T Cell Differentiation in Tissue Microenvironments
Feb 02–05, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers:
Greg M Delgoffe, Amanda Lund, Nikhil S Joshi and Laura K. Mackay
In Person
On Demand
Feb 02–05, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers:
Greg M Delgoffe, Amanda Lund, Nikhil S Joshi and Laura K. Mackay
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandSunday, February 2, 2025
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
British/Columbia Foyer
Welcome Mixer
6:00–8:00 PM
British/Columbia Foyer
Monday, February 3, 2025
Breakfast
7:30–8:30 AM
Pacific Ballroom, Vancouver Island Room
Poster Setup
8:00–8:30 AM
Pacific Ballroom, Vancouver Island Room
Poster Viewing
8:00–5:00 PM
Pacific Ballroom, Vancouver Island Room
Welcome and Keynote Address (Joint)
8:30–9:30 AM
Columbia Ballroom
* Nikhil S Joshi, Yale University School of Medicine
Session Chair
Session Chair
* Shruti Naik, Icahn School of Medicine at Mount Sinai
Session Chair
Session Chair
Yasmine Belkaid, Pasteur Institut
Inflammatory Memory and Heterologous Protection
Inflammatory Memory and Heterologous Protection
Vaccines and Anti-Pathogen Responses (Joint)
9:30–11:30 AM
Columbia Ballroom
* Amanda Lund, New York University
Session Chair
Session Chair
* Renato Ostuni, Ospedale San Raffaele S.r.l.
Session Chair
Session Chair
Bana Jabri, University of Chicago
Exploring the Drivers of Viral Pathogenicity
Exploring the Drivers of Viral Pathogenicity
David B Masopust, University of Minnesota
Resident Memory in Infection and Vaccination
Resident Memory in Infection and Vaccination
Mihai G. Netea, Radboud University
Trained Immunity in Infection
Trained Immunity in Infection
Coffee Break
10:00–10:20 AM
British/Columbia Foyer
Award Recipient Acknowledgement
10:20–10:25 AM
Columbia Ballroom
Lunch
11:30–12:30 PM
Pacific Ballroom, Vancouver Island Room
Poster Session 1
12:00–2:30 PM
Pacific Ballroom, Vancouver Island Room
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Columbia Ballroom
* Pamela Rosato, Dartmouth College
Session Chair
Session Chair
Derek Bangs, University of Washington
Tertiary Lymphoid Structures Provide a Tissue Niche for Lung-Resident TCF1+ CD4+ Progenitors During Allergic Asthma
Tertiary Lymphoid Structures Provide a Tissue Niche for Lung-Resident TCF1+ CD4+ Progenitors During Allergic Asthma
Aybuke Garipcan, CSHL
Epithelial YAP orchestrates epithelial – immune crosstalk to facilitate intestinal immune surveillance
Epithelial YAP orchestrates epithelial – immune crosstalk to facilitate intestinal immune surveillance
Elliot Akama-Garren, Harvard Medical School
Stromal Cell PD-L1 Limits T Follicular Regulatory Cell Differentiation
Stromal Cell PD-L1 Limits T Follicular Regulatory Cell Differentiation
Erica Culberson, Cincinnati Children's Hospital Medical Center
Intestinal microbiota program protective CD8+ T cell responses against influenza infection in newborns
Intestinal microbiota program protective CD8+ T cell responses against influenza infection in newborns
Mark A. Travis, University of Manchester
A Subset of CD4+ Effector Memory T Cells Limit Immunity to Pulmonary Viral Infection and Prevent Tissue Pathology Via Activation of Latent TGF-Beta
A Subset of CD4+ Effector Memory T Cells Limit Immunity to Pulmonary Viral Infection and Prevent Tissue Pathology Via Activation of Latent TGF-Beta
Daniel Campbell, Benaroya Research Institute
An IL-2 Mutein Increases Regulatory T Cell Suppression of Dendritic Cells Via IL-10 and CTLA-4 to Promote T Cell Anergy
An IL-2 Mutein Increases Regulatory T Cell Suppression of Dendritic Cells Via IL-10 and CTLA-4 to Promote T Cell Anergy
Laure Le Corre, Université de Montréal
Notch-Driven BATF Activity Promotes the Differentiation of Terminal Effector CD8 T Cells
Notch-Driven BATF Activity Promotes the Differentiation of Terminal Effector CD8 T Cells
