Immunity and Aging

Oct 01–04, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Danica Chen, Sun Hur and Joan Mannick

  In Person
  On Demand

Oct 01–04, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers: Danica Chen, Sun Hur and Joan Mannick

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, October 1, 2023
Arrival and Registration  
10:00–2:00 PM
 Grand Foyer
Welcome Mixer  
12:00–2:00 PM
 Valley Foyer
Monday, October 2, 2023
Breakfast  
1:00–2:00 AM
 Garibaldi A/B
Welcoming Remarks (Organizers) and Keynote Address  
2:00–3:00 AM
 Rainbow Theater
* Danica Chen, University of California, Berkeley
Session Chair
John Sedivy, Brown University
The Repeatome and Aging
Hallmarks of Aging  
3:00–5:15 AM
 Rainbow Theater
* Cynthia Kenyon, Calico Life Sciences
Session Chair
* Joan Mannick, Tornado Therapeutics
Session Chair
Danica Chen, University of California, Berkeley
Hematopoietic Stem Cell Aging
Ana Maria Cuervo, Albert Einstein College of Medicine
Proteostasis and Aging
Paul Robbins, University of Minnesota
Immune Dysfunction Drives Systemic Senescence and Aging
Peter James Mullen, University of Southern California
Short Talk: Short Talk: A Metabolic Atlas of Aging
Coffee Break  
3:30–3:50 AM
 Valley Foyer
Poster Setup  
5:15–7:00 AM
 Garibaldi A/B
On Own for Lunch  
5:15–11:00 AM
Poster Viewing  
7:00–4:00 PM
 Garibaldi A/B
Workshop 1: Aging Immune System: From Hematopoietic Stem Cells to Innate and Adaptive Immunity  
8:30–10:30 AM
 Rainbow Theater
* Kenneth Walsh, University of Virginia School of Medicine
Session Chair
* Mary Mohrin, Genentech
Session Chair
Mary Mohrin, Genentech
Manf Regulates Age-Associated Changes In Hematopoietic Stem And Progenitor Cell Driven Repair Of Peripheral Fibrotic Tissue
Rong Lu, University of Southern California
Age-associated Imbalance of Adaptive and Innate immune Systems Originates from a Subset of Stem Cells
Chiraag Kapadia, Baylor College of Medicine
Murine Clonal Hematopoiesis is Common with Age and Accelerated Following Infection
Ines Fernandez Maestre, Memorial Sloan Kettering Center
Understanding Senescence in Clonal Hematopoiesis
Wenxiang Zhang, Boston Childrens Hospital/Harvard Medical School
Ladder-like Multimerization of FoxP3 Enables Microsatellite Recognition and DNA Bridging
Armin Aabish Gandhi, Sanford Burnham Prebys Medical Discovery Institute
Investigating the Effect of an Aged Liver Microenvironment on Immune Surveillance and Predisposition to Cancer
Annette Johanna Lis, Saarland University
Faster Cytotoxicity with Age: Increased Perforin and Granzyme Levels Shift CD8+ T Cells from Apoptotic to Necrotic Killers in the Elderly
Michelle Rice, University of Southern California
MOTS-c is a Mitochondrial-encoded Host Defense Peptide that Regulates Monocyte-to-Macrophage Differentiation in an Age-dependent Manner
Coffee Available  
10:30–11:00 AM
 Valley Foyer
Immunity, Aging, and Diseases I  
11:00–1:00 PM
 Rainbow Theater
* Feng Shao, National Institute of Biological Sciences
Session Chair
* Sun Hur, Harvard Medical School
Session Chair
Feng Shao, National Institute of Biological Sciences
Inflammasomes
Kenneth Walsh, University of Virginia School of Medicine
Clonal Hematopoiesis: Consequences of Somatic Mutations in the Aging Immune System
