Innate Immune Memory: Mechanisms and Consequences
Feb 02–05, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers:
Shruti Naik, Keke C. Fairfax, and Renato Ostuni
In Person
On Demand
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Feb 02–05, 2025 | Fairmont Hotel Vancouver, Vancouver, BC, Canada
Scientific Organizers: Shruti Naik, Keke C. Fairfax, and Renato Ostuni
Shruti Naik
Keke C. Fairfax
Renato Ostuni
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandSunday, February 2, 2025
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
British/Columbia Foyer
Welcome Mixer
6:00–8:00 PM
British/Columbia Foyer
Monday, February 3, 2025
Breakfast
7:30–8:30 AM
Pacific Ballroom, Vancouver Island Room
Poster Setup
8:00–8:30 AM
Pacific Ballroom, Vancouver Island Room
Poster Viewing
8:00–5:00 PM
Pacific Ballroom, Vancouver Island Room
Welcome and Keynote Address (Joint)
8:30–9:30 AM
Columbia Ballroom
* Shruti Naik, Icahn School of Medicine at Mount Sinai
Session Chair
Session Chair
* Nikhil S Joshi, Yale University School of Medicine
Session Chair
Session Chair
Yasmine Belkaid, Pasteur Institut
Inflammatory Memory and Heterologous Protection
Inflammatory Memory and Heterologous Protection
Vaccines and Anti-Pathogen Responses (Joint)
9:30–11:30 AM
Columbia Ballroom
* Amanda Lund, New York University
Session Chair
Session Chair
* Renato Ostuni, Ospedale San Raffaele S.r.l.
Session Chair
Session Chair
Bana Jabri, University of Chicago
Exploring the Drivers of Viral Pathogenicity
Exploring the Drivers of Viral Pathogenicity
David B Masopust, University of Minnesota
Resident Memory in Infection and Vaccination
Resident Memory in Infection and Vaccination
Mihai G. Netea, Radboud University
Trained Immunity in Infection
Trained Immunity in Infection
Coffee Break
10:00–10:20 AM
British/Columbia Foyer
Award Recipient Acknowledgement
10:20–10:25 AM
Columbia Ballroom
Lunch
11:30–12:30 PM
Pacific Ballroom, Vancouver Island Room
Poster Session 1
12:00–2:30 PM
Pacific Ballroom, Vancouver Island Room
Symposia Spotlight 1: Late Breaking Research
2:30–4:30 PM
British Ballroom
* Payal Damani-Yokota, NYU Langone Medical Center
Session Chair
Session Chair
Vanessa Cristaldi, NYU Langone
Remote Presentation: A Persistent Vascular Endothelial Inflammatory State Maintains Local Immune Surveillance in Skin Post Infection
Remote Presentation: A Persistent Vascular Endothelial Inflammatory State Maintains Local Immune Surveillance in Skin Post Infection
M. Carrie Miceli, University of California, Los Angeles
Transcriptomics Reveals DMD Driven Cell Dynamics and Mechanisms of Fibroblast Inflammatory Tissue Priming in Human Dystrophic Muscle
Transcriptomics Reveals DMD Driven Cell Dynamics and Mechanisms of Fibroblast Inflammatory Tissue Priming in Human Dystrophic Muscle
Payal Damani-Yokota, NYU Langone Medical Center
Helminth-Driven NAM Reprogramming Confers Disease Tolerance Against Subsequent Respiratory Viral Infection
Helminth-Driven NAM Reprogramming Confers Disease Tolerance Against Subsequent Respiratory Viral Infection
Roni Nowarski, BRIGHAM AND WOMEN'S HOSPITAL
A Metabolic Switch Orchestrated by Il-18 and Cgamp Programs Tolerogenic Memory in the Gut
A Metabolic Switch Orchestrated by Il-18 and Cgamp Programs Tolerogenic Memory in the Gut
Alexander Lercher, The Rockefeller University
Antiviral Innate Immune Memory in Alveolar Macrophages Following SARS-Cov-2 Infection
Antiviral Innate Immune Memory in Alveolar Macrophages Following SARS-Cov-2 Infection
In Su Cheon, University of Virginia
Infection-Experienced Alveolar Macrophages Sustain Airway T Cell Memory
Infection-Experienced Alveolar Macrophages Sustain Airway T Cell Memory
* Quen J. Cheng, University of California, Los Angeles
IRF1 Cooperates with ISGF3 or GAF To Regulate Specificity of De Novo Enhancers
IRF1 Cooperates with ISGF3 or GAF To Regulate Specificity of De Novo Enhancers
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Mechanisms of Innate Immune Memory
5:00–7:00 PM
British Ballroom
Golnaz Vahedi, University of Pennsylvania
Remote Presentation: Optical Reconstruction of Chromatin Architecture Reveals Dynamics of Genome Organization
Remote Presentation: Optical Reconstruction of Chromatin Architecture Reveals Dynamics of Genome Organization
* Renato Ostuni, Ospedale San Raffaele S.r.l.
