery Applications
Krzysztof Palczewski, University of California, Irvine
Precision Genome Editing in the Eye
Suzie Pun, University of Washington
Cytosolic Delivery of Macromolecules: Vehicle Design and Lessons Learned in Delivery Limitations

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