Circulating Metabolic Intermediates as Fuels and Signals
Oct 08–11, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers:
Sven Enerbäck, Joshua D. Rabinowitz, and Sarah-Maria Fendt
In Person
On Demand
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Oct 08–11, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Sven Enerbäck, Joshua D. Rabinowitz, and Sarah-Maria Fendt
Sven Enerbäck
Joshua D. Rabinowitz
Sarah-Maria Fendt
Available Formats:
Supported by the Directors' Fund
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandBooking Function
Fundraising
Merchandise Options
Registration Options
Sunday, October 8, 2023
Arrival and Registration
10:00–2:00 PM
Ballroom Lobby
Welcome Mixer
12:00–2:00 PM
Ballroom Lobby
Monday, October 9, 2023
Breakfast
1:00–2:00 AM
Golden Cliff / Eagles
Welcome and Keynote Session (Joint)
2:00–3:30 AM
Ballroom 1-3
* Sven Enerbäck, University of Gothenburg
Session Chair
Session Chair
* Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Session Chair
Session Chair
June L. Round, University of Utah
Microbes with Benefits: Microbe-immune Interactions that Promote Metabolic Health
Microbes with Benefits: Microbe-immune Interactions that Promote Metabolic Health
Bruce M. Spiegelman, Dana-Farber Cancer Institute
Inputs and Outputs of Adipose
Inputs and Outputs of Adipose
Coffee Break
3:30–3:50 AM
Ballroom Lobby
Microbiota and Circulating Metabolites in Host Physiology and Immunity (Joint)
3:50–5:15 AM
Ballroom 1-3
* Tim Hand, University of Pittsburgh
Session Chair
Session Chair
Kathryn E. Wellen, University of Pennsylvania
Understanding the Interplay Between Diet, Acetyl-CoA synthesis, and Hepatic Lipid Homeostasis
Understanding the Interplay Between Diet, Acetyl-CoA synthesis, and Hepatic Lipid Homeostasis
Michael A. Fischbach, Stanford University
Microbiota Derived Metabolites and Host Physiology
Microbiota Derived Metabolites and Host Physiology
Nicole D. Sonnert, Yale University
Short Talk: Short Talk: A Host-Microbiota Interactome Reveals Extensive Transkingdom Connectivity
Short Talk: Short Talk: A Host-Microbiota Interactome Reveals Extensive Transkingdom Connectivity
Erica Maissy, UCSD
Short Talk: Short Talk: Gut Microbial Bile Acid Modifications With Engineered Native Bacteria Ameliorate Metabolic Features In Polycystic Ovary Syndrome
Short Talk: Short Talk: Gut Microbial Bile Acid Modifications With Engineered Native Bacteria Ameliorate Metabolic Features In Polycystic Ovary Syndrome
Poster Setup
5:15–7:00 AM
Superior/Wasatch
On Own for Lunch
5:15–11:00 AM
Poster Viewing
7:00–4:00 PM
Superior/Wasatch
Workshop 1
9:00–10:30 AM
Ballroom 3 Lobby
* Karthikeyani Chellappa, Brown University
Session Chair
Session Chair
Haopeng Xiao, Dana-Farber Cancer Institute/ Harvard Medical School
A Multiomic Systems Approach to Mechanistically Characterize Novel Regulators of Metabolic Pathways
A Multiomic Systems Approach to Mechanistically Characterize Novel Regulators of Metabolic Pathways
Rachel K. Meyer, University of Arizona
Impact of Postprandial Butyrate Production on Hepatic Glucose Production via Colonic and Hepatic Signaling Pathways
Impact of Postprandial Butyrate Production on Hepatic Glucose Production via Colonic and Hepatic Signaling Pathways
Joseph R. Visker, University of Utah
Targeting the Mitochondrial Pyruvate Carrier (MPC1) Ameliorates Myocardial Ischemic Reperfusion Injury in Mice
Targeting the Mitochondrial Pyruvate Carrier (MPC1) Ameliorates Myocardial Ischemic Reperfusion Injury in Mice
Karthikeyani Chellappa, Brown University
Microbial NAD Metabolism: Missing Link in Organismal NAD Biology
Microbial NAD Metabolism: Missing Link in Organismal NAD Biology
Adam J. Rauckhorst, University of Iowa
Pathways of Hepatic De Novo Lipogenesis
Pathways of Hepatic De Novo Lipogenesis
Samuel M. Lancaster, Stanford University
Deep Metabolic Phenotyping of Newborn Cord Blood Reveals Maternal-fetal Interactions and Disease Risk
Deep Metabolic Phenotyping of Newborn Cord Blood Reveals Maternal-fetal Interactions and Disease Risk
Coffee Available
10:30–11:00 AM
Ballroom Lobby
Intermediary Metabolites as Fuels
11:00–1:00 PM
Ballroom 3
* Sarah-Maria Fendt, VIB-KU Leuven
Session Chair
Session Chair
* Joshua D. Rabinowitz, Princeton University
Session Chair
Session Chair
Joshua D. Rabinowitz, Princeton University
Lactate as Waste and Fuel
Lactate as Waste and Fuel
Marc K. Hellerstein, University of California, Berkeley
Flux in Humans.Very Useful.
