Decoding HIV Persistence: Strategies for Curing HIV Infection
Apr 16–19, 2026 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers:
Mathias Lichterfeld, Afam Okoye, Marina F. Caskey, and Caroline T. Tiemessen
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Apr 16–19, 2026 | Beaver Run Conference Center, Breckenridge, CO, United States
Scientific Organizers: Mathias Lichterfeld, Afam Okoye, Marina F. Caskey, and Caroline T. Tiemessen
Mathias Lichterfeld, MD
Brigham and Women's Hospital
Afam Okoye, PhD
Oregon Health & Science University
Marina F. Caskey, MD
Rockefeller University
Caroline T. Tiemessen, PhD
National Institute for Communicable Diseases
Available Formats:
Supported by:
Livestream
In Person
On Demand
***Meeting program subject to change.
Available Formats: = Livestream = In Person = On DemandThursday, April 16, 2026
Fundraising
Booking Function
Merchandise Options
Registration Options
Registration
4:00–8:00 PM
3rd Floor Foyer
Welcome Mixer
6:00–8:00 PM
3rd Floor Foyer
Friday, April 17, 2026
Breakfast
7:00–8:00 AM
Summit Gallery
Welcome Remarks (Joint)
8:00–8:10 AM
Breckenridge Ballroom
Keynote Address (Joint)
8:10–9:00 AM
Breckenridge Ballroom
Alexandra Trkola, University of Zürich
HIV Vaccines: Learning from the Swiss X-BNAb Cohort for Prevention and Cure
HIV Vaccines: Learning from the Swiss X-BNAb Cohort for Prevention and Cure
Immune Interventions Interfacing HIV Prevention and Cure (Joint)
9:00–11:30 AM
Breckenridge Ballroom
Mauricio A. Martins, University of Florida
Promoting Persistent bNAb Expression in NHPs through AAV-Mediated Gene Transfer
Promoting Persistent bNAb Expression in NHPs through AAV-Mediated Gene Transfer
Devi SenGupta, Gilead Sciences, Inc.
Long-acting ART in HIV Prevention and Cure
Long-acting ART in HIV Prevention and Cure
Leonidas Stamatatos, Fred Hutchinson Cancer Research Center
Vaccination of PLWH, using 426C Derived Immunogens
Vaccination of PLWH, using 426C Derived Immunogens
Cristina Ceriani, Emory University
Short Talk: Influence of SIV Gag Vaccination on CD8⁺ T Cell Immunity and SIV Viral Dynamics
Short Talk: Influence of SIV Gag Vaccination on CD8⁺ T Cell Immunity and SIV Viral Dynamics
Nicolas M Galvez Arriagada †, Ragon Institute of Mass General, MIT and Harvard
Short Talk: Vectored Delivery of bNAbs Prevents Rebound of Clinical HIV Isolate During Antiretroviral Therapy Interruption
Short Talk: Vectored Delivery of bNAbs Prevents Rebound of Clinical HIV Isolate During Antiretroviral Therapy Interruption
Coffee Break
9:30–9:50 AM
1st Floor Foyer
Award Recipient Acknowledgement
9:50–9:55 AM
Breckenridge Ballroom
Poster Setup
11:30–1:00 PM
Peaks 1 - 3
On Own for Lunch
11:30–5:00 PM
Poster Viewing
1:00–10:00 PM
Peaks 1 - 3
Symposia Spotlight 1
2:30–4:30 PM
Breckenridge Ballroom
Archana V. Boopathy, Gilead Sciences Inc
Combination of Ad5/MVA Vaccine with Immunomodulation Partially Prevents Rebound in Chronic SIVmac251-infected ART-suppressed Rhesus Macaques
Combination of Ad5/MVA Vaccine with Immunomodulation Partially Prevents Rebound in Chronic SIVmac251-infected ART-suppressed Rhesus Macaques
Patricia A Hahn †, Wertheim UF Scripps Institute
AAV-Vectored Delivery of eCD4-Ig and 10-1074 Enables Durable ART-Free Virologic Control in SHIV-Infected Rhesus Macaques
AAV-Vectored Delivery of eCD4-Ig and 10-1074 Enables Durable ART-Free Virologic Control in SHIV-Infected Rhesus Macaques
Chiara Hornung †, Univeristy Hospital Cologne
Long-Term Control of HIV-1 by AAVMYO-Mediated Expression of a Potent Broadly Neutralizing Antibody
