Joint with: Stromal Immunology in Health and Disease
Fibrosis: Cross Organ Pathology and Pathways to Clinical Development
Feb 02–05, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Florian Rieder, Tatiana Kisseleva, and Marco Prunotto
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Feb 02–05, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Florian Rieder, Tatiana Kisseleva, and Marco Prunotto
Florian Rieder, MD
Cleveland Clinic
Tatiana Kisseleva, MD, PhD
University of California, San Diego
Marco Prunotto, PhD
Medicxi
Available Formats:
Supported by:
In Person
On Demand
***Meeting program subject to change.
Available Formats: = In Person = On DemandMonday, February 2, 2026
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Van Horne Foyer
Welcome Mixer
6:00–8:00 PM
Van Horne Foyer
Tuesday, February 3, 2026
Breakfast
7:00–8:00 AM
President's Hall
Welcome and Keynote Address (Joint)
8:00–9:00 AM
Van Horne A/B
Thomas A Wynn, Pfizer
Anti-Fibrotic Therapy: Thinking outside the TGF-beta box
Anti-Fibrotic Therapy: Thinking outside the TGF-beta box
From Fibroblasts to Fibrosis, and Back Again (Joint)
9:00–11:30 AM
Van Horne A/B
Boris Hinz, St. Michael's Hospital and University of Toronto
To Push or Pull? How the Mechanical Environment Affects Stromal Activation
To Push or Pull? How the Mechanical Environment Affects Stromal Activation
Sheila A. Stewart, Washington University School of Medicine
Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy
Stromal Reprogramming Sensitizes Metastatic Breast Cancer to Immunotherapy
Michael B. Brenner, Harvard Medical School
Notch and Wnt Signaling in Inflammatory Fibroblast-Mediated Pathology
Notch and Wnt Signaling in Inflammatory Fibroblast-Mediated Pathology
Gisli Jenkins, Imperial College London
Short Talk: DEMISTIFIing Multi-Organ Fibrosis
Short Talk: DEMISTIFIing Multi-Organ Fibrosis
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
Van Horne Foyer
Award Recipient Acknowledgement
9:50–9:55 AM
Van Horne A/B
Poster Setup
11:30–1:00 PM
Van Horne C
On Own for Lunch
11:30–2:30 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Symposia Spotlight 1
2:30–4:30 PM
Van Horne A
Anil Bhushan †, University of California, San Francisco
Osteoprotegerin Enables Pathological Senescent Progenitor Cells to Accumulate in Adipose Tissues, Promote Fibrosis, and Impair Glucose Homeostasis in Obesity
Osteoprotegerin Enables Pathological Senescent Progenitor Cells to Accumulate in Adipose Tissues, Promote Fibrosis, and Impair Glucose Homeostasis in Obesity
Khristian Bauer-Rowe †, STANFORD
Creeping Fat Adipocytes Can Transdifferentiate Into Pro-Fibrotic CTHRC1+ Fibroblasts in Intestinal Fibrosis
Creeping Fat Adipocytes Can Transdifferentiate Into Pro-Fibrotic CTHRC1+ Fibroblasts in Intestinal Fibrosis
Yao Zhang †, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Spatiotemporal Decoding Reveals Pro-Fibrotic Niche Transitions in Intestinal Fibrosis of Crohn’s Disease
Spatiotemporal Decoding Reveals Pro-Fibrotic Niche Transitions in Intestinal Fibrosis of Crohn’s Disease
Eric Nelius †, University of Zurich
HIF Signaling and Type 2 Innate Lymphoid Cell Effector Functions in the Lung: A Tale of Inflammation versus Regeneration
HIF Signaling and Type 2 Innate Lymphoid Cell Effector Functions in the Lung: A Tale of Inflammation versus Regeneration
Irina Ferapontova †, University of Zurich
Combined Ribosome Profiling and Immunopeptidomics of Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis reveal Therapeutic Vulnerabilities
Combined Ribosome Profiling and Immunopeptidomics of Fibroblasts from Patients with Idiopathic Pulmonary Fibrosis reveal Therapeutic Vulnerabilities
Valerie Horsley †, Yale University
Nuclear Mechanosensing Regulates Fibrosis Via Epigenetic Induction of Fibrotic Gene Expression
Nuclear Mechanosensing Regulates Fibrosis Via Epigenetic Induction of Fibrotic Gene Expression
Allen Wang †, University of California, San Diego
Single Cell Multiomics Reveals Drivers of Metabolic Dysfunction-Associated Steatohepatitis
Single Cell Multiomics Reveals Drivers of Metabolic Dysfunction-Associated Steatohepatitis
Souradipta Ganguly, Sanford Burnham Prebys Medical Discovery Institute
Mechanistic Understanding of MASLD-Driven Liver-Heart Dysfunction and its Reversibility
Mechanistic Understanding of MASLD-Driven Liver-Heart Dysfunction and its Reversibility