Flux in Humans.Very Useful.
Maria Dolores Moya-Garzon, Stanford
Short Talk: Short Talk: A Family of Orphan Ketone Metabolites that Regulates Energy Homeostasis
Short Talk: Short Talk: A Family of Orphan Ketone Metabolites that Regulates Energy Homeostasis
Eric S. Goetzman, University of Pittsburgh
Short Talk: Short Talk: Dodecanedioic Acid as an Alternative Metabolic Fuel
Short Talk: Short Talk: Dodecanedioic Acid as an Alternative Metabolic Fuel
Elaine Y. Hsiao, University of California, Los Angeles
Microbiome-diet Interactions for Regulating Neuronal Activity
Microbiome-diet Interactions for Regulating Neuronal Activity
Social Hour with Lite Bites
1:00–2:00 PM
Superior/Wasatch
Poster Session 1
1:30–4:00 PM
Superior/Wasatch
Tuesday, October 10, 2023
Breakfast
1:00–2:00 AM
Golden Cliff / Eagles
Muscle and Exercise
2:00–5:00 AM
Ballroom 3
* Katrien De Bock, Swiss Federal Institute of Technology
Session Chair
Session Chair
George A. Brooks, University of California, Berkeley
Muscle and Whole Body Lactate Kinetics: Organ-Organ, Cell-Cell, Intracellular, and Postprandial Lactate Shuttles
Muscle and Whole Body Lactate Kinetics: Organ-Organ, Cell-Cell, Intracellular, and Postprandial Lactate Shuttles
Katrien De Bock, Swiss Federal Institute of Technology
Glutamine Metabolism and Muscle Stem Cell Fate Decisions
Glutamine Metabolism and Muscle Stem Cell Fate Decisions
Zoltan Arany, University of Pennsylvania
Metabolic Flux in Exercise
Metabolic Flux in Exercise
Charlotte Mann, ETHZ
Short Talk: Short Talk: Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Reprogramming Glycolytic Muscle Metabolism
Short Talk: Short Talk: Sulfur Amino Acid Restriction Enhances Exercise Capacity in Mice by Reprogramming Glycolytic Muscle Metabolism
Arthur Kaser, University of Cambridge
Short Talk: Short Talk: A Purine Nucleotide Cycle Interlocking Energy Metabolism is Widespread across the Organism
Short Talk: Short Talk: A Purine Nucleotide Cycle Interlocking Energy Metabolism is Widespread across the Organism
Coffee Break
3:00–3:20 AM
Ballroom Lobby
Poster Setup
5:00–7:00 AM
Superior/Wasatch
On Own for Lunch
5:00–11:00 AM
Poster Viewing
7:00–4:00 PM
Superior/Wasatch
Career Roundtable (Joint)
9:00–10:30 AM
Ballroom 1-3
Zoltan Arany, University of Pennsylvania
Professor
Professor
Rose L. Szabady, Ferring Pharmaceuticals, Inc.
Associate Director, IBD Research
Associate Director, IBD Research
Elaine Y. Hsiao, University of California, Los Angeles
Associate Professor
Associate Professor
Romina S. Goldszmid, NCI, National Institutes of Health
Earl Stadtman Investigator
Earl Stadtman Investigator
Harry Sokol, INSERM
Professor
Professor
Coffee Available
10:30–11:00 AM
Ballroom Lobby
Metabolite Drivers of Health and Disease
11:00–1:00 PM
Ballroom 3
* Sven Enerbäck, University of Gothenburg
Session Chair
Session Chair
* Sarah-Maria Fendt, VIB-KU Leuven
Session Chair
Session Chair
Sarah-Maria Fendt, VIB-KU Leuven
Metabolic Rewiring Driving Metastasis Formation
Metabolic Rewiring Driving Metastasis Formation
Lora K. Heisler, Rowett Institute, University of Aberdeen
Metabolites Influencing Obesity and Type 2 Diabetes
Metabolites Influencing Obesity and Type 2 Diabetes
Gregory S. Ducker, University of Utah
Flexibility of Carbohydrate Metabolism in the Normal and Failing Heart
Flexibility of Carbohydrate Metabolism in the Normal and Failing Heart
Kyle N Dunlap, University of Utah
Short Talk: Short Talk: A Functional Genomics Screen Reveals an Essential Citrulline Transporter
Short Talk: Short Talk: A Functional Genomics Screen Reveals an Essential Citrulline Transporter
Social Hour with Lite Bites
1:00–2:00 PM
Superior/Wasatch
Poster Session 2
1:30–4:00 PM
Superior/Wasatch
Wednesday, October 11, 2023
Breakfast
1:00–2:00 AM
Golden Cliff / Eagles
Metabolites as Signaling Molecules
2:00–5:00 AM
Ballroom 3
* Joshua D. Rabinowitz, Princeton University
Session Chair
Session Chair
* Sven Enerbäck, University of Gothenburg
