From Systems Immunology to Immunoengineering
Jan 11–14, 2026 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers:
Alexander Hoffmann, Eicke Latz, and Stacey D Finley
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Jan 11–14, 2026 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Alexander Hoffmann, Eicke Latz, and Stacey D Finley
Alexander Hoffmann, PhD
University of California, Los Angeles
Alexander Hoffmann, Ph.D., is Professor of Microbiology, Immunology and Molecular Genetics and director of the Institute for Quantitative and Computational Biosciences at UCLA. Dr. Hoffman is a systems immunologist, trained in biochemistry, molecular cell biology, and computational biology. His research focuses on the signaling systems that control innate and adaptive immunity, especially in how NF?B and IRF signaling dynamics are regulated and how these pathways function in normal and disease states. He has organized numerous scientific conferences and meetings, including a past 2014 Keystone Symposia meeting.
Eicke Latz
University of Bonn
Eicke Latz, M.D., Ph.D., is Scientific Director of the German Rheumatology Research Center (DRFZ) and Professor of Experimental Rheumatology at Charité Universitätsmedizin Berlin, Germany. Dr. Latz's work is crucial for understanding and developing treatments for chronic inflammatory diseases. Originally training as an intensive care physician, Dr. Latz later specialized in inflammation research, with a particular focus on how the innate immune system maintains health and under what circumstances it can promote disease. His research aims to translate findings into new therapeutic and preventive approaches. He has extensive experience in the organization of scientific symposia, including the 2016 Keystone Symposia conference on Myeloid Cells.
Stacey D Finley, PhD
University of Southern California
Stacey Finley, Ph.D., is Professor of Biomedical Engineering, and Quantitative & Computational Biology at the University of Southern California. She is a computational systems biologist whose research focuses on developing experimentally validated, mechanistic, multi-scale models that predict emergent properties of complex networks and how intracellular networks regulate cell function. She also has applied these insights to engineer cell behavior, especially in controlling tumor growth. She has co-chaired the NIH NCI Cancer Systems Biology Consortium and joint NCI/NSF Square Table Meetings on “Emergent Properties in Cancer Systems.”
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandSunday, January 11, 2026
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Registration
4:00–8:00 PM
British Columbia Foyer
Welcome Mixer
6:00–8:00 PM
British Columbia Foyer
Monday, January 12, 2026
Breakfast
7:30–8:30 AM
Vancouver Island Room
Welcome and Keynote Session (Joint)
8:30–10:00 AM
British / Columbia Ballroom
Marcia C. Haigis, Harvard Medical School
Investigating the Role of Metabolites in Immune Cells across Scales: Spanning Molecules and Cells to the Host
Investigating the Role of Metabolites in Immune Cells across Scales: Spanning Molecules and Cells to the Host
Christina S. Leslie, Memorial Sloan-Kettering Cancer Center
T Cell Mediated Immunity; Chromatin States; Comp Bio
T Cell Mediated Immunity; Chromatin States; Comp Bio
Coffee Break
10:00–10:20 AM
British Columbia Foyer
Award Recipient Acknowledgement
10:20–10:25 AM
British / Columbia Ballroom
Inside the Cell's Kitchen: Mastering the Art of Nutrient Signaling (Joint)
10:25–12:25 PM
British / Columbia Ballroom
Dequina Angelina Nicholas, University of California, Irvine
Metabolite Control of Immune Cell Specificity
Metabolite Control of Immune Cell Specificity
Eicke Latz, University of Bonn
Myeloid Cell Signaling/Immunometabolism/Personalized Medicine
Myeloid Cell Signaling/Immunometabolism/Personalized Medicine
Steven J. Bensinger, University of California, Los Angeles