Long-Term Control of HIV-1 by AAVMYO-Mediated Expression of a Potent Broadly Neutralizing Antibody
Chia Jung Li, Ragon Institute of Mass General, MIT, and Harvard
Epitope-Driven Fc Effector Functions of HIV-1 Broadly Neutralizing Antibodies are Enhanced via Fc Engineering
Epitope-Driven Fc Effector Functions of HIV-1 Broadly Neutralizing Antibodies are Enhanced via Fc Engineering
Kezia Singgih, The University of Melbourne
Vδ2+ T-Cells in the Presence of Zoledronate Can Clear HIV Productively and Latently Infected CD4+ T-Cells: A Novel Strategy for Off-the-Shelf Therapy
Vδ2+ T-Cells in the Presence of Zoledronate Can Clear HIV Productively and Latently Infected CD4+ T-Cells: A Novel Strategy for Off-the-Shelf Therapy
Christopher Stringham, Duke University
A Non-Neutralizing MPER Antibody Induced Durable CD8 T Cell-Mediated Plasma Viral Load Control in SHIV-Infected Rhesus Macaques
A Non-Neutralizing MPER Antibody Induced Durable CD8 T Cell-Mediated Plasma Viral Load Control in SHIV-Infected Rhesus Macaques
Hiroshi Takata, Oregon Health and Science University
Administration of the IL-15 Superagonist N-803 at the Time of ART Interruption Enhances NK and T Cell Proliferation And Activation Prior To Viral Rebound
Administration of the IL-15 Superagonist N-803 at the Time of ART Interruption Enhances NK and T Cell Proliferation And Activation Prior To Viral Rebound
Elena Vendrame †, Gilead Sciences, Inc
Safety, Pharmacokinetics, and Pharmacodynamics of Amtabafusp, a Bispecific T-Cell Engager, in Virologically Suppressed People with HIV-1
Safety, Pharmacokinetics, and Pharmacodynamics of Amtabafusp, a Bispecific T-Cell Engager, in Virologically Suppressed People with HIV-1
Coffee Available
4:30–5:00 PM
1st Floor Foyer
Immune Targeting of HIV-1 Reservoir Cells: Obstacles and Opportunities
5:00–7:00 PM
Breckenridge Ballroom
Brad Jones, Weill Cornell Medicine
HIV Reservoir Cell Resistance to Immune-Mediated Killing
HIV Reservoir Cell Resistance to Immune-Mediated Killing
Michel C. Nussenzweig, HHMI/Rockefeller University
HIV-1 Reservoir Dynamics
HIV-1 Reservoir Dynamics
Kiera L. Clayton, University of Massachusetts Medical School
NK Cell Targeting of the HIV Reservoir
NK Cell Targeting of the HIV Reservoir
Mihai L Azoitei, Duke University
Short Talk: A New Strategy to Eliminate HIV Infected Cells by Targeting HLA-E-peptide Complexes with Engineered Monoclonal Antibodies
Short Talk: A New Strategy to Eliminate HIV Infected Cells by Targeting HLA-E-peptide Complexes with Engineered Monoclonal Antibodies
David D. Ho †, Aaron Diamond AIDS Research Center (ADARC), Columbia University Medical Center
Short Talk: Activation of the HIV Latent Reservoir by a Bispecific Biological Construct and Elimination of Productively Infected Cells by a Pyroptotic Small Molecule
Short Talk: Activation of the HIV Latent Reservoir by a Bispecific Biological Construct and Elimination of Productively Infected Cells by a Pyroptotic Small Molecule
Social Hour with Dinner
7:00–8:00 PM
Summit Gallery
Poster Session 1
7:30–10:00 PM
Peaks 1 - 3
Saturday, April 18, 2026
Breakfast
7:00–8:00 AM
Summit Gallery
Tailoring Gene- and Cell-Therapy Approaches for HIV Cure: Promises and Pitfalls
8:00–11:00 AM
Breckenridge Ballroom
Afam Okoye, Oregon Health & Science University
Optimizing T Cell Responses for Post-ART Control
Optimizing T Cell Responses for Post-ART Control
James L. Riley, University of Pennsylvania
Immune-Based Cell Therapies
Immune-Based Cell Therapies
Lydie Trautmann, Military HIV Research Program
Therapeutic Vaccine Trials in Humans
Therapeutic Vaccine Trials in Humans
Daniel Dornbusch, Excision Bio Inc.