Session Chair
Session Chair
Sven Enerbäck, University of Gothenburg
How Foxk1 and Foxk2 Regulate Aerobic Glycolysis – Implications for Systemic Energy Homeostasis and Type 2 Diabetes
How Foxk1 and Foxk2 Regulate Aerobic Glycolysis – Implications for Systemic Energy Homeostasis and Type 2 Diabetes
Mariia Yuneva, Francis Crick Institute
Identifying Metabolic Requirements of Tumours in vivo
Identifying Metabolic Requirements of Tumours in vivo
Edward T. Chouchani, Dana-Farber Cancer Institute
Mechanisms of Protein Regulation by Lactate
Mechanisms of Protein Regulation by Lactate
Christine Vohwinkel, University of Colorado, School of Medicine
Lactate Mediated Metabolic Cross-talk Between Alveolar Macrophages and Epithelium in Acute Lung Injury Attenuates Excessive inflammation via histone lactylation
Lactate Mediated Metabolic Cross-talk Between Alveolar Macrophages and Epithelium in Acute Lung Injury Attenuates Excessive inflammation via histone lactylation
Coffee Break
3:00–3:20 AM
Ballroom Lobby
Poster Setup
5:00–7:00 AM
Superior/Wasatch
On Own for Lunch
5:00–11:00 AM
Poster Viewing
7:00–4:00 PM
Superior/Wasatch
Workshop 2
9:00–10:30 AM
Ballroom 3/Lobby
* Andrea Galmozzi, UW Madison SMPH
Session Chair
Session Chair
Andrea Galmozzi, UW Madison SMPH
Adipose Heme Biosynthesis Regulates Metabolic Homeostasis and Energy Expenditure
Adipose Heme Biosynthesis Regulates Metabolic Homeostasis and Energy Expenditure
Anthony Verkerke, BIDMC
BCAA Flux in Brown Fat Regulates Insulin Sensitivity Independent of Thermogenesis
BCAA Flux in Brown Fat Regulates Insulin Sensitivity Independent of Thermogenesis
Tong Wang, Brigham and Women’s Hospital; Harvard Medical School
Machine Learning for Precision Nutrition
Machine Learning for Precision Nutrition
Jaclyn A Rivas, University of New Mexico Health Sciences
Metabolomic and Transcriptomic Alterations in the Colon of Mice with Metabolic Syndrome in the Absence of Inflammation
Metabolomic and Transcriptomic Alterations in the Colon of Mice with Metabolic Syndrome in the Absence of Inflammation
Hadar Israeli, Hadassa Medical School, Hebrew University
Unraveling Weight Loss-Independent Mechanisms following Sleeve Gastrectomy for Alleviating Non-Alcoholic Fatty Liver Disease
Unraveling Weight Loss-Independent Mechanisms following Sleeve Gastrectomy for Alleviating Non-Alcoholic Fatty Liver Disease
Genki Ichihara, Keio University School of Medicine
MRP1-dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion
MRP1-dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion
Coffee Available
10:30–11:00 AM
Ballroom Lobby
* Joanna Kalucka, Aarhus University
Session Chair
Session Chair
Michelle F. Clasquin, Pfizer, Inc.
Expanding the Chemical Space of Synthetic Metabolites to Study a Protein of Unknown Function with Therapeutic Potential in NASH
Expanding the Chemical Space of Synthetic Metabolites to Study a Protein of Unknown Function with Therapeutic Potential in NASH
Joanna Kalucka, Aarhus University
Heterogeneity of Vascular Endothelial Cells in Human Adipose Tissue: Implications for Health and Disease
Heterogeneity of Vascular Endothelial Cells in Human Adipose Tissue: Implications for Health and Disease
Bowen Tan, Rockefeller University
Short Talk: Short Talk: Cellular and Molecular Basis of Leptin Resistance
Short Talk: Short Talk: Cellular and Molecular Basis of Leptin Resistance
Rémi Montané, Restore Institute
Short Talk: Short Talk: Regulation of Systemic Lactate Fluxes by Brown and Beige Adipose Tissues
Short Talk: Short Talk: Regulation of Systemic Lactate Fluxes by Brown and Beige Adipose Tissues
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
12:45–1:00 PM
Ballroom 3
Social Hour with Lite Bites
1:00–2:00 PM
Superior/Wasatch
Poster Session 3
1:30–4:00 PM
Superior/Wasatch
Obesity and Metabolic Syndrome
5:00–6:45 PM
Ballroom 3
Thursday, October 12, 2023
Departure
2:00–2:00 AM
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