Michel DuPage, University of California, Berkeley
H3k27me3 Chromatin Modifications Act as a Rheostat for Treg Function in Inflamed Tissues
H3k27me3 Chromatin Modifications Act as a Rheostat for Treg Function in Inflamed Tissues
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Metabolic Control of T Cell Differentiation in Tissues
5:00–7:00 PM
Columbia Ballroom
* Robert L Eil, Oregon Health & Science University
Session Chair
Session Chair
Diane Mathis, Harvard Medical School
T Cell Differentiation in Metabolic Tissues
T Cell Differentiation in Metabolic Tissues
* Greg M Delgoffe, University of Pittsburgh
Metabolic Regulation of T Cell Differentiation
Metabolic Regulation of T Cell Differentiation
Roberta Zappasodi, Weill Cornell Medical College of Cornell University
Metabolic Control of Tissue-Infiltrating Regulatory T Cells
Metabolic Control of Tissue-Infiltrating Regulatory T Cells
Will Bailis, University of Pennsylvania
Coordinating T Cell Adaptation During Nutrient Stress
Coordinating T Cell Adaptation During Nutrient Stress
On Own for Dinner
7:00–8:00 PM
Tuesday, February 4, 2025
Breakfast
7:30–8:30 AM
Pacific Ballroom, Vancouver Island Room
Meet the Editors (Joint)
7:35–8:25 AM
Pacific Ballroom, Vancouver Island Room
* Montserrat Cols Vidal, Journal of Experimental Medicine
Senior Scientific Editor
Senior Scientific Editor
* Ursula Weiss, Nature
Senior Editor
Senior Editor
* Laurie A. Dempsey, Springer Nature
Senior Editor, Nature Immunology
Senior Editor, Nature Immunology
* Lucy A Bird, Springer Nature
Senior Editor, Nature Reviews Immunology
Senior Editor, Nature Reviews Immunology
* Cheri Sirois, Cell Press
Senior Scientific Editor, Cell
Senior Scientific Editor, Cell
* Jodi Gullicksrud, Cell Press
Scientific Editor, Immunity
Scientific Editor, Immunity
* Claire Olingy, American Association for the Advancement of Science (AAAS)
Senior Editor, Science Immunology
Senior Editor, Science Immunology
T Cell Trafficking In, Around, and Out of Tissues
8:30–11:30 AM
Columbia Ballroom
* Tessa Bergsbaken, Rutgers New Jersey Medical School
Session Chair
Session Chair
* Amanda Lund, New York University
Lymphatics and T Cell Tissue Egress in Health and Disease
Lymphatics and T Cell Tissue Egress in Health and Disease
Pilar Alcaide, Tufts University School of Medicine
T Cell Migration and Function in Cardiac Tissue
T Cell Migration and Function in Cardiac Tissue
Judith N. Mandl, McGill University
Migration of T Cells Through Challenging Microenvironments
Migration of T Cells Through Challenging Microenvironments
Donna L Farber, Columbia University Medical Center
Resident Memory T Cells Across Human Tissues
Resident Memory T Cells Across Human Tissues
Roham Parsa, Chan Zuckerberg Biohub New York
Short Talk: Tracking Polyclonal CD4+ T Cells Reveals Organ-Specific Selection and Function During Infection
Short Talk: Tracking Polyclonal CD4+ T Cells Reveals Organ-Specific Selection and Function During Infection
Valentina Venzin, Vita-Salute San Raffaele University
Short Talk: CD4+T Cells License Kupffer Cells to Revert the CD8+T Cell Dysfunction Induced by Hepatocellular Priming
Short Talk: CD4+T Cells License Kupffer Cells to Revert the CD8+T Cell Dysfunction Induced by Hepatocellular Priming
Coffee Break
9:30–9:50 AM
British/Columbia Foyer
Poster Setup
11:30–1:00 PM
Pacific Ballroom, Vancouver Island Room
On Own for Lunch
11:30–1:30 PM
Poster Viewing
1:00–10:00 PM
Pacific Ballroom, Vancouver Island Room
Symposia Spotlight 2: Emerging Technologies (Joint)
1:30–3:30 PM
Columbia Ballroom
* Priyadharshini Devarajan, Stony Brook University School of Medicine
Session Chair
Session Chair
Zoltan Maliga, Harvard Medical School
Single Cell Spatial Atlas of T-Cell Phenotypes in Patient Tumors, Inflamed Tissues and Neoadjuvant Response