Mechanisms of Response and Memory to Stimulation in Macrophages
Mechanisms of Response and Memory to Stimulation in Macrophages
* Diana Hargreaves, The Salk Institute for Biological Studies
Regulation of Macrophage Inflammation by BAF Chromatin Remodeling Complexes
Regulation of Macrophage Inflammation by BAF Chromatin Remodeling Complexes
Aoife O'Farrell, University of Pennsylvania
Short Talk: Long Term Stimulus Specificity of Memory in Human Macrophages
Short Talk: Long Term Stimulus Specificity of Memory in Human Macrophages
Aleksandr Gorin, University of California, Los Angeles
Short Talk: Interferon Gamma Induced Innate Immune Memory in Macrophages is Dependent on Sustained JAK/STAT Signaling
Short Talk: Interferon Gamma Induced Innate Immune Memory in Macrophages is Dependent on Sustained JAK/STAT Signaling
On Own for Dinner
7:00–8:00 PM
Tuesday, February 4, 2025
Breakfast
7:30–8:30 AM
Pacific Ballroom, Vancouver Island Room
Meet the Editors (Joint)
7:35–8:25 AM
Pacific Ballroom, Vancouver Island Room
* Montserrat Cols Vidal, Journal of Experimental Medicine
Senior Scientific Editor
Senior Scientific Editor
* Ursula Weiss, Nature
Senior Editor
Senior Editor
* Laurie A. Dempsey, Springer Nature
Senior Editor, Nature Immunology
Senior Editor, Nature Immunology
* Lucy A Bird, Springer Nature
Senior Editor, Nature Reviews Immunology
Senior Editor, Nature Reviews Immunology
* Cheri Sirois, Cell Press
Senior Scientific Editor, Cell
Senior Scientific Editor, Cell
* Jodi Gullicksrud, Cell Press
Scientific Editor, Immunity
Scientific Editor, Immunity
* Claire Olingy, American Association for the Advancement of Science (AAAS)
Senior Editor, Science Immunology
Senior Editor, Science Immunology
Inflammatory Memory and Disease
8:30–11:30 AM
British Ballroom
* Kari C Nadeau, Harvard T.H. Chan School of Public Health
Exposome, Inflammatory Training and Allergic Disease
Exposome, Inflammatory Training and Allergic Disease
Przemyslaw Sapieha, University of Montreal
Obesity, Innate Immune Training, and Neuroinflammation
Obesity, Innate Immune Training, and Neuroinflammation
Kathryn J Moore, New York University Medical Center
Inflammatory Memory in Cardiovascular Disease and Cancer
Inflammatory Memory in Cardiovascular Disease and Cancer
Dusan Bogunovic, Columbia University
Post-Translational Governance of Innate Immune Memory
Post-Translational Governance of Innate Immune Memory
Cassia Braga, Yale University
Short Talk: Chronic Lung Inflammation in Cystic Fibrosis Drives Maladaptive Innate Immune Memory in Hematopoietic Stem Cells
Short Talk: Chronic Lung Inflammation in Cystic Fibrosis Drives Maladaptive Innate Immune Memory in Hematopoietic Stem Cells
* Helene M Liu, National Taiwan University
Dysregulated MDA5-Mediated Innate Immune Memory and M5c RNA Modification in Autoimmune Disease
Dysregulated MDA5-Mediated Innate Immune Memory and M5c RNA Modification in Autoimmune Disease
Coffee Break
9:30–9:50 AM
British/Columbia Foyer
Poster Setup
11:30–1:00 PM
Pacific Ballroom, Vancouver Island Room
On Own for Lunch
11:30–1:30 PM
Poster Viewing
1:00–10:00 PM
Pacific Ballroom, Vancouver Island Room
Symposia Spotlight 2: Emerging Technologies (Joint)
1:30–3:30 PM
Columbia Ballroom
* Priyadharshini Devarajan, Stony Brook University School of Medicine
Session Chair
Session Chair
Zoltan Maliga, Harvard Medical School
Single Cell Spatial Atlas of T-Cell Phenotypes in Patient Tumors, Inflamed Tissues and Neoadjuvant Response
Single Cell Spatial Atlas of T-Cell Phenotypes in Patient Tumors, Inflamed Tissues and Neoadjuvant Response
Whitney Harrington, University of Washington