Regulation of Immune Cell Function by Lipid Metabolism
Regulation of Immune Cell Function by Lipid Metabolism
Greg M Delgoffe †, University of Pittsburgh
Short Talk: Postprandial Alterations to Systemic Metabolism Durably Enhance T Cell Immunity
Short Talk: Postprandial Alterations to Systemic Metabolism Durably Enhance T Cell Immunity
Joel Babdor †, University of Pennsylvania
Short Talk: Microbiome Mediators Control the Immune Tone in Health and Disease
Short Talk: Microbiome Mediators Control the Immune Tone in Health and Disease
Poster Setup
12:25–1:00 PM
British / Columbia Ballroom
On Own for Lunch
12:25–2:30 PM
Poster Viewing
1:00–10:00 PM
British / Columbia Ballroom
Symposia Spotlight 1: Multi-Scale Communication and Coordination
2:30–4:30 PM
British Ballroom
Prabal Chhibbar †, University of Pittsburgh
Discovering Viral Evolutionary Constraints Essential For Hijacking Host Cellular Machinery To Design Broadly Neutralizing Immunotherapies
Discovering Viral Evolutionary Constraints Essential For Hijacking Host Cellular Machinery To Design Broadly Neutralizing Immunotherapies
Tyler T Dao †, MIT
Robust T Cell Activation Kills Tumors Regardless of T Cell Specificity
Robust T Cell Activation Kills Tumors Regardless of T Cell Specificity
Janani Baskaran †, Yale University
In Vitro Macrophage-Tumor-Fibroblast Spheroid Co-Cultures Model Evolution and Heterogeneity of Tumor-Associated Macrophages
In Vitro Macrophage-Tumor-Fibroblast Spheroid Co-Cultures Model Evolution and Heterogeneity of Tumor-Associated Macrophages
Erika M. Palmieri †, National Cancer Institure (NCI) / NIH
Metabolic Reprogramming of Tumor Microenvironment by Nitric Oxide
Metabolic Reprogramming of Tumor Microenvironment by Nitric Oxide
Jacob Parres-Gold †, Caltech
Contextual Computation by Competitive Protein Dimerization Networks
Contextual Computation by Competitive Protein Dimerization Networks
Antonella Prisco †, Institute of Genetics and Biophysics
Modeling the Magnitude and Persistence of the Antibody Response Through the Contributions of Different Subsets of Antibody-Secreting Cells
Modeling the Magnitude and Persistence of the Antibody Response Through the Contributions of Different Subsets of Antibody-Secreting Cells
Taehyun Kim †, University of British Columbia
A Microbiome-Derived Metabolite Suppresses Neutrophilic Airway Inflammation in Type 2-Low Asthma
A Microbiome-Derived Metabolite Suppresses Neutrophilic Airway Inflammation in Type 2-Low Asthma
Heekyong Rachel Bae †, Kyungpook National University
Chronic Interferon-γ Signaling Bridges Obesity to Female-Predominant Autoimmune Diseases through M1-Linked Type I IFN Amplification
Chronic Interferon-γ Signaling Bridges Obesity to Female-Predominant Autoimmune Diseases through M1-Linked Type I IFN Amplification
Coffee Available
4:30–5:00 PM
British Columbia Foyer
Circuits to Regulate Immune Cell Function
5:00–7:00 PM
British Ballroom
Catera L Wilder, University of California, San Francisco
The Integration of Molecular Mechanisms Controlling Signaling Specificity
The Integration of Molecular Mechanisms Controlling Signaling Specificity
Jamie Spangler, Johns Hopkins University
Directed Evolution to Cytokine-Antibody Fusions
Directed Evolution to Cytokine-Antibody Fusions
Ellen V. Rothenberg, California Institute of Technology
Regulatory Networks for T Cell Development
Regulatory Networks for T Cell Development
Jishnu Das †, University of Pittsburgh
Short Talk: A Unified Network Systems Approach Uncovers a Core Novel Program Underlying T Follicular Helper Cell Differentiation
Short Talk: A Unified Network Systems Approach Uncovers a Core Novel Program Underlying T Follicular Helper Cell Differentiation
Amelie Papineau †, Ottawa Hospital Research Institute
Short Talk: Investigating the Transcriptional Reprogramming of NK Cells Under Chronic Stimulation
