Joint with: Aging: Immune Function and Organ Health
Innate Immunity: Diversity in Host Defense and Disease
Mar 22–25, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers:
Kate Schroder, Jonathan C. Kagan, and Petr Broz
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Mar 22–25, 2026 | Fairmont Banff Springs, Banff, AB, Canada
Scientific Organizers: Kate Schroder, Jonathan C. Kagan, and Petr Broz
Kate Schroder, PhD
University of Queensland
Jonathan C. Kagan, PhD
Harvard Medical School
Petr Broz, PhD
University of Lausanne
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandSunday, March 22, 2026
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
Riverview Lounge
Welcome Mixer
6:00–8:00 PM
Riverview Lounge
Monday, March 23, 2026
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Welcome Remarks (Joint)
8:00–8:10 AM
Cascade Ballroom
Keynote Address (Joint)
8:10–9:00 AM
Cascade Ballroom
Beth Stevens, Boston Children's Hospital, Harvard Medical School
Macrophage-Microglia Crosstalk in Aging
Macrophage-Microglia Crosstalk in Aging
Targeting Innate Immunity for Healthy Aging (Joint)
9:00–11:30 AM
Cascade Ballroom
Katrin Andreasson, Stanford University
Talk Title to be Announced
Talk Title to be Announced
Andrea Ablasser, Ecole Polytechnique Fédérale de Lausanne
cGAS-STING Modulators and Cell Senescence
cGAS-STING Modulators and Cell Senescence
Oliver Hahn, Calico Life Sciences LLC
Short Talk: Decoding Drivers of Microglia Aging Via Heterochronic Myeloid Cell Replacement
Short Talk: Decoding Drivers of Microglia Aging Via Heterochronic Myeloid Cell Replacement
Cecilia G de Magalhaes, Brigham and Women's Hospital - Harvard Medical School
Short Talk: Targeting Brain Biological Age and Function through Young Microglia Transplantation
Short Talk: Targeting Brain Biological Age and Function through Young Microglia Transplantation
Susan B Carpenter, University of California, Santa Cruz
Short Talk: The Long Noncoding RNA, GAPLINC, Functions in Trans as a Critical Regulator of Metabolic and Inflammatory Genes in Macrophages
Short Talk: The Long Noncoding RNA, GAPLINC, Functions in Trans as a Critical Regulator of Metabolic and Inflammatory Genes in Macrophages
Byron F Mobbs †, The institute for Molecular Bioscience, The University of Queensland
Short Talk: Inflammasome Inhibitors in Disease: Is There a Therapeutic Trade-off of Compromised Host Defence?
Short Talk: Inflammasome Inhibitors in Disease: Is There a Therapeutic Trade-off of Compromised Host Defence?
Coffee Break
9:30–9:50 AM
Riverview Lounge
Award Recipient Acknowledgement
9:50–9:55 AM
Cascade Ballroom
Poster Setup
11:30–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:30–5:00 PM
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Symposia Spotlight 1
2:30–4:30 PM
Cascade Ballroom
Rune Hartmann †, Aarhus University
STING Recruits the NEMO/IKK Complex Via M1-Linked Ubiquitin to Induce NF-κB Activation
STING Recruits the NEMO/IKK Complex Via M1-Linked Ubiquitin to Induce NF-κB Activation
Ana Kitanovic, German Rheumatology Research Center Berlin
Decoding Innate Immune Heterogeneity Using Multi-omics: Early Mechanistic Profiles from an Ongoing Precision-Immunology Program
Decoding Innate Immune Heterogeneity Using Multi-omics: Early Mechanistic Profiles from an Ongoing Precision-Immunology Program
Chang Yoon Moon †, Icahn School of Medicine
Unlike Macrophages, Dying Cell-derived Polyamines Modulate Dendritic Cell Phagocytosis and Adaptive Priming
Unlike Macrophages, Dying Cell-derived Polyamines Modulate Dendritic Cell Phagocytosis and Adaptive Priming
Ella L Brunsting †, University of Maryland, Baltimore
Type I Interferon Transcriptionally Suppresses Immune Response Genes Through ISGF3 Independent Mechanisms
