Joint with: Autophagy: Mechanisms to Therapy
Membrane Dynamics, Repair and Disease
Feb 02–05, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers:
James H. Hurley, Phyllis Hanson, and Gilbert Di Paolo
Livestream
In Person
On Demand
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Feb 02–05, 2026 | Keystone Resort, Keystone, CO, United States
Scientific Organizers: James H. Hurley, Phyllis Hanson, and Gilbert Di Paolo
James H. Hurley, PhD
University of California, Berkeley
Phyllis Hanson, MD, PhD
University of Michigan
Gilbert Di Paolo, PhD
Denali Therapeutics Inc.
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandMonday, February 2, 2026
Fundraising
Booking Function
Merchandise Options
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Registration
4:00–8:00 PM
Longs Peak Foyer
Welcome Mixer
6:00–8:00 PM
Longs Peak Foyer
Tuesday, February 3, 2026
Breakfast
7:00–8:00 AM
Quandary Peak
Welcome Remarks (Joint)
8:00–8:10 AM
Longs Peak
Keynote Address (Joint)
8:10–9:00 AM
Longs Peak
* Anne Simonsen, University of Oslo
* James H. Hurley, University of California, Berkeley
Erika L Holzbaur, University of Pennsylvania
Mitophagy and Lysophagy in Neurons
Mitophagy and Lysophagy in Neurons
Intersections of Specialized Autophagy Mechanisms (Joint)
9:00–11:15 AM
Longs Peak
* Anne Simonsen, University of Oslo
Session Chair
Session Chair
Felix Randow, Medical Research Council
Selective Autophagy through Ubiquitylation of Non-protein Targets
Selective Autophagy through Ubiquitylation of Non-protein Targets
Oliver Florey, Babraham Institute
Conjugation of ATG8s to Single Membranes
Conjugation of ATG8s to Single Membranes
Jayanta Debnath, University of California, San Francisco
Non-Canonical ATG8ylation and Secretion
Non-Canonical ATG8ylation and Secretion
Coffee Break
9:30–9:50 AM
Longs Peak Foyer
Poster Setup
11:15–1:00 PM
Quandary Peak
On Own for Lunch
11:15–2:30 PM
Poster Viewing
1:00–10:00 PM
Quandary Peak
Symposia Spotlight 1 (Joint)
2:30–4:30 PM
Longs Peak
* James A Olzmann, University of California, Berkeley
Session Chair
Session Chair
* Oliver Florey, Babraham Institute
Session Chair
Session Chair
Rupert Beale, The Francis Crick Institute
Targeting of ATG8s to Different Compartments Mediated by V-ATPase V1H Recruitment of ATG16L1
Targeting of ATG8s to Different Compartments Mediated by V-ATPase V1H Recruitment of ATG16L1
Ruben D Elias, Scripps Research
LLOMe Exposure Results in the Cathepsin C-Mediated Intralysosomal Generation of Membranolytic Amyloid Fibrils Alongside Promiscuous Dipeptide Ligation
LLOMe Exposure Results in the Cathepsin C-Mediated Intralysosomal Generation of Membranolytic Amyloid Fibrils Alongside Promiscuous Dipeptide Ligation
Andreas Jenny, Albert Einstein College of Medicine
The role of Lamp1 in the Non-Cell Autonomous Regulation of Endo-Lysosomal Acidification
The role of Lamp1 in the Non-Cell Autonomous Regulation of Endo-Lysosomal Acidification
Minghao Chen, UC Berkeley
Structure and Activation of the Human Autophagy-initiating ULK1C:PI3KC3-C1 Supercomplex
Structure and Activation of the Human Autophagy-initiating ULK1C:PI3KC3-C1 Supercomplex
Michael G Hanna, Penn State University
Bridge-like Lipid transfer Protein 3A (BLTP3A) in the Response to Lysosome Damage
Bridge-like Lipid transfer Protein 3A (BLTP3A) in the Response to Lysosome Damage
Ya-Cheng Liao, Columbia University Medical Center
ANXA11 Coordinates RNA Granules and mRNA Translation at Damaged Lysosomes
ANXA11 Coordinates RNA Granules and mRNA Translation at Damaged Lysosomes
Jonathan X Meng, Gladstone Institutes
Metabolism-Dependent GARP Complex Protection of Neurons Against Alpha-Synuclein Toxicity
Metabolism-Dependent GARP Complex Protection of Neurons Against Alpha-Synuclein Toxicity
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Mitochondria and Ferroptosis
5:00–7:00 PM