Vishva M. Dixit, Genentech, Inc.
NF-KB and Inflammation
Myong-Hee Mia Sung, NIH
Short Talk: Short Talk: Double Knock-in Reporter Mice Reveal NF-κB Trajectories in Signaling, Immune Cell Development, and Aging
Nan-ping Weng, NIA, National Institutes of Health
Short Talk: Short Talk: Transcriptome and Mutation Changes of Human CD8+ T Cells Across Nine dDecades of Life
Social Hour with Lite Bites  
1:00–2:00 PM
 Garibaldi A/B
Poster Session 1  
1:30–4:00 PM
 Garibaldi A/B
Tuesday, October 3, 2023
Breakfast  
1:00–2:00 AM
 Garibaldi A/B
Inflammaging  
2:00–5:00 AM
 Rainbow Theater
* Andrew Brack, University of California San Francisco
Session Chair
* John Sedivy, Brown University
Chair Person
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
Remote Presentation: cGAS Signaling and Senescence
David Furman, Buck Institute for Research on Aging
Inflammatory Age Connects Non-communicable Multimorbidity and Immunosenescence
Cornelia M. Weyand, Stanford University
Mechanisms Underlying T Cell Aging
Anthony J. Covarrubias, UCLA
Short Talk: Short Talk: The Role of Macrophage Senescence in Inflammaging and Metabolic Disease: Aging at the Cross Roads of Inflammation and Metabolism
Anissa A. Widjaja, DUKE-NUS Medical School
Short Talk: Short Talk: Inhibition of an Immunometabolic Axis of IL11-mTORC1 Activation Extends Mammalian Healthspan
Ana M. Basso, Abbvie
Short Talk: Short Talk: Targeting Immunosenescence for Age-associated Immune Dysfunction and Diseases
Francesca Castoldi, Karolinska Institutet
Short Talk: Short Talk: Anti-senescence Immunotherapy: Targeting Senescence Associated Immune Checkpoints in Tissue Injury
Coffee Break  
3:00–3:20 AM
 Valley Foyer
Poster Setup  
5:00–7:00 AM
 Garibaldi A/B
On Own for Lunch  
5:00–11:00 AM
Poster Viewing  
7:00–4:00 PM
 Garibaldi A/B
Career Roundtable  
9:00–10:30 AM
 Sea to Sky B
Tyler J. Curiel, Dartmouth College
Professor of Medicine
Hong I. Wan, Tallac Therapeutics
President, Chief Executive Officer and Co-Founder
Dinis Pedro Calado, Francis Crick Institute
Senior Group Leader
Myong-Hee Mia Sung, NIH
Earl Stadtman Investigator & Chief, Transcription Systems Dynamics and Biology Unit
Coffee Available  
10:30–11:00 AM
 Valley Foyer
Immunity, Aging, and Diseases II  
11:00–1:00 PM
 Rainbow Theater
* Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital
Session Chair
* Gerald S. Shadel, The Salk Institute for Biological Studies
Session Chair
Anjana Rao, La Jolla Institute for Immunology
Potential Role of DNA Methylation/Demethylation Pathways in Cellular Senescence and Aging
Jenny P.Y. Ting, University of North Carolina at Chapel Hill
Importance of Innate Immune Receptors in Adaptive Lymphocytes
Gerald S. Shadel, The Salk Institute for Biological Studies
Nucleic Acid-Mediated Mitonuclear Signaling
Sun Hur, Harvard Medical School
Self Assemblies in Transcriptional Regulation of T Cell Development –– AIRE
Social Hour with Lite Bites  
1:00–2:00 PM
 Garibaldi A/B
Poster Session 2  
1:30–4:00 PM
 Garibaldi A/B
Workshop 2: Aging, Vaccination, COVID-19  
8:30–10:30 AM
 Rainbow Theater
* Stanley Perlman, University of Iowa
Session Chair
* Albert C Shaw, Yale School of Medicine
Session Chair
Albert C Shaw, Yale School of Medicine
Effects of Age and Influenza Vaccination on Human Platelet Response
