Cardiometabolism in Health and Disease
Jan 26–29, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Daniel P Kelly, Rong Tian, and William C. Sessa
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Jan 26–29, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Daniel P Kelly, Rong Tian, and William C. Sessa
Daniel P Kelly, MD
University of Pennsylvania
Daniel P. Kelly, M.D., is a Professor of Medicine at the University of Pennsylvania and Director of the Cardiovascular Institutes at the University of Pennsylvania and Children’s Hospital of Philadelphia. Dr. Kelly is a distinguished cardiologist and physician-scientist known for his contributions to the transcriptional control of mitochondrial function and the metabolic origins of heart disease. Recently, the Kelly lab found that the failing heart relies on ketone bodies as a fuel, work that has led to first-in-human studies of ketone supplementation in heart failure. Dr. Kelly has extensive experience in organizing national and international conferences including Keystone Symposia meetings and American Heart Association conferences.
Rong Tian
University of Washington
Rong Tian, M.D., Ph.D., is Professor and Director of the Interdisciplinary Mitochondria & Metabolism Center at the University of Washington. Dr. Tian is a renowned expert in cardiac metabolism and mitochondrial function. Dr. Tian's early research revealed that pathological heart hypertrophy reprograms glucose and fatty acid metabolism, prioritizing cell growth over energy supply. Her studies on NAD metabolism, mitochondrial stress response, and inflammation have provided a strong rationale for mitochondria-targeted therapies. Dr. Tian has organized multiple national and international conferences including a Keystone Symposia meeting and a Gordon Research Conference. She is the Editor-in-Chief for Journal of Molecular and Cellular Cardiology.
William C. Sessa, PhD
Yale School of Medicine
William C. Sessa, Ph.D., is Senior Vice President and Chief Scientific Officer of Internal Medicine at Pfizer where he oversees discovery through proof-of-concept Phase 2b studies in areas of obesity and cardio-renal diseases. Dr. Sessa is also the Alfred Gilman Emeritus Professor of Pharmacology at Yale School of Medicine and prior to joining Pfizer in 2022 was the Director of the Vascular Biology & Therapeutics Program and Vice Chairman in the Department of Pharmacology. His research has focused on the vascular endothelium as a regulator of cardiovascular diseases such as heart failure, hypertension and atherosclerosis. He has extensive experience in organizing national and international conferences.
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Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandMonday, January 26, 2026
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Longs Peak Foyer
Welcome Mixer Sponsored by Lilly
6:00–8:00 PM
Longs Peak Foyer
Tuesday, January 27, 2026
Breakfast
7:00–8:00 AM
Quandary Peak
Welcome Remarks (Joint)
8:00–8:10 AM
Longs/Grays Peaks
Keynote Address (Joint)
8:10–9:00 AM
Longs/Grays Peaks
Richard D DiMarchi, Indiana University
The Chemical Evolution of Peptides To Transform Human Health
The Chemical Evolution of Peptides To Transform Human Health
Beyond Weight Loss: New Directions for Obesity Therapeutics (Joint)
9:00–11:30 AM
Longs/Grays Peaks
Rachel J. Roth Flach, Valo Health
Using Human Data & Machine Learning Techniques to Identify Heart Failure Phenogroups & Application to New Target Discovery & Validation
Using Human Data & Machine Learning Techniques to Identify Heart Failure Phenogroups & Application to New Target Discovery & Validation
Susan Quaggin, Northwestern University
A United Vision for Kidney and Cardiovascular Disease Treatment
A United Vision for Kidney and Cardiovascular Disease Treatment
James Trevaskis, Eli Lilly
Incretins for MASH Treatment
Incretins for MASH Treatment
Riccardo Panella, Aalborg University
Short Talk: From Fat Selectivity to Rebound Prevention: RES-010 As A Novel Backbone for Obesity Therapy
Short Talk: From Fat Selectivity to Rebound Prevention: RES-010 As A Novel Backbone for Obesity Therapy
Taha Bugra Gungul, University of Virginia
Short Talk: A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs
Short Talk: A Brain Reward Circuit Inhibited By Next-Generation Weight Loss Drugs