Grays Peak
* Judith Frydman, Stanford University
Session Chair
Session Chair
Ana J. García-Sáez, Max Planck Institute of Biophysics
Mitochondrial Membrane Dynamics in Cell Death
Mitochondrial Membrane Dynamics in Cell Death
James A Olzmann, University of California, Berkeley
Guardians of the Membrane: Preventing Lipid Peroxidation and Ferroptosis
Guardians of the Membrane: Preventing Lipid Peroxidation and Ferroptosis
Whitney Henry, Massachusetts Institute of Technology
Peroxisomes, Membrane Lipids, and Iron: Tuning Ferroptosis Vulnerability in Cancer
Peroxisomes, Membrane Lipids, and Iron: Tuning Ferroptosis Vulnerability in Cancer
Martin Graef, Cornell University
Short Talk: Mitophagy Scales Mitochondrial Network Size
Short Talk: Mitophagy Scales Mitochondrial Network Size
Shilong Yang, Rutgers the State University of New Jersey
Short Talk: Membrane Phase Separation Drives NINJ1 In-Plane Assembly
Short Talk: Membrane Phase Separation Drives NINJ1 In-Plane Assembly
Social Hour with Dinner
7:00–8:00 PM
Quandary Peak
Poster Session 1
7:30–10:00 PM
Quandary Peak
Wednesday, February 4, 2026
Breakfast
7:00–8:00 AM
Quandary Peak
Keynote Address (Joint)
8:00–8:45 AM
Longs Peak
* Phyllis Hanson, University of Michigan
Session Chair
Session Chair
* Dan Baird, Casma Tx
Session Chair
Session Chair
Harald Stenmark, Oslo University Hospital
An ER for Injured Lysosomes
An ER for Injured Lysosomes
Lysosomal Membrane Repair: ESCRTs and Beyond (Joint)
8:45–11:00 AM
Longs Peak
* Dan Baird, Casma Tx
Session Chair
Session Chair
Phyllis Hanson, University of Michigan
Calcium and ESCRTs in Membrane Repair
Calcium and ESCRTs in Membrane Repair
James H. Hurley, University of California, Berkeley
ESCRTs as Suppressors of Amyloid Spread
ESCRTs as Suppressors of Amyloid Spread
Claudio Bussi, Nanyang Technological University
Biomolecular Condensates and Lysosome Repair
Biomolecular Condensates and Lysosome Repair
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
Award Recipient Acknowledgement
9:20–9:25 AM
Longs Peak
On Own for Lunch
11:00–1:00 PM
Poster Setup
11:00–1:00 PM
Quandary Peak
Poster Viewing
1:00–10:00 PM
Quandary Peak
Career Roundtable (Joint)
3:00–4:30 PM
Longs Peak
Joseph D. Mancias, Dana-Farber Cancer Institute
Associate Professor & Attending Radiation Oncologist
Associate Professor & Attending Radiation Oncologist
Samantha Nelson, Cell Press
Scientific Editor
Scientific Editor
Pei-I Tsai, ASAP/Berkeley
Neuroscientist and Cell Biologist
Neuroscientist and Cell Biologist
Nicholas T Hertz, Montara Therapeutics, Inc.
President & CEO
President & CEO
Coffee Available
4:30–5:00 PM
Longs Peak Foyer
Membrane Damage and Resilience
5:00–7:00 PM
Grays Peak
* Hijai Regina Shin, University of Texas Southwestern Medical Center
Session Chair
Session Chair
Patrick Lusk, Yale University
Nuclear Membrane Rupture and Resilience
Nuclear Membrane Rupture and Resilience
Vishva M. Dixit, Genentech, Inc.
Membrane Damage and Inflammation
Membrane Damage and Inflammation
Feng Shao, National Institute of Biological Sciences
Membrane Damage in Infection and Innate Immunity
Membrane Damage in Infection and Innate Immunity
Aakriti Jain, UT Southwestern Medical Center
Short Talk: LASER Senses Lysosomal Damage and Initiates ESCRT Assembly for Membrane Repair
Short Talk: LASER Senses Lysosomal Damage and Initiates ESCRT Assembly for Membrane Repair
Suhong Xu, Zhejiang University
Short Talk: ESCRT-III Oligomerization Restores Membrane Tension to Facilitate Membrane Repair
Short Talk: ESCRT-III Oligomerization Restores Membrane Tension to Facilitate Membrane Repair
Social Hour with Dinner
7:00–8:00 PM
Quandary Peak
Poster Session 2
7:30–10:00 PM
Quandary Peak
Thursday, February 5, 2026
Breakfast
7:00–8:00 AM
Quandary Peak
Membrane Homeostasis and Neurodegeneration
8:00–11:00 AM
Grays Peak
* Vishva M. Dixit, Genentech, Inc.