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Mechanisms of the Extracellular Matrix Environment Driving Disease
5:00–7:00 PM
Van Horne A
Rachel Lennon, University of Manchester
The Matrisome in Disease Pathology
The Matrisome in Disease Pathology
Natalie J. Torok, Stanford University
Viscoelasticity Promoting Cancer Progression
Viscoelasticity Promoting Cancer Progression
Detlef Schuppan, Beth Israel Deaconess Medical Center
Targeting the ECM to Treat Liver Fibrosis and Liver Cancer
Targeting the ECM to Treat Liver Fibrosis and Liver Cancer
Peleg Hasson, Technion - Israel Institute of Technology
Short Talk: Inhibiting Enzyme-Mediated Fibronectin Fibrillogenesis – A Novel Mechanism For Fibrosis Inhibition
Short Talk: Inhibiting Enzyme-Mediated Fibronectin Fibrillogenesis – A Novel Mechanism For Fibrosis Inhibition
Kate Hitpass Romero †, The University of Auckland
Short Talk: Age-Related Meningeal Extracellular Matrix Remodeling Compromises CNS Lymphatic Function;
Short Talk: Age-Related Meningeal Extracellular Matrix Remodeling Compromises CNS Lymphatic Function;
Social Hour with Dinner
7:00–8:00 PM
President's Hall
Poster Session 1
7:30–10:00 PM
Van Horne C
Wednesday, February 4, 2026
Breakfast
7:00–8:00 AM
President's Hall
Fibroblast Heterogenity across Organs: A Critical Basis for Discovery and Therapy Translation
8:00–10:30 AM
Van Horne A
Suzanne Devkota, Cedars-Sinai Medical Center
Microbiome Influence on Adipose Tissue Fibrosis
Microbiome Influence on Adipose Tissue Fibrosis
Florian Rieder, Cleveland Clinic
Fibroblast interactions in Intestinal Fibrosis
Fibroblast interactions in Intestinal Fibrosis
Stefanie Dimmeler, Institute of Cardiovascular Regeneration
Persistent Fibroblast Activation in the Hypertrophic Human Heart
Persistent Fibroblast Activation in the Hypertrophic Human Heart
Dean Sheppard, University of California, San Francisco
The Alveolar Fibroblast Lineage in Lung Inflammation and Fibrosis
The Alveolar Fibroblast Lineage in Lung Inflammation and Fibrosis
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Panel Discussion 1: Fibroblast Heterogeneity Across Organs
10:30–11:00 AM
Van Horne A
Poster Setup
11:00–1:00 PM
Van Horne C
On Own for Lunch
11:00–3:30 PM
Poster Viewing
1:00–10:00 PM
Van Horne C
Career Roundtable (Joint)
3:30–4:30 PM
Van Horne B
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Mechanisms that Drive the Progression and Regression of Fibrosis
5:00–7:00 PM
Van Horne A
Scott L Friedman, Icahn School of Medicine at Mount Sinai
Genetics linked with Fibrosis: Commonalities and Differences across Organs
Genetics linked with Fibrosis: Commonalities and Differences across Organs
Pilar Alcaide, University of Miami - Miller School of Medicine
The Crossroad of Inflammation and Fibrosis: Fibroblast and Immune Cell Interactions
The Crossroad of Inflammation and Fibrosis: Fibroblast and Immune Cell Interactions
Tatiana Kisseleva, University of California, San Diego
Mechanisms of Regression of Liver Fibrosis
Mechanisms of Regression of Liver Fibrosis
Blandine Baffert, UVA
Short Talk: ELMO1 Efferocytosis Protects Against Nephrotoxic Injury And Counters Fibrosis
Short Talk: ELMO1 Efferocytosis Protects Against Nephrotoxic Injury And Counters Fibrosis
Lesley A. Hill †, University of British Columbia
Short Talk: Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and their Impact on Liver Regeneration, Fibrosis and Resolution
Short Talk: Mechanisms Regulating Mesenchymal Stromal Cell Quiescence and their Impact on Liver Regeneration, Fibrosis and Resolution
Social Hour with Dinner
7:00–8:00 PM
President's Hall
Poster Session 2
7:30–10:00 PM
Van Horne C
Thursday, February 5, 2026
Breakfast
7:00–8:00 AM
President's Hall
Drug Development Pathways for Fibrosis – From Mechanisms to Medicine
8:00–10:30 AM
Van Horne A
David A Brenner, Sanford Burnham Prebys
Preclinical Models of Fibrosis: Are we able to Predict Therapy Response
Preclinical Models of Fibrosis: Are we able to Predict Therapy Response
Marco Prunotto, Medicxi
Drug Development Pathways for Fibrotic Diseases: Lessons Learned
Drug Development Pathways for Fibrotic Diseases: Lessons Learned
Andrea Sáez, Agomab Therapeutics
Local Delivery ALK5 Inhibitors to Treat Lung and Intestinal Fibrosis
Local Delivery ALK5 Inhibitors to Treat Lung and Intestinal Fibrosis
Shannon J Turley, Amgen Inc.