CRISPR for HIV Cure: Human Clinical Trial Data
CRISPR for HIV Cure: Human Clinical Trial Data
Sophie Sayettat, University Hospital Cologne
Short Talk: Durable Suppression of Viremia by Lipid Nanoparticle-Formulated mRNA Encoding for a Highly Potent HIV-1 Neutralizing Antibody
Short Talk: Durable Suppression of Viremia by Lipid Nanoparticle-Formulated mRNA Encoding for a Highly Potent HIV-1 Neutralizing Antibody
Yiming Yin, Boston Children's Hospital
Short Talk: In Vivo Affinity Maturation of Engineered B Cells Expressing HIV-1 bnAbs in Mice and Non-Human Primates
Short Talk: In Vivo Affinity Maturation of Engineered B Cells Expressing HIV-1 bnAbs in Mice and Non-Human Primates
Coffee Break
9:00–9:20 AM
1st Floor Foyer
Poster Setup
11:00–1:00 PM
Peaks 1 - 3
On Own for Lunch
11:00–5:00 PM
Poster Viewing
1:00–10:00 PM
Peaks 1 - 3
Panel: Perspectives: Personalized Medicine & Patient-Centered Strategies (Joint)
1:30–2:45 PM
Breckenridge Ballroom
Career Roundtable (Joint)
3:00–4:30 PM
Breckenridge Ballroom
Coffee Available
4:30–5:00 PM
1st Floor Foyer
Mechanisms of HIV Persistence: Insights and Innovations
5:00–7:00 PM
Breckenridge Ballroom
Mathias Lichterfeld, Brigham and Women's Hospital
Epigenetic Mechanisms of HIV Persistence
Epigenetic Mechanisms of HIV Persistence
Roy Matkovic, Université de Paris, Institut Cochin
The HUSH Complex and HIV Silencing
The HUSH Complex and HIV Silencing
Nomonde Bengu, Umkhuseli Innovations
Sex Differences in HIV Reservoir Cell Persistence
Sex Differences in HIV Reservoir Cell Persistence
Mirko Paiardini †, Emory University, ENPRC
Short Talk: Repeated Enhancement of Antiviral Immune Responses Via IL-10 and PD-1 Blockades Durably Controls Viral Rebound and the Intact Reservoir Following ART Interruption in SIV-Infected Rhesus Macaques
Short Talk: Repeated Enhancement of Antiviral Immune Responses Via IL-10 and PD-1 Blockades Durably Controls Viral Rebound and the Intact Reservoir Following ART Interruption in SIV-Infected Rhesus Macaques
Katharine J Bar, University of Pennsylvania
Short Talk: Early ART and Autologous Neutralizing Antibodies Shape the HIV Reservoir and Rebound Virus Populations in an NHP Model of BnAb Therapy
Short Talk: Early ART and Autologous Neutralizing Antibodies Shape the HIV Reservoir and Rebound Virus Populations in an NHP Model of BnAb Therapy
Social Hour with Dinner
7:00–8:00 PM
Summit Gallery
Poster Session 2
7:30–10:00 PM
Peaks 1 - 3
Sunday, April 19, 2026
Breakfast
7:00–8:00 AM
Summit Gallery
No One Left Behind: HIV Cure Research Across the Age Continuum
8:00–11:00 AM
Breckenridge Ballroom
Caroline T. Tiemessen, National Institute for Communicable Diseases
HIV Immune Responses Across the Age Spectrum
HIV Immune Responses Across the Age Spectrum
Deborah Persaud, Johns Hopkins University School of Medicine
HIV Remission in Infants
HIV Remission in Infants
Roger Shapiro, Harvard School of Public Health
Triple Combinations of Broadly-Neutralizing Antibodies in Children
Triple Combinations of Broadly-Neutralizing Antibodies in Children
Catherine K Koofhethile, Botswana Harvard Health Partnership
Viral Reservoirs and Immune Responses in Adolescents and Young Adults with HIV
Viral Reservoirs and Immune Responses in Adolescents and Young Adults with HIV
Siddappa Byrareddy †, University of Nebraska Medical Center
