Joint with: Targeted Delivery of Nucleic Acid Medicines
Precision Genome Engineering: From Laboratory to Clinic

Jan 25–28, 2027 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Erik J. Sontheimer and Leonela Amoasii

  In Person
  On Demand
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Jan 25–28, 2027 | Keystone Resort, Keystone, CO, United States

Scientific Organizers: Erik J. Sontheimer and Leonela Amoasii

Supported by the  Directors' Fund

***Meeting program subject to change.

Available Formats:   = In Person     = On Demand
Monday, January 25, 2027
Registration
4:00–8:00 PM
Welcome Mixer
6:00–8:00 PM
Tuesday, January 26, 2027
Breakfast
7:00–8:00 AM
Welcome Remarks (Joint)
8:00–8:10 AM
Keynote Address (Joint)
8:10–9:00 AM
Speaker to be Announced
Viral Delivery of Genome Editors and Genetic Medicines (Joint)
9:00–11:15 AM
Beverly L. Davidson, Children’s Hospital of Philadelphia and University of Pennsylvania
AAV Capsid Engineering for Broad CNS Distribution
Sonia Vallabh, Broad Institute
Development of Medicines to Treat Prion Diseases: A Personal Journey
Charles Gersbach, Duke University
AAV-Delivered Epigenome Editors
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
Panel Discussion: Lessons Learned So Far: From Concept to Clinic
11:15–12:15 PM
Poster Setup
12:15–1:00 PM
On Own for Lunch
12:15–5:00 PM
Poster Viewing
1:00–10:00 PM
Symposia Spotlight 1: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Next-Generation Editing Tools: Continuing Innovation to Push the Limits of Genome Engineering
5:00–7:00 PM
Jennifer A. Doudna, HHMI/University of California, Berkeley
CRISPR Genome Editing
Erik J Sontheimer, University of Massachusetts Medical School
Next-Generation Genome Editing Platforms
Weixin Tang, University of Chicago
Reprogramming Deaminase Specificity for Precise Base Editing
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Wednesday, January 27, 2027
Breakfast
7:00–8:00 AM
Machine-Learned Molecules: AI-Driven Design in Genome Engineering & Delivery
8:00–11:00 AM
Silvana Konermann †, Stanford University School of Medicine
Protein Design and Genome Editor Enhancement
Peter Cameron, Profluent Bio
Building Customized Editors via Large Language Model-Based Protein Design
Martin Pacesa, University of Zurich
Computational Design of Next Generation Gene Editing Tools
Speaker to be Announced
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Poster Setup
11:00–1:00 PM
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Career Roundtable
3:00–4:30 PM
Coffee Available
4:30–5:00 PM
Editing with Confidence: Evaluating Safety, Specificity, and Genomic Integrity
5:00–7:00 PM
Maria Mirotsou, Scribe Therapeutics
Advancing In Vivo CRISPR CasX-Based Therapies to Target Key Dyslipidemia Drivers
Shengdar Q Tsai, St. Jude Children's Research Hospital
Off-Target Profiling for Base and Prime Editing
Marcello Maresca, AstraZeneca
Enhancing Prime Editing Platforms for in vivo Applications
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Posters
7:30–10:00 PM
Thursday, January 28, 2027
Breakfast
7:00–8:00 AM
Redefining Editors: From CRISPR Biology to Recombination and Integration
8:00–11:00 AM
Jason D. Fontenot, Stylus Medicine
Talk Title to be Announced
Sangsu Bae, Seoul National University
Precise ADAR Base Editors and Prime Editor Enhancers
Kathleen Collins, University of California, Berkeley
Transgene Insertion Editing with Engineered Retroelements
Hiroshi Nishimasu, RCAST, The University of Tokyo
Engineering Programmable Transposases
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
On Own for Lunch
11:00–5:00 PM
Symposia Spotlight 2: Late-breaking research presentations selected from abstract submissions
2:30–4:30 PM
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
In vivo Genome Editing via Non-Viral Delivery (Joint)
5:00–6:15 PM
Birgit C Schultes, Intellia Therapeutics Inc.
mRNA/LNP based Gene Editing
Rebecca Ahrens-Nicklas, Children's Hospital of Philadelphia
Personalized Therapeutic Genome Editing for Hepatic Inborn Errors of Metabolism
Short Talk(s) Chosen from Abstracts
Closing Keynote Speaker (Joint)
6:15–7:00 PM
Eric N. Olson, University of Texas Southwestern Medical Center
Single-AAV base Editing Therapies for Duchenne Muscular Dystrophy
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:00–7:15 PM
Social Hour with Dinner
7:15–8:15 PM
Cash Bar
8:00–11:00 PM
Entertainment
8:00–11:00 PM
Friday, January 29, 2027
Departure
12:00–11:59 PM

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