Short Talk: Investigating the Transcriptional Reprogramming of NK Cells Under Chronic Stimulation
Social Hour with Dinner
7:00–8:00 PM
Vancouver Island Room
Poster Session 1
7:30–10:00 PM
British / Columbia Ballroom
Tuesday, January 13, 2026
Breakfast
7:30–8:30 AM
Vancouver Island Room
Immune Cell Coordination in Tissues
8:30–11:30 AM
British Ballroom
Soumen Basak, National Institute of Immunology
Inflammatory Disease: Math Modeling and Mouse Studies
Inflammatory Disease: Math Modeling and Mouse Studies
Elsje Pienaar, Purdue University
Multi-Scale Modeling of Host Immune, Pathogen and Drug Dynamics
Multi-Scale Modeling of Host Immune, Pathogen and Drug Dynamics
Musa M. Mhlanga, Radboud Institute for Molecular Life Sciences
Epigenetics at the Apex of Vaccination and Senescence
Epigenetics at the Apex of Vaccination and Senescence
Benedict Seddon †, University College London
Short Talk: Ontogeny of Foxp3+ Regulatory T cells in Health and Malignant Disease
Short Talk: Ontogeny of Foxp3+ Regulatory T cells in Health and Malignant Disease
Fangwen Zhao †, Center for Molecular Medicine
Short Talk: Integrative Chromatin Accessibility Atlas of Rare Monogenic Immunodeficiencies Reveals Shared and Distinct Dysregulation of Immune Cell Identity
Short Talk: Integrative Chromatin Accessibility Atlas of Rare Monogenic Immunodeficiencies Reveals Shared and Distinct Dysregulation of Immune Cell Identity
Michael Raddatz †, UCLA
Short Talk: The Genetic Architecture of Cellular Inflammation in Metabolic Syndrome
Short Talk: The Genetic Architecture of Cellular Inflammation in Metabolic Syndrome
Xin Liu †, Tsinghua University
Short Talk: Tissue-Patrolling GZMK⁺ CD8⁺ T Cells Fuel Recurrence of Airway Inflammatory Diseases
Short Talk: Tissue-Patrolling GZMK⁺ CD8⁺ T Cells Fuel Recurrence of Airway Inflammatory Diseases
Coffee Break
9:30–9:50 AM
British Columbia Foyer
Poster Setup
11:30–1:00 PM
British / Columbia Ballroom
On Own for Lunch
11:30–2:00 PM
Poster Viewing
1:00–10:00 PM
British / Columbia Ballroom
Panel Discussion 1: How to Measure Immune Health
2:00–3:00 PM
British Ballroom
Meet the Pioneers (Joint)
3:15–4:30 PM
Coffee Available
4:30–5:00 PM
British Columbia Foyer
Dynamic Control of Immunity
5:00–7:00 PM
British Ballroom
Nicolas Chevrier, University of Chicago
Systems Analysis of Disease Pathogenesis
Systems Analysis of Disease Pathogenesis
Alexander Hoffmann, University of California, Los Angeles
Modeling Antibody Responses
Modeling Antibody Responses
Edward Botchwey, Georgia Tech & Emory University
Bio-Materials Controlling Immune Cell Function
Bio-Materials Controlling Immune Cell Function
Narges Moradi †, University of Helsinki
Short Talk: Unlocking Immune Potential in EGFR-mutated Lung Cancer Using Targeted Protein Degradation
Short Talk: Unlocking Immune Potential in EGFR-mutated Lung Cancer Using Targeted Protein Degradation
Leyuan Ma †, Children's Hospital Of Phildadelphia/University of Pennsylvania
Short Talk: Early Bystander Effect of Vaccine Boosting of CAR T Cells Reinvigorates Endogenous anti-Tumor T Cell Immunity to Regress Pancreatic Cancer
Short Talk: Early Bystander Effect of Vaccine Boosting of CAR T Cells Reinvigorates Endogenous anti-Tumor T Cell Immunity to Regress Pancreatic Cancer
Social Hour with Dinner
7:00–8:00 PM
Vancouver Island Room
Poster Session 2
7:30–10:00 PM
British / Columbia Ballroom
Wednesday, January 14, 2026
Breakfast
7:30–8:30 AM
Vancouver Island Room
Technology Driving Immune Research
8:30–11:30 AM
British Ballroom
Felix Meissner, University Hospital Bonn
Systems Proteomics, Dissecting Immune Language by Secretomics
Systems Proteomics, Dissecting Immune Language by Secretomics
Fan Liu, Leibniz-Forschungsinstitut für Molekulare Pharmakologie
Using Cross-Linking Mass Spectrometry to Decode Immune Signaling
Using Cross-Linking Mass Spectrometry to Decode Immune Signaling
Jenny Jiang, University of Pennsylvania
Immune Engineering, T Cell Receptor