Session Chair
Session Chair
Alyssa Coyne, Johns Hopkins University School of Medicine
Overactivation of ESCRT-III Nuclear Surveillance in Neurodegeneration: Mechanistic Insights and Therapeutic Targeting
Overactivation of ESCRT-III Nuclear Surveillance in Neurodegeneration: Mechanistic Insights and Therapeutic Targeting
Shawn Ferguson, Yale University
LRRK2-Dependent Responses to Lysosome Stress
LRRK2-Dependent Responses to Lysosome Stress
Judith Frydman, Stanford University
ESCRTs and Proteostasis
ESCRTs and Proteostasis
Angela Cacace, Arvinas Inc
LRRK2 Degradation in the Brain Reprograms Lysosomal and Neurodegenerative Pathways – Discovery to Clinical Translation
LRRK2 Degradation in the Brain Reprograms Lysosomal and Neurodegenerative Pathways – Discovery to Clinical Translation
Utpal Das, University of California San Diego
Short Talk: Aβ Induces Endolysosomal Dysfunction by Prompting Hyperphosphorylation of RabGTPases, Disrupting Membrane Integrity
Short Talk: Aβ Induces Endolysosomal Dysfunction by Prompting Hyperphosphorylation of RabGTPases, Disrupting Membrane Integrity
Patrick A. Lewis, Royal Veterinary College
Short Talk: A Role for GPNMB in Sensing and Responding to Lysosomal Stress
Short Talk: A Role for GPNMB in Sensing and Responding to Lysosomal Stress
Coffee Break
9:00–9:20 AM
Longs Peak Foyer
On Own for Lunch
11:00–2:30 PM
Symposia Spotlight 2 (Joint)
2:30–4:30 PM
Longs Peak
* Ivan Dikic, Goethe University Medical School
Session Chair
Session Chair
* Martin Graef, Cornell University
Session Chair
Session Chair
Zi Gao, Scripps Research
TAX1BP1 Emerges as a Candidate Proteaphagy Receptor Through Global Protein Turnover Mapping
TAX1BP1 Emerges as a Candidate Proteaphagy Receptor Through Global Protein Turnover Mapping
Chris Shoemaker, Dartmouth College
Decoding and Predicting Autophagy Interactions at Scale
Decoding and Predicting Autophagy Interactions at Scale
Stephanie Spada, NIH/Oxford
TRIM5α Couples Membrane Targeting with Noncanonical Autophagy to Restrict Viral Infection
TRIM5α Couples Membrane Targeting with Noncanonical Autophagy to Restrict Viral Infection
Simon Wilkinson, University of Edinburgh
FAM134B Clustering and ER-phagy Driven by Multi-functional, Phase-separated Degradation Hubs
FAM134B Clustering and ER-phagy Driven by Multi-functional, Phase-separated Degradation Hubs
Spencer Nelson, University of California, San Diego
Protein Ubiquitination and Phase Separation Regulate Membrane Scission in a Minimally Reconstructed HIV-1 Budding System
Protein Ubiquitination and Phase Separation Regulate Membrane Scission in a Minimally Reconstructed HIV-1 Budding System
Berrak Ugur, Yale University
Exploring Targeting Mechanisms and Potential Function of VPS13B in Golgi Membrane Dynamics
Exploring Targeting Mechanisms and Potential Function of VPS13B in Golgi Membrane Dynamics
Noah Weisleder, University of Kentucky
Modified Antibody Fusion Proteins with Tripartite Motif Family Protein 72 (TRIM72) Increase Plasma Membrane Repair to Treat Muscular Dystrophy Models
Modified Antibody Fusion Proteins with Tripartite Motif Family Protein 72 (TRIM72) Increase Plasma Membrane Repair to Treat Muscular Dystrophy Models
Coffee Available
4:30–5:00 PM
Quandary Peak
Lysosome Homeostasis and Lysosome-Directed Drug Discovery
5:00–6:45 PM
Grays Peak
Haoxing Xu, Zhejiang University
Molecular Physiology of Lysosomes
Molecular Physiology of Lysosomes
Hijai Regina Shin, University of Texas Southwestern Medical Center
Lysosome Cholesterol Signaling in Neuronal Health and Disease
Lysosome Cholesterol Signaling in Neuronal Health and Disease
Gilbert Di Paolo, Denali Therapeutics Inc.
Leveraging a Transferrin Receptor-Based Transport Vehicle for Lysosomal Enzyme/Protein Replacement Therapy in Neurodegenerative Diseases
Leveraging a Transferrin Receptor-Based Transport Vehicle for Lysosomal Enzyme/Protein Replacement Therapy in Neurodegenerative Diseases
Jay Xiaojun Tan, University of Pittsburgh
Short Talk: Directional ER-to-Lysosome Lipid Transfer Mediates Lysosomal Vacuolation
Short Talk: Directional ER-to-Lysosome Lipid Transfer Mediates Lysosomal Vacuolation
Meeting Wrap-Up: Outcomes and Future Directions
6:45–7:00 PM
Grays Peak
Social Hour with Dinner
7:00–8:00 PM
Quandary Peak
Entertainment
8:00–9:00 PM
Quandary Peak
Cash Bar
8:00–9:00 PM
Quandary Peak
Friday, February 6, 2026
Departure
12:00–11:59 PM
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