Coffee Break
9:30–9:50 AM
Longs Peak Foyer
Meet the Editors (Joint)
11:30–12:30 PM
Longs/Grays Peaks
* Rong Tian, University of Washington
Poster Setup
11:30–1:00 PM
Quandary Peak
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
Quandary Peak
Symposia Spotlight 1: Emerging Therapies, Lifestyle Interventions and AI Approaches (Joint)
2:30–4:30 PM
Longs/Grays Peaks
Jiyuan Piao, University of Alberta
Discovery of Snail Molecule in Hibernating Snails that Rewires Fuel Sensing and Induces Quiescence in Mouse Fibroblasts and Cardioprotective Hibernation in Mice Hearts
Discovery of Snail Molecule in Hibernating Snails that Rewires Fuel Sensing and Induces Quiescence in Mouse Fibroblasts and Cardioprotective Hibernation in Mice Hearts
Pieterjan Dierickx, Max Planck for Heart & Lung Research
Metabolic Regulation of Circadian Rhythmicity in the Aging Female Heart
Metabolic Regulation of Circadian Rhythmicity in the Aging Female Heart
Ashutosh Tomar, University Heidelberg
Disruption of CaMKII–HDAC4 Axis Protects Against Maladaptive Metabolic Remodelling in Metabolic HFpEF
Disruption of CaMKII–HDAC4 Axis Protects Against Maladaptive Metabolic Remodelling in Metabolic HFpEF
Trace Thome, University of Pennsylvania
SGLT2 Inhibitors Activate PANK1 in Human Hearts Augmenting Cardiac Metabolism
SGLT2 Inhibitors Activate PANK1 in Human Hearts Augmenting Cardiac Metabolism
Michelle To, Svensson Lab, Stanford University
A BRINP3-Derived Peptide Drives Non-Aversive Appetite Suppression via PVH Circuits
A BRINP3-Derived Peptide Drives Non-Aversive Appetite Suppression via PVH Circuits
Richard G. Kibbey, Yale University
Small Molecule Activators of Pyruvate Kinase: Preserving Muscle while Treating Obesity
Small Molecule Activators of Pyruvate Kinase: Preserving Muscle while Treating Obesity
Joanne Hsieh, Gordian Biotechnology
Parallelized In Vivo Screening in Visceral Adipocytes to Identify Novel Targets for Safe Weight Loss
Parallelized In Vivo Screening in Visceral Adipocytes to Identify Novel Targets for Safe Weight Loss
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Metabolic Origins of Heart Health and Disease
5:00–7:00 PM
Grays Peak
Daniel P Kelly, University of Pennsylvania
Modulating Cardiac Maturation in the Failing Heart
Modulating Cardiac Maturation in the Failing Heart
Catherine Makarewich, Cincinnati Children's Hospital Medical Center
Microproteins as Targets in the Diseased Heart
Microproteins as Targets in the Diseased Heart
David A Kass, Johns Hopkins Hospital
Integrated OMIC and Physiologic Interrogation of HFpEF
Integrated OMIC and Physiologic Interrogation of HFpEF
Lin Liu, Baylor College of Medicine
Short Talk: YAP Creates a Distinct Metabolic State to Regenerate the Heart
Short Talk: YAP Creates a Distinct Metabolic State to Regenerate the Heart
Natasha Maria James, The Ohio State University
Short Talk: Uncovering Heart–Adipose Tissue Crosstalk: Natriuretic Peptides and Their Role In BAT-Mediated Metabolic Health
Short Talk: Uncovering Heart–Adipose Tissue Crosstalk: Natriuretic Peptides and Their Role In BAT-Mediated Metabolic Health
Social Hour with Dinner
7:00–8:00 PM
Quandary Peak
Poster Session 1
7:30–10:00 PM
Quandary Peak
Wednesday, January 28, 2026
Breakfast
7:00–8:00 AM
Quandary Peak
Metabolic Contributions to Vascular Health and Disease
8:00–11:00 AM
Grays Peak
Michael Simons, Yale University
Metabolic Control of Vascular Cell Fate
Metabolic Control of Vascular Cell Fate
Katrien De Bock, Swiss Federal Institute of Technology
Metabolic Determinants of Angiogenesis in Disease States
Metabolic Determinants of Angiogenesis in Disease States
Yajaira Suarez, Yale School of Medicine
Regulators of Macrophage or Endothelial Cell Functions in Atherosclerosis
Regulators of Macrophage or Endothelial Cell Functions in Atherosclerosis
Zoltan Arany, University of Pennsylvania
Metabolic Determinants of Vascular Function
Metabolic Determinants of Vascular Function
Antentor O Hinton Jr., Vanderbilt University School of Medicine
Short Talk: DRP1 Dysregulation Couples Mitochondrial Dynamics, Lipid Droplet Remodeling, and Impaired Muscle Oxygenation in Peripheral Artery Disease
Short Talk: DRP1 Dysregulation Couples Mitochondrial Dynamics, Lipid Droplet Remodeling, and Impaired Muscle Oxygenation in Peripheral Artery Disease
Mitchell E. Granade, Pfizer Inc.
