Joint with: Circulating Metabolic Intermediates as Fuels and Signals
Mechanisms of Microbiota-Immune Interactions-Towards the Next Decade

Oct 08–11, 2023 | Snowbird Resort, Snowbird, UT, United States
Scientific Organizers: Jorge Henao-Mejia, Eran Elinav, and Lora V. Hooper

  In Person
  On Demand
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Oct 08–11, 2023 | Snowbird Resort, Snowbird, UT, United States

Scientific Organizers: Jorge Henao-Mejia, Eran Elinav, and Lora V. Hooper

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Sunday, October 8, 2023
Arrival and Registration  
4:00–8:00 PM
 Ballroom Lobby
Welcome Mixer  
6:00–8:00 PM
 Ballroom Lobby
Monday, October 9, 2023
Breakfast  
7:00–8:00 AM
 Golden Cliff / Eagles
Welcome and Keynote Session (Joint)  
8:00–9:30 AM
 Ballroom 1-3
* Sven Enerbäck, University of Gothenburg
Session Chair
* Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Session Chair
June L. Round, University of Utah
Microbes with Benefits: Microbe-immune Interactions that Promote Metabolic Health
Bruce M. Spiegelman, Dana-Farber Cancer Institute
Inputs and Outputs of Adipose
Coffee Break  
9:30–9:50 AM
 Ballroom Lobby
Microbiota and Circulating Metabolites in Host Physiology and Immunity (Joint)  
9:50–11:15 AM
 Ballroom 1-3
* Tim Hand, University of Pittsburgh
Session Chair
Kathryn E. Wellen, University of Pennsylvania
Understanding the Interplay Between Diet, Acetyl-CoA synthesis, and Hepatic Lipid Homeostasis
Michael A. Fischbach, Stanford University
Microbiota Derived Metabolites and Host Physiology
Nicole D. Sonnert, Yale University
Short Talk: Short Talk: A Host-Microbiota Interactome Reveals Extensive Transkingdom Connectivity
Erica Maissy, UCSD
Short Talk: Short Talk: Gut Microbial Bile Acid Modifications With Engineered Native Bacteria Ameliorate Metabolic Features In Polycystic Ovary Syndrome
Poster Setup  
11:15–1:00 PM
 Superior/Wasatch
On Own for Lunch  
11:15–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Superior/Wasatch
Workshop 1: Decoding the Mechanisms of Immune-host Commensals Interactions  
2:30–4:30 PM
 Ballroom 1 - 2
* Michael A. Silverman, Children's Hospital of Philadelphia
Session Chair
Juan D. Matute, Harvard Medical School & Massachusetts General Brigham
Intelectin-1 Binds and Alters the Localization of the Mucus Barrier-modifying Bacterium Akkermansia Muciniphila
Mariia Taguer, Merck Research Labs
Spatial Recovery of the Gut Microbiome after Antibiotics Perturbation
Shaina Carroll, University of California, Berkeley
Identification and Characterization of Dendritic Cells Presenting Akkermansia Muciniphila Antigens in the Gut
Masaya Arai, Osaka University
Antigen-specific Stimulation Induced and Augmented Peripherally Derived Treg Cells which Establish Treg-specific Epigenome and Orchestrate Oral Tolerance
Emrah Altindis, Boston College
A Microbiota-derived Insulin Epitope Mimic and Type 1 Diabetes Onset
Djenet Bousbaine, Stanford University
Decoding and Engineering the B Cell Response to Skin Commensal Microbes
Gregory P. Donaldson, Rockefeller University
Immunoglobulin A Suppresses Tumorigenesis by Counteracting Epithelial Responses to Microbiota
Naama Geva-Zatorsky, Technion
Remote Presentation: Functional Plasticity in the Gut Microbiota and Phage-host Interactions