The Impact of Age on T Cell Phenotype in the Lower Female Genital Tract
The Impact of Age on T Cell Phenotype in the Lower Female Genital Tract
Jia Zhu, University of Washington
Spatial Immune Profiling Reveals T-cell Landscape and Local Interactions Associated with Disease Expression in Human Herpesvirus Infection
Spatial Immune Profiling Reveals T-cell Landscape and Local Interactions Associated with Disease Expression in Human Herpesvirus Infection
Kelli A McCord, Baylor College of Medicine
Phenotypic Analysis and Spatial Profiling of Antigen-Specific T Cells in Head and Neck Cancer
Phenotypic Analysis and Spatial Profiling of Antigen-Specific T Cells in Head and Neck Cancer
* Hannah R Knight, University of Chicago
High-Throughput Screen Identifies Non-Inflammatory Small Molecule Inducers of Trained Immunity
High-Throughput Screen Identifies Non-Inflammatory Small Molecule Inducers of Trained Immunity
Zoe Schaefer, University of Florida
Multi-Level Proteomics Reveals Epigenetic Signatures in BCG-mediated Macrophage Activation
Multi-Level Proteomics Reveals Epigenetic Signatures in BCG-mediated Macrophage Activation
Career Roundtable (Joint)
3:30–4:30 PM
British Ballroom
Megan K. MacLeod, Glasgow University
Associate Professor
Associate Professor
Charles E. Whitehurst, Boehringer Ingelheim Pharmaceuticals, Inc.
Distinguished Research Fellow, Immunology & Respiratory Discovery Sciences
Distinguished Research Fellow, Immunology & Respiratory Discovery Sciences
Ai Ing Lim, Princeton University
Assistant Professor
Assistant Professor
Maximilian Heeg, Allen Institute
Assistant Investigator
Assistant Investigator
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Inflammatory Memory in Long-Lived Tissue Progenitor Cells
5:00–7:00 PM
British Ballroom
* Shruti Naik, Icahn School of Medicine at Mount Sinai
Inflammatory Memory in Epithelial Stem Cells
Inflammatory Memory in Epithelial Stem Cells
Semir Beyaz, Cold Spring Harbor Laboratory
Metabolic Training of Intestinal Stem Cells
Metabolic Training of Intestinal Stem Cells
Steven Z. Josefowicz, Weill Cornell Medical College
Epigenetic Regulation of Inflammation
Epigenetic Regulation of Inflammation
* Megan K. MacLeod, Glasgow University
Lung Structural Cells are Altered by Influenza Virus Leading to Rapid Immune Protection Following Re-Challenge
Lung Structural Cells are Altered by Influenza Virus Leading to Rapid Immune Protection Following Re-Challenge
Phoenix P Miao, The University of Chicago
Short Talk: Aging-Associated Chronic Inflammation Induces Epigenetic Scars in Epithelial Stem Cells
Short Talk: Aging-Associated Chronic Inflammation Induces Epigenetic Scars in Epithelial Stem Cells
Social Hour with Lite Bites
7:00–8:00 PM
Pacific Ballroom, Vancouver Island Room
Poster Session 2
7:30–10:00 PM
Pacific Ballroom, Vancouver Island Room
Wednesday, February 5, 2025
Breakfast
7:30–8:30 AM
Pacific Ballroom, Vancouver Island Room
Intergenerational, Transgenerational and Early Life Training
8:30–11:30 AM
British Ballroom
* Keke C. Fairfax, University of Utah
Dissecting the Role of Biological Sex in Training of the Myeloid Lineage
Dissecting the Role of Biological Sex in Training of the Myeloid Lineage
Colin C. Conine, University of Pennsylvania
Transgenerational Inheritance of Host-Microbe Crosstalk
Transgenerational Inheritance of Host-Microbe Crosstalk
Ai Ing Lim, Princeton University
Maternal-Offspring Immune Partnership
Maternal-Offspring Immune Partnership
Petter Brodin, Karolinska Institutet
Early Life Imprinting of Human Immune System
Early Life Imprinting of Human Immune System
* Jonas Schulte-Schrepping, German Center for Neurodegenerative Diseases (DZNE)