Duygu Ucar, The Jackson Laboratory
Distinct Baseline Immune Characteristics Associated with Responses to Conjugated and Unconjugated Pneumococcal Polysaccharide Vaccines in Older Adults
Marine Barthez, University of California Berkeley
SIRT2 Suppresses Aging-associated Inflammation and Vulnerability to COVID-19
Ines Sturmlechner, Mayo Clinic
Age-related Mis-differentiation of Antigen-specific Memory T Cells to Regulatory T Cell Phenotypes After Vaccination
Debbie Van Baarle, National Institute of Public Health and Environment
Baseline Immunotypes Identify Individuals at Risk of Low Vaccine Responsiveness
Anne-Marie Buisman, The Institute of Public Health and the Environment, The Netherlands
A Large Heterogeneity in Health Characteristics and Frailty of the Ageing Population Influences the COVID-19 Vaccine Responsiveness
Liam B. Healy, Harvard University/Boston Children's Hospital
ROS-dependent Palmitoylation is an Obligate Licensing Modification for GSDMD Pore Formation
Pingze Zhang, Max Planck Institute for Biology of Ageing
S6K Regulates Inflammageing, Immunosenescence and Lifespan through the Endolysosomal System
Wednesday, October 4, 2023
Breakfast  
1:00–2:00 AM
 Garibaldi A/B
Harnessing Big Data Sets to Understand Immunity and Aging  
2:00–5:00 AM
 Rainbow Theater
* Rong Lu, University of Southern California
Session Chair
* Anthony J. Covarrubias, UCLA
Session Chair
Mihai G. Netea, Radboud University
Impact of Aging on Trained Immunity
Thirumala-Devi Kanneganti, St. Jude Children's Research Hospital
Molecular Mechanisms of Innate Immunity and Inflammation in Health and Disease
Isabel Beerman, National Institute on Aging
Epigenetic Alterations of Aged HSCs
Ryan Englander, Jackson Laboratory for Genomic Medicine
Short Talk: Short Talk: Age-related Intron Retention in STAT2 Modulates Antiviral and Antitumor Immunity
Charlotte Moss, University of Sheffield
Short Talk: Short Talk: Transcription Factors MYC and USF1 Drive Chronic Macrophage Dysfunction in Ageing
Nicole L. La Gruta, University of Melbourne
Short Talk: Short Talk: Epigenetic Changes Associated with Distinct Signatures of Aging-related CD8 T Cell Dysfunction
Sophia Liu, Ragon Institute
Short Talk: Short Talk: Spatiotemporal Dynamics of the Thymus Reveal Changes Underlying Immune Decline and Regeneration
Coffee Break  
3:00–3:20 AM
 Valley Foyer
On Own for Lunch  
5:00–11:00 AM
Coffee Available  
10:30–11:00 AM
 Valley Foyer
Clinical Applications  
11:00–12:45 PM
 Rainbow Theater
* Joan Mannick, Tornado Therapeutics
Session Chair
* Tyler J. Curiel, Dartmouth College
Session Chair
Joan Mannick, Tornado Therapeutics
Targeting Immunosenescence with mTOR Inhibitors in Older Adults
Tyler J. Curiel, Dartmouth College
Age Effects on Immune Checkpoint Expression and ICB Efficacy
Stanley Perlman, University of Iowa
COVID-19 and Aging
Yin Huang, Lyell Immunopharma
Short Talk: Short Talk: Rejuvenation of Aged T Cells: Enhancing Function and Therapeutic Potential in Solid Tumor
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
12:45–1:00 PM
 Rainbow Theater
Social Hour with Lite Bites  
1:00–2:00 PM
 Garibaldi A/B
Cash Bar  
2:00–3:00 PM
 Garibaldi A/B
Thursday, October 5, 2023
Departure  
1:00–5:59 PM

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