Short Talk: Aging-Associated Expansion of HIV/SIV Reservoirs
Short Talk: Aging-Associated Expansion of HIV/SIV Reservoirs
Edna Ferreira †, Johns Hopkins University
Short Talk: Sex-Based Differences in HIV and SIV Cellular Reservoirs
Short Talk: Sex-Based Differences in HIV and SIV Cellular Reservoirs
Coffee Break
9:00–9:20 AM
1st Floor Foyer
On Own for Lunch
11:00–5:00 PM
Meet the Editors (Joint)
1:15–2:15 PM
Breckenridge Ballroom
Symposia Spotlight 2
2:30–4:30 PM
Breckenridge Ballroom
Catarina P Ananias Saez †, Northwestern University
A 3D Human Intestinal Organoid Model Reveals Gut-Driven Inhibition of HIV Transcription
A 3D Human Intestinal Organoid Model Reveals Gut-Driven Inhibition of HIV Transcription
Deanna A. Kulpa, Emory University
Bcl-2 Inhibition Decreases the Established Intact Reservoir in SIV-infected, ART-Suppressed Rhesus Macaques
Bcl-2 Inhibition Decreases the Established Intact Reservoir in SIV-infected, ART-Suppressed Rhesus Macaques
Ayisha Mahama †, University of South Dakota
HIV gp120 Selectively Activates the IRE1α–XBP1 Pathway to Drive Microglial Inflammation
HIV gp120 Selectively Activates the IRE1α–XBP1 Pathway to Drive Microglial Inflammation
Grace Marshall, University of Miami
Assessing the Chronicity of the HIV-1 Myeloid Reservoir
Assessing the Chronicity of the HIV-1 Myeloid Reservoir
JC Mudd, Tulane national biomedical research center
SIV and HIV-1 Proviruses are Preferentially Enriched in Genes that Become Down-Regulated upon CD4 T Cell Proliferation
SIV and HIV-1 Proviruses are Preferentially Enriched in Genes that Become Down-Regulated upon CD4 T Cell Proliferation
Alexander O. Pasternak, Amsterdam UMC
Majority of Infected Cells in Peripheral Blood of PWH on ART Transcribe Cell-Associated HIV-1 gag RNA
Majority of Infected Cells in Peripheral Blood of PWH on ART Transcribe Cell-Associated HIV-1 gag RNA
Julia Prigann †, Gladstone Institutes
Multimodal Silencing of HIV-1 Transcription by Human KRAB-Zinc Finger Proteins
Multimodal Silencing of HIV-1 Transcription by Human KRAB-Zinc Finger Proteins
Zoe R. Wallace, Immunocore
TCR Labelling for Detection of HIV Reservoir Cells by Flow Cytometry
TCR Labelling for Detection of HIV Reservoir Cells by Flow Cytometry
Coffee Available
4:30–5:00 PM
1st Floor Foyer
B Cell Responses and Broadly-Neutralizing Antibodies: Trials and Tribulations (Joint)
5:00–6:45 PM
Breckenridge Ballroom
Marina F. Caskey, Rockefeller University
Combined Immunotherapy with IL-15 Agonists and Broadly-Neutralizing Antibodies
Combined Immunotherapy with IL-15 Agonists and Broadly-Neutralizing Antibodies
Paula M. Cannon, University of Southern California, Keck School of Medicine
Engineering B Cells as in vivo bnAb Factories
Engineering B Cells as in vivo bnAb Factories
William Schief, Moderna, Scripps, and IAVI
Combining Germline Targeting Approaches Across Diverse bNAb Epitopes
Combining Germline Targeting Approaches Across Diverse bNAb Epitopes
Meeting Wrap-Up: Outcomes and Future Directions (Organizers)
6:45–7:00 PM
Breckenridge Ballroom
Social Hour with Dinner
7:00–8:00 PM
Summit Gallery
Entertainment
8:00–9:00 PM
Colorado Ballroom
Cash Bar
8:00–9:00 PM
Peaks 1 - 3
Monday, April 20, 2026
Departure
12:00–11:59 PM
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