Type I Interferon Transcriptionally Suppresses Immune Response Genes Through ISGF3 Independent Mechanisms
Prasanna Suresh, University of Cambridge
Toll-like Receptor Signalling Outcomes are Directed by the Stoichiometry of the Endogenous TRIFosome
Toll-like Receptor Signalling Outcomes are Directed by the Stoichiometry of the Endogenous TRIFosome
Heather Teague, National Institutes of Health
Heterogeneity of Human Pulmonary Neutrophils Following Endotoxin Exposure
Heterogeneity of Human Pulmonary Neutrophils Following Endotoxin Exposure
Tsaffrir Zor †, Tel Aviv University
The Endogenous Sphingolipid Sulfatide Affects Inflammation Via Multiple Receptors – TLR4/MD-2, TLR2 and the Inflammasome
The Endogenous Sphingolipid Sulfatide Affects Inflammation Via Multiple Receptors – TLR4/MD-2, TLR2 and the Inflammasome
Emma L Kuan †, Allen Institute for Immunology
Dissecting Type I and II Interferon Impacts on Human Immune Cells in Disease by a Cell Type-Specific Interferon Response Atlas
Dissecting Type I and II Interferon Impacts on Human Immune Cells in Disease by a Cell Type-Specific Interferon Response Atlas
Coffee Available
4:30–5:00 PM
Riverview Lounge
Cell Type-Specific Innate Immune Responses
5:00–7:00 PM
Cascade Ballroom
Arturo Zychlinsky, Max Planck Institute for Infection Biology
NETosis and Inflammation
NETosis and Inflammation
Veit Hornung, Ludwig-Maximilians-University Munich
The CARD8 Inflammasome Drives T Cell Death
The CARD8 Inflammasome Drives T Cell Death
Jose Ordovas-Montanes, Boston Children's Hospital and Harvard Medical School
Deconstructing Barrier Tissues Identifies Tipping Points
Deconstructing Barrier Tissues Identifies Tipping Points
Mariana J. Kaplan, NIAMS, National Institutes of Health
Neutrophil Dysregulation in Systemic Autoimmunity
Neutrophil Dysregulation in Systemic Autoimmunity
Social Hour with Dinner
7:00–8:00 PM
Alberta/New Brunswick
Poster Session 1
7:30–10:00 PM
Alberta/New Brunswick
Tuesday, March 24, 2026
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Innate Immune Signaling I: Inflammatory Response
8:00–11:00 AM
Cascade Ballroom
Jelena Bezbradica Mirkovic, University of Oxford
Innate Cell-Cell Crosstalk in Sterile Inflammation
Innate Cell-Cell Crosstalk in Sterile Inflammation
Alan P Watt, NodThera
NLRP3 Inhibitors for the Treatment of CardioMetabolic Disease and Obesity
NLRP3 Inhibitors for the Treatment of CardioMetabolic Disease and Obesity
Jonathan C. Kagan, Harvard Medical School
Regulation of Innate Immunity
Regulation of Innate Immunity
Michael Crackower, Ventus Therapeutics
Therapeutic Development of Inhibitors of Canonical and Non-Canonical Inflammasome Signaling
Therapeutic Development of Inhibitors of Canonical and Non-Canonical Inflammasome Signaling
Shuntaro Abe, Hokkaido university
Short Talk: Regulatory Mechanisms of Intracellular Protein Carboxylation and Its Role in Antiviral Response
Short Talk: Regulatory Mechanisms of Intracellular Protein Carboxylation and Its Role in Antiviral Response
Cristhian Cadena, Genentech
Short Talk: IRF2 Degradation Tunes the Innate Immune Response
Short Talk: IRF2 Degradation Tunes the Innate Immune Response
Coffee Break
9:00–9:20 AM
Riverview Lounge
Poster Setup
11:00–1:00 PM
Alberta/New Brunswick
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Alberta/New Brunswick
Panel: Perspectives: Personalized Medicine & Patient-Centered Strategies (Joint)
1:45–2:45 PM
Cascade Ballroom
Career Roundtable (Joint)
3:00–4:30 PM
Alhambra Ballroom
Coffee Break with Hot Chocolate, Firepits & Mountain Views
4:00–5:00 PM
Conservatory Terrace
Inflammaging (Joint)
5:00–7:00 PM
Cascade Ballroom
Vishva M. Dixit, Genentech, Inc.