A Journey of Resilience: Investigating Hematopoietic Adaptations to Early-Life Stress and their Impact on Neurodegenerative Disease Development
A Journey of Resilience: Investigating Hematopoietic Adaptations to Early-Life Stress and their Impact on Neurodegenerative Disease Development
Taylor Miller-Ensminger, University of Pennsylvania
Short Talk: Paternal Immune Activation Confers Epigenetically Inherited Protection to Offspring During Viral Infection
Short Talk: Paternal Immune Activation Confers Epigenetically Inherited Protection to Offspring During Viral Infection
Coffee Break
9:30–9:50 AM
British/Columbia Foyer
Poster Setup
11:30–1:00 PM
Pacific Ballroom, Vancouver Island Room
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
Pacific Ballroom, Vancouver Island Room
Health Equity Forum
3:00–4:30 PM
British Ballroom
* Graeme J Koelwyn, Simon Fraser University
Session Chair
Session Chair
* Stephanie Z Xie, University Health Network
Session Chair
Session Chair
Jed Friedman, University of Oklahoma
Colonization with Enterobacteriaceae Strain from Human Neonates Born to Mothers with Obesity Promotes Immune Cell Remodeling in Mice
Colonization with Enterobacteriaceae Strain from Human Neonates Born to Mothers with Obesity Promotes Immune Cell Remodeling in Mice
Graeme J Koelwyn, Simon Fraser University
Myocardial Infarction Imprints Long-Term Dysfunctional Monocyte Reprogramming
Myocardial Infarction Imprints Long-Term Dysfunctional Monocyte Reprogramming
Eva Kaufmann, Queen's University
Deciphering the Influence of the Immune Environment on Trained Immunity Induction
Deciphering the Influence of the Immune Environment on Trained Immunity Induction
Sarah Crome, University Health Network & University of Toronto
Natural Killer Cells Exhibit Resistance to Immunosuppression and Develop a Memory-Like Phenotype in Kidney Antibody-Mediated Rejection
Natural Killer Cells Exhibit Resistance to Immunosuppression and Develop a Memory-Like Phenotype in Kidney Antibody-Mediated Rejection
Iris K Gratz, University of Salzburg
Skin Cancer in Patients With Recessive Dystrophic Epidermolysis Bullosa Is Associated With Dysregulated T Cells
Skin Cancer in Patients With Recessive Dystrophic Epidermolysis Bullosa Is Associated With Dysregulated T Cells
Stephanie Z Xie, University Health Network
A Human Blood Stem Cell Subset That Retains Memory of Inflammatory Stress
A Human Blood Stem Cell Subset That Retains Memory of Inflammatory Stress
Coffee Available
4:30–5:00 PM
British/Columbia Foyer
Epigenetic Training of Innate-like and Adaptive Lymphocytes (Joint)
5:00–6:45 PM
Columbia Ballroom
* Greg M Delgoffe, University of Pittsburgh
Session Chair
Session Chair
Ananda W. Goldrath, University of California, San Diego
Epigenetic Regulation of CD8 T Cell Differentiation and Function
Epigenetic Regulation of CD8 T Cell Differentiation and Function
* Colleen Lau, Cornell University
AP-1 Factors Epigenetically Regulate Innate and Adaptive Immune Memory Formation During Viral Infection
AP-1 Factors Epigenetically Regulate Innate and Adaptive Immune Memory Formation During Viral Infection
Maziar Divangahi, McGill University
Trained Immunity in Anti-Pathogen Responses
Trained Immunity in Anti-Pathogen Responses
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint)
6:45–7:00 PM
Columbia Ballroom
Social Hour with Lite Bites
7:00–8:00 PM
Pacific Ballroom, Vancouver Island Room
Poster Session 3
7:30–10:00 PM
Pacific Ballroom, Vancouver Island Room
Thursday, February 6, 2025
Fundraising
Departure
12:00–11:59 PM
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