Immune Engineering, T Cell Receptor
Alyssa Rosenbloom †, Nomic Bio
Short Talk: Identification and Toxicity Profiling of Immunomodulatory Compounds by High-throughput Proteomics
Short Talk: Identification and Toxicity Profiling of Immunomodulatory Compounds by High-throughput Proteomics
Suehyun Cho †, Max Planck School
Short Talk: Recording Host-Pathogen Interactions with Salmonella enterica serovar Typhimurium to Trace Long-Term Immune Consequences of Infection
Short Talk: Recording Host-Pathogen Interactions with Salmonella enterica serovar Typhimurium to Trace Long-Term Immune Consequences of Infection
Amanda Hornick †, MIT
Short Talk: Interrogating Antiviral Antibody Responses with Multiplexed, High-Throughput Serum Assays
Short Talk: Interrogating Antiviral Antibody Responses with Multiplexed, High-Throughput Serum Assays
Paula P Coelho †, Genentech
Short Talk: Systematic Integrated Characterization of Macrophage Plasticity from Molecular Profiles to Cell Images
Short Talk: Systematic Integrated Characterization of Macrophage Plasticity from Molecular Profiles to Cell Images
Coffee Break
9:30–9:50 AM
British Columbia Foyer
On Own for Lunch
11:30–1:45 PM
Symposia Spotlight 2: Dynamics and Heterogeneity
1:45–3:15 PM
British Ballroom
Adam P Williamson †, Bryn Mawr College
Protective Clearance in Health and Disease: An Integrated Approach to Understand and Engineer Phagocyte Biology
Protective Clearance in Health and Disease: An Integrated Approach to Understand and Engineer Phagocyte Biology
Helen Huang †, UCLA
Temporal Proof-reading for B-cell Selection
Temporal Proof-reading for B-cell Selection
Ziwei Tian †, University of Colorado Denver, Anschutz Medical Campus
Sparse Time Series Chain Graphical Model Dissects the Sequential Humoral–Cellular Immune Dynamics in IV-BCG Vaccinated NHPs against Tuberculosis
Sparse Time Series Chain Graphical Model Dissects the Sequential Humoral–Cellular Immune Dynamics in IV-BCG Vaccinated NHPs against Tuberculosis
Michihiro Nakamura †, Yamaguchi University Graduate School of Medicine
Heterogeneous Uptake Dynamics Uncover Macrophage-Specificity in the Immune System
Heterogeneous Uptake Dynamics Uncover Macrophage-Specificity in the Immune System
Joshua A McKeever †, University of Chicago
Vitamin D Receptor Modulates NF-κB Bandwidth to Promote Transcriptional Diversity across Thymic Epithelia for Immune Tolerance
Vitamin D Receptor Modulates NF-κB Bandwidth to Promote Transcriptional Diversity across Thymic Epithelia for Immune Tolerance
Riley Mullins †, WASHINGTON UNIVERSITY IN ST LOUIS
Scalable Transcription Factor Mapping Uncovers the Regulatory Dynamics of Natural and Synthetic Transcription Factors in Human T Cell States
Scalable Transcription Factor Mapping Uncovers the Regulatory Dynamics of Natural and Synthetic Transcription Factors in Human T Cell States
Panel Discussion 2: Immunology in the Age of AI
3:30–4:30 PM
British Ballroom
Coffee Available
4:30–5:00 PM
British Columbia Foyer
Systems Metabolism in Health and Disease (Joint)
5:00–6:00 PM
British / Columbia Ballroom
Leif S Ludwig, Berlin Institute of Health and Max Delbrück Center for Molecular Medicine
Single-Cell Multi-Omics of Mitochondrial DNA Disorders
Single-Cell Multi-Omics of Mitochondrial DNA Disorders
Stacey D Finley, University of Southern California
Signaling and Metabolic States in Immunotherapy
Signaling and Metabolic States in Immunotherapy
Closing Keynote Address (Joint)
6:00–6:45 PM
British / Columbia Ballroom
Jeffrey C Rathmell, University of Chicago
Immunometabolism in Health and Disease
Immunometabolism in Health and Disease
Meeting Wrap-Up: Outcomes and Future Directions (Joint)
6:45–7:00 PM
British / Columbia Ballroom
Social Hour with Dinner
7:00–8:00 PM
Vancouver Island Room
Cash Bar
8:00–11:00 PM
Entertainment
8:00–11:00 PM
Thursday, January 15, 2026
Departure
12:00–11:59 PM
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