Oct 01–04, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:
Danica Chen, Sun Hur, and Joan Mannick

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Scientific Organizers: Danica Chen, Sun Hur, and Joan Mannick
Danica Chen
Sun Hur
Joan Mannick
***Meeting program subject to change.
Available Formats: = In Person = On DemandBooking Function
Sunday, October 1, 2023
Monday, October 2, 2023
Session Chair
The Repeatome and Aging
Session Chair
Session Chair
Hematopoietic Stem Cell Aging
Proteostasis and Aging
Immune Dysfunction Drives Systemic Senescence and Aging
Short Talk: Short Talk: A Metabolic Atlas of Aging
Session Chair
Session Chair
Manf Regulates Age-Associated Changes In Hematopoietic Stem And Progenitor Cell Driven Repair Of Peripheral Fibrotic Tissue
Age-associated Imbalance of Adaptive and Innate immune Systems Originates from a Subset of Stem Cells
Murine Clonal Hematopoiesis is Common with Age and Accelerated Following Infection
Understanding Senescence in Clonal Hematopoiesis
Ladder-like Multimerization of FoxP3 Enables Microsatellite Recognition and DNA Bridging
Investigating the Effect of an Aged Liver Microenvironment on Immune Surveillance and Predisposition to Cancer
Faster Cytotoxicity with Age: Increased Perforin and Granzyme Levels Shift CD8+ T Cells from Apoptotic to Necrotic Killers in the Elderly
MOTS-c is a Mitochondrial-encoded Host Defense Peptide that Regulates Monocyte-to-Macrophage Differentiation in an Age-dependent Manner
Session Chair
Session Chair
Inflammasomes
Clonal Hematopoiesis: Consequences of Somatic Mutations in the Aging Immune System
NF-KB and Inflammation
Short Talk: Short Talk: Double Knock-in Reporter Mice Reveal NF-κB Trajectories in Signaling, Immune Cell Development, and Aging
Short Talk: Short Talk: Transcriptome and Mutation Changes of Human CD8+ T Cells Across Nine dDecades of Life
Tuesday, October 3, 2023
Session Chair
Chair Person
Remote Presentation: cGAS Signaling and Senescence
Inflammatory Age Connects Non-communicable Multimorbidity and Immunosenescence
Mechanisms Underlying T Cell Aging
Short Talk: Short Talk: The Role of Macrophage Senescence in Inflammaging and Metabolic Disease: Aging at the Cross Roads of Inflammation and Metabolism
Short Talk: Short Talk: Inhibition of an Immunometabolic Axis of IL11-mTORC1 Activation Extends Mammalian Healthspan
Short Talk: Short Talk: Targeting Immunosenescence for Age-associated Immune Dysfunction and Diseases
Short Talk: Short Talk: Anti-senescence Immunotherapy: Targeting Senescence Associated Immune Checkpoints in Tissue Injury
Professor of Medicine
President, Chief Executive Officer and Co-Founder
Senior Group Leader
Earl Stadtman Investigator & Chief, Transcription Systems Dynamics and Biology Unit
Session Chair
Session Chair
Potential Role of DNA Methylation/Demethylation Pathways in Cellular Senescence and Aging
Importance of Innate Immune Receptors in Adaptive Lymphocytes
Nucleic Acid-Mediated Mitonuclear Signaling
Self Assemblies in Transcriptional Regulation of T Cell Development –– AIRE
Session Chair
Session Chair
Effects of Age and Influenza Vaccination on Human Platelet Response
Distinct Baseline Immune Characteristics Associated with Responses to Conjugated and Unconjugated Pneumococcal Polysaccharide Vaccines in Older Adults
SIRT2 Suppresses Aging-associated Inflammation and Vulnerability to COVID-19
Age-related Mis-differentiation of Antigen-specific Memory T Cells to Regulatory T Cell Phenotypes After Vaccination
Baseline Immunotypes Identify Individuals at Risk of Low Vaccine Responsiveness
A Large Heterogeneity in Health Characteristics and Frailty of the Ageing Population Influences the COVID-19 Vaccine Responsiveness
ROS-dependent Palmitoylation is an Obligate Licensing Modification for GSDMD Pore Formation
S6K Regulates Inflammageing, Immunosenescence and Lifespan through the Endolysosomal System
Wednesday, October 4, 2023
Session Chair
Session Chair
Impact of Aging on Trained Immunity
Molecular Mechanisms of Innate Immunity and Inflammation in Health and Disease
Epigenetic Alterations of Aged HSCs
Short Talk: Short Talk: Age-related Intron Retention in STAT2 Modulates Antiviral and Antitumor Immunity
Short Talk: Short Talk: Transcription Factors MYC and USF1 Drive Chronic Macrophage Dysfunction in Ageing
Short Talk: Short Talk: Epigenetic Changes Associated with Distinct Signatures of Aging-related CD8 T Cell Dysfunction
Short Talk: Short Talk: Spatiotemporal Dynamics of the Thymus Reveal Changes Underlying Immune Decline and Regeneration
Session Chair
Session Chair
Targeting Immunosenescence with mTOR Inhibitors in Older Adults
Age Effects on Immune Checkpoint Expression and ICB Efficacy
COVID-19 and Aging
Short Talk: Short Talk: Rejuvenation of Aged T Cells: Enhancing Function and Therapeutic Potential in Solid Tumor
Thursday, October 5, 2023
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