Single Cell Spatial Atlas of T-Cell Phenotypes in Patient Tumors, Inflamed Tissues and Neoadjuvant Response
Whitney Harrington, University of Washington
The Impact of Age on T Cell Phenotype in the Lower Female Genital Tract
The Impact of Age on T Cell Phenotype in the Lower Female Genital Tract
Jia Zhu, University of Washington
Spatial Immune Profiling Reveals T-cell Landscape and Local Interactions Associated with Disease Expression in Human Herpesvirus Infection
Spatial Immune Profiling Reveals T-cell Landscape and Local Interactions Associated with Disease Expression in Human Herpesvirus Infection
Kelli A McCord, Baylor College of Medicine
Phenotypic Analysis and Spatial Profiling of Antigen-Specific T Cells in Head and Neck Cancer
Phenotypic Analysis and Spatial Profiling of Antigen-Specific T Cells in Head and Neck Cancer
Iain D Fraser, NIAID, National Institutes of Health
Endogenous Cytokine Reporter Macrophages Facilitate Identification of Novel Innate Immune Training Compounds that can Reactivate Latent HIV
Endogenous Cytokine Reporter Macrophages Facilitate Identification of Novel Innate Immune Training Compounds that can Reactivate Latent HIV
* Hannah R Knight, University of Chicago
High-Throughput Screen Identifies Non-Inflammatory Small Molecule Inducers of Trained Immunity
High-Throughput Screen Identifies Non-Inflammatory Small Molecule Inducers of Trained Immunity
Zoe Schaefer, University of Florida
Multi-Level Proteomics Reveals Epigenetic Signatures in BCG-mediated Macrophage Activation
Multi-Level Proteomics Reveals Epigenetic Signatures in BCG-mediated Macrophage Activation
Career Roundtable (Joint)
3:30–4:30 PM
British Ballroom
Megan K. MacLeod, Glasgow University
Associate Professor
Associate Professor
Charles E. Whitehurst, Boehringer Ingelheim Pharmaceuticals, Inc.
Distinguished Research Fellow, Immunology & Respiratory Discovery Sciences
Distinguished Research Fellow, Immunology & Respiratory Discovery Sciences
Ai Ing Lim, Princeton University
Assistant Professor
Assistant Professor
Maximilian Heeg, Allen Institute
Assistant Investigator
Assistant Investigator
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Perspectives: T Cell Residence vs. Exhaustion
5:00–7:00 PM
Columbia Ballroom
* Justin Milner, UNC
Session Chair
Session Chair
* Laura K. Mackay, University of Melbourne
Deconvoluting Tissue-Resident and Exhausted T Cells in Tissues and Tumors
Deconvoluting Tissue-Resident and Exhausted T Cells in Tissues and Tumors
Sharanya Wijesinghe, The Peter Doherty Institute for Infection and Immunity/ The University of Melbourne
Short Talk: Induction of TRM Programming by Tumor Residing Stem-Like CD8+ T Cells Limit Anti-Cancer Immunity
Short Talk: Induction of TRM Programming by Tumor Residing Stem-Like CD8+ T Cells Limit Anti-Cancer Immunity
Will D Green, University of North Carolina at Chapel Hill
Short Talk: Molecular Architecture of CD8 T Cell Adaptation to Tissue and Tumor Microenvironments
Short Talk: Molecular Architecture of CD8 T Cell Adaptation to Tissue and Tumor Microenvironments
Hanna N Degefu, Dartmouth College
Short Talk: Resident Memory T Cell Heterogeneity in the Human Brain
Short Talk: Resident Memory T Cell Heterogeneity in the Human Brain
E. John Wherry, University of Pennsylvania
Exhaustion and Residency of CD8+ T Cells
Exhaustion and Residency of CD8+ T Cells
Social Hour with Lite Bites
7:00–8:00 PM
Pacific Ballroom, Vancouver Island Room
Poster Session 2
7:30–10:00 PM
Pacific Ballroom, Vancouver Island Room
Wednesday, February 5, 2025
Breakfast
7:30–8:30 AM
Pacific Ballroom, Vancouver Island Room
Differentiation of T Cells Within Tissues in Disease
8:30–11:30 AM
Columbia Ballroom
* Michel DuPage, University of California, Berkeley
Session Chair
Session Chair
Christine Carine Moussion, Genentech, Inc.
