Joint with: Metabolic Approaches to Chronic Liver Disease
Fibrosis Frontiers: From Basic Mechanisms to Precision Therapies
Mar 01–04, 2027 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
Rafael Kramann, Rebekka Schneider, and Neil C. Henderson
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Mar 01–04, 2027 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: Rafael Kramann, Rebekka Schneider, and Neil C. Henderson
Rafael Kramann, MD, PhD
RWTH Aachen University
Rafael Kramann, M.D., Ph.D., FASN, FERA is a physician-scientist and Professor of Medicine at RWTH Aachen University, where he chairs the Department of Medicine II and directs the Center for Phase Transition in Chronic Disease. His research focuses on mechanisms driving multi-organ fibrosis, integrating single-cell and spatial genomics, gene editing, systems biology and ex vivo disease models to identify therapeutic targets. He has authored over 250 scientific publications, founded biotechnology companies focused on antifibrotics, and has extensive experience leading international research consortia and organizing interdisciplinary scientific meetings.
Rebekka Schneider, MD, PhD
Erasmus MC
Rebekka K. Schneider, M.D., Ph.D., is a physician-scientist and Professor of Cell and Tumor Biology and Director of the Department of Cell and Tumor Biology at RWTH Aachen University and Erasmus MC. She leads a translational research program investigating fibrosis, malignant niche remodeling and phase transitions in chronic disease, using single-cell and spatial genomics, functional and systems biology, gene perturbation and advanced disease models. She drives clinical translation, including investigator-initiated trials, has co-founded a biotechnology spinout developing anti-fibrotic therapies, and holds leadership roles across international scientific, editorial, and advisory committees.
Neil C. Henderson, MD, PhD
Institute of Regeneration and Repair, University of Edinburgh
Neil C. Henderson, M.D., Ph.D., is Chair of Tissue Repair and Regeneration at the Institute for Regeneration and Repair at the University of Edinburgh, and an Honorary Consultant Hepatologist. His laboratory studies the cellular and molecular mechanisms that drive organ fibrosis, as well as the pathways underlying wound healing and tissue regeneration, using single-cell and spatial genomics to define pro-fibrogenic cell populations in the human liver, lung, and kidney. He completed his Ph.D. at the MRC Centre for Inflammation Research in Edinburgh and postdoctoral training at the University of California, San Francisco. He is a Fellow of the Academy of Medical Sciences and the American Association for the Study of Liver Diseases.
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandBooking Function
Merchandise Options
Registration Options
Monday, March 1, 2027
Fundraising
Registration
4:00–8:00 PM
Longs Peak Foyer
Welcome Mixer
6:00–8:00 PM
Longs Peak Foyer
Tuesday, March 2, 2027
Breakfast
7:00–8:00 AM
Quandary Peak
Welcome Remarks
8:00–8:10 AM
Longs Peak
Keynote Address
8:10–9:00 AM
Longs Peak
Carine Boustany, Boehringer Ingelheim
Drug Discovery in Fibrosis
Drug Discovery in Fibrosis
Developing Novel Therapeutics in Fibrotic Disease
9:00–11:15 AM
Longs Peak
Thomas A Wynn, Pfizer
Anti-Inflammatory Therapeutics in Organ Fibrosis
Anti-Inflammatory Therapeutics in Organ Fibrosis
Paul J Yaworsky, Mediar Therapeutics
Targeting EphrinB2 and SMOC2 in Fibrotic Disease
Targeting EphrinB2 and SMOC2 in Fibrotic Disease
Catherine Hines, GlaxoSmithKline
Biomarkers and Imaging as Readouts in Clinical Testing
Biomarkers and Imaging as Readouts in Clinical Testing
Short Talk(s) Chosen from Abstracts
Coffee Break
9:30–9:50 AM
Longs Peak Foyer
Jessica Langer, Helmsley Trust Introduction
11:15–11:20 AM
Longs Peak
Meet the Editors
11:25–12:25 PM
Longs Peak
Poster Setup
12:25–1:00 PM
Quandary Peak
On Own for Lunch
12:25–2:30 PM
Poster Viewing
1:00–10:00 PM
Quandary Peak
Symposia Spotlight 1
2:30–4:30 PM
Longs Peak
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
From Identification of Novel Therapies to Early Clinical Testing in Fibrosis
5:00–7:00 PM
Longs Peak
Rachel Lennon, University of Manchester
Novel Therapies for Scarring of the Glomerulus
Novel Therapies for Scarring of the Glomerulus
Rebekka Schneider, Erasmus MC
