Oct 01–04, 2023 | Whistler Conference Centre, Whistler, BC, Canada
Scientific Organizers:
Shane Crotty, Michela Locci, and Jennifer L. Gommerman

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Scientific Organizers: Shane Crotty, Michela Locci, and Jennifer L. Gommerman
Shane Crotty
Michela Locci
Jennifer L. Gommerman
***Meeting program subject to change.
Available Formats: = In Person = On DemandBooking Function
Fundraising
Sunday, October 1, 2023
Monday, October 2, 2023
Session Chair
Session Chair
Session Chair
Hyperactivated PI3Kd, in a Human Primary Immunodeficiency, Influences Tfh and Germinal Centers, Altering Self and Commensal Reactivity and Humoral Immunity
Session Chair
Session Chair
Functional Genomics of Metabolic Control of Tfh Differentiation
Regulation of Tfh Cells by Ferroptosis
Biogenesis and Recall of CD4 and cTFH Responses to Viral Infection and Vaccination
Short Talk: Short Talk: Transcription Factor Mef2d Functions as a Critical Rheostat to Control SAP- and IL-21-Dependent Humoral Immunity
Session Chair
Session Chair
Air Pollutants Induce an IgE-promoting Follicular Helper T Cell Subset Independently of CD301b+ DCs
IL-12 Drives the Differentiation of Human T Follicular Regulatory Cells
Layers of T Cell Redundancy in the Gut Enable Resilient Food-specific IgA Production
Tracking Germinal Center B Cell Cycling in vivo
Early Stroma-driven Notch Signals are Required for T Follicular Helper Cell Differentiation and Germinal Center Responses to SARS-CoV-2 mRNA Vaccines
Regulation of BCR-mediated Ca2+ Mobilization by MIZ1-TIMBIM4 Safeguards IgG1+ GC B Cell Positive Selection
Follicular Helper T Cells Lacking KLF2 are no Longer Susceptible to Natural Killer Cell Immunoregulation
Session Chair
Session Chair
Secondary Germinal Centers and Recall of Memory B Cells
Regulation of Plasma Cell Egress from Secondary Lymphoid Tissues and its Retention in Bone Marrow
B Cell Selection in Germinal Centers
Short Talk: Short Talk: Intrinsically Determined Turnover Underlies Broad Heterogeneity in Plasma-cell Lifespan
Short Talk: Short Talk: IFN-γ Production by Tfh Cells Control Lung Memory B Cell Responses to Influenza
Tuesday, October 3, 2023
Session Chair
Session Chair
Unexpected Tumor-Reactive Antibodies
Neoantigen-Driven B Cell and CD4 T Follicular Helper Cell Collaboration Promotes Anti-Tumor CD8 T Cell
Meningeal Inflammation in Multiple Sclerosis – What are B Cells Doing?
The Importance of Tfh and Germinal Centers in Regulating Immunodominance for Vaccines Against Challenging Targets
Short Talk: Short Talk: Microbiota Induced Humoral Immunity is Driven by Autonomous Skin-intrinsic Germinal Centers
Short Talk: Short Talk: The Activity of Tertiary Lymphoid Structures in High Grade Serous Ovarian Cancer is Governed by Site, Stroma, and Cellular Interactions
Professor of Medicine
President, Chief Executive Officer and Co-Founder
Senior Group Leader
Earl Stadtman Investigator & Chief, Transcription Systems Dynamics and Biology Unit
Session Chair
Session Chair
Germinal Center Responses to COVID-19 and Influenza Vaccination in Humans
The CTLA-4-IL-21 Axis in the Regulation of T Cell / B Cell Collaboration
Mechanisms of Germinal Center Induction by mRNA Vaccines
Short Talk: Short Talk: Longitudinal Tracking of Upper Respiratory Tract Germinal Center Populations
Short Talk: Short Talk: Distinct Features of a Peripheral T Helper Subset that Majorly Drives the B Cell Response in Dengue
Wednesday, October 4, 2023
Session Chair
Session Chair
B Cell– and T Cell–intrinsic Regulation of Germinal Centers by Thymic Stromal Lymphopoietin
IL-4 Downregulates BCL6 to Promote Memory B Cell Selection in Germinal Centers
Short Talk: Short Talk: B Cell-reactive Triad of B Cells, Follicular Helper and Regulatory T Cells at Homeostasis
Short Talk: Short Talk: T Cell-dependent B Cell Responses are Shaped by the Amount, Affinity and Specificity of Antigen-specific Antibody
Short Talk: Short Talk: Recycling of Memory B Cells Between Germinal Center and Lymph Node Subcapsular Sinus Supports Affinity Maturation to Antigenic Drift
Short Talk: Short Talk: Dynamic Regulation of T Follicular Cells throughout Time in the GC Space
Remote Presentation: Novel Human TLR7 Mutations cause Human Lupus and Impact both Germinal Center B Cells and Helper T Cells
Session Chair
Session Chair
A Distinct Phenotype of Polarized Memory B Cell Holds IgE Memory
Plasmodium-specific Memory B Cells Generated in the Absence of Germinal Centers are Biased Towards High Avidity Epitopes and have Limited Ability to Self-renew
The Dynamics of TCR Specificity Groups Between Secondary Lymphoid Organs and the Periphery Reveal Mechanisms of Age-associated Immune Dysfunction
B Cell-intrinsic Changes with Age do not Impair B Cell Responses to Immunisation
Arenavirus Cross-reactive Memory B Cells Afford Protection against Lassa Virus Infection
Role of B Cell Adapter for PI-3 Kinase (BCAP) in Antigen Internalization and Processing
Blunting Specific T-dependent Antibody Responses by Exploiting Affinity Selection with Engineered 'Decoy' Exogenous B Cells
Session Chair
Session Chair
T-B Interactions and B-Cell Memory
Establishment of Resident Memory B Cells in the Lung, and the Potential of Intranasal Vaccines
Germinal Center B Cell Dynamics in the Gut
Short Talk: Short Talk: Divergent Intracellular Nutrient Sensing Pathways Modulate Plasma Cell Function
Session Chair
Mast Cells Help Organize Peyer’s Patch Niche for Induction of IgA Responses
Thursday, October 5, 2023
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