The Circuitry of Inflammatory Cell Death Signaling
The Circuitry of Inflammatory Cell Death Signaling
Eicke Latz, University of Bonn
Inflammasomes in Innate Immune Memory and Inflammaging
Inflammasomes in Innate Immune Memory and Inflammaging
Emily Goldberg, UCSF
Inflammaging
Inflammaging
Julia Belk †, Stanford
Short Talk: Origins of Microglia in Human Aging
Short Talk: Origins of Microglia in Human Aging
Kirsten Kenney, Institute for Molecular Bioscience
Short Talk: Stress, Diet and the Inflammasome: NLRP3’s Role in Maintaining Hepatic Homeostasis
Short Talk: Stress, Diet and the Inflammasome: NLRP3’s Role in Maintaining Hepatic Homeostasis
Social Hour with Dinner
7:00–8:00 PM
Alberta/New Brunswick
Poster Session 2
7:30–10:00 PM
Alberta/New Brunswick
Wednesday, March 25, 2026
Breakfast
7:00–8:00 AM
Alberta/New Brunswick
Innate Immune Signaling II: Inflammatory Cell Death
8:00–11:00 AM
Cascade Ballroom
Kate Schroder, University of Queensland
Cell Explosion by Pyroptosis Escalates Immune Responses
Cell Explosion by Pyroptosis Escalates Immune Responses
James M. Murphy, Walter and Eliza Hall Institute of Medical Research
Getting Better- The Emergence of the Necroptotic Cell Death Effector, MLKL, as a Therapeutic Target in Inflammatory Disease
Getting Better- The Emergence of the Necroptotic Cell Death Effector, MLKL, as a Therapeutic Target in Inflammatory Disease
Kaiwen Chen, National University of Singapore
Multiple Cell Death Pathways Coordinate Antimicrobial Responses
Multiple Cell Death Pathways Coordinate Antimicrobial Responses
Ella N Hartenian, University of Lausanne
Short Talk: Membrane Tension drives Opening of NINJ1 Lesions in Dying Cells
Short Talk: Membrane Tension drives Opening of NINJ1 Lesions in Dying Cells
Benjamin E Steinberg, Hospital for Sick Children
Short Talk: Ninjurin-1 Mediated Plasma Membrane Rupture is Required for Sepsis-Induced Blood-Brain Barrier Permeabilization
Short Talk: Ninjurin-1 Mediated Plasma Membrane Rupture is Required for Sepsis-Induced Blood-Brain Barrier Permeabilization
Kyungsub Kim †, Tufts University
Short Talk: Interplay of Shigella T3SS Effectors in Inhibition of Epithelial Cell Death
Short Talk: Interplay of Shigella T3SS Effectors in Inhibition of Epithelial Cell Death
Mathilde Hansen †, NTNU
Short Talk: NINJ1 Is Activated by Mycobacterium tuberculosis ESX-1 Secreted Effector EsxA and Mediates Necrosis of Infected Human Macrophages
Short Talk: NINJ1 Is Activated by Mycobacterium tuberculosis ESX-1 Secreted Effector EsxA and Mediates Necrosis of Infected Human Macrophages
Coffee Break
9:00–9:20 AM
Riverview Lounge
On Own for Lunch
11:00–5:00 PM
Symposia Spotlight 2
2:30–4:30 PM
Cascade Ballroom
Fiachra Humphries, UMass Chan medical school
Non-canonical TLR Signaling Restricts Cytosolic LPS Detection
Non-canonical TLR Signaling Restricts Cytosolic LPS Detection
Daniel Lingwood, Harvard Medical School
Spatial Control Of Cytokine Activation To Promote Immune Defense At The Respiratory Surface
Spatial Control Of Cytokine Activation To Promote Immune Defense At The Respiratory Surface
Wenqing Zhou, UMass Chan Medical School
RORgt+ APCs Sense Gut Microbiota Through STING to Initiate Immune Tolerance
RORgt+ APCs Sense Gut Microbiota Through STING to Initiate Immune Tolerance
Andrew Sandstrom, University of Texas Southwestern Medical Center
Recognition of Viral E3 Ligase Activity by the NLRP1 Inflammasome
Recognition of Viral E3 Ligase Activity by the NLRP1 Inflammasome
Francis L Fontanilla †, University of Nebraska Medical Center
Chlamydia trachomatis Modulation of Epithelial Innate Immunity: Implications on Host Interferon Response & Pathogen Dissemination
Chlamydia trachomatis Modulation of Epithelial Innate Immunity: Implications on Host Interferon Response & Pathogen Dissemination
Marie Siwicki, university of Calgary
Neutrophil Diversity in the Host Defense Niche
Neutrophil Diversity in the Host Defense Niche
Benjamin tenOever, NYU School of Medicine
Fidelity Errors as the Nexus of Innate Sensing, Viral Fitness, and Evolution
Fidelity Errors as the Nexus of Innate Sensing, Viral Fitness, and Evolution
Jingru Sun, Washington State University
Neuronal NMUR-1 Signaling Regulates Innate Immune Specificity and Energy Homeostasis in Host Defense
Neuronal NMUR-1 Signaling Regulates Innate Immune Specificity and Energy Homeostasis in Host Defense
Coffee Available
4:30–5:00 PM
Riverview Lounge
Cell Autonomous Innate Immunity
5:00–6:30 PM
Cascade Ballroom
Russell E Vance, University of California, Berkeley
Pattern recognition without receptors
Pattern recognition without receptors
Petr Broz, University of Lausanne
Inflammasomes as Guardians Against Intracellular Pathogens
Inflammasomes as Guardians Against Intracellular Pathogens
Charlotte Odendall, King's College London
EMBO Young Investigator Lecture: Interferon-Mediated Defense Against Enteric Bacterial Pathogens
EMBO Young Investigator Lecture: Interferon-Mediated Defense Against Enteric Bacterial Pathogens
Closing Keynote Address
6:30–7:15 PM
Cascade Ballroom
Kate A Fitzgerald, University of Massachusetts Medical School
Molecular Mechanisms Controlling Inflammatory Responses
Molecular Mechanisms Controlling Inflammatory Responses
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
7:15–7:30 PM
Cascade Ballroom
Social Hour with Dinner
7:30–8:30 PM
Alberta/New Brunswick
Entertainment
8:00–11:00 PM
Cash Bar
8:00–11:00 PM
Thursday, March 26, 2026
Departure
12:00–11:59 PM
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