From Single Cell Genomics to Novel Targets in Fibrotic Disease and Clinical Testing
From Single Cell Genomics to Novel Targets in Fibrotic Disease and Clinical Testing
Frank A Anania, US Food and Drug Administration
Regulatory Steps Towards Approval of Novel Antifibrotic Therapies
Regulatory Steps Towards Approval of Novel Antifibrotic Therapies
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Quandary Peak
Poster Session 1
7:30–10:00 PM
Quandary Peak
Wednesday, March 3, 2027
Breakfast
7:00–8:00 AM
Quandary Peak
Mapping Fibrotic Disease using Single Cell and Spatial Genomics
8:00–11:00 AM
Longs Peak
Rafael Kramann, RWTH Aachen University
Mapping Kidney and Cardiac Fibrosis to Identify Novel Therapeutic Targets
Mapping Kidney and Cardiac Fibrosis to Identify Novel Therapeutic Targets
Neil C. Henderson, Institute of Regeneration and Repair, University of Edinburgh
Spatial Mapping of Human Liver Fibrosis
Spatial Mapping of Human Liver Fibrosis
Jörg H Distler, University Hospital Düsseldorf
Mapping Pulmonary and Skin Fibrosis
Mapping Pulmonary and Skin Fibrosis
Benjamin D. Humphreys, Washington University
Single Cell and Spatial Genomics to Map Kidney Fibrosis
Single Cell and Spatial Genomics to Map Kidney Fibrosis
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
Panel Discussion 1: How to Launch a Startup
11:10–12:10 PM
Longs Peak
Rafael Kramann, RWTH Aachen University
Rebekka Schneider, Erasmus MC
Neil C. Henderson, Institute of Regeneration and Repair, University of Edinburgh
Paul J Yaworsky, Mediar Therapeutics
Poster Setup
12:10–1:00 PM
Quandary Peak
On Own for Lunch
12:10–3:00 PM
Poster Viewing
1:00–10:00 PM
Quandary Peak
Career Roundtable
3:00–4:30 PM
Longs Peak
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Fibrosis in Cancer and Aging
5:00–7:00 PM
Longs Peak
Natalie J. Torok, Stanford University
The Role of Matrix in Liver Cancer Progression and Aging
The Role of Matrix in Liver Cancer Progression and Aging
Simón Méndez-Ferrer, University of Cambridge
Mechanisms of Fibrosis Hematopoietic Malignancies
Mechanisms of Fibrosis Hematopoietic Malignancies
Melanie Koenigshoff, University of Pittsburgh
Role of Senescence and Aging in Pulmonary Fibrosis
Role of Senescence and Aging in Pulmonary Fibrosis
Short Talk(s) Chosen from Abstracts
Social Hour with Dinner
7:00–8:00 PM
Quandary Peak
Poster Session 2
7:30–10:00 PM
Quandary Peak
Thursday, March 4, 2027
Breakfast
7:00–8:00 AM
Quandary Peak
Organ Specific and Conserved Mechanisms of Organ Fibrosis
8:00–11:00 AM
Longs Peak
Valerie Horsley, Yale University
Mechanisms of Skin Fibrosis
Mechanisms of Skin Fibrosis
Meritxell Huch, Max Planck Institute of Molecular Cell Biology and Genetics
Modeling Fibrosis ex vivo
Modeling Fibrosis ex vivo
Katalin Susztak, University of Pennsylvania
Mechanisms of Kidney Fibrosis
Mechanisms of Kidney Fibrosis
Kory J. Lavine, Washington University School of Medicine
Mechanisms of Cardiac Fibrosis
Mechanisms of Cardiac Fibrosis
Short Talk(s) Chosen from Abstracts
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
Panel Discussion 2: Why Are We not Seeing Progress / Therapeutic Success in Some Areas? What Are We Missing and How can We Address these Challenges/ Lessons from Clinical Trials?
11:10–12:10 PM
Longs Peak
On Own for Lunch
12:10–2:30 PM
Symposia Spotlight 2: AI & Big Data in Drug Development
2:30–4:30 PM
Longs Peak
Short Talks Chosen from Abstracts
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Need for Multimodal Therapies, New Modalities and Lessons Learned from Clinical Trials
5:00–6:45 PM
Longs Peak
Grant Budas, Gilead
Multimodal Therapies for Fibrotic Disease
Multimodal Therapies for Fibrotic Disease
Vincent F Fiore, Boehringer Ingelheim
Mechanisms of Fibrosis in IBD, Boehringer Ingelheim
Mechanisms of Fibrosis in IBD, Boehringer Ingelheim
Scott L Friedman, Icahn School of Medicine at Mount Sinai
Lessons Learned from Clinical Trials and Regulatory Aspects in Fibrotic Disease
Lessons Learned from Clinical Trials and Regulatory Aspects in Fibrotic Disease
Short Talk(s) Chosen from Abstracts
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Longs Peak
Social Hour with Dinner
7:00–8:00 PM
Quandary Peak
Entertainment
8:00–9:00 PM
Quandary Peak
Cash Bar
8:00–9:00 PM
Quandary Peak
Friday, March 5, 2027
Departure
12:00–11:59 PM
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