Short Talk: CD300LG Binds to Triglyceride-rich Lipoproteins and Facilitates Postprandial Lipid Clearance
Short Talk: CD300LG Binds to Triglyceride-rich Lipoproteins and Facilitates Postprandial Lipid Clearance
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
Poster Setup
11:00–1:00 PM
Quandary Peak
On Own for Lunch
11:00–3:00 PM
Poster Viewing
1:00–10:00 PM
Quandary Peak
Career Roundtable (Joint)
1:30–2:45 PM
Longs Peak
Panel Discussion: SGLT2 and GLP-1: Potential Mechanisms of Cardioprotective Actions
3:00–4:30 PM
Grays Peak
* Daniel P Kelly, University of Pennsylvania
Moderator
Moderator
* William C. Sessa, Yale School of Medicine
Moderator
Moderator
Justin H Berger, Washington University School of Medicine
Panelist
Panelist
Zoltan Arany, University of Pennsylvania
Panelist
Panelist
Murielle M Véniant-Ellison, Amgen Inc.
Panelist
Panelist
Matthias H. Tschöp, Ludwig-Maximilians-Universität München (LMU)
Panelist
Panelist
Susan Quaggin, Northwestern University
Panelist
Panelist
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Mitochondria and Cardiometabolic Disease
5:00–7:00 PM
Grays Peak
Rong Tian, University of Washington
Mitochondria in HFpEF
Mitochondria in HFpEF
E. Dale Abel, David Geffen School of Medicine and UCLA Health
Mitochondrial Dynamics and Cardiometabolic Disease
Mitochondrial Dynamics and Cardiometabolic Disease
Yibin Wang, Duke-NUS, Singapore
Branched-Chain Amino Acid Metabolism in the Failing Heart
Branched-Chain Amino Acid Metabolism in the Failing Heart
Jiuzhou Huo, Cincinnati Children's Hospital Medical Center
Short Talk: MCU-Dependent Alterations in Mitochondrial Calcium Dynamics Alters Metabolism and Fuel Selection in the Heart
Short Talk: MCU-Dependent Alterations in Mitochondrial Calcium Dynamics Alters Metabolism and Fuel Selection in the Heart
Sumeet A Khetarpal, University of Virginia School of Medicine
Short Talk: PGC-1α–Driven Secretion of PLBD1 in the Heart Promotes Mitochondrial Function and Confers Cardioprotection
Short Talk: PGC-1α–Driven Secretion of PLBD1 in the Heart Promotes Mitochondrial Function and Confers Cardioprotection
Social Hour with Dinner
7:00–8:00 PM
Quandary Peak
Poster Session 2
7:30–10:00 PM
Quandary Peak
Thursday, January 29, 2026
Breakfast
7:00–8:00 AM
Quandary Peak
Emerging Therapies for Obesity and Cardiometabolic Diseases (Joint)
8:00–11:00 AM
Longs/Grays Peaks
Matthias H. Tschöp, Ludwig-Maximilians-Universität München (LMU)
Dual and Triple Co-Agonists: From Discovery to Best-in-Class
Dual and Triple Co-Agonists: From Discovery to Best-in-Class
Kirsten Raun, Novo Nordisk A/S
Amylin: The All-Inclusive Obesity Therapeutic
Amylin: The All-Inclusive Obesity Therapeutic
Thomas A Lutz, University of Zürich
Amylin Physiology and its Therapeutic Potential to Treat Metabolic Diseases
Amylin Physiology and its Therapeutic Potential to Treat Metabolic Diseases
Murielle M Véniant-Ellison, Amgen Inc.