Coffee Available  
4:30–5:00 PM
 Ballroom Lobby
Microbiota and Circulating Metabolites in Host Physiology and Immunity II  
5:00–7:00 PM
 Ballroom 1 - 2
* Noah W. Palm, Yale University
Session Chair
Noah W. Palm, Yale University
Mapping Uncharted Landscapes of Host-Microbiota Communication
Jorge Henao-Mejia, University of Pennsylvania and Children's Hospital of Philadelphia
Regulation of Tumor-Associated Macrophage (TAM) Polarity by the Microbiota
Nicola Gagliani, University of Hamburg
The Effects of Short-term Dietary Interventions on Immunity and Tumor Therapies
Xiaofei Yu, Fudan University
Short Talk: Short Talk: Early Immune Activation Protects against Psychological Stress via Interleukin-22
Siva Karthik Varanasi, The Salk Institute for Biological Studies
Short Talk: Short Talk: Microbial Derived Bile Acids Influence Liver Immunity during Viral Infection and Cancer
Social Hour with Lite Bites  
7:00–8:00 PM
 Superior/Wasatch
Poster Session 1  
7:30–10:00 PM
 Superior/Wasatch
Tuesday, October 10, 2023
Breakfast  
7:00–8:00 AM
 Golden Cliff / Eagles
Microbiota, Inflammation and Host Metabolism  
8:00–11:00 AM
 Ballroom 1 - 2
* Theresa Alenghat, Cincinnati Children’s Hospital
Session Chair
Lora V. Hooper, University of Texas Southwestern Medical Center
Immune-Microbiota Interactions and Nutrient Absorption
Theresa Alenghat, Cincinnati Children’s Hospital
Regulation of the Host-Microbiota Relationship
Dan R. Littman, HHMI/New York University School of Medicine
Instruction of T Cell Programs by the Commensal Microbiota
Sean Spencer, Stanford University
Short Talk: Short Talk: Fermented Food-derived Bacterial Metabolites Participate in a Transkingdom Metabolic Network to Regulate Intestinal Immunity and Diet Induced Obesity
Daniel Mucida, Rockefeller University
Remote Presentation: Microbiota and Neuro-Immune Interactions
Coffee Break  
9:00–9:20 AM
 Ballroom Lobby
Poster Setup  
11:00–1:00 PM
 Superior/Wasatch
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Superior/Wasatch
Career Roundtable (Joint)  
3:00–4:30 PM
 Ballroom 1-3
Zoltan Arany, University of Pennsylvania
Professor
Rose L. Szabady, Ferring Pharmaceuticals, Inc.
Associate Director, IBD Research
Elaine Y. Hsiao, University of California, Los Angeles
Associate Professor
Romina S. Goldszmid, NCI, National Institutes of Health
Earl Stadtman Investigator
Harry Sokol, INSERM
Professor
Coffee Available  
4:30–5:00 PM
 Ballroom Lobby
Microbiota Immune Interactions in Early Life  
5:00–7:00 PM
 Ballroom 1 - 2
* Meghan A. Koch, Fred Hutchinson Cancer Research
Session Chair
Tim Hand, University of Pittsburgh
Microbiota and Necrotizing Enterocolitis
Meghan A. Koch, Fred Hutchinson Cancer Research
Maternal Antibodies Regulate Host-Microbiota Mutualism in Early Life
Petter Brodin, Karolinska Institutet
Early Life Immune Development and Intestinal Tolerance
Michael A. Silverman, Children's Hospital of Philadelphia
Short Talk: Short Talk: Arresting Microbiome Development Limits Immune System Maturation And Resistance To Infection
Melody Zeng, Weill Cornell Medicine
Short Talk: Short Talk: Gut Bacteria-Derived Serotonin in Early-Life Immune Tolerance
Social Hour with Lite Bites  
7:00–8:00 PM
 Superior/Wasatch
Poster Session 2  
7:30–10:00 PM
 Superior/Wasatch
Wednesday, October 11, 2023