T Cell Function in Tumor Tissue, in situ Tumor Arrays
T Cell Function in Tumor Tissue, in situ Tumor Arrays
Stephen C Jameson, University of Minnesota Medical School
T Cell Differentiation in Tissues
T Cell Differentiation in Tissues
* Nikhil S Joshi, Yale University School of Medicine
Tissue Cues of T Cell Differentiation in Autoimmunity and Cancer
Tissue Cues of T Cell Differentiation in Autoimmunity and Cancer
Fiona M. Powrie, University of Oxford
Tissue Instruction of T Cell Differentiation
Tissue Instruction of T Cell Differentiation
Niklas Beumer, University Medical Center of the Johannes Gutenberg University Mainz
Short Talk: Transposable Elements Become Demethylated During the Differentiation of Human Regulatory T Cells in Skin Tissue
Short Talk: Transposable Elements Become Demethylated During the Differentiation of Human Regulatory T Cells in Skin Tissue
Jie Sun, University of Virginia
Short Talk: Blimp-1-expressing respiratory Th1 effector cells help mucosal IgA production
Short Talk: Blimp-1-expressing respiratory Th1 effector cells help mucosal IgA production
Coffee Break
9:30–9:50 AM
British/Columbia Foyer
Poster Setup
11:30–1:00 PM
Pacific Ballroom, Vancouver Island Room
On Own for Lunch
11:30–5:00 PM
Poster Viewing
1:00–10:00 PM
Pacific Ballroom, Vancouver Island Room
Symposia Spotlight 3
2:30–4:30 PM
Columbia Ballroom
* Simone L Park, University of Pennsylvania
Session Chair
Session Chair
* Lalit K Beura, Brown University
Session Chair
Session Chair
Upasana Das Adhikari, Massachusetts General Hospital/ Harvard med School
Immunometabolic Dysregulation of Intestinal CD8+ T Cells Results in Loss of Intestinal Barrier Integrity in People with HIV
Immunometabolic Dysregulation of Intestinal CD8+ T Cells Results in Loss of Intestinal Barrier Integrity in People with HIV
Robert L Eil, Oregon Health & Science University
Ionic Imbalances in the TME Shape T Cell Metabolism Through Nutrient Processing and Consumption
Ionic Imbalances in the TME Shape T Cell Metabolism Through Nutrient Processing and Consumption
Tessa Bergsbaken, Rutgers New Jersey Medical School
GPR132 Regulates the Magnitude of T cell Responses During Infection and Cancer
GPR132 Regulates the Magnitude of T cell Responses During Infection and Cancer
Nicole Scharping, UCSD
Proteostasis Enables T Cell Differentiation Potential and Sustains TIL Function in Cancer
Proteostasis Enables T Cell Differentiation Potential and Sustains TIL Function in Cancer
Sagar P Bapat, University of California, San Francisco
Diet on Disease Onset is a Critical Modifier of Inflammatory Disease Trajectory
Diet on Disease Onset is a Critical Modifier of Inflammatory Disease Trajectory
Sydney Ramirez, La Jolla Institute for Immunology
Longitudinal Tracking of Human Upper Airway T Cells
Longitudinal Tracking of Human Upper Airway T Cells
Leticia Monin Aldama, Imperial College London
Regulation Of Gut Γδ T Cell Activation by Innate and Adaptive TCR Engagement
Regulation Of Gut Γδ T Cell Activation by Innate and Adaptive TCR Engagement
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Epigenetic Training of Innate-like and Adaptive Lymphocytes (Joint)
5:00–6:45 PM
Columbia Ballroom
* Greg M Delgoffe, University of Pittsburgh
Session Chair
Session Chair
Ananda W. Goldrath, University of California, San Diego
Epigenetic Regulation of CD8 T Cell Differentiation and Function
Epigenetic Regulation of CD8 T Cell Differentiation and Function
* Colleen Lau, Cornell University
AP-1 Factors Epigenetically Regulate Innate and Adaptive Immune Memory Formation During Viral Infection
AP-1 Factors Epigenetically Regulate Innate and Adaptive Immune Memory Formation During Viral Infection
Maziar Divangahi, McGill University
Innate and Adaptive Cross-Talk in Infection
Innate and Adaptive Cross-Talk in Infection
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint)
6:45–7:00 PM
Columbia Ballroom
Social Hour with Lite Bites
7:00–8:00 PM
Pacific Ballroom, Vancouver Island Room
Poster Session 3
7:30–10:00 PM
Pacific Ballroom, Vancouver Island Room
Fundraising
Thursday, February 6, 2025
Departure
12:00–11:59 PM
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