Unlocking the Power of GIPR and GLP-1R Targeting for Effective Weight Loss and Metabolic Improvement
Unlocking the Power of GIPR and GLP-1R Targeting for Effective Weight Loss and Metabolic Improvement
Shan Parikh, Yale University
Short Talk: TLC-1180 Reverses Obesity, Improves Myocardial Insulin Sensitivity, and Enhances Cardiac Fitness in a Murine Model of Diet-Induced Obesity
Short Talk: TLC-1180 Reverses Obesity, Improves Myocardial Insulin Sensitivity, and Enhances Cardiac Fitness in a Murine Model of Diet-Induced Obesity
Timo D Müller, Helmholtz Munich
Short Talk: An Unimolecular GIPR:GLP-1R:PPAR𝛼,𝛾,𝛿 Quintuple Agonist Eliminates Obesity and Insulin Resistance in Mice
Short Talk: An Unimolecular GIPR:GLP-1R:PPAR𝛼,𝛾,𝛿 Quintuple Agonist Eliminates Obesity and Insulin Resistance in Mice
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
On Own for Lunch
11:00–2:30 PM
Panel: Perspectives: Personalized Medicine & Patient-Centered Strategies (Joint)
1:00–2:00 PM
Longs/Grays Peaks
Tiffany M Powell-Wiley, NHLBI, National Institutes of Health
Panelsit
Panelsit
Kevin Grove, Versant Ventures
Panelist
Panelist
Roger D. Cone, University of Michigan
Panelist
Panelist
Symposia Spotlight 2: Leveraging New Technologies, Experimental Approaches and AI for Cardiometabolic Research
2:30–4:30 PM
Grays Peak
Naoto Muraoka, Gordian Biotechnology
Identification of Therapeutic Targets in Heart Failure with Preserved Ejection Fraction Via In vivo Mosaic Screening
Identification of Therapeutic Targets in Heart Failure with Preserved Ejection Fraction Via In vivo Mosaic Screening
Spencer Haws, University of Wisconsin-Madison
Manipulating Cardiomyocyte Senescence via the Metabolism-Chromatin Axis
Manipulating Cardiomyocyte Senescence via the Metabolism-Chromatin Axis
Lara E Celebi, University of Notre Dame
3D Model of Adipocyte Hypertrophy-Induced Atrial Dysfunction for Therapeutic Screening
3D Model of Adipocyte Hypertrophy-Induced Atrial Dysfunction for Therapeutic Screening
Shinsuke Nirengi, Ohio State University Wexner Medical Center
9-HODE is an Exercise-Induced Adipokine that Improves Insulin Sensitivity
9-HODE is an Exercise-Induced Adipokine that Improves Insulin Sensitivity
Short Talk(s) Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Environmental and Social Modulators of CV Health and Disease
5:00–6:45 PM
Grays Peak
Martin E. Young, University of Alabama at Birmingham
Circadian Control of the Heart in Health and Disease
Circadian Control of the Heart in Health and Disease
Danica Chen, University of California, Berkeley
Aging and Cardiovascular Health
Aging and Cardiovascular Health
Tiffany M Powell-Wiley, NHLBI, National Institutes of Health
Social Determinants of Obesity and Cardiovascular Risk
Social Determinants of Obesity and Cardiovascular Risk
Hayley Barta, The Ohio State University
Short Talk: Glucocorticoids Disrupt Mitochondrial Quality Control Through Metabolic Reprogramming in the Heart
Short Talk: Glucocorticoids Disrupt Mitochondrial Quality Control Through Metabolic Reprogramming in the Heart
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Grays Peak
Social Hour with Dinner
7:00–8:00 PM
Quandary Peak
Cash Bar
8:00–11:00 PM
Quandary Peak
Entertainment
8:00–11:00 PM
Longs Peak
Friday, January 30, 2026
Departure
12:00–11:59 PM
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