Breakfast  
7:00–8:00 AM
 Golden Cliff / Eagles
Microbiota, Tumorigenesis, and Cancer Immunotherapy  
8:00–11:00 AM
 Ballroom 1 - 2
* Romina S. Goldszmid, NCI, National Institutes of Health
Session Chair
Romina S. Goldszmid, NCI, National Institutes of Health
Regulation of the Tumor Microenvironment by the Diet and Microbiota
Thomas Gajewski, University of Chicago
Microbiota and Cancer Immunotherapy
Jens Puschhof, Deutsches Krebsforschungszentrum
Modelling Cancer-Microbe Interactions with Organoids and Organs-on-Chips
Liz Shepherd, Novome Biotechnologies
Microbial Cell Therapy: Engineering Gut Residents to Treat Disease
Yiyin (Erin) Erin Chen, Broad Institute of MIT and Harvard
Short Talk: Short Talk: Engineering Skin Commensal Bacteria for Tumor Immunotherapy
Joon Seok Park, Harvard Medical School
Short Talk: Short Talk: Targeting PD-L2–RGMb Overcomes Microbiome-related Immunotherapy Resistance
Coffee Break  
9:00–9:20 AM
 Ballroom Lobby
Poster Setup  
11:00–1:00 PM
 Superior/Wasatch
On Own for Lunch  
11:00–5:00 PM
Poster Viewing  
1:00–10:00 PM
 Superior/Wasatch
Workshop 2: Dietary Therapeutic Interventions in Autoimmunity and Cancer  
2:30–4:30 PM
 Ballroom 1 - 2
* Nicola Gagliani, University of Hamburg
Session Chair
Margaret Alexander, University of California, San Francisco
A Diet-dependent Host Metabolite Shapes the Gut Microbiota to Protect from Autoimmunity
Asael Roichman, Princeton University
The Gut Microbiome Regulates the Anti-cancer Activity of PI3K Inhibitors
Abby E. Overacre, University of Pittsburgh
Too Sweet to be True: Sucralose Ablates Immunotherapy Response through Microbiome Disruption.
Khiem Lam, National Institutes of Health
Tumor-Intrinsic Factors Dictate the Beneficial Effect of Microbiota Intervention on Anti-Cancer Response
Annabell Bachem, The University of Melbourne
Improving CD8 T Cell-mediated Melanoma Control by Targeting Microbiota-derived Metabolites
Isabelle Bourdeau Julien, Université Laval
Metabolite Profile Response to Short-Term Dietary Interventions
Cate Ward, Stanford School of Medicine
Exploring the Interplay of Plant-Based Diets, Microbiota, and Metabolites: Implications for Cardiovascular Disease Prevention
Harry Sokol, INSERM
Role of the Gut Microbiota in Tryptophan Metabolism: A System Biology Approach
Coffee Available  
4:30–5:00 PM
 Ballroom Lobby
Microbiota, Inflammation and Protective Immunity  
5:00–6:45 PM
 Ballroom 1 - 2
* Shruti Naik, New York University Langone Health
Session Chair
Eran Elinav, Weizmann Institute of Science
Remote Presentation: Nutrition, Microbiota and Innate Immunity in Epithelial Cells
Shruti Naik, New York University Langone Health
Skin Microbiota and Tissue Repair
Rose L. Szabady, Ferring Pharmaceuticals, Inc.
Development of Live Microbial Therapeutics for Treatment of Human IBD
Michael C Abt, University of Pennsylvania
Short Talk: Short Talk: Therapeutic Intervention Restores Host Responsiveness to Microbiota Transplant Treatment of C. Difficile Infection
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)  
6:45–7:00 PM
 Ballroom 1 - 2
Social Hour with Lite Bites  
7:00–8:00 PM
 Superior/Wasatch
Poster Session 3  
7:30–10:00 PM
 Superior/Wasatch
Thursday, October 12, 2023
Departure  
8:00–8:00 AM

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