Elucidating Regulators of Pathogenic Stroma in Fibrotic and Inflammatory Diseases
Elucidating Regulators of Pathogenic Stroma in Fibrotic and Inflammatory Diseases
Coffee Break
9:00–9:20 AM
Van Horne Foyer
Panel Discussion 2: Preclinical Evaluation and Clinical Development in Fibrotic Diseases
10:30–11:00 AM
Van Horne A
On Own for Lunch
11:00–2:30 PM
Lysyl Oxidase Inhibitors in Fibrotic Diseases: A Two-Pronged Therapeutic Approach Targeting Collagen Cross-Linking and Cell Signallin
2:30–4:30 PM
Van Horne A
Na Li †, Shanghai University of Medicine and Health Sciences
Short Talk: Targeting Cholesterol Biosynthesis (DHCR7) and PPAR Signaling to Reverse Fibrosis and Inflammation Across MetALD/MASH Models
Short Talk: Targeting Cholesterol Biosynthesis (DHCR7) and PPAR Signaling to Reverse Fibrosis and Inflammation Across MetALD/MASH Models
Lorena Rosas †, The Ohio State University
Short Talk: BAX Activation by BTSA1.2 Drives Senolysis of CTHRC1-positive Fibroblasts to Alleviate Pulmonary Fibrosis
Short Talk: BAX Activation by BTSA1.2 Drives Senolysis of CTHRC1-positive Fibroblasts to Alleviate Pulmonary Fibrosis
Michael Jeffrey Podolsky †, Weill Cornell Medical College
SEL1L Regulates Lung Collagen Homeostasis
SEL1L Regulates Lung Collagen Homeostasis
Preeti Yadav, University of california san francisco
Arginase 1-Dependent Myeloid–Fibroblast Metabolic Coupling Drives Collagen Synthesis in Lung
Arginase 1-Dependent Myeloid–Fibroblast Metabolic Coupling Drives Collagen Synthesis in Lung
Rafael Contreras, University of Alabama at Birmingham
Centromeric and Mitochondrial DNA Instability as Upstream Triggers of cGAS-STING-Mediated Fibrosis in Systemic Sclerosis
Centromeric and Mitochondrial DNA Instability as Upstream Triggers of cGAS-STING-Mediated Fibrosis in Systemic Sclerosis
Geoffrey Teixeira, Alentis Therapeutics
Claudin-1: A Cross-Organ Driver of Barrier Dysfunction with Disease-Modifying, Pan-Organ Antifibrotic Potential
Claudin-1: A Cross-Organ Driver of Barrier Dysfunction with Disease-Modifying, Pan-Organ Antifibrotic Potential
Wolfgang Merkt †, University of Heidelberg
NK Cell Immunotherapy Reverses Lung Fibrosis by Eliminating Senescent Fibroblasts
NK Cell Immunotherapy Reverses Lung Fibrosis by Eliminating Senescent Fibroblasts
Wolfgang Jarolimek, Syntara Ltd
Lysyl Oxidase Inhibitors in Fibrotic Diseases: A Two-Pronged Therapeutic Approach Targeting Collagen Cross-Linking and Cell Signalling
Lysyl Oxidase Inhibitors in Fibrotic Diseases: A Two-Pronged Therapeutic Approach Targeting Collagen Cross-Linking and Cell Signalling
Coffee Available
4:30–5:00 PM
Van Horne Foyer
Therapeutic Modulation of Stromal Cell Function (Joint)
5:00–6:45 PM
Van Horne A/B
Viviana Cremasco, Novartis Biomedical Research
TGFb Neutralization and Tumor Stroma Modulation: From Bench to Bed
TGFb Neutralization and Tumor Stroma Modulation: From Bench to Bed
Yuval Rinkevich, Helmholtz Zentrum München, GmbH
Regenerative Medicine and Tissue Repair
Regenerative Medicine and Tissue Repair
Burkhard Ludewig, Kantonsspital St. Gallen
Immunomodulation of Myocardial Fibrosis
Immunomodulation of Myocardial Fibrosis
Meeting Wrap-Up: Outcomes and Future Directions (Organizers) (Joint)
6:45–7:00 PM
Van Horne A/B
Social Hour with Dinner
7:00–8:00 PM
President's Hall
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Friday, February 6, 2026
Departure